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    • 3. 发明授权
    • Antibacterial peptide
    • 抗菌肽
    • US07452856B2
    • 2008-11-18
    • US11093875
    • 2005-03-29
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • A61K38/00C07K17/00
    • C07K14/4723
    • The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.
    • 本发明提供了一种基于CAP11的新型肽,并且提供了抗细菌剂,LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物,每种含有肽作为 活性成分。 肽具有以下氨基酸序列(SEQ ID NO:1):X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03(其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基,X03表示阳离子性氨基酸残基,X04表示非极性氨基酸残基或阳离子性氨基酸残基,X05表示非极性氨基酸残基或极性不带电氨基 酸残基)。 各抗菌剂,脂多糖 - 细胞结合抑制剂和药物(例如细菌感染处理剂或内毒素 - 休克抑制剂)均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽,其形成α-螺旋,其中氨基酸沿着α-螺旋排列,使得当以螺旋轮表示时,存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。
    • 4. 发明申请
    • Antibacterial peptide
    • 抗菌肽
    • US20090149632A1
    • 2009-06-11
    • US12148094
    • 2008-04-16
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • C07K7/00C07K1/00
    • C07K14/4723
    • The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.
    • 本发明提供了一种基于CAP11的新型肽,并且提供了抗细菌剂,LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物,每种含有肽作为 活性成分。 肽具有以下氨基酸序列(SEQ ID NO:1):X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03(其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基,X03表示阳离子性氨基酸残基,X04表示非极性氨基酸残基或阳离子性氨基酸残基,X05表示非极性氨基酸残基或极性不带电氨基 酸残基)。 各抗菌剂,脂多糖 - 细胞结合抑制剂和药物(例如细菌感染处理剂或内毒素 - 休克抑制剂)均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽,其形成α-螺旋,其中氨基酸沿着α-螺旋排列,使得当以螺旋轮表示时,存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。
    • 8. 发明授权
    • Antibacterial peptide
    • 抗菌肽
    • US08242082B2
    • 2012-08-14
    • US12148094
    • 2008-04-16
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • A61K38/10
    • C07K14/4723
    • The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.
    • 本发明提供了一种基于CAP11的新型肽,并且提供了抗细菌剂,LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物,每种含有肽作为 活性成分。 肽具有以下氨基酸序列(SEQ ID NO:1):X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03(其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基,X03表示阳离子性氨基酸残基,X04表示非极性氨基酸残基或阳离子性氨基酸残基,X05表示非极性氨基酸残基或极性不带电氨基 酸残基)。 各抗菌剂,脂多糖 - 细胞结合抑制剂和药物(例如细菌感染处理剂或内毒素 - 休克抑制剂)均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽,其形成α-螺旋,其中氨基酸沿α螺旋排列,使得当以螺旋轮表示时,存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。
    • 9. 发明申请
    • Antibacterial peptide
    • US20060009374A1
    • 2006-01-12
    • US11093875
    • 2005-03-29
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • Isao NagaokaDaiju OkudaShin YomogidaHiroshi Tamura
    • A61K38/16C07K14/195
    • C07K14/4723
    • The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.