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1. 发明授权

US4654211A New compound, FR-900451, production and use thereof 失效
标题翻译：新化合物，FR-900451，其生产和使用
公开(公告)号：US4654211A
公开(公告)日：1987-03-31
申请号：US677013
申请日：1984-11-30
申请人： Masami Ezaki , Seiji Hashimoto , Tadaaki Komori , Kazuyoshi Umehara , Masanobu Kohsaka
发明人： Masami Ezaki , Seiji Hashimoto , Tadaaki Komori , Kazuyoshi Umehara , Masanobu Kohsaka
IPC分类号： C07G11/00 , A61K35/74 , A61K36/07 , A61P31/04 , C12N1/20 , C12P1/06 , C12R1/465 , A61K35/00
CPC分类号： C12P1/06 , Y10S435/886
摘要： Antibiotic FR-900451 is produced by Streptomyces griseorubiginosus No. 43708 (FERM BP-699).
摘要翻译：抗生素FR-900451由灰霉链霉菌No.43708（FERM BP-699）生产。

2. 发明授权

US4950605A FR-900493 substance, a process for its production and a pharmaceutical composition containing the same 失效
标题翻译： FR-900493物质，其生产方法和含有该物质的药物组合物
公开(公告)号：US4950605A
公开(公告)日：1990-08-21
申请号：US319042
申请日：1989-03-06
申请人： Kozo Ochi , Masami Ezaki , Morita Iwami , Tadaaki Komori , Masanobu Kohsaka
发明人： Kozo Ochi , Masami Ezaki , Morita Iwami , Tadaaki Komori , Masanobu Kohsaka
IPC分类号： A61K35/74 , A61P31/04 , C07G11/00 , C12P1/04 , C12P21/04 , C12R1/07
CPC分类号： C12P1/04 , Y10S435/834
摘要： FR-900493 is a compound of molecular formula C.sub.20 H.sub.33 N.sub.5 O.sub.11 which may be recovered from Bacillus cultures, possesses antimicrobial activity, and may be used for the treatment and prevention of infectious diseases in humans and animals.

3. 发明授权

US4313935A Antibiotic FR-900129 substance, a process for the preparation thereof and pharmaceutical compositions containing the same 失效
标题翻译：抗生素FR-900129物质，其制备方法和含有它们的药物组合物
公开(公告)号：US4313935A
公开(公告)日：1982-02-02
申请号：US125486
申请日：1980-02-28
申请人： Tadaaki Komori , Michio Yamashita , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Tadaaki Komori , Michio Yamashita , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： C07G11/00 , C12P1/06 , C12R1/465 , A61K35/00 , C12P13/00
CPC分类号： C12R1/465 , C12P1/06 , Y10S435/886
摘要： Prodn. of FR-900129 comprises culturing a Streptomyces n. 4012 category which is analogous to Streptomyces misakiensis and Steptomyces aburaviensis, i.e. Streptomyces avellaneus No. 4012, at 25.degree. C. to 30.degree. C. during 50 to 100 hours in a culture medium which consists of a carbon source (e.g. glucose, fructose, glycerin, starch, galactose, maltose, dextrin), an organic or inorganic nitrogen source (e.g. yeast extract, peptone, cottonseed cake, soyabean powder, cornsteep liquor, dry yeast, ammonium nitrate, ammonium sulphate, ammonium phosphate, urea and amino acid) and an inorganic salt (e.g. calcium carbonate, sodium phosphate, potassium phosphate, sodium chloride, potassium chloride, magnesium salt and copper salt). The produced FR-900129 is isolated by a collecting step, a purifying step, a vacuum condensation step, a freeze-drying step, a pH adjusting step, a cationic, anionic or nonionic resin treating step, an active carbon adsorption step and a crystallizing and recrystallizing step. The isolated material may then be converted to its adduct salt or its ester conventionally.
摘要翻译：产品的FR-900129包括培养Streptomyces n。 4012类似于Streptomyces misakiensis和Steptomyces aburaviensis（即Streptomyces avellaneus No.4012），在25℃至30℃下在50至100小时内在由碳源（例如葡萄糖，果糖，甘油，淀粉，半乳糖，麦芽糖，糊精），有机或无机氮源（例如酵母提取物，蛋白胨，棉籽饼，大豆粉，玉米浸液，干酵母，硝酸铵，硫酸铵，磷酸铵，尿素和氨基酸）和无机盐（例如碳酸钙，磷酸钠，磷酸钾，氯化钠，氯化钾，镁盐和铜盐）。生产的FR-900129通过收集步骤，纯化步骤，真空冷凝步骤，冷冻干燥步骤，pH调节步骤，阳离子，阴离子或非离子树脂处理步骤，活性炭吸附步骤和结晶和重结晶步骤。然后可以将分离的材料通常转化为其加合物盐或其酯。

4. 发明授权

US4479942A Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof 失效
标题翻译：四氢呋喃羧酸衍生物，其制备方法及其药物组合物
公开(公告)号：US4479942A
公开(公告)日：1984-10-30
申请号：US403117
申请日：1982-07-29
申请人： Michio Yamashita , Tadaaki Komori , Junji Hosoda , Yoshio Kawai , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Kazuo Sakane , Hiroyuki Setoi , Tsutomu Teraji
发明人： Michio Yamashita , Tadaaki Komori , Junji Hosoda , Yoshio Kawai , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Kazuo Sakane , Hiroyuki Setoi , Tsutomu Teraji
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P31/04 , C07H19/16 , C12P19/40 , C07H17/00 , C07H19/06
CPC分类号： C12R1/645 , C07H19/16 , C12P19/40 , Y02P20/55
摘要： This invention relates to tetrahydrofuran-carboxylic acid derivatives, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is amino or acylamino andR.sup.3 is carboxy or a protected carboxy groupor a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及抗微生物活性的四氢呋喃 - 羧酸衍生物，其具有下式：其中R1是氨基或被保护的氨基，R2是氨基或酰基氨基，R3是羧基或被保护的羧基或药学上可接受的盐其中。

5. 发明授权

US4861774A Method of treating tumors using tetracyclo compounds 失效
标题翻译：使用四环化合物治疗肿瘤的方法
公开(公告)号：US4861774A
公开(公告)日：1989-08-29
申请号：US947759
申请日：1986-12-30
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/18 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55
摘要： The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及一种治疗哺乳动物癌或肉瘤肿瘤的方法，包括向所述哺乳动物施用有效量的下式的四环化合物：其中R 1为甲酰基，被保护的甲酰基，羟甲基，保护的羟甲基，芳基氨基甲基羧基，保护的羧基，芳基亚氨基甲基，羟基亚氨基甲基，烷氧基亚氨基甲基，酰氧基亚氨基甲基，氨基甲酰基甲基或芳基氨基丙基甲基，R2是羟基，烷氧基或被保护的羟基，R3是氢，R4是甲基，羟甲基或保护的羟甲基，或R3和R4组合在一起形成亚甲基或氧代，R 5为羟基，烷氧基或保护的羟基，R 6为氢，亚氨基保护基或烷基，及其药学上可接受的盐。

6. 发明授权

US4645765A Tetracyclo compounds and a pharmaceutical composition containing the same 失效
标题翻译：四环化合物和含有它们的药物组合物
公开(公告)号：US4645765A
公开(公告)日：1987-02-24
申请号：US743616
申请日：1985-06-11
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/04 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55 , Y10S435/886
摘要： New tetracyclo compounds of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl,R.sup.2 is hydroxy, alkoxy or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof, which have pharmacological activities such as antitumor activity, antimicrobial activity, and the like, and a process for their production and a pharmaceutical composition containing the same.
摘要翻译：新的下式的四环化合物：其中R 1是甲酰基，保护的甲酰基，羟甲基，保护的羟甲基，芳基氨基甲基，羧基，被保护的羧基或取代的亚氨基甲基，R2是羟基，烷氧基或保护的羟基，R3是氢， R 4是甲基，羟甲基或被保护的羟甲基，或者R 3和R 4结合在一起形成亚甲基或氧代，R 5是羟基，烷氧基或保护的羟基，R 6是氢，亚氨基保护基或烷基，及其药学上可接受的盐，具有抗肿瘤活性，抗菌活性等药理活性，及其制造方法和含有该药物组合物的药物组合物。

7. 发明授权

US4743555A Biologically pure culture of Streptomyces sandaensis No. 6897 失效
标题翻译： Streptomyces sandaensis No.6897的生物纯培养
公开(公告)号：US4743555A
公开(公告)日：1988-05-10
申请号：US913478
申请日：1986-09-30
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/04 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55 , Y10S435/886
摘要： A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.

8. 发明授权

US4128546A Process for the purification of FR-1923 substance 失效
标题翻译： FR-1923物质纯化方法
公开(公告)号：US4128546A
公开(公告)日：1978-12-05
申请号：US694906
申请日：1976-06-10
申请人： Masaru Kurita , Kazuyoshi Jomon , Tadaaki Komori , Isami Nakatani , Masahiro Tsuji
发明人： Masaru Kurita , Kazuyoshi Jomon , Tadaaki Komori , Isami Nakatani , Masahiro Tsuji
IPC分类号： C07D205/085 , C12P17/10 , C07D205/08
CPC分类号： C07D205/085 , C12P17/10
摘要： Purification of Fr-1923 antibiotic substance by treatment with a macroporous non-ionic adsorption resin such as styrene-divinyl benzene copolymer or acrylic ester polymer.
摘要翻译：通过用大孔非离子吸附树脂如苯乙烯 - 二乙烯基苯共聚物或丙烯酸酯聚合物处理来纯化Fr-1923抗生素物质。

9. 发明授权

US4018772A Process for the purification of bicyclomycin 失效
标题翻译：纯化双环霉素的方法
公开(公告)号：US4018772A
公开(公告)日：1977-04-19
申请号：US541929
申请日：1975-01-17
申请人： Masaru Kurita , Kazuyoshi Jomon , Tadaaki Komori , Isami Nakatani
发明人： Masaru Kurita , Kazuyoshi Jomon , Tadaaki Komori , Isami Nakatani
IPC分类号： C12P17/18 , A61K20060101 , A61K31/395 , A61K31/495 , A61K35/66 , A61K35/74 , C07D241/00 , C07D487/08 , C07G11/00 , C11D9/14 , C12P1/06 , C12P13/00 , C12R1/465
CPC分类号： C07D487/04
摘要： A process for the purification of bicyclomycin by treating a solution thereof with a macroporous nonionic adsorption resin.
摘要翻译：一种通过用大孔非离子吸附树脂处理其溶液来纯化双环霉素的方法。

10. 发明授权

US4472300A Azetidinone derivatives and process for preparation thereof 失效
标题翻译：氮杂环丁酮衍生物及其制备方法
公开(公告)号：US4472300A
公开(公告)日：1984-09-18
申请号：US130205
申请日：1980-03-13
申请人： Takashi Kamiya , Yoshihisa Saito , Masashi Hashimoto , Osamu Nakaguti , Teruo Oku , Youichi Shiokawa , Takao Takaya , Tadaaki Komori , Tsutomu Teraji , Keiji Hemmi , Hisashi Takasugi
发明人： Takashi Kamiya , Yoshihisa Saito , Masashi Hashimoto , Osamu Nakaguti , Teruo Oku , Youichi Shiokawa , Takao Takaya , Tadaaki Komori , Tsutomu Teraji , Keiji Hemmi , Hisashi Takasugi
IPC分类号： C07D205/085 , C07D473/00 , C07D205/08 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D473/00 , C07D205/085
摘要： New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 amino or acylamino, and A is selected from a variety of groups.
摘要翻译：新的抗微生物氮杂环丁酮衍生物及其下式的盐：其中R 1氨基或酰氨基，A选自多种基团。

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