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1. 发明授权

US4423218A Antibiotic neplanocin A 失效
标题翻译：抗生素neplanocin A
公开(公告)号：US4423218A
公开(公告)日：1983-12-27
申请号：US205350
申请日：1980-11-03
申请人： Masaru Otani , Satoshi Yaginuma , Masatoshi Tsujino , Naoki Muto , Tetsu Saito , Tadashiro Fujii
发明人： Masaru Otani , Satoshi Yaginuma , Masatoshi Tsujino , Naoki Muto , Tetsu Saito , Tadashiro Fujii
IPC分类号： C07D473/00 , C12P19/40 , C07D473/32
CPC分类号： C07D473/00 , C12P19/40 , C12R1/01
摘要： Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.
摘要翻译：通过培养Ampullariella sp产生式的抗生素neplanocin A。 A 11079FERM-P No.4494在营养培养基中，然后从培养基中分离出由此产生的neplanocin A.

2. 发明授权

US4321376A Neplanocin-B and -F 失效
标题翻译： Neplanocin-B和-F
公开(公告)号：US4321376A
公开(公告)日：1982-03-23
申请号：US101126
申请日：1979-12-07
申请人： Masaru Otani , Satoshi Yaginuma , Masatoshi Tsujino , Naoki Muto , Tetsu Saito , Tadashiro Fujii
发明人： Masaru Otani , Satoshi Yaginuma , Masatoshi Tsujino , Naoki Muto , Tetsu Saito , Tadashiro Fujii
IPC分类号： C07D473/34 , A61K31/52 , A61P25/24 , A61P25/26 , A61P35/00 , C07D473/00 , C12P17/18 , C12P19/40 , C12R1/01 , C12R1/645 , C07D473/32
CPC分类号： C07D473/00 , C12P19/40 , C12R1/01
摘要： Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.
摘要翻译：其中Y为氧或价键的式“IMAGE”的Neplanocin-B和-F通过培养Ampullariella sp。在营养培养基中的11079FERM-P No.4494，然后从培养基中分离由此产生的奈普兰诺B和-F。

3. 发明授权

US4291021A Novel macrolide antibiotics and preparation thereof 失效
标题翻译：新型大环内酯类抗生素及其制备方法
公开(公告)号：US4291021A
公开(公告)日：1981-09-22
申请号：US37846
申请日：1979-05-10
申请人： Masaru Otani , Shuzo Satoi , Naoki Muto , Tetsu Saito , Tadashiro Fujii , Seiji Katsumata , Mitsuo Hayashi , Masaru Ono
发明人： Masaru Otani , Shuzo Satoi , Naoki Muto , Tetsu Saito , Tadashiro Fujii , Seiji Katsumata , Mitsuo Hayashi , Masaru Ono
IPC分类号： A23K20/195 , C07H17/08 , C12P1/06 , C12P19/60 , A61K35/74
CPC分类号： C07H17/08 , A23K20/195 , C12P1/06 , Y10S435/867
摘要： A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.
摘要翻译：属于小单孢菌属的微生物物种，即小单孢菌属（Micomonospora sp。 A 11725被发现能够生产新型大环内酯类抗生素A 11725 I，A 11725 II和A 11725 III。还发现新抗生素A 11725 Ia和A 11725 IIa通过分别对抗生素A 11725 I和A 11725 II进行化学修饰而得到。所有这些抗生素或其盐对葡萄球菌或支原体等各种微生物表现出优异的抗菌和抗支原体活性，因此可用于包括药物在内的各种目的。

4. 发明授权

US4288429A Antibiotic planothiocins 失效
标题翻译：抗生素扁桃体
公开(公告)号：US4288429A
公开(公告)日：1981-09-08
申请号：US175677
申请日：1980-08-05
申请人： Tadashiro Fujii , Satoshi Yaginuma , Naoki Muto , Mitsuo Hayashi
发明人： Tadashiro Fujii , Satoshi Yaginuma , Naoki Muto , Mitsuo Hayashi
IPC分类号： A23K1/17 , A23K1/18 , C12P1/06 , A61K35/00
CPC分类号： C12P1/06 , A23K20/195 , A23K50/30
摘要： A group of sulfur-containing antibiotics, planothiocin-A, -B, -C, -D, -E, -F and -G, are produced by culturing Actinoplanes sp. A12526 in a nutrient medium, and separating the thus-produced planothiocins therefrom. The novel antibiotics have utility in therapeutic or prophylactic antibacterial compositions or feed additives for livestock, poultry or fish.
摘要翻译：一系列含硫抗生素，平滑蛋白-A，-B，-C，-D，-E，-F和-G，通过培养动植物飞虱素产生。 A12526在营养培养基中，并从其中分离由此产生的血清白蛋白。新型抗生素可用于治疗或预防性抗菌组合物或牲畜，家禽或鱼类的饲料添加剂。

5. 发明授权

US4349667A Aminoglycoside antibiotic G-367-2 失效
标题翻译：氨基糖苷类抗生素G-367-2
公开(公告)号：US4349667A
公开(公告)日：1982-09-14
申请号：US166974
申请日：1980-07-09
申请人： Tadashiro Fujii , Shuzo Satoi , Naoki Muto , Mitsuo Hayashi , Akira Kodama , Masaru Otani
发明人： Tadashiro Fujii , Shuzo Satoi , Naoki Muto , Mitsuo Hayashi , Akira Kodama , Masaru Otani
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C12P19/48 , C12R1/465 , A61K31/71 , C07H15/22
CPC分类号： C12R1/01 , C12P19/485
摘要： Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.
摘要翻译：认为具有式“IMAGE”的氨基糖苷类抗生素G-367-2是通过在营养培养基中培养Dactylosporangium thailandense G-367FERM-P No.4840而分离产生的抗生素而制备的。对革兰氏阴性菌具有很强的抗菌作用。

6. 发明授权

US4297486A Aminoglycoside antibiotic G-367-1 and method for the production thereof 失效
标题翻译：氨基糖苷类抗生素G-367-1及其生产方法
公开(公告)号：US4297486A
公开(公告)日：1981-10-27
申请号：US137292
申请日：1980-04-03
申请人： Tadashiro Fujii , Shuzo Satoi , Naoki Muto , Mitsuo Hayashi , Akira Kodama , Masaru Otani
发明人： Tadashiro Fujii , Shuzo Satoi , Naoki Muto , Mitsuo Hayashi , Akira Kodama , Masaru Otani
IPC分类号： C07H15/236 , C12P19/48 , C07H15/22
CPC分类号： C12R1/01 , C07H15/236 , C12P19/485
摘要： Aminoglycoside antibiotic G-367-1 believed to have the formulae ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.
摘要翻译：通过在营养培养基中培养Dactylosporangium thailandense G-367 FERM-P No.4840，分离产生的抗生素，产生了具有式“IMAGE”的氨基糖苷类抗生素G-367-1。对革兰氏阴性菌具有很强的抗菌作用。

7. 发明授权

US5081023A Antibiotic L53-18A and process for preparation thereof 失效
标题翻译：抗生素L53-18A及其制备方法
公开(公告)号：US5081023A
公开(公告)日：1992-01-14
申请号：US457255
申请日：1989-12-27
申请人： Satoshi Yaginuma , Atsuki Morishita , Naoki Muto , Kenya Ishizawa , Mitsuo Hayashi , Tetsu Saito
发明人： Satoshi Yaginuma , Atsuki Morishita , Naoki Muto , Kenya Ishizawa , Mitsuo Hayashi , Tetsu Saito
IPC分类号： C12P1/06 , A61K35/74 , A61P31/04 , C07G11/00 , C07H17/08 , C12P19/62 , C12R1/01
CPC分类号： C07H17/08 , C12P19/62 , Y10S435/911
摘要： A antibiotic L53-18A and a pharmaceutically acceptable salt thereof which are useful for treatment of bacterial inventions are obtained by culturing, for example, Saccharopolyspora sp. L53-18 (FERM BP 2231) in a medium and the antibiotic accumulated therein is collected.

8. 发明授权

US4254256A Amino sugar compound 失效
标题翻译：氨基糖化合物
公开(公告)号：US4254256A
公开(公告)日：1981-03-03
申请号：US968697
申请日：1978-12-12
申请人： Masaru Otani , Tetsu Saito , Shuzo Satoi , Junzo Mizoguchi , Naoki Muto
发明人： Masaru Otani , Tetsu Saito , Shuzo Satoi , Junzo Mizoguchi , Naoki Muto
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/715 , A61P3/08 , A61P3/10 , C07H15/203 , C07H15/22 , C12P19/26 , C12P19/46 , A61K31/73 , C07H5/06
CPC分类号： C12R1/465 , C07H15/22 , C12P19/26
摘要： An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Streptomyces.
摘要翻译：由以下通式表示的氨基糖化合物：其中m为0〜8的整数，n为1〜8的整数，m + n为1〜 8）具有强的糖苷酶抑制作用，通过培养产生属于链霉菌属的微生物的氨基糖化合物而产生。

9. 发明申请

US20050088273A1 Coated varistor 失效
标题翻译：涂层压敏电阻
公开(公告)号：US20050088273A1
公开(公告)日：2005-04-28
申请号：US10506054
申请日：2003-06-24
申请人： Tsutomu Kitsui , Minoru Ouchi , Naoki Muto
发明人： Tsutomu Kitsui , Minoru Ouchi , Naoki Muto
IPC分类号： H01C7/10 , H01C1/028 , H01C7/102 , H01C17/02
CPC分类号： H01C17/02 , H01C1/028 , H01C7/102
摘要： A varistor includes a varistor element, a first layer which is porous on the varistor element, and a second layer on the first coating. The thickness t (mm) of the second layer is not smaller than 1.3/V, where V(ml/g) is the volume of pores of the first layer exposed to an outside of the first layer. This varistor includes the outer layers protected from being broken even when a non-ohmic interface in a voltage non-linear resistor is broken down with a voltage exceeding a rated level.
摘要翻译：变阻器包括变阻器元件，在变阻器元件上是多孔的第一层，以及第一层上的第二层。第二层的厚度t（mm）不小于1.3 / V，其中V（ml / g）是暴露于第一层外部的第一层的孔的体积。即使当电压非线性电阻器中的非欧姆接口以超过额定电压的电压分解时，该压敏电阻器也包括防止外部层损坏的外层。

10. 发明授权

US4605615A L-glutamic acid oxidase (H.sub.2 O.sub.2 -generating), its production and analytical method therefor 失效
标题翻译： L-谷氨酸氧化酶（H2O2生成），其生产和分析方法
公开(公告)号：US4605615A
公开(公告)日：1986-08-12
申请号：US472174
申请日：1983-03-02
申请人： Hidehiko Ishikawa , Hideo Misaki , Naoki Muto
发明人： Hidehiko Ishikawa , Hideo Misaki , Naoki Muto
IPC分类号： C12N9/52 , C12N9/02 , C12N9/06 , C12Q1/26 , C12R1/465 , C12Q1/52 , C12Q1/36
CPC分类号： C12N9/0022 , C12Q1/26 , Y10S435/886
摘要： L-glutamic acid oxidase having the following biochemical properties:(a) substrate specificity: L-glutamic acid,(b) enzyme action: catalyzes a reaction which forms one mole of .alpha.-ketoglutaric acid, one mole of ammonia and one mole of hydrogen peroxide from one mole of L-glutamic acid, one mole of oxygen and one mole of water, as follows: ##STR1## This oxidase is produced by culturing microorganisms belonging to genus Streptomyces in a nutrient medium and isolating the thus-produced L-glutamic acid oxidase. Particular microorganisms of genus Streptomyces are sp. A7700 FERM P-6241 (NRRL No. 15267) and sp. 8063 FERM P-6242 (NRRL No. 15268). The oxidase can be used for detecting L-glutamic acid or L-glutamate, in an aqueous sample, because it catalyzes a reaction which forms one mole of .alpha.-ketoglutaric acid, one mole of ammonia and one mole of hydrogen peroxide from one mole of glutamic acid, one mole of oxygen and one mole of water. Thus, the consumed oxygen can be quantitatively determined, or the generated .alpha.-glutaric acid or ammonia or hydrogen peroxide can be quantitatively determined.
摘要翻译：具有以下生物化学性质的L-谷氨酸氧化酶：（a）底物特异性：L-谷氨酸，（b）酶作用：催化形成1摩尔α-酮戊二酸，1摩尔氨和1摩尔氢的反应 1摩尔L-谷氨酸，1摩尔氧和1摩尔水的过氧化物如下：该氧化酶是通过在营养培养基中培养属于链霉菌属的微生物而产生的，并分离由此产生的 L-谷氨酸氧化酶。链霉菌属的特殊微生物是sp。 A7700 FERM P-6241（NRRL No. 15267）和sp。 8063 FERM P-6242（NRRL No. 15268）。氧化酶可用于检测水样品中的L-谷氨酸或L-谷氨酸，因为它催化反应，其形成1摩尔α-酮戊二酸，1摩尔氨和1摩尔过氧化氢从1摩尔谷氨酸，1摩尔氧和1摩尔水。因此，可以定量测定消耗的氧气，或者可以定量测定产生的α-戊二酸或氨或过氧化氢。

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