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1. 发明授权

US06066858A Autoradiographic process 失效
标题翻译：放射自显影过程
公开(公告)号：US06066858A
公开(公告)日：2000-05-23
申请号：US982102
申请日：1997-11-17
申请人： Motoko Kawasaki , Katsumi Hayashi , Masashi Hakamata , Keiji Mori
发明人： Motoko Kawasaki , Katsumi Hayashi , Masashi Hakamata , Keiji Mori
IPC分类号： G01N33/60 , G03B42/00
CPC分类号： G01N33/60
摘要： An autoradiographic process for obtaining locational information on two or more radioactively labeled substances which have different energy or half-life and are contained in a sample such as tissue of an organism. Specifically, the process includes the steps of placing the sample on a stimulable phosphor sheet having a plastic cover layer to cause the stimulable phosphor to absorb radiation energy of the labeled substances and reading the absorbed radiation energy out of the phosphor to obtain an image signal corresponding to one radioactively labeled substance and placing the sample on a stimulable phosphor sheet having a thinner plastic cover layer or no cover film to cause the stimulable phosphor to absorb radiation energy of the labeled substances and reading the absorbed radiation energy out of the phosphor to obtain image signals corresponding to plural radioactively labeled substances. Then, the process includes the step of subjecting the image signals of (a) and (b) to subtraction processing so that image signals corresponding to plural radioactively labeled substances can be separately obtained.
摘要翻译：一种放射自显影方法，用于获得具有不同能量或半衰期并且包含在诸如生物体的组织的样品中的两种或更多种放射性标记物质的位置信息。具体而言，该方法包括以下步骤：将样品放置在具有塑料覆盖层的可刺激的荧光体片上，以使可刺激的荧光体吸收标记物质的辐射能量并从磷光体中读出吸收的辐射能量，以获得相应的图像信号一种放射性标记的物质，并将样品放置在具有较薄塑料覆盖层或不具有覆盖膜的可刺激的荧光粉片上，以使可刺激的荧光体吸收标记物质的辐射能并从磷光体中读出吸收的辐射能量以获得图像对应于多个放射性标记物质的信号。然后，该处理包括对（a）和（b）的图像信号进行减法处理，从而可以分别获得与多个放射性标记物质对应的图像信号。

2. 发明授权

US08749787B2 Fluorescence detecting apparatus and fluorescence detecting method 有权
标题翻译：荧光检测装置及荧光检测方法
公开(公告)号：US08749787B2
公开(公告)日：2014-06-10
申请号：US13045361
申请日：2011-03-10
申请人： Junpei Shiraishi , Masashi Hakamata
发明人： Junpei Shiraishi , Masashi Hakamata
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , G01N21/6428
摘要： Excitation light beam is irradiated onto a test region while shifting the irradiation position thereof, when performing analysis of a target substance using an analysis chip having the test region within a flow channel through which a sample solution is caused to flow, for capturing the target substance within the sample solution. Fluorescence generated at the test region is detected as a plurality of adjustment fluorescence signals. The target substance is analyzed using fluorescence generated when the excitation light beam is irradiated at an irradiation position within the test region determined based on the plurality of adjustment fluorescence signals.
摘要翻译：激发光束在移动其照射位置的同时照射到测试区域上，当使用具有测试区域的分析芯片进行目标物质的分析时，所述测试区域在通过其的样品溶液流过的流动通道内，用于捕获目标物质在样品溶液中。在测试区域产生的荧光被检测为多个调节荧光信号。使用在基于多个调整荧光信号确定的测试区域内的照射位置照射激发光束时产生的荧光来分析目标物质。

3. 发明授权

US06707058B2 Radiation image read-out method and apparatus 失效
标题翻译：辐射图像读出方法和装置
公开(公告)号：US06707058B2
公开(公告)日：2004-03-16
申请号：US10022807
申请日：2001-12-20
申请人： Taizo Akimoto , Masashi Hakamata
发明人： Taizo Akimoto , Masashi Hakamata
IPC分类号： G02B2602
CPC分类号： G03B42/08
摘要： A stimulable phosphor sheet stored thereon a radiation image is two-dimensionally scanned by a stimulating light beam by projecting the light beam along a main scanning line extending in a main scanning direction and moving one of the stimulable phosphor sheet and the stimulating light beam in a sub-scanning direction relatively to the other so that the stimulable phosphor sheet is exposed to the stimulating light beam along a plurality of main scanning lines arranged in the sub-scanning direction at a predetermined pitch and stimulated emission emitted from the part of the stimulable phosphor sheet exposed to the stimulating light beam is photoelectrically converted to an electric image signal by a photoelectric convertor. The power of the stimulating light beam is controlled depending on the pitch at which the main scanning lines are arranged in the sub-scanning direction.
摘要翻译：通过沿着主扫描方向延伸的主扫描线投射光束，通过刺激光束对存储有放射线图像的可刺激的荧光体片进行二维扫描，并将可激发的荧光体片和刺激光束中的一个移动到副扫描方向相对于另一方，使得可刺激的荧光体片沿预定间距沿副扫描方向布置的多个主扫描线暴露于刺激光束，并且从可刺激荧光体的一部分发射的受激发射暴露于刺激光束的片被光电转换器光电转换成电图像信号。刺激光束的功率根据主扫描线沿副扫描方向排列的间距来控制。

4. 发明授权

US07830521B2 Detection apparatus, detection method, and optically transparent member 有权
标题翻译：检测装置，检测方法和透光构件
公开(公告)号：US07830521B2
公开(公告)日：2010-11-09
申请号：US11864711
申请日：2007-09-28
申请人： Hiroaki Yamamoto , Toshihito Kimura , Hitoshi Shimizu , Masashi Hakamata
发明人： Hiroaki Yamamoto , Toshihito Kimura , Hitoshi Shimizu , Masashi Hakamata
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N2021/157
摘要： Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.
摘要翻译：提供了能够检测精度降低的检测装置，检测方法和光学透明构件。通过包含在图像处理部分38中的卷积部分80执行卷积，以获取指示在该界面处被全反射并以多个角度入射的光束的光强度分布的分布信息介质块52，以便在介质块52的界面处被全反射。通过由图像处理部分38中包含的检测精度评估部分86对由所获取的分布信息指示的光强度分布执行空间频率分辨率，从而导出光束的每个空间频率的光强度分布。通过将导出的光强度分布与针对每个空间频率预定的阈值进行比较来检测精度。

5. 外观设计

USD561624S1 Sensor chip for biochemical analysis 有权
公开(公告)号：USD561624S1
公开(公告)日：2008-02-12
申请号：US29266471
申请日：2006-09-22
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Masashi Hakamata , Hideyuki Morimoto , Hiroyuki Ota
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Masashi Hakamata , Hideyuki Morimoto , Hiroyuki Ota

6. 外观设计

USD561623S1 Sensor chip for biochemical analysis 有权
标题翻译：传感器芯片进行生化分析
公开(公告)号：USD561623S1
公开(公告)日：2008-02-12
申请号：US29266470
申请日：2006-09-22
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Hideyuki Morimoto , Hiroyuki Ota , Masayasu Konishi , Yoshiyuki Kunuki
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Hideyuki Morimoto , Hiroyuki Ota , Masayasu Konishi , Yoshiyuki Kunuki

7. 外观设计

USD561053S1 Prism of sensor chip for biochemical analysis 有权
标题翻译：传感器芯片棱镜用于生化分析
公开(公告)号：USD561053S1
公开(公告)日：2008-02-05
申请号：US29266439
申请日：2006-09-21
申请人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki
设计人： Nobuhiko Ogura , Katsuaki Muraishi , Hitoshi Shimizu , Masashi Hakamata , Yasunobu Sakaguchi , Yoshiyuki Kunuki

8. 发明申请

US20070259193A1 Method for forming a film by spin coating 有权
标题翻译：通过旋涂形成膜的方法
公开(公告)号：US20070259193A1
公开(公告)日：2007-11-08
申请号：US11362741
申请日：2006-02-28
申请人： Yukou Saito , Masashi Hakamata
发明人： Yukou Saito , Masashi Hakamata
IPC分类号： B05D3/12
CPC分类号： G01N21/553 , Y10T428/31511 , Y10T428/31692 , Y10T428/31855
摘要： It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.
摘要翻译：本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。本发明提供了一种用于制造传感器的固体基板的方法，该传感器在旋转涂层的表面上具有涂层，其中待涂布的基材在涂布溶剂的蒸气压为50％至100％的气氛中旋转，相对于饱和蒸气压，以便在待涂覆的基底上形成涂层溶液的薄膜。

9. 发明授权

US06759673B2 Radiation image readout method and apparatus 失效
标题翻译：辐射图像读出方法及装置
公开(公告)号：US06759673B2
公开(公告)日：2004-07-06
申请号：US10162197
申请日：2002-06-05
申请人： Taizo Akimoto , Masashi Hakamata
发明人： Taizo Akimoto , Masashi Hakamata
IPC分类号： G01N2304
CPC分类号： G01T1/2014
摘要： A radiation image readout apparatus scans an excitation light in a main scanning direction and a sub scanning direction over a stimulable phosphor sheet, on which radiation energy has been stored, and detects the stimulated emission emitted thereupon; wherein, various types of phosphor sheets can be read out at a high resolution and high sensitivity. The excitation light energy level for obtaining an adequate sensitivity for each type of phosphor sheet is obtained. A controller controls the intensity of the excitation light emitted from the light source and the speed of the scanning mechanism, that is, the readout speed, whereby the excitation light projected onto a phosphor sheet of which the diffusion rate has been controlled by the inclusion therein of an navy blue colorant is of a greater energy level than the excitation light projected onto the white stimulable phosphor sheet not containing the navy blue colorant.
摘要翻译：放射线图像读出装置在主扫描方向和副扫描方向上扫描已经存储有辐射能的可刺激的荧光体片，并检测其上发射的受激发射; 其中可以以高分辨率和高灵敏度读出各种类型的荧光片。获得用于获得每种类型的荧光粉片的足够灵敏度的激发光能级。控制器控制从光源发射的激发光的强度和扫描机构的速度，即读出速度，由此投射到通过包含其中的扩散速率被控制的荧光体片上的激发光的海蓝色着色剂的能量水平比投射到不含海蓝色着色剂的白色可激发荧光粉片上的激发光更大。

10. 发明申请

US20110242541A1 OPTICAL MEMBER AND SURFACE PLASMON RESONANCE MEASURING APPARATUS 有权
标题翻译：光学部件和表面质子共振测量装置
公开(公告)号：US20110242541A1
公开(公告)日：2011-10-06
申请号：US13076368
申请日：2011-03-30
申请人： Masashi Hakamata
发明人： Masashi Hakamata
IPC分类号： G01N21/55 , G02B5/04 , G02B27/56
CPC分类号： G01N21/648 , G01N21/05
摘要： The shape of a prism is set such that an excitation light beam that enters the prism to cause surface plasmon resonance to be generated is not irradiated onto the corners of the prism after being totally reflected within the prism. The angle of a surface that the excitation light exits the prism is set to an angle at which the excitation light beam is not totally reflected. Thereby, the excitation light beam returning to a light source, and being scattered within the prism are prevented, and therefore the accuracy of measurements can be improved.
摘要翻译：棱镜的形状被设定为使得入射到棱镜中以产生表面等离子体共振的激发光束在棱镜中被全反射之后不会照射到棱镜的角上。激发光离开棱镜的表面的角度被设定为激发光束未被全反射的角度。由此，防止了返回到光源并在棱镜内散射的激发光束，因此能够提高测量精度。

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