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1. 发明申请

US20110098767A1 SYSTEM FOR AUTOMATICALLY MINIMIZING CARDIAC OXYGEN CONSUMPTION AND CARDIAC DISEASE TREATING SYSTEM USING THE SAME 有权
标题翻译：使用相同方法自动最小化心脏氧化消耗和心脏疾病治疗系统
公开(公告)号：US20110098767A1
公开(公告)日：2011-04-28
申请号：US12279753
申请日：2007-02-16
申请人： Masaru Sugimachi , Kazunori Uemura , Atsunori Kamiya , Kenji Sunagawa , Michio Yamaji
发明人： Masaru Sugimachi , Kazunori Uemura , Atsunori Kamiya , Kenji Sunagawa , Michio Yamaji
IPC分类号： A61N1/365
CPC分类号： A61B5/0215 , A61B5/029 , A61B5/4866 , A61N1/36557
摘要： [PROBLEMS] A system for automatically minimizing cardiac oxygen consumption that is capable of estimating a patient's amount of cardiac oxygen consumption with high accuracy and moreover capable of minimizing the amount of cardiac oxygen consumption and a cardiac disease treating system are provided.[MEANS FOR SOLVING PROBLEMS] The cardiac disease treating system 10 comprises an input part 12 for inputting a patient's 20 indexes of kinetics of blood circulation including at least heart rate, a cardiac oxygen consumption calculation monitor unit 14 for calculating the estimated value of said patient's 20 amount of cardiac oxygen consumption based on the indexes of kinetics of blood circulation input from the input part 12, and a cardiac oxygen consumption curtailment unit 16 for comparing the heart rate input from the input part 12 and the critical heart rate minimizing the estimated value of amount of cardiac oxygen consumption calculated by the cardiac oxygen consumption monitor unit 14 and controlling the patient's 20 heart rate in conformity with the results of this comparison.
摘要翻译： [问题]提供一种用于自动最小化心脏氧消耗的系统，其能够以高精度估计患者的心脏耗氧量并且还能够最小化心脏氧消耗量和心脏疾病治疗系统。解决问题的手段心脏病治疗系统10包括：输入部12，用于输入至少包括心率的患者的血液循环动力学20个指标;心脏耗氧量计算监测单元14，用于计算所述患者的心率的估计值; 基于从输入部分12输入的血液循环动力学指标的20个心脏耗氧量和用于比较从输入部分12输入的心率和将估计值最小化的临界心率的心脏耗氧量削减单元16 由心脏氧消耗监测单元14计算的心脏氧消耗量，并根据该比较的结果控制患者的20个心率。

2. 发明授权

US08262581B2 Solid tissue impedance estimating method, cardiac output calculating method, pulmonary artery wedge pressure calculating method, cardiac output monitoring device, cardiac output monitoring system, pulmonary artery wedge pressure monitoring device, and pulmonary artery wedge pressure monitoring system 有权
标题翻译：固体组织阻抗估计方法，心输出量计算方法，肺动脉楔压计算方法，心输出量监测装置，心输出量监测系统，肺动脉楔压监测装置和肺动脉楔压监测系统
公开(公告)号：US08262581B2
公开(公告)日：2012-09-11
申请号：US11950169
申请日：2007-12-04
申请人： Kazunori Uemura , Masashi Inagaki , Masaru Sugimachi , Kazuo Shimizu , Masatoshi Kobayashi
发明人： Kazunori Uemura , Masashi Inagaki , Masaru Sugimachi , Kazuo Shimizu , Masatoshi Kobayashi
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/0295 , A61B5/053
摘要： A practical method for estimating cardiac output and pulmonary artery wedge pressure with good accuracy is provided. A method is provided for estimating the impedance arising from solid tissue by determining the impedance at the intersection between the line of identity and the extrapolated regression line, where the regression line is obtained by linearly regressing the maximum value to the minimum value of the impedance signal of each of multiple data sets, where each data set contains the maximum value and the minimum value of the impedance signal during one cardiac cycle, where impedance signal is obtained between a can electrode implanted in the left thoracic wall and an electrode inserted into the coronary vein, over a specific period of time following the infusion of hypertonic saline into the pulmonary circulation.
摘要翻译：提供了一种准确估计心输出量和肺动脉楔形压力的实用方法。提供了一种用于通过确定身份线与外推回归线之间的交叉点处的阻抗来估计由固体组织产生的阻抗的方法，其中回归线通过将最大值线性回归到阻抗信号的最小值而获得其中每个数据集包含在一个心动周期期间的阻抗信号的最大值和最小值，其中在植入在左胸壁的罐电极和插入冠状动脉的电极之间获得阻抗信号在输注高渗盐水进入肺循环后的特定时间段内静脉。

3. 发明申请

US20110144714A1 BLOOD PRESSURE REGULATING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION 有权
标题翻译：血液压力调节系统采用生物生物学调节功能
公开(公告)号：US20110144714A1
公开(公告)日：2011-06-16
申请号：US13032923
申请日：2011-02-23
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： A blood pressure regulating system uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising at least one blood pressure sensing means which senses blood pressure and outputs a input blood pressure signal, a calculating means which receives the input blood pressure signal, calculates a transfer function by computing a Fourier transform of a normal blood pressure signal and a normal sympathetic nerve activity from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a sympathetic nerve stimulation signal using a convolution integral between the input blood pressure signal and the impulse response, and outputs the sympathetic nerve stimulation signal, and a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.
摘要翻译：血压调节系统使用天然调节规则来估计响应于血压变化的至少一个神经活动，包括至少一个感测血压并输出输入血压信号的血压感测装置，接收所述血压调节系统的计算装置输入血压信号，通过计算正常血压信号的傅立叶变换和正常心血管系统的正常交感神经活动计算传递函数，通过计算转移函数的傅里叶逆变换计算脉冲响应，计算交感神经刺激信号使用输入血压信号和脉冲响应之间的卷积积分，并输出交感神经刺激信号，以及刺激装置，其接收交感神经刺激信号，并且刺激基于交感神经支配血管的交感神经刺激信号使血压受到调节。

4. 发明申请

US20110144710A1 CARDIAC PACING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION 有权
标题翻译： CARDIAC PACING系统通过取代原生态生物监管功能
公开(公告)号：US20110144710A1
公开(公告)日：2011-06-16
申请号：US13030200
申请日：2011-02-18
申请人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
发明人： Kenji SUNAGAWA , Masaru SUGIMACHI , Takayuki SATO
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： The present invention provides a cardiac pacing system based on biological activities, comprising: a) at least one nerve activity sensing means which senses nerve activity of a cardiac sympathetic nerve and/or a vagal nerve, and outputs a plurality of input nerve activity signals; b) a calculating means which receives the input nerve activity signals, calculates a transfer function by computing a Fourier transform of normal nerve activity signals and a normal heart rate signal from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of pacing signals for control of a heart rate using a convolution integral between the input nerve activity signals and the impulse response, and outputs the pacing signals; and c) a pacing means which receives the pacing signals, and stimulates the heart based on the pacing signals such that heart rate is regulated.
摘要翻译：本发明提供一种基于生物活性的心脏起搏系统，包括：a）至少一个感测心脏交感神经和/或迷走神经神经活动的神经活动感测装置，并输出多个输入神经活动信号; b）接收输入神经活动信号的计算装置，通过计算正常神经活动信号的傅立叶变换和来自正常心血管系统的正常心率信号来计算传递函数，通过计算脉冲响应来计算脉冲响应传递函数，使用输入的神经活动信号和脉冲响应之间的卷积积分来计算多个起搏信号用于控制心率，并输出起搏信号; 以及c）起搏装置，其接收起搏信号，并且基于起搏信号刺激心脏使心率得到调节。

5. 发明申请

US20080139958A1 SOLID TISSUE IMPEDANCE ESTIMATING METHOD, CARDIAC OUTPUT CALCULATING METHOD, PULMONARY ARTERY WEDGE PRESSURE CALCULATING METHOD, CARDIAC OUTPUT MONITORING DEVICE, CARDIAC OUTPUT MONITORING SYSTEM, PULMONARY ARTERY WEDGE PRESSURE MONITORING DEVICE, AND PULMONARY ARTERY WEDGE PRESSURE MONITORING SYSTEM 有权
标题翻译：固体组织阻抗估计方法，心脏输出计算方法，脉搏动力学压力计算方法，心脏输出监测装置，心脏输出监测系统，脉搏血压计压力监测装置和脉动血压计压力监测系统
公开(公告)号：US20080139958A1
公开(公告)日：2008-06-12
申请号：US11950169
申请日：2007-12-04
申请人： Kazunori UEMURA , Masashi INAGAKI , Masaru SUGIMACHI , Kazuo SHIMIZU , Masatoshi KOBAYASHI
发明人： Kazunori UEMURA , Masashi INAGAKI , Masaru SUGIMACHI , Kazuo SHIMIZU , Masatoshi KOBAYASHI
IPC分类号： A61B5/053
CPC分类号： A61B5/029 , A61B5/0295 , A61B5/053
摘要： A practical method for estimating cardiac output and pulmonary artery wedge pressure with good accuracy is provided. The present invention provides a method for estimating the impedance arising from solid tissue by determining the impedance at the intersection between the line of identity and the extrapolated regression line, where the regression line is obtained by linearly regressing the maximum value to the minimum value of the impedance signal of each of multiple data sets, where each data set contains the maximum value and the minimum value of the impedance signal during one cardiac cycle, where impedance signal is obtained between a can electrode implanted in the left thoracic wall and an electrode inserted into the coronary vein, over a specific period of time following the infusion of hypertonic saline into the pulmonary circulation.
摘要翻译：提供了一种准确估计心输出量和肺动脉楔形压力的实用方法。本发明提供一种用于通过确定身份行与外推回归线之间的交叉点处的阻抗来估计由固体组织产生的阻抗的方法，其中回归线通过将最大值线性回归到最小值多个数据组中的每一个的阻抗信号，其中每个数据集包含在一个心动周期期间的阻抗信号的最大值和最小值，其中在插入左胸壁的罐电极和插入到左胸壁的电极之间获得阻抗信号冠状静脉，在高渗盐水输入肺循环后的特定时间段内。

6. 发明申请

US20050288718A1 Medical treatment system using biological regulation function alternate, cardiac pacing system based on the medical treatment system, blood pressure regulating system, and cardiac disease treating system 有权
标题翻译：使用生物调节功能的医疗系统，基于医疗系统的心脏起搏系统，血压调节系统和心脏病治疗系统
公开(公告)号：US20050288718A1
公开(公告)日：2005-12-29
申请号：US10523539
申请日：2002-08-05
申请人： Kenji Sunagawa , Masaru Sugimachi , Takayuki Sato
发明人： Kenji Sunagawa , Masaru Sugimachi , Takayuki Sato
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/365 , A61N1/36514
摘要： A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.
摘要翻译：一种基于生物活性的医疗处理系统，其特征在于用于感测由生物活性产生的生物活性信息并输出生物活性信号的生物活性检测装置，用于接收，分析和处理来自生物活性检测装置的生物活性信号的计算装置，计算生物体刺激信号，并输出生物体刺激信号，以及生物体刺激装置，用于接收由计算装置计算的生物体刺激信号，并根据生物体刺激信号刺激生物体。还公开了一种基于治疗系统，血压调节系统和心脏疾病治疗系统的心脏起搏系统。

7. 发明授权

US08000791B2 Cardiac pacing system and distributed cardiac pacing system 有权
标题翻译：心脏起搏系统和分布式心脏起搏系统
公开(公告)号：US08000791B2
公开(公告)日：2011-08-16
申请号：US12103011
申请日：2008-04-15
申请人： Kenji Sunagawa , Masaru Sugimachi , Masashi Inagaki
发明人： Kenji Sunagawa , Masaru Sugimachi , Masashi Inagaki
IPC分类号： A61N1/375 , A61N1/378
CPC分类号： A61N1/37288 , A61N1/368 , A61N1/37205 , A61N1/3756 , A61N1/3785 , H01M8/16 , Y02E60/527
摘要： A distributed cardiac pacing system comprises a first ultra miniature integrated cardiac pacemaker adapted to be placed in an atrial myocardium and a second ultra miniature integrated cardiac pacemaker adapted to be placed in a ventricular myocardium.
摘要翻译：分布式心脏起搏系统包括适于放置在心房心肌中的第一超微型集成心脏起搏器和适于放置在心室心肌中的第二超微型集成心脏起搏器。

8. 发明申请

US20090221923A1 Cardiac Disease Treatment System 有权
标题翻译：心脏疾病治疗系统
公开(公告)号：US20090221923A1
公开(公告)日：2009-09-03
申请号：US11719400
申请日：2004-11-18
申请人： Kazunori Uemura , Atsumori Kamiya , Masaru Sugimachi , Kenji Sunagawa
发明人： Kazunori Uemura , Atsumori Kamiya , Masaru Sugimachi , Kenji Sunagawa
IPC分类号： A61B5/029 , A61B5/0215
CPC分类号： A61M5/1723 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61M5/14244 , A61M2230/30
摘要： Problems To provide a cardiac disease treatment system for accurately diagnosing the functional cause of an abnormality of a cardiac disease by analyzing the hemodynamic state of a patient, automatically performing medication in accordance with the diagnosis result, and treating the cardiac disease. Means for Solving Problems The cardiac disease treatment system is characterized by comprising input means (2) for inputting the cardiac output value of the patient, the left atrial pressure value and/or the right atrial pressure value, first calculating means (31) for calculating the pumping ability value of the left heart or the right heart from the inputted cardiac output and the left or right atrial pressure value, first comparing means (41) for comparing the pumping ability value of the left heart or the right heart with a target pumping ability value, and first medicating means (51) for medicating the patient in accordance with the result of the comparison by the first comparing means (41).
摘要翻译：问题提供一种心脏疾病治疗系统，用于通过分析患者的血液动力学状态，根据诊断结果自动进行药物，以及治疗心脏病，来准确诊断心脏病异常的功能原因。解决问题的手段心脏疾病治疗系统的特征在于包括输入装置（2），用于输入患者的心输出量值，左心房压力值和/或右心房压力值，第一计算装置（31），用于计算来自输入的心输出量的左心脏或右心脏的泵送能力值和左心房或右心房压力值，用于将左心脏或右心脏的抽吸能力值与目标泵送的第一比较装置（41）能力值，以及用于根据第一比较装置（41）的比较结果对患者进行治疗的第一药剂装置（51）。

9. 发明授权

US08340749B2 System for automatically minimizing cardiac oxygen consumption and cardiac disease treating system using the same 有权
标题翻译：用于自动最小化心脏氧消耗的系统和使用其的心脏疾病治疗系统
公开(公告)号：US08340749B2
公开(公告)日：2012-12-25
申请号：US12279753
申请日：2007-02-16
申请人： Masaru Sugimachi , Kazunori Uemura , Atsunori Kamiya , Kenji Sunagawa , Michio Yamaji
发明人： Masaru Sugimachi , Kazunori Uemura , Atsunori Kamiya , Kenji Sunagawa , Michio Yamaji
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61B5/029 , A61B5/4866 , A61N1/36557
摘要： A cardiac disease treating system has an input part for inputting a patient's indexes of kinetics of blood circulation including at least heart rate, a cardiac oxygen consumption calculation monitor unit for calculating the estimated value of said patient's amount of cardiac oxygen consumption based on the indexes of kinetics of blood circulation input from the input part, and a cardiac oxygen consumption curtailment unit for comparing the heart rate input from the input part and the critical heart rate minimizing the estimated value of amount of cardiac oxygen consumption calculated by the cardiac oxygen consumption monitor unit and controlling the patient's heart rate in conformity with the results of this comparison.
摘要翻译：心脏疾病治疗系统具有输入部，用于输入至少包括心率的患者的血液循环动力学指标，心脏耗氧量计算监测单元，用于根据患者的心脏氧消耗量的指标计算所述患者心脏耗氧量的估计值从输入部输入的血液循环的动力学，以及用于比较从输入部输入的心率和临床心率的心脏氧消耗量缩小单元，其将由心脏氧消耗监测单元计算出的心脏氧消耗量的估计值减至最小并根据该比较的结果控制患者的心率。

10. 发明授权

US08282563B2 Cardiac disease treatment system 有权
标题翻译：心脏病治疗系统
公开(公告)号：US08282563B2
公开(公告)日：2012-10-09
申请号：US11719400
申请日：2004-11-18
申请人： Kazunori Uemura , Atsunori Kamiya , Masaru Sugimachi , Kenji Sunagawa
发明人： Kazunori Uemura , Atsunori Kamiya , Masaru Sugimachi , Kenji Sunagawa
IPC分类号： A61B5/02
CPC分类号： A61M5/1723 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61M5/14244 , A61M2230/30
摘要： ProblemsTo provide a cardiac disease treatment system for accurately diagnosing the functional cause of an abnormality of a cardiac disease by analyzing the hemodynamic state of a patient, automatically performing medication in accordance with the diagnosis result, and treating the cardiac disease.Means for solving problemsThe cardiac disease treatment system is characterized by comprising input means (2) for inputting the cardiac output value of the patient, the left atrial pressure value and/or the right atrial pressure value, first calculating means (31) for calculating the pumping ability value of the left heart or the right heart from the inputted cardiac output and the left or right atrial pressure value, first comparing means (41) for comparing the pumping ability value of the left heart or the right heart with a target pumping ability value, and first medicating means (51) for medicating the patient in accordance with the result of the comparison by the first comparing means (41).
摘要翻译：问题提供一种心脏疾病治疗系统，用于通过分析患者的血液动力学状态，根据诊断结果自动进行药物，以及治疗心脏病，来准确诊断心脏病异常的功能原因。解决问题的手段心脏疾病治疗系统的特征在于包括用于输入患者的心输出量的输入装置（2），左心房压力值和/或右心房压力值，第一计算装置（31），用于计算来自输入的心输出量的左心脏或右心脏的泵送能力值和左心房或右心房压力值，用于将左心脏或右心脏的抽吸能力值与目标泵送的第一比较装置（41）能力值，以及用于根据第一比较装置（41）的比较结果对患者进行治疗的第一药剂装置（51）。

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