专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07745671B2 Method for producing scyllo-inositol 有权
标题翻译：鲨肌醇的制备方法
公开(公告)号：US07745671B2
公开(公告)日：2010-06-29
申请号：US10576030
申请日：2004-10-14
申请人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
发明人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
IPC分类号： C07C35/16 , C07H1/06 , C07C35/46
CPC分类号： C12P7/02 , C07C29/145 , C12N9/0004 , C12N9/0006 , C12P7/18 , C12P7/26
摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.
摘要翻译：旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌内糖; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。通过使用这些酶或微生物，产生鲨肌醇。此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸络合物，将所述络合物与液体混合物分离，将鲨肌醇纯化将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。

2. 发明申请

US20130196417A1 METHOD FOR PRODUCING SCYLLO-INOSITOL 有权
标题翻译：生产氯霉素的方法
公开(公告)号：US20130196417A1
公开(公告)日：2013-08-01
申请号：US13791172
申请日：2013-03-08
申请人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
发明人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
IPC分类号： C12N9/00
CPC分类号： C12P7/02 , C07C29/145 , C12N9/0004 , C12N9/0006 , C12P7/18 , C12P7/26
摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.
摘要翻译：旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌内糖; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。通过使用这些酶或微生物，产生鲨肌醇。此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸复合物，将络合物与液体混合物分离，将鲨肌醇纯化将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。

3. 发明授权

US08409833B2 Method for producing scyllo-inositol 有权
标题翻译：鲨肌醇的制备方法
公开(公告)号：US08409833B2
公开(公告)日：2013-04-02
申请号：US12712635
申请日：2010-02-25
申请人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
发明人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
IPC分类号： C12P19/02
CPC分类号： C12P7/02 , C07C29/145 , C12N9/0004 , C12N9/0006 , C12P7/18 , C12P7/26
摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.
摘要翻译：旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌内糖; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。通过使用这些酶或微生物，产生鲨肌醇。此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸络合物，将络合物与液体混合物分离，将鲨肌醇纯化将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。

4. 发明申请

US20060240534A1 Process for producing scyllo-inositol 有权
标题翻译：生产鲨肌醇的方法
公开(公告)号：US20060240534A1
公开(公告)日：2006-10-26
申请号：US10576030
申请日：2004-10-14
申请人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
发明人： Masanori Yamaguchi , Yuichi Kita , Tetsuya Mori , Kenji Kanbe , Akihiro Tomoda , Atsushi Takahashi , Wakako Ichikawa
IPC分类号： C12P9/00 , C12P7/02 , C12N9/02 , C12N1/21
CPC分类号： C12P7/02 , C07C29/145 , C12N9/0004 , C12N9/0006 , C12P7/18 , C12P7/26
摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.
摘要翻译：旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌蛋白; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。通过使用这些酶或微生物，产生鲨肌醇。此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸络合物，将所述络合物与液体混合物分离，将鲨肌醇纯化将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。

5. 发明授权

US06818430B1 Process for producing L-epi-2-inosose and novel process for producing epi-inositol 失效
标题翻译：制备L-表 - 二烯糖的方法和制备表肌醇的新方法
公开(公告)号：US06818430B1
公开(公告)日：2004-11-16
申请号：US09980453
申请日：2002-02-12
申请人： Atsushi Takahashi , Kenji Kanbe , Tetsuya Mori , Yuichi Kita , Tsuyoshi Tamamura , Tomio Takeuchi
发明人： Atsushi Takahashi , Kenji Kanbe , Tetsuya Mori , Yuichi Kita , Tsuyoshi Tamamura , Tomio Takeuchi
IPC分类号： C12P1902
CPC分类号： C12R1/18 , C12P19/02 , C12R1/38 , C12R1/64
摘要： Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, there is used inexpensive myo-inositol as a starting compound. That is, there is now developed a new process which comprises reacting myo-inositol with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. Further, a novel process is provided, which comprises reacting the so produced L-epi-2-inosose with a reducing agent made of an alkali metal boron hydride or any other alkali metal hydride in an aqueous reaction medium, to produce epi-inositol and myo-inositol, and then isolating epi-inositol from the resulting reaction product composed of the epi-inositol and myo-inositol.
摘要翻译：提供了用于有效生产L-外 - 二糖和外消旋肌醇的新方法，其可用作各种药物或用于合成各种药物的中间体。在这些方法中，使用廉价的肌醇作为起始化合物。也就是说，现在开发了一种新的方法，其包括使肌醇与能够将肌醇转化为L-表 - 2-inosose的革兰氏阴性细菌反应，从而通过转化肌内 - 肌醇进入L-epi-2-inosose。此外，提供了一种新的方法，其包括使如此制备的L-表 - 2-异糖与在水性反应介质中由碱金属硼氢化物或任何其它碱金属氢化物制成的还原剂反应，以产生表肌醇和肌醇，然后从由肌醇和肌醇组成的反应产物中分离表肌醇。

6. 发明授权

US07157268B2 Process for producing L-epi-2-inosose and novel process for producing epi-inositol using microorganisms 失效
标题翻译：利用微生物生产外延蛋白-2-inosose的方法和生产表肌醇的新方法
公开(公告)号：US07157268B2
公开(公告)日：2007-01-02
申请号：US10852153
申请日：2004-05-25
申请人： Atsushi Takahashi , Kenji Kanbe , Tetsuya Mori , Yuichi Kita , Tsuyoshi Tamamura , Tomio Takeuchi
发明人： Atsushi Takahashi , Kenji Kanbe , Tetsuya Mori , Yuichi Kita , Tsuyoshi Tamamura , Tomio Takeuchi
IPC分类号： C12P19/02 , C12N1/20
CPC分类号： C12R1/18 , C12P19/02 , C12R1/38 , C12R1/64
摘要： Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, inexpensive myo-inositol is used as a starting compound which is reacted with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. A biologically pure culture of Pseudomonas sp. AB 10215 strain is also provided which has a characteristic nature of being capable of converting myo-inositol into L-epi-2-inosose.
摘要翻译：提供了用于有效生产L-外 - 二糖和外消旋肌醇的新方法，其可用作各种药物或用于合成各种药物的中间体。在该方法中，使用廉价的肌醇作为起始化合物，其与能够将肌醇转化为L-外 - 二糖的革兰氏阴性细菌反应，从而通过转化产生L-表二-2-糖的肌醇变为L-epi-2-inosose。假单胞菌属的生物纯培养物还提供了AB 10215菌株，其特征在于能够将肌醇转化为L-表 - 2-inosose。

7. 发明授权

US09610367B2 Particle and contrast agent having the particle 有权
公开(公告)号：US09610367B2
公开(公告)日：2017-04-04
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K9/00 , A61K49/00 , A61K9/51 , A61K49/22 , B82Y15/00 , B82Y30/00
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

8. 发明授权

US09515277B2 Organic electroluminescent element, organic EL display device and organic EL illumination 有权
标题翻译：有机电致发光元件，有机EL显示装置和有机EL照明
公开(公告)号：US09515277B2
公开(公告)日：2016-12-06
申请号：US12935416
申请日：2009-08-12
申请人： Kazuki Okabe , Atsushi Takahashi , Tomohiro Abe , Yasuyuki Tsurutani , Hideki Sato
发明人： Kazuki Okabe , Atsushi Takahashi , Tomohiro Abe , Yasuyuki Tsurutani , Hideki Sato
IPC分类号： H01L51/50 , C08G61/12 , C08G73/02 , C08L65/00 , C08L79/02 , C09K11/06 , H05B33/14 , H01L51/00
CPC分类号： H01L51/5012 , C08G61/12 , C08G73/026 , C08G2261/135 , C08G2261/141 , C08G2261/1424 , C08G2261/3162 , C08L65/00 , C08L79/02 , C09K11/06 , C09K2211/1433 , H01L51/0035 , H01L51/0043 , H01L51/0058 , H01L51/006 , H01L51/0067 , H01L51/008 , H01L51/0081 , H01L51/5048 , H05B33/14
摘要： To provide an organic electroluminescent element having a low driving voltage, high current efficiency and high voltage efficiency.An organic electroluminescent element comprising an anode, a cathode and an organic layer disposed between the anode and the cathode, wherein the organic layer comprises a mixed layer containing a light-emitting low molecular compound and/or a charge-transporting low molecular compound in a film containing an insolubilized polymer obtained by insolubilizing an insolubilizing polymer, and, adjacent to the mixed layer, a layer containing a light-emitting low molecular compound and a charge-transporting low molecular compound and not containing an insolubilized polymer.
摘要翻译：一种有机电致发光元件，包括阳极，阴极和设置在阳极和阴极之间的有机层，其中有机层包括含有发光低分子化合物和/或电荷输送低分子化合物的混合层，含有通过使不溶性聚合物不溶化而得到的不溶性聚合物和与混合层相邻的含有发光低分子化合物和电荷输送性低分子化合物并且不含不溶性聚合物的层的膜。

9. 发明授权

US09009519B2 Timing control device and control method thereof 有权
标题翻译：定时控制装置及其控制方法
公开(公告)号：US09009519B2
公开(公告)日：2015-04-14
申请号：US13569378
申请日：2012-08-08
申请人： Atsushi Takahashi
发明人： Atsushi Takahashi
IPC分类号： G06F1/14 , F02D41/28 , F02D41/24
CPC分类号： H03K3/017 , F02D41/2403 , F02D41/28 , F02D2250/14 , G06F1/14
摘要： Provided is a timing control device including: a storage unit that stores multiple pieces of timing control information including identification information and expected value data; a first selector that selectively outputs any of the multiple pieces of timing control information; a second selector that selectively outputs any of data items output from data output devices based on the identification information; a reference data generation unit that generates reference data based on expected value data and a data item output from the second selector in synchronization with a switching of the timing control information; a comparator that compares the reference data with the data item output from the second selector and outputs a coincidence signal when the reference data and the data item coincide with each other; and an output control unit that outputs a timing signal according to the coincidence signal.
摘要翻译：提供了一种定时控制装置，包括：存储单元，存储包括识别信息和期望值数据的多个定时控制信息; 第一选择器，其选择性地输出所述多个定时控制信息中的任何一个; 第二选择器，其基于所述识别信息选择性地输出从数据输出设备输出的任何数据项; 参考数据生成单元，其与定时控制信息的切换同步地基于期望值数据和从第二选择器输出的数据项生成参考数据; 比较器，当参考数据和数据项彼此一致时，比较参考数据和从第二选择器输出的数据项，并输出一致信号; 以及输出控制单元，其根据所述一致信号输出定时信号。

10. 发明授权

US08912145B2 Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease 有权
标题翻译：用于预防和/或治疗阿尔茨海默病的疫苗组合物
公开(公告)号：US08912145B2
公开(公告)日：2014-12-16
申请号：US13290960
申请日：2011-11-07
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
IPC分类号： C12N15/62 , C12N15/82 , A61P25/28 , A61K38/00 , A61K38/08 , A61K36/48 , C07K7/06 , C12N15/12 , C12N15/29 , A61K39/00 , C07K14/415 , C07K14/47
CPC分类号： A61K39/0007 , A61K2039/55516 , A61K2039/6031 , C07K14/415 , C07K14/4711 , C12N15/62 , C12N15/8257 , C12N15/8258
摘要： A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.
摘要翻译：一种用于预防和/或治疗阿尔茨海默氏病的疫苗组合物，其包含通过插入单个或串联重复的多个淀粉样蛋白复合物制备的融合蛋白; 具有衍生自淀粉样蛋白N末端的5至15个连续氨基酸残基的抗原肽; 肽成野生型种子储存蛋白。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式