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1. 发明授权

US08921114B2 Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product 有权
标题翻译：癌症诊断支持系统，癌症诊断支持信息提供方法和计算机程序产品
公开(公告)号：US08921114B2
公开(公告)日：2014-12-30
申请号：US12197714
申请日：2008-08-25
申请人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
发明人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
IPC分类号： G06F19/24 , G06F19/20 , G06F19/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A diagnosis support system for cancer is disclosed that comprises: a measurement value acquiring section for acquiring a measurement value of a first cancer patient; a sample data memory for storing sample data of a plurality of cancer patients different from the first patient; a reference range determination section for determining a reference range based on the measurement value of the first cancer patient; a display unit; and a display controller for controlling the display unit to display a diagnosis support screen showing the clinical information included in the sample data having measurement value within the reference range. A method of providing cancer diagnosis support information and a computer program product are also disclosed.
摘要翻译：公开了一种用于癌症的诊断支持系统，包括：测量值获取部分，用于获取第一癌症患者的测量值; 用于存储与第一患者不同的多个癌症患者的样本数据的样本数据存储器; 参考范围确定部分，用于基于第一癌症患者的测量值来确定参考范围; 显示单元; 以及显示控制器，用于控制显示单元显示诊断支持屏幕，其显示包含在具有参考范围内的测量值的样本数据中的临床信息。还公开了提供癌症诊断支持信息的方法和计算机程序产品。

2. 发明申请

US20050131057A1 Taxane chemosensitivity prediction test 失效
标题翻译：紫杉烷化学敏感性预测试验
公开(公告)号：US20050131057A1
公开(公告)日：2005-06-16
申请号：US10926409
申请日：2004-08-25
申请人： Naoto Ueno , Hideki Ishihara , Tamotsu Sudo , Tomoko Matsushima
发明人： Naoto Ueno , Hideki Ishihara , Tamotsu Sudo , Tomoko Matsushima
IPC分类号： A61K31/337 , C12Q1/68 , G01N33/574
CPC分类号： A61K31/337 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cycle molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle parameters (molecules) such as CDK1 kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin B1, Cyclin E expression, p21 expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.
摘要翻译：本发明提供了确定癌细胞对紫杉烷的化学敏感性的方法，包括评估紫杉烷对癌细胞中一种或多种细胞周期分子的表达水平或活性的影响。这种方法利用自动分析系统，其中诸如CDK1激酶活性，CDK1表达，CDK2激酶活性，CDK2表达，MAD2表达，细胞周期蛋白B1，细胞周期蛋白E表达，p21表达和CDK6表达的细胞周期参数（分子）被评估。本发明还提供了获得对紫杉烷敏感的癌细胞的细胞周期特征的方法。

3. 发明授权

US08160821B2 Method for supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs and a device for supporting a diagnosis for an effect of a treatment by using anthracycline anticancer drugs 失效
标题翻译：支持通过使用蒽环类抗癌药物治疗效果的诊断的方法和通过使用蒽环类抗癌药物进行治疗效果的支持诊断的装置
公开(公告)号：US08160821B2
公开(公告)日：2012-04-17
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

4. 发明授权

US08014960B2 Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US08014960B2
公开(公告)日：2011-09-06
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G01N33/50
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

5. 发明申请

US20090054739A1 DIAGNOSIS SUPPORT SYSTEM FOR CANCER, DIAGNOSIS SUPPORT INFORMATION PROVIDING METHOD FOR CANCER, AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：癌症诊断支持系统，诊断支持信息提供癌症和计算机程序产品的方法
公开(公告)号：US20090054739A1
公开(公告)日：2009-02-26
申请号：US12197714
申请日：2008-08-25
申请人： Hideki ISHIHARA , Tomoko Matsushima , Masaki Shibayama
发明人： Hideki ISHIHARA , Tomoko Matsushima , Masaki Shibayama
IPC分类号： A61B5/00 , G06Q50/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A diagnosis support system for cancer is disclosed that comprises: a measurement value acquiring section for acquiring a measurement value of a first cancer patient; a sample data memory for storing sample data of a plurality of cancer patients different from the first patient; a reference range determination section for determining a reference range based on the measurement value of the first cancer patient; a display unit; and a display controller for controlling the display unit to display a diagnosis support screen showing the clinical information included in the sample data having measurement value within the reference range. A method of providing cancer diagnosis support information and a computer program product are also disclosed.
摘要翻译：公开了一种用于癌症的诊断支持系统，包括：测量值获取部分，用于获取第一癌症患者的测量值; 用于存储与第一患者不同的多个癌症患者的样本数据的样本数据存储器; 参考范围确定部分，用于基于第一癌症患者的测量值来确定参考范围; 显示单元; 以及显示控制器，用于控制显示单元显示诊断支持屏幕，其显示包含在具有参考范围内的测量值的样本数据中的临床信息。还公开了提供癌症诊断支持信息的方法和计算机程序产品。

6. 发明申请

US20060292645A1 Method and reagent for measuring kinase activity 审中-公开
标题翻译：测定激酶活性的方法和试剂
公开(公告)号：US20060292645A1
公开(公告)日：2006-12-28
申请号：US11473550
申请日：2006-06-23
申请人： Tomoko Matsushima , Hideki Ishihara
发明人： Tomoko Matsushima , Hideki Ishihara
IPC分类号： G01N33/574
CPC分类号： C12Q1/485 , G01N33/573 , G01N33/57446
摘要： A method of measuring the activity of a kinase to which imatinib mesylate can bind is described. In the method, a kinase contained in a sample, to which imatinib mesylate can bind, a substrate for the kinase, and ATP are mixed. A phosphate group of ATP is thereby transferred to a tyrosine residue of the substrate by the action of the kinase. After a labeled substance capable of binding is bound to the substrate having the phosphate group transferred thereto, a signal emitted by the labeled substance is detected. On the basis of this detection result, the activity of the kinase is calculated.
摘要翻译：描述了测量甲磺酸伊马替尼可以结合的激酶活性的方法。在该方法中，包含在甲磺酸伊马替尼可以结合的样品中的激酶用于激酶的底物和ATP混合。因此ATP的磷酸基团通过激酶的作用转移到底物的酪氨酸残基。在能够结合的标记物质与转移了磷酸基团的底物结合后，检测出被标记物质发出的信号。在该检测结果的基础上，计算激酶的活性。

7. 发明授权

US08131520B2 Cancer diagnostic device 有权
标题翻译：癌症诊断装置
公开(公告)号：US08131520B2
公开(公告)日：2012-03-06
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F7/60 , G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

8. 发明申请

US20090248316A1 METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS 失效
标题翻译：通过使用蒽环类抗生素药物来治疗治疗效果的诊断方法和用于支持通过使用安非他酮类抗生素治疗药物治疗效果的装置的方法
公开(公告)号：US20090248316A1
公开(公告)日：2009-10-01
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

9. 发明申请

US20090105960A1 Device for supporting diagnosis of a cancer and a device for predicting an effects of anthracycline anticancer drugs 有权
标题翻译：用于支持癌症诊断的装置和用于预测蒽环类抗癌药物的作用的装置
公开(公告)号：US20090105960A1
公开(公告)日：2009-04-23
申请号：US12286699
申请日：2008-10-01
申请人： Hideki Ishihara , Tomoko Matsushima
发明人： Hideki Ishihara , Tomoko Matsushima
IPC分类号： G01N33/48
CPC分类号： G01N33/57484 , C12Q1/485 , G01N2333/9121 , G01N2800/52 , G06F19/20 , G06F19/24
摘要： A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.
摘要翻译：公开了一种用于支持癌症诊断的装置，其提供用于决定是否向被检查的癌症患者施用蒽环类抗癌药物的信息。具体地说，该装置构成为能够从要检查的癌症患者的恶性肿瘤获得两种细胞周期蛋白依赖性激酶（CDK）的活性和表达，并从两种CDK中获得CDK参数。此外，设备确定包括预定CDK参数的样本数据，以及确定的样本数据的显示信息。根据上述成分，使用者能够容易地知道尽管施用了蒽环类抗癌药物，癌肿瘤患者的肿瘤是否与待检查的癌症患者的肿瘤相似。。

10. 发明申请

US20060173632A1 Method for predicting effectiveness of chemotherapy 有权
标题翻译：预防化疗有效性的方法
公开(公告)号：US20060173632A1
公开(公告)日：2006-08-03
申请号：US11330137
申请日：2006-01-12
申请人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
发明人： Yasuhiro Torikoshi , Yuko Kawasaki , Satoshi Nakayama , Hideki Ishihara , Tomoko Matsushima
IPC分类号： G06F19/00
CPC分类号： C12Q1/485 , G01N33/57484 , G01N2800/52
摘要： A method for predicting an effectiveness of chemotherapy is described. The method comprises a comparing step and a predicting step. The comparing step is a step of comparing a threshold value with a parameter of a cyclin dependent kinase (CDK) included in a sample containing a tumor cell obtained from a human patient. The predicting step is a step of predicting the effectiveness based on a comparison result of said comparing step. Above stated parameter is selected from the group consisting of an activity, an expression level, and a ratio of activity to expression level.
摘要翻译：描述了一种预测化疗有效性的方法。该方法包括比较步骤和预测步骤。比较步骤是将阈值与包含在从人类患者获得的肿瘤细胞的样品中包含的细胞周期蛋白依赖性激酶（CDK）的参数进行比较的步骤。预测步骤是基于所述比较步骤的比较结果来预测有效性的步骤。上述参数选自活性，表达水平以及活性与表达水平之比组成的组。

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