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1. 发明授权

US12111443B2 Method for making photochromic contact lenses 有权
公开(公告)号：US12111443B2
公开(公告)日：2024-10-08
申请号：US17688041
申请日：2022-03-07
申请人： Alcon Inc.
发明人： Michelle Plavnik , Richard Charles Breitkopf , Steve Yun Zhang , Zahra Bassampour , Chandana Kolluru
IPC分类号： G02B1/04 , B29D11/00 , B29K83/00 , B29K105/00 , C08G77/20 , C08L83/04 , G02C7/04 , G02C7/10
CPC分类号： G02B1/043 , B29D11/00057 , B29D11/00067 , B29D11/00134 , B29D11/00192 , C08G77/20 , C08L83/04 , G02C7/04 , G02C7/102 , G02C7/108 , B29K2083/00 , B29K2105/0061 , B29K2995/0018 , C08L2201/10 , C08L2203/02 , C08L2312/00 , G02B2207/109
摘要： Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying a first polymerizable fluid composition containing at least one photochromic compound on a central portion of the molding surface of a female mold half to form a circular layer; partially photocuring, in situ, the circular layer in the female mold half by using a visible light; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of thermally curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the molding surfaces of the female mold half and a male mold half.

2. 发明公开

US20230406995A1 OPHTHALMIC DEVICES CONTAINING LOCALIZED GRAFTED NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20230406995A1
公开(公告)日：2023-12-21
申请号：US18457455
申请日：2023-08-29
申请人： Johnson & Johnson Vision Care, Inc.
发明人： Brian Aitken , Charles W. Scales , Joe M. Wood , Michael F. Widman
IPC分类号： C08G18/61 , G02B1/04 , C08G18/04 , C08G18/62 , B29D11/00 , C08L51/08 , G02C7/04 , C08F290/06
CPC分类号： C08G18/61 , G02B1/043 , C08G18/04 , C08G18/6225 , B29D11/00067 , C08L51/085 , G02C7/04 , C08F290/068 , B29D11/00076 , C08G2270/00
摘要： Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator; (c) contacting the crosslinked substrate network with a grafting composition containing one or more ethylenically unsaturated compounds, wherein the contacting is conducted under conditions such that the grafting composition penetrates into the crosslinked substrate network; and (d) activating the covalently bound activatable free radical initiator at one or more selective regions of the crosslinked substrate network such that the grafting composition polymerizes with the crosslinked substrate network at the selective regions.

3. 发明公开

US20230158760A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开
公开(公告)号：US20230158760A1
公开(公告)日：2023-05-25
申请号：US17991174
申请日：2022-11-21
申请人： Alcon Inc.
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C09D177/06
CPC分类号： B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C09D177/06 , G02B1/10 , G02B1/18 , G02B1/043 , G02C7/049 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , G02C2202/06 , G02C2202/16
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a watersoluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

4. 发明授权

US10502977B2 Medical device with pre-defined space and related methods 有权
公开(公告)号：US10502977B2
公开(公告)日：2019-12-10
申请号：US15509479
申请日：2015-09-22
申请人： EP Global Communications, Inc.
发明人： David T. Markus , Michael C. Hayes , Arthur Back , Victoria Tran , Rachel Marullo
IPC分类号： G02C7/04 , B29D11/00 , G02B1/04 , B29K83/00 , B29K105/16
CPC分类号： G02C7/049 , B29D11/00048 , B29D11/00067 , B29D11/00134 , G02B1/043 , B29K2083/00 , B29K2105/16 , B29K2995/0018
摘要： A medical device including a pre-defined space such as a geometric shape or void. In one approach, the pre-defined space provides desired rigidity and more comfort for a user. There is also provided an approach which enables engravings and accommodates electronics, mechanical objects, or other rigid or unique shapes to be embedded within a medical device such as a contact lens. When adapted to swellable substrates, the resulting swelled material can leave a gap around a perimeter of embedded structure.

5. 发明授权

US09810812B2 Method for producing contact lenses with durable lubricious coatings thereon 有权
公开(公告)号：US09810812B2
公开(公告)日：2017-11-07
申请号：US15249587
申请日：2016-08-29
申请人： Novartis AG
发明人： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
IPC分类号： G02C7/00 , G02C7/02 , G02C7/04 , G02B1/04 , C08J7/12 , B29D11/00
CPC分类号： G02B1/043 , B29D11/00048 , B29D11/00067 , B29D11/00125 , C08J7/123 , C08J2383/08 , C08J2433/02 , C08J2471/00 , C08J2477/00
摘要： The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

6. 发明申请

US20170038499A1 COMPOSITION FOR MANUFACTURING CONTACT LENSES AND METHOD FOR MANUFACTURING CONTACT LENSES BY USING THE SAME 审中-公开
标题翻译：用于制造接触透镜的组合物和使用其制造接触透镜的方法
公开(公告)号：US20170038499A1
公开(公告)日：2017-02-09
申请号：US15297163
申请日：2016-10-19
申请人： BenQ Materials Corporation
发明人： Fan-Dan JAN
IPC分类号： G02B1/04 , B29D11/00 , C08G77/388 , C08F230/08 , C08F226/10
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00067 , B29K2039/06 , B29K2083/00 , B29K2105/00 , B29K2105/0002 , B29K2105/0005 , B29K2105/24 , B29K2995/0092 , C08F226/10 , C08F230/08 , C08G77/38 , C08G77/388 , C08L83/04 , C08L83/08 , C08L101/14 , C08F226/08 , C08F220/20 , C08F2222/1013
摘要： Methods for manufacturing contact lenses are provided. In an embodiment, the method includes mixing a siloxane macromer represented by the following formula (I), a hydrophilic monomer, a crosslinking agent or a siloxane macromer represented by the following formula (II), and an initiator to form a mixture. Then the mixture is injected into a mold of contact lens and heated to form contact lenses. The formula (I) and the formula (II) are shown respectively as the following: wherein R1, R2 and R3 are independently C1-C4 alkyl groups, R4 is C1-C6 alkyl group, R5 is a residue obtained by removing NCO group from an aliphatic or aromatic diisocyanate, R6 and R7 are independently alkylene groups, and n is an integer of 4-80, m is an integer of 3-40. wherein p is an integer of 4-80 and q is an integer of 3-40.
摘要翻译：其中p是4-80的整数，q是3-40的整数。

7. 发明授权

US09539761B2 Process, device and composite part for manufacturing a hybrid lens 有权
标题翻译：用于制造混合透镜的工艺，器件和复合部件
公开(公告)号：US09539761B2
公开(公告)日：2017-01-10
申请号：US14234858
申请日：2012-08-14
申请人： Emmanuel Veillard
发明人： Emmanuel Veillard
IPC分类号： B29D11/00 , B29C65/00 , G02B1/04 , G02C7/04 , B29C65/48
CPC分类号： B29C66/9532 , B29C65/48 , B29D11/00 , B29D11/00038 , B29D11/00048 , B29D11/00067 , B29D11/00259 , G02B1/043 , G02C7/049 , Y10T156/125
摘要： The present invention relates to a process and to a device for manufacturing a hybrid contact lens (7, 21), from a composite part formed of a rigid central portion connected to a soft peripheral portion (9, 23) by an adhesive material (10, 24), to such a part and to such a lens. Starting from an oxygen-permeable rigid disc (2) and from a previously hydrated hydrophilic soft disc (3), a composite part (1) comprising three superposed layers is formed by bonding one disc to the other, said composite part (1) is dried for a defined time sufficient to allow the dehydration of the soft disc, then said composite part is dry cut with a machining tool by presenting the face of the hydrophilic soft portion (3) toward the tool in order to obtain the hybrid lens, by making a release strip (26) on the outer circumference (27) of the rigid peripheral portion.
摘要翻译：本发明涉及一种制造复合隐形眼镜（7,21）的方法和装置，该复合隐形眼镜从由刚性中心部分形成的复合部分形成，所述刚性中心部分通过粘合材料（10,21）连接到软周边部分（9,23），24），到这样的部分和这样的镜头。从透氧刚性盘（2）和预先水合的亲水性软盘（3）开始，通过将一个盘粘合到另一个上而形成包括三个重叠层的复合部件（1），所述复合部件（1）是干燥规定的时间足以允许软盘脱水，然后通过使亲水软部分（3）的表面朝向工具将所述复合部件用机械工具进行干式切割，以获得混合透镜，通过在刚性周边部分的外周（27）上形成释放带（26）。

8. 发明授权

US09523793B2 Composition for manufacturing contact lenses and method for manufacturing contact lenses by using the same 有权
公开(公告)号：US09523793B2
公开(公告)日：2016-12-20
申请号：US13488420
申请日：2012-06-04
申请人： Fan-Dan Jan
发明人： Fan-Dan Jan
IPC分类号： G02B1/04 , C08L83/00 , C08F230/08 , C08G77/38 , C08G77/388 , B29D11/00 , B29K83/00 , B29K105/00 , B29K105/24
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00067 , B29K2039/06 , B29K2083/00 , B29K2105/00 , B29K2105/0002 , B29K2105/0005 , B29K2105/24 , B29K2995/0092 , C08F226/10 , C08F230/08 , C08G77/38 , C08G77/388 , C08L83/04 , C08L83/08 , C08L101/14 , C08F226/08 , C08F220/20 , C08F2222/1013
摘要： A composition is provided for manufacturing contact lenses including a siloxane macromer represented by the following formula (I): wherein R1, R2 and R3 are independently C1-C4 alkyl groups, R4 is C1-C6 alkyl group, R5 is a residue obtained by removing NCO group from an aliphatic or aromatic diisocyanate, R6 and R7 are independently alkylene groups, and n is an integer of about 4-80, m is an integer of about 3-40; a crosslinking agent or a siloxane macromer represented by the following formula (II), wherein p is an integer of 4-80 and q is an integer of 3-40: and an initiator.

9. 发明授权

US08944592B2 Silicone hydrogel lens with a crosslinked hydrophilic coating 有权
标题翻译：硅胶水凝胶透镜与交联的亲水涂层
公开(公告)号：US08944592B2
公开(公告)日：2015-02-03
申请号：US13948206
申请日：2013-07-23
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/00 , G02C7/02 , G02B1/04 , G02C7/04
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译：本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成，和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

10. 发明申请

US20140185005A1 COMFORTABLE OPHTHALMIC DEVICE AND METHODS OF ITS PRODUCTION 审中-公开
标题翻译：舒适的眼镜装置及其生产方法
公开(公告)号：US20140185005A1
公开(公告)日：2014-07-03
申请号：US14196006
申请日：2014-03-04
申请人： Johnson & Johnson Vision Care, Inc.
发明人： Kevin P. McCabe , Robert B. Steffen , Hélène Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie Wong Meyers , Douglas G. Vanderlaan , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill
IPC分类号： G02C13/00 , G02B1/04
CPC分类号： G02B1/043 , A61L12/04 , A61L12/08 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/452 , B29D11/00067 , B29K2039/06 , G02C7/049 , G02C13/00
摘要： This invention relates to comfortable ophthalmic devices and methods of producing such devices.
摘要翻译：本发明涉及舒适的眼科装置及其制造方法。

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