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    • 7. 发明申请
    • Apparatus and method of assay in utilizing attenuated total reflection
    • 利用衰减全反射的装置和测定方法
    • US20060068489A1
    • 2006-03-30
    • US11239202
    • 2005-09-30
    • Katsuaki MuraishiNobuhiko Ogura
    • Katsuaki MuraishiNobuhiko Ogura
    • C12M1/34
    • G01N21/553G01N21/272G01N2035/1032Y10S435/808Y10S436/805
    • An assay apparatus is loaded with a sensor unit as surface plasmon resonance (SPR) biosensor, which includes a transparent dielectric medium and thin film. A first surface of the thin film is a thin film/dielectric interface. Its sensing surface causes reaction of sample fluid. An optical assay unit assays reaction of the sample fluid by detecting illuminating light reflected by the interface. Measured data from the optical assay unit is compared with a reference parameter, to evaluate suitability of the measured data for analysis. If lack of the suitability is estimated in the evaluation, a succeeding density of the sample fluid to be used in a succeeding evaluating assay is determined according to the measured data with the estimated lack of the suitability. The sample fluid is prepared at the succeeding density by mixing with diluent fluid, and then is used for the succeeding evaluating assay.
    • 测定装置装载有作为表面等离子体共振(SPR)生物传感器的传感器单元,其包括透明电介质和薄膜。 薄膜的第一表面是薄膜/电介质界面。 其感测表面引起样品液体的反应。 光学测定单元通过检测由界面反射的照明光来测定样品流体的反应。 将光学测定单元的测量数据与参考参数进行比较,以评估测量数据对分析的适用性。 如果在评估中估计缺乏合适性,则在随后的评估测定中使用的样品流体的随后密度根据估计的不适合性的测量数据来确定。 样品流体通过与稀释液混合制备成随后的密度,然后用于随后的评估测定。
    • 8. 发明授权
    • Radiation image read-out apparatus
    • 辐射图像读出装置
    • US4886968A
    • 1989-12-12
    • US225443
    • 1988-07-28
    • Masahiro OhnishiNobuhiko OguraKatsuaki Muraishi
    • Masahiro OhnishiNobuhiko OguraKatsuaki Muraishi
    • G01T1/29H04N1/00H04N1/06
    • G03B42/08G01T1/2014H04N1/0057H04N1/00588H04N1/00591H04N1/00607H04N1/0061H04N1/00618H04N1/0283H04N1/0607H04N1/0635H04N1/0664
    • A radiation image read-out apparatus comprises a sheet holding device for holding an image-recorded stimulable phosphor sheet on a cylindrical surface, and a spinner provided with a deflection mirror for reflecting stimulating rays coming from a semi-transparent mirror to the stimulable phosphor sheet, and a condensing lens for converging the reflected stimulating rays on the stimulable phosphor sheet. The spinner rotates the deflection mirror and the condensing lens to scan the stimulating rays in a main scanning direction on the stimulable phosphor sheet, and the sheet holding device is moved normal to the main scanning direction. A detection lens converges light emitted by the stimulable phosphor sheet upon exposure to the stimulating rays, passing through the condensing lens and coming from the semi-transparent mirror. An aperture plate having an aperture allowing the passage of only the omitted light thus converged is provided at a position of convergence by the detection lens, and a photodetector is provided at the rear of the aperture plate.
    • 放射线图像读取装置包括用于将图像记录的可激发荧光体片保持在圆柱形表面上的片材保持装置和设置有用于将来自半透明反射镜的刺激光线反射到可刺激荧光粉片的偏转镜的旋转器 以及用于使反射的刺激光线会聚在可刺激的荧光体片上的聚光透镜。 旋转器旋转偏转镜和聚光透镜,以在可激发的荧光体片上的主扫描方向上扫描刺激光线,并且片材保持装置垂直于主扫描方向移动。 检测透镜会将由可刺激的荧光体片发射的光会聚到穿过聚光透镜并从半透明反射镜中吸收的刺激光线上。 在通过检测透镜会聚的位置处设置有具有允许仅会使会聚的省略的光通过的孔的孔板,并且在孔板的后部设置光电检测器。
    • 9. 发明授权
    • Measuring sensor utilizing attenuated total reflection and measuring chip assembly
    • 测量传感器利用衰减全反射和测量芯片组装
    • US07064837B2
    • 2006-06-20
    • US10120518
    • 2002-04-12
    • Nobufumi MoriKatsumi HayashiMasayuki NayaNobuhiko OguraYoshiyuki Kunuki
    • Nobufumi MoriKatsumi HayashiMasayuki NayaNobuhiko OguraYoshiyuki Kunuki
    • G01N21/55G01N1/10
    • G01N21/553
    • Disclosed herein is a sensor utilizing attenuated total reflection. The sensor is constructed of a measuring chip, an optical system, and a measuring section. The measuring chip is equipped with a dielectric block, a thin film layer formed on the dielectric block, and a liquid-sample holding portion for holding a liquid sample. The optical system is used to make a light beam enter the dielectric block at various angles of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer. The measuring section measures the state of attenuated total reflection, based on the intensity of the light beam totally reflected at the interface. The liquid-sample holding portion has an opening at its top surface. The sensor further has a lid supply mechanism for placing a lid on the opening to prevent evaporation of the liquid sample.
    • 这里公开了一种利用衰减全反射的传感器。 传感器由测量芯片,光学系统和测量部分构成。 测量芯片配备有介质块,形成在介质块上的薄膜层和用于保持液体样品的液体样品保持部分。 光学系统用于使光束以不同的入射角进入介质块,使得在介电块和薄膜层之间的界面处满足全内反射条件。 测量部分根据在界面全反射的光束的强度来测量衰减全反射的状态。 液体样品保持部分在其顶表面上具有开口。 传感器还具有用于将盖放置在开口上以防止液体样品蒸发的盖供给机构。
    • 10. 发明授权
    • Apparatus and method of assay in utilizing attenuated total reflection
    • 利用衰减全反射的装置和测定方法
    • US07465588B2
    • 2008-12-16
    • US11239202
    • 2005-09-30
    • Katsuaki MuraishiNobuhiko Ogura
    • Katsuaki MuraishiNobuhiko Ogura
    • G01N33/553
    • G01N21/553G01N21/272G01N2035/1032Y10S435/808Y10S436/805
    • An assay apparatus is loaded with a sensor unit as surface plasmon resonance (SPR) biosensor, which includes a transparent dielectric medium and thin film. A first surface of the thin film is a thin film/dielectric interface. Its sensing surface causes reaction of sample fluid. An optical assay unit assays reaction of the sample fluid by detecting illuminating light reflected by the interface. Measured data from the optical assay unit is compared with a reference parameter, to evaluate suitability of the measured data for analysis. If lack of the suitability is estimated in the evaluation, a succeeding density of the sample fluid to be used in a succeeding evaluating assay is determined according to the measured data with the estimated lack of the suitability. The sample fluid is prepared at the succeeding density by mixing with diluent fluid, and then is used for the succeeding evaluating assay.
    • 测定装置装载有作为表面等离子体共振(SPR)生物传感器的传感器单元,其包括透明电介质和薄膜。 薄膜的第一表面是薄膜/电介质界面。 其感测表面引起样品液体的反应。 光学测定单元通过检测由界面反射的照明光来测定样品流体的反应。 将光学测定单元的测量数据与参考参数进行比较,以评估测量数据对分析的适用性。 如果在评估中估计缺乏合适性,则在随后的评估测定中使用的样品流体的随后密度根据估计的不适合性的测量数据来确定。 样品流体通过与稀释液混合制备成随后的密度,然后用于随后的评估测定。