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1. 发明申请

US20090248316A1 METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS 失效
标题翻译：通过使用蒽环类抗生素药物来治疗治疗效果的诊断方法和用于支持通过使用安非他酮类抗生素治疗药物治疗效果的装置的方法
公开(公告)号：US20090248316A1
公开(公告)日：2009-10-01
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

2. 发明授权

US08160821B2 Method for supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs and a device for supporting a diagnosis for an effect of a treatment by using anthracycline anticancer drugs 失效
标题翻译：支持通过使用蒽环类抗癌药物治疗效果的诊断的方法和通过使用蒽环类抗癌药物进行治疗效果的支持诊断的装置
公开(公告)号：US08160821B2
公开(公告)日：2012-04-17
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

3. 发明授权

US08014960B2 Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US08014960B2
公开(公告)日：2011-09-06
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G01N33/50
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

4. 发明申请

US20090246809A1 METHOD OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE, AND A DEVICE OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US20090246809A1
公开(公告)日：2009-10-01
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： C12Q1/48 , C12M1/34 , C12M1/36
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

5. 发明授权

US08921114B2 Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product 有权
标题翻译：癌症诊断支持系统，癌症诊断支持信息提供方法和计算机程序产品
公开(公告)号：US08921114B2
公开(公告)日：2014-12-30
申请号：US12197714
申请日：2008-08-25
申请人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
发明人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
IPC分类号： G06F19/24 , G06F19/20 , G06F19/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A diagnosis support system for cancer is disclosed that comprises: a measurement value acquiring section for acquiring a measurement value of a first cancer patient; a sample data memory for storing sample data of a plurality of cancer patients different from the first patient; a reference range determination section for determining a reference range based on the measurement value of the first cancer patient; a display unit; and a display controller for controlling the display unit to display a diagnosis support screen showing the clinical information included in the sample data having measurement value within the reference range. A method of providing cancer diagnosis support information and a computer program product are also disclosed.
摘要翻译：公开了一种用于癌症的诊断支持系统，包括：测量值获取部分，用于获取第一癌症患者的测量值; 用于存储与第一患者不同的多个癌症患者的样本数据的样本数据存储器; 参考范围确定部分，用于基于第一癌症患者的测量值来确定参考范围; 显示单元; 以及显示控制器，用于控制显示单元显示诊断支持屏幕，其显示包含在具有参考范围内的测量值的样本数据中的临床信息。还公开了提供癌症诊断支持信息的方法和计算机程序产品。

6. 发明申请

US20090054739A1 DIAGNOSIS SUPPORT SYSTEM FOR CANCER, DIAGNOSIS SUPPORT INFORMATION PROVIDING METHOD FOR CANCER, AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：癌症诊断支持系统，诊断支持信息提供癌症和计算机程序产品的方法
公开(公告)号：US20090054739A1
公开(公告)日：2009-02-26
申请号：US12197714
申请日：2008-08-25
申请人： Hideki ISHIHARA , Tomoko Matsushima , Masaki Shibayama
发明人： Hideki ISHIHARA , Tomoko Matsushima , Masaki Shibayama
IPC分类号： A61B5/00 , G06Q50/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A diagnosis support system for cancer is disclosed that comprises: a measurement value acquiring section for acquiring a measurement value of a first cancer patient; a sample data memory for storing sample data of a plurality of cancer patients different from the first patient; a reference range determination section for determining a reference range based on the measurement value of the first cancer patient; a display unit; and a display controller for controlling the display unit to display a diagnosis support screen showing the clinical information included in the sample data having measurement value within the reference range. A method of providing cancer diagnosis support information and a computer program product are also disclosed.
摘要翻译：公开了一种用于癌症的诊断支持系统，包括：测量值获取部分，用于获取第一癌症患者的测量值; 用于存储与第一患者不同的多个癌症患者的样本数据的样本数据存储器; 参考范围确定部分，用于基于第一癌症患者的测量值来确定参考范围; 显示单元; 以及显示控制器，用于控制显示单元显示诊断支持屏幕，其显示包含在具有参考范围内的测量值的样本数据中的临床信息。还公开了提供癌症诊断支持信息的方法和计算机程序产品。

7. 发明申请

US20070202555A1 Method for judging feature of malignant tumor 失效
标题翻译：判断恶性肿瘤特征的方法
公开(公告)号：US20070202555A1
公开(公告)日：2007-08-30
申请号：US11711053
申请日：2007-02-27
申请人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
发明人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57415 , C12Q1/485 , G01N2333/4739 , G01N2333/9121 , G06F19/24
摘要： A method for judging feature of malignant tumor is described. The method comprises obtaining step, first comparing step, second comparing step and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell. The first comparing step comprises comparing a first threshold value with the third parameter. The second comparing comprises comparing a second threshold value with the fourth parameter. The judging step comprises judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.
摘要翻译：描述了判断恶性肿瘤特征的方法。该方法包括获得步骤，第一比较步骤，第二比较步骤和判断步骤。获得步骤包括基于包含在恶性肿瘤的肿瘤细胞中的第一细胞周期蛋白依赖性激酶（第一CDK）的活性和表达水平获得第一参数，第二参数基于第二细胞周期蛋白依赖性激酶的活性和表达水平（第二CDK），基于第一参数和第二参数的第三参数，以及基于包含在肿瘤细胞中的细胞周期蛋白的表达水平的第四参数。第一比较步骤包括将第一阈值与第三参数进行比较。第二比较包括将第二阈值与第四参数进行比较。判断步骤包括基于第一比较步骤和第二比较步骤的比较结果判断恶性肿瘤的特征。

8. 发明授权

US08041514B2 Method for judging feature of malignant tumor 失效
标题翻译：判断恶性肿瘤特征的方法
公开(公告)号：US08041514B2
公开(公告)日：2011-10-18
申请号：US11711053
申请日：2007-02-27
申请人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
发明人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57415 , C12Q1/485 , G01N2333/4739 , G01N2333/9121 , G06F19/24
摘要： A method for judging feature of malignant tumor is described. The method comprises obtaining step, first comparing step, second comparing step and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell. The first comparing step comprises comparing a first threshold value with the third parameter. The second comparing comprises comparing a second threshold value with the fourth parameter. The judging step comprises judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.
摘要翻译：描述了判断恶性肿瘤特征的方法。该方法包括获得步骤，第一比较步骤，第二比较步骤和判断步骤。获得步骤包括基于包含在恶性肿瘤的肿瘤细胞中的第一细胞周期依赖性激酶（第一CDK）的活性和表达水平获得第一参数，第二参数基于第二细胞周期蛋白依赖性激酶的活性和表达水平（第二CDK），基于第一参数和第二参数的第三参数，以及基于包含在肿瘤细胞中的细胞周期蛋白的表达水平的第四参数。第一比较步骤包括将第一阈值与第三参数进行比较。第二比较包括将第二阈值与第四参数进行比较。判断步骤包括基于第一比较步骤和第二比较步骤的比较结果判断恶性肿瘤的特征。

9. 发明申请

US20050131057A1 Taxane chemosensitivity prediction test 失效
标题翻译：紫杉烷化学敏感性预测试验
公开(公告)号：US20050131057A1
公开(公告)日：2005-06-16
申请号：US10926409
申请日：2004-08-25
申请人： Naoto Ueno , Hideki Ishihara , Tamotsu Sudo , Tomoko Matsushima
发明人： Naoto Ueno , Hideki Ishihara , Tamotsu Sudo , Tomoko Matsushima
IPC分类号： A61K31/337 , C12Q1/68 , G01N33/574
CPC分类号： A61K31/337 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cycle molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle parameters (molecules) such as CDK1 kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin B1, Cyclin E expression, p21 expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.
摘要翻译：本发明提供了确定癌细胞对紫杉烷的化学敏感性的方法，包括评估紫杉烷对癌细胞中一种或多种细胞周期分子的表达水平或活性的影响。这种方法利用自动分析系统，其中诸如CDK1激酶活性，CDK1表达，CDK2激酶活性，CDK2表达，MAD2表达，细胞周期蛋白B1，细胞周期蛋白E表达，p21表达和CDK6表达的细胞周期参数（分子）被评估。本发明还提供了获得对紫杉烷敏感的癌细胞的细胞周期特征的方法。

10. 发明授权

US08131520B2 Cancer diagnostic device 有权
标题翻译：癌症诊断装置
公开(公告)号：US08131520B2
公开(公告)日：2012-03-06
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F7/60 , G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

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