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1. 发明申请

US20080300642A1 REGENERATION TREATMENT APPARATUS, OPERATING METHOD THEREOF, AND REGENERATION TREATMENT METHOD 审中-公开
标题翻译：再生处理装置，其操作方法和再生处理方法
公开(公告)号：US20080300642A1
公开(公告)日：2008-12-04
申请号：US12129360
申请日：2008-05-29
申请人： Masashi INAGAKI , Masaru SUGIMACHI , Meihua LI , Can ZHENG , Masatoshi KOBAYASHI , Kazuo SHIMIZU
发明人： Masashi INAGAKI , Masaru SUGIMACHI , Meihua LI , Can ZHENG , Masatoshi KOBAYASHI , Kazuo SHIMIZU
IPC分类号： A61N1/362
CPC分类号： A61N1/36114
摘要： The cell viability in cell transplantation is improved so as to achieve sufficient repair of organ. There is provided a regeneration treatment apparatus comprising: a heart rate detector which detects a heart rate of a patient; a memory part which stores a heart rate prior to stimulation; stimulating electrodes which stimulate a vagus nerve that controls an organ having transplanted cells; and a control unit which controls an intensity of a stimulation signal to be output from the stimulating electrodes to the vagus nerve so that the heart rate of the patient detected by the heart rate detector is decreased by 5 to 20% as compared to the state prior to the stimulation.
摘要翻译：改善细胞移植中的细胞活力，以达到器官的充分修复。提供了一种再生处理装置，包括：心率检测器，其检测患者的心率; 存储部，其在刺激之前存储心率; 刺激电极，其刺激控制具有移植细胞的器官的迷走神经; 以及控制单元，其控制从刺激电极输出到迷走神经的刺激信号的强度，使得由心率检测器检测到的患者的心率与先前状态相比降低5至20％刺激。

2. 发明申请

US20080139958A1 SOLID TISSUE IMPEDANCE ESTIMATING METHOD, CARDIAC OUTPUT CALCULATING METHOD, PULMONARY ARTERY WEDGE PRESSURE CALCULATING METHOD, CARDIAC OUTPUT MONITORING DEVICE, CARDIAC OUTPUT MONITORING SYSTEM, PULMONARY ARTERY WEDGE PRESSURE MONITORING DEVICE, AND PULMONARY ARTERY WEDGE PRESSURE MONITORING SYSTEM 有权
标题翻译：固体组织阻抗估计方法，心脏输出计算方法，脉搏动力学压力计算方法，心脏输出监测装置，心脏输出监测系统，脉搏血压计压力监测装置和脉动血压计压力监测系统
公开(公告)号：US20080139958A1
公开(公告)日：2008-06-12
申请号：US11950169
申请日：2007-12-04
申请人： Kazunori UEMURA , Masashi INAGAKI , Masaru SUGIMACHI , Kazuo SHIMIZU , Masatoshi KOBAYASHI
发明人： Kazunori UEMURA , Masashi INAGAKI , Masaru SUGIMACHI , Kazuo SHIMIZU , Masatoshi KOBAYASHI
IPC分类号： A61B5/053
CPC分类号： A61B5/029 , A61B5/0295 , A61B5/053
摘要： A practical method for estimating cardiac output and pulmonary artery wedge pressure with good accuracy is provided. The present invention provides a method for estimating the impedance arising from solid tissue by determining the impedance at the intersection between the line of identity and the extrapolated regression line, where the regression line is obtained by linearly regressing the maximum value to the minimum value of the impedance signal of each of multiple data sets, where each data set contains the maximum value and the minimum value of the impedance signal during one cardiac cycle, where impedance signal is obtained between a can electrode implanted in the left thoracic wall and an electrode inserted into the coronary vein, over a specific period of time following the infusion of hypertonic saline into the pulmonary circulation.
摘要翻译：提供了一种准确估计心输出量和肺动脉楔形压力的实用方法。本发明提供一种用于通过确定身份行与外推回归线之间的交叉点处的阻抗来估计由固体组织产生的阻抗的方法，其中回归线通过将最大值线性回归到最小值多个数据组中的每一个的阻抗信号，其中每个数据集包含在一个心动周期期间的阻抗信号的最大值和最小值，其中在插入左胸壁的罐电极和插入到左胸壁的电极之间获得阻抗信号冠状静脉，在高渗盐水输入肺循环后的特定时间段内。

3. 发明申请

US20080319502A1 CARDIAC PACING SYSTEM AND DISTRIBUTED CARDIAC PACING SYSTEM 有权
标题翻译： CARDIAC PACING系统和分布式CARDIAC PACING系统
公开(公告)号：US20080319502A1
公开(公告)日：2008-12-25
申请号：US12103011
申请日：2008-04-15
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Masashi INAGAKI
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Masashi INAGAKI
IPC分类号： A61N1/365
CPC分类号： A61N1/37288 , A61N1/368 , A61N1/37205 , A61N1/3756 , A61N1/3785 , H01M8/16 , Y02E60/527
摘要： A micro integrated cardiac pacemaker includes a control unit for outputting a control signal according to cardiograph information, heart stimulating means for stimulating heart tissue in response to the control signal, cardiograph information extracting means for extracting cardiograph information and outputting it to the control unit, and a power supply unit for supplying drive power. The power supply unit is a biological fuel cell that takes out electrons by oxidation of a biological fuel. The biological fuel cell includes an anode and a cathode. An oxidase of a biological fuel and a mediator are immobilized on the cathode. Blood and/or body fluid are used as an electrolytic solution, and a biological fuel and oxygen in the blood and/or the fluid are used. The biological fuel cell is attached to the end of a catheter and implanted into the heart, and the catheter is withdrawn, without incising the breast.
摘要翻译：微型集成心脏起搏器包括：用于根据心电图信息输出控制信号的控制单元，响应于控制信号刺激心脏组织的心脏刺激装置;心电图仪信息提取装置，用于提取心电图信息并将其输出到控制单元;以及用于提供驱动电力的电源单元。电源单元是通过生物燃料的氧化而取出电子的生物燃料电池。生物燃料电池包括阳极和阴极。生物燃料和介体的氧化酶固定在阴极上。使用血液和/或体液作为电解液，并且使用血液和/或流体中的生物燃料和氧气。生物燃料电池连接到导管的末端并植入心脏，导管被取出，而不会切开乳房。

4. 发明申请

US20110144714A1 BLOOD PRESSURE REGULATING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION 有权
标题翻译：血液压力调节系统采用生物生物学调节功能
公开(公告)号：US20110144714A1
公开(公告)日：2011-06-16
申请号：US13032923
申请日：2011-02-23
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： A blood pressure regulating system uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising at least one blood pressure sensing means which senses blood pressure and outputs a input blood pressure signal, a calculating means which receives the input blood pressure signal, calculates a transfer function by computing a Fourier transform of a normal blood pressure signal and a normal sympathetic nerve activity from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a sympathetic nerve stimulation signal using a convolution integral between the input blood pressure signal and the impulse response, and outputs the sympathetic nerve stimulation signal, and a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.
摘要翻译：血压调节系统使用天然调节规则来估计响应于血压变化的至少一个神经活动，包括至少一个感测血压并输出输入血压信号的血压感测装置，接收所述血压调节系统的计算装置输入血压信号，通过计算正常血压信号的傅立叶变换和正常心血管系统的正常交感神经活动计算传递函数，通过计算转移函数的傅里叶逆变换计算脉冲响应，计算交感神经刺激信号使用输入血压信号和脉冲响应之间的卷积积分，并输出交感神经刺激信号，以及刺激装置，其接收交感神经刺激信号，并且刺激基于交感神经支配血管的交感神经刺激信号使血压受到调节。

5. 发明申请

US20110144710A1 CARDIAC PACING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION 有权
标题翻译： CARDIAC PACING系统通过取代原生态生物监管功能
公开(公告)号：US20110144710A1
公开(公告)日：2011-06-16
申请号：US13030200
申请日：2011-02-18
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： The present invention provides a cardiac pacing system based on biological activities, comprising: a) at least one nerve activity sensing means which senses nerve activity of a cardiac sympathetic nerve and/or a vagal nerve, and outputs a plurality of input nerve activity signals; b) a calculating means which receives the input nerve activity signals, calculates a transfer function by computing a Fourier transform of normal nerve activity signals and a normal heart rate signal from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of pacing signals for control of a heart rate using a convolution integral between the input nerve activity signals and the impulse response, and outputs the pacing signals; and c) a pacing means which receives the pacing signals, and stimulates the heart based on the pacing signals such that heart rate is regulated.
摘要翻译：本发明提供一种基于生物活性的心脏起搏系统，包括：a）至少一个感测心脏交感神经和/或迷走神经神经活动的神经活动感测装置，并输出多个输入神经活动信号; b）接收输入神经活动信号的计算装置，通过计算正常神经活动信号的傅立叶变换和来自正常心血管系统的正常心率信号来计算传递函数，通过计算脉冲响应来计算脉冲响应传递函数，使用输入的神经活动信号和脉冲响应之间的卷积积分来计算多个起搏信号用于控制心率，并输出起搏信号; 以及c）起搏装置，其接收起搏信号，并且基于起搏信号刺激心脏使心率得到调节。

6. 发明申请

US20080215107A1 CARDIAC PACING SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATMENT SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION 有权
标题翻译： CARDIAC PACING系统，血压调节系统，以及通过采用原生生物监管功能的心脏病治疗系统
公开(公告)号：US20080215107A1
公开(公告)日：2008-09-04
申请号：US12103786
申请日：2008-04-16
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.
摘要翻译：一种基于生物活性的医疗处理系统，其特征在于用于感测由生物活性产生的生物活性信息并输出生物活性信号的生物活性检测装置，用于接收，分析和处理来自生物活性检测装置的生物活性信号的计算装置，计算生物体刺激信号，并输出生物体刺激信号，以及生物体刺激装置，用于接收由计算装置计算的生物体刺激信号，并根据生物体刺激信号刺激生物体。还公开了一种基于治疗系统，血压调节系统和心脏疾病治疗系统的心脏起搏系统。

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