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1. 发明授权

US4178454A Stabilized prostaglandin E composition 失效
标题翻译：稳定的前列腺素E组成
公开(公告)号：US4178454A
公开(公告)日：1979-12-11
申请号：US950451
申请日：1978-10-11
申请人： Masanobu Naruto , Kiyotaka Ohno , Norio Naruse
发明人： Masanobu Naruto , Kiyotaka Ohno , Norio Naruse
IPC分类号： A61K31/557 , C07C405/00 , C07C177/00
CPC分类号： A61K31/557 , C07C405/00 , C07C405/0025
摘要： The degradation of prostaglandins E is prevented or minimized by combining prostaglandins E with methylhesperidin.
摘要翻译：通过将前列腺素E与亚甲基橙皮苷组合来预防或最小化前列腺素E的降解。

2. 发明授权

US5496849A Sulfonic acid derivative and its pharmaceutical application 失效
标题翻译：磺酸衍生物及其制药应用
公开(公告)号：US5496849A
公开(公告)日：1996-03-05
申请号：US244141
申请日：1994-05-17
申请人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
发明人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
IPC分类号： C07D307/93 , A61K31/34 , C07D307/78 , C07D307/80
CPC分类号： C07D307/93
摘要： The present invention discloses sulfonamide derivative represented by the following general formula: ##STR1## [wherein, R.sub.1 is(i) --COOR.sub.2 (where, R.sub.2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) an alkyl having 1 to 14 carbon atoms) or,(ii) --C(.dbd.O)--R.sub.3 (wherein, R.sub.3 represents an alkyl having 1 to 4 carbon atoms); A is(i) --(CH.sub.2)n-- (wherein, n represents an integer of 0 to 3),(ii) --CH.dbd.CH--, or the group:(iii) --O--C(R.sub.4) (R.sub.5)-- (wherein, R.sub.4 and R.sub.5 represent (1) hydrogen or (2) an alkyl having 1 to 4 carbon atoms, and R.sub.4 and R.sub.5 may be identical or different); and,w is NH or --O--], as well as a thromboxane A2 receptor antagonistic drug having said derivative for its active ingredient.Since the compound of the present invention has excellent thromboxane A2 receptor antagonistic action, it can be used as a thromboxane A2 receptor antagonist of high activity and long duration.
摘要翻译： PCT No.PCT / JP93 / 01339 Sec。 371日期：1994年5月17日 102（e）日期1994年5月17日PCT提交1993年9月17日PCT公布。出版物WO94 / 06785 日本3月3日公开本发明公开了由以下通式表示的磺酰胺衍生物：其中，R 1为（ⅰ）-COOR 2（其中，R 2为（1）氢），（2）药理学上可接受的阳离子，或（3）具有1至14个碳原子的烷基）或（ii）-C（= O）-R 3（其中，R 3表示具有1至4个碳原子的烷基）; A是（i） - （CH 2）n - （其中，n表示0至3的整数），（ii）-CH = CH-或基团：（iii）-OC（R4）（R5） - （其中，R4和R5表示（1）氢或（2）具有1至4个碳原子的烷基，R4和R5可以相同或不同）; 和w是NH或-O-]，以及具有所述衍生物作为其活性成分的血栓素A2受体拮抗药。由于本发明化合物具有优异的血栓素A2受体拮抗作用，因此可用作活性高且持续时间长的血栓烷A2受体拮抗剂。

3. 发明授权

US4912319A Detector device for mixing ratio for gasoline and alcohol or the like 失效
标题翻译：用于汽油和酒精等的混合比的检测装置
公开(公告)号：US4912319A
公开(公告)日：1990-03-27
申请号：US160632
申请日：1988-02-26
申请人： Shigeru Miyata , Yoshihiro Matsubara , Kiyotaka Ohno
发明人： Shigeru Miyata , Yoshihiro Matsubara , Kiyotaka Ohno
IPC分类号： G01N21/41 , G01J1/16 , G01J1/44 , G01N21/43 , G01N21/85
CPC分类号： G01N21/43 , G01J2001/1636 , G01J2001/444 , G01N21/85 , G01N2201/0621 , Y10S250/903
摘要： A detector device for mixing ratio for gasoline and alcohol include an optically permeable column, one end of which is coated with a light-reflective layer. The circumferential surface of the column is at least partly immersed in mixing liquid of gasoline and alcohol.The light beams enter the column to be incident on said circumferential surface of the column and reflect from the circumferential surface to be incident on said light reflective-layer to reflect therefrom. The reflected light beams impinge on a photo diode which outputs in accordance with the intensity of the light beams impinged.The diametrical and lengthwise dimension of the column being determined such as to provide incidence angles of the reflected light beams changing from a minimum angle corresponding to the critical angle when the mixing liquid ratio is at the lower limit of the predetermined range to a maximum angle corresponding to the critical angle when the mixing liquid ratio is at the upper limit of the predetermined range.
摘要翻译：用于汽油和醇的混合比的检测器装置包括光学透析柱，其一端涂覆有光反射层。柱的圆周表面至少部分浸没在汽油和酒精的混合液体中。光束进入柱入射到柱的所述圆周表面上并从圆周表面反射入射到所述光反射层上以从其反射。反射光束照射到根据照射的光束的强度输出的光电二极管。确定柱的直径和纵向尺寸，以便当混合液比在预定范围的下限至对应的最大角度时，提供从与临界角对应的最小角度改变的反射光束的入射角当混合液体比例在预定范围的上限时达到临界角。

4. 发明授权

US5086071A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives 失效
标题翻译： 2,5,6,7-四取代-4,8-间 - 间 - 苯基PGI 2衍生物
公开(公告)号：US5086071A
公开(公告)日：1992-02-04
申请号：US493109
申请日：1990-03-13
申请人： Kiyotaka Ohno , Atsushi Ohtake , Takashi Endoh , Shigeki Itou , Kazuhiro Hoshi
发明人： Kiyotaka Ohno , Atsushi Ohtake , Takashi Endoh , Shigeki Itou , Kazuhiro Hoshi
IPC分类号： C07D307/93 , A61K31/557 , A61P33/10 , A61P43/00 , C07C405/00
CPC分类号： C07D307/93
摘要： Pharmaceutically useful compounds are 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives which are excellently stable and potent in vivo.

5. 发明授权

US4775692A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives 失效
标题翻译： 2,5,6,7-四去甲-4,8-间 - 间 - 亚苯基PGI 2衍生物
公开(公告)号：US4775692A
公开(公告)日：1988-10-04
申请号：US7291
申请日：1987-01-23
申请人： Kiyotaka Ohno , Atsushi Ohtake , Hiroshi Nagase , Shintaro Nishio , Toshiya Takahashi , Hisanori Wakita
发明人： Kiyotaka Ohno , Atsushi Ohtake , Hiroshi Nagase , Shintaro Nishio , Toshiya Takahashi , Hisanori Wakita
IPC分类号： C07D307/93 , A61K31/335
CPC分类号： C07D307/93
摘要： Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, X, R.sub.2 and R.sub.3 are as defined herein.
摘要翻译：本文公开了表现出优异的体内持续时间和活性的新型前列腺素I2（PGI2）衍生物，所述衍生物由以下通式表示：其中R1，X，R2和R3如本文所定义。

6. 发明授权

US4564620A 5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them 失效
标题翻译： 5,6,7-三硝基-4,8-间 - 间 - 亚苯基PGI 2衍生物和含有它们的抗溃疡，抗血栓形成和抗高血压药物组合物
公开(公告)号：US4564620A
公开(公告)日：1986-01-14
申请号：US567755
申请日：1984-01-03
申请人： Kiyotaka Ohno , Hiroshi Nagase , Mamoru Ishikawa , Kazuhisa Matsumoto , Shintaro Nishio
发明人： Kiyotaka Ohno , Hiroshi Nagase , Mamoru Ishikawa , Kazuhisa Matsumoto , Shintaro Nishio
IPC分类号： A61K31/34 , A61K31/343 , A61K31/557 , A61K31/5575 , A61P43/00 , C07C17/093 , C07C29/00 , C07C29/17 , C07C51/16 , C07C405/00 , C07D307/93 , C07D307/937 , C07D309/12 , C07D405/12 , C07D407/12 , C07D493/04 , C07F7/18
CPC分类号： C07F7/1852 , C07C17/093 , C07C29/172 , C07C309/00 , C07C51/16 , C07D307/93 , C07B2200/07 , Y02P20/55
摘要： Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17-.alpha.-methyl-20-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI.sub.2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI.sub.2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2. They are useful in treatment of ulcers, thrombii and hypertension for example.
摘要翻译：药用有用的化合物是5,6,7-三硝基-4,8-间 - 间 - 亚苯基PGI 2衍生物，例如5,6,7-三硝基-4,8-间 - 间 - 亚苯基 - 13,14-二脱氢PGI 2， 5,6,7-三硝基-4,8-间 - 间 - 亚苯基-16,16-二甲基PGI2,5,6,7-三硝基-4,8-间 - 间 - 亚苯基-17-α-甲基-20 - 低聚PGI2,5,6,7-三硝基-4,8-间 - 间 - 亚苯基-17,18,19,20-四去甲-16-苯氧基PGI2,5,6,7-三硝基-4,8-间（5-甲基-1,3-亚苯基）PGI 2和5,6,7-三硝基-4,8-间 - （5-甲基-1,3-亚苯基）间 - 亚苯基-2,3-二脱氢-16,17,18,19,20-戊基或-15-苯基PGI 2。它们可用于治疗溃疡，血栓和高血压。

7. 发明授权

US5401768A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2, derivative, manufacturing process thereof and its use 失效
标题翻译： 2,5,6,7-四去甲-4,8-间间亚苯基PGI 2，其衍生物及其制备方法及其用途
公开(公告)号：US5401768A
公开(公告)日：1995-03-28
申请号：US90995
申请日：1993-07-13
申请人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
发明人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
IPC分类号： C07D307/93 , C07D407/14 , C07D493/04 , A61K31/34
CPC分类号： C07D407/14 , C07D307/93 , C07D493/04
摘要： Disclosed are 2,5,6,7-tetranor-4,8-inter-m-phemylene PGI.sub.2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, which are useful as pharmaceuticals.These compounds are useful as an antiulcer drug, antihypertensive drug, antithrombus drug or the like.
摘要翻译： PCT No.PCT / JP88 / 01048 Sec。 371日期1989年8月14日 102（e）日期1989年8月14日PCT提交1988年10月14日PCT公布。出版物WO89 / 03387 日期：1989年4月20日。公开的是2,5,6,7-四去甲-4,8-间m-亚氨基PGI 2衍生物，如16-甲基-2,5,6,7-四去甲-4,8- 间 - 亚苯基PGI 2及其甲酯，17-甲基-2,5,6,7-四酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯，15-苯基-2,5,6， 7,16,17,18,19,20-壬腈-4,8-间间 - 亚苯基PGI2,16-甲基-17-苯基-2,5,6,7,18,19,20-庚酮-4 ，8-间 - 间 - 亚苯基PGI2,16,16-二甲基-17-苯基-2,5,6,7,18,19,20-庚烷-4,8-间间苯撑PGI2,16-甲基 -16-苯氧基-2,5,6,7,17,18,19,20-辛腈-4,8-间间苯撑PGI2,16-甲基-16-苯氧基-2,5,6,7， 18,19,20-庚酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯和3-脱羧基-3-羟甲基-16-甲基-16-苯氧基-2,5,6,7,18， 19,20-庚酮-4,8-间间 - 亚苯基PGI2，其可用作药物。这些化合物可用作抗溃疡药，抗高血压药，抗血栓药物等。

8. 发明授权

US4880939A 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI.sub.2 derivatives 失效
标题翻译： 2,5,6,7-四去甲-18,18,19,19-四脱氢-4,8-间 - 间 - 亚苯基PGI 2衍生物
公开(公告)号：US4880939A
公开(公告)日：1989-11-14
申请号：US128878
申请日：1987-12-04
申请人： Kiyotaka Ohno , Toshiya Takahashi , Shintaro Nishio
发明人： Kiyotaka Ohno , Toshiya Takahashi , Shintaro Nishio
IPC分类号： A61K31/557 , A61P1/04 , A61P7/02 , A61P9/08 , A61P11/08 , A61P15/04 , A61P43/00 , C07D307/93
CPC分类号： C07D307/93
摘要： Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent physiological activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.

9. 发明授权

US4822804A 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them 失效
标题翻译： 5,6,7， - 三硝基-4,8-间间亚苯基2-或PGI 2衍生物和含有它们的抗溃疡，抗血栓形成和抗高血压药物组合物
公开(公告)号：US4822804A
公开(公告)日：1989-04-18
申请号：US102391
申请日：1987-09-29
申请人： Kiyotaka Ohno , Hiroshi Nagase , Mamoru Ishikawa , Kazuhisa Matsumoto , Shintaro Nishio
发明人： Kiyotaka Ohno , Hiroshi Nagase , Mamoru Ishikawa , Kazuhisa Matsumoto , Shintaro Nishio
IPC分类号： A61K31/34 , A61K31/343 , A61K31/557 , A61K31/5575 , A61P43/00 , C07C17/093 , C07C29/00 , C07C29/17 , C07C51/16 , C07C405/00 , C07D307/93 , C07D307/937 , C07D309/12 , C07D405/12 , C07D407/12 , C07D493/04 , C07F7/18
CPC分类号： C07F7/1852 , C07C17/093 , C07C29/172 , C07C309/00 , C07C51/16 , C07D307/93 , C07B2200/07 , Y02P20/55
摘要： Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl-.omega.-homo PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl-.omega.-homo PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl-.omega.-homo PGI.sub.2,5,6, 7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16-p ropoxy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-etho xy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-prop oxy PGI.sub.2,5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-phenoxy PGI.sub.2 and methyl esters thereof.5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16 -phenoxy PGI.sub.2 or its methyl ester, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-methyl-16-phenox y PGI.sub.2 or its methyl ester.They are useful in treatment of ulcers, thrombii and hypertension for example.

10. 发明授权

US4474802A 5,6,7-Trinor-4,8-inter-m-phenylene prostaglandin I.sub.2 derivatives useful in anti-ulcer, hypotensive and platelet aggregation inhibiting compositions 失效
标题翻译：可用于抗溃疡，降血压和血小板聚集抑制组合物的5,6,7-三 - 间-4,8-间 - 间 - 亚苯基前列腺素I2衍生物
公开(公告)号：US4474802A
公开(公告)日：1984-10-02
申请号：US459226
申请日：1983-01-19
申请人： Kiyotaka Ohno , Hiroshi Nagase , Kazuhisa Matsumoto , Shintaro Nishio
发明人： Kiyotaka Ohno , Hiroshi Nagase , Kazuhisa Matsumoto , Shintaro Nishio
IPC分类号： A61K31/34 , A61K31/343 , A61K31/557 , A61P7/02 , A61P9/08 , A61P43/00 , C07C29/124 , C07C29/56 , C07D307/93 , C07D493/04 , C07F9/40
CPC分类号： C07D493/04 , C07C29/124 , C07C29/56 , C07D307/93 , C07F9/4015
摘要： A compound of the formula ##STR1## wherein R.sup.1 is a pharmaceutically acceptable cation, hydrogen or n-alkyl of 1 to 12 carbon atoms; R.sup.2 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R.sup.3 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R.sup.4 is hydrogen, methyl or ethyl; R.sup.5 is n-alkyl of 1 to 5 carbon atoms; n is an integer of 0 to 4; A is --CH.sub.2 --CH.sub.2 -- or trans --CH.dbd.CH--; and X is --CH.sub.2 --CH.sub.2 -- or trans --CH.dbd.CH--. The compounds are useful in anti-ulcer, hypotensive and platelet aggregation inhibiting compositions.
摘要翻译：式（I）的化合物，其中R1是药学上可接受的阳离子，1至12个碳原子的氢或正烷基; R2为氢，2〜10个碳原子的酰基或7〜13个碳原子的芳酰基; R3为氢，2〜10个碳原子的酰基或7〜13个碳原子的芳酰基; R4是氢，甲基或乙基; R5是1〜5个碳原子的正烷基; n为0〜4的整数。 A是-CH 2 -CH 2 - 或反-CH = CH-; 并且X是-CH 2 -CH 2 - 或反-CH = CH-。该化合物可用于抗溃疡，降血压和血小板聚集抑制组合物。

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