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1. 发明申请

US20110246413A1 METHOD FOR JUDGING RISK OF CANCER RECURRENCE, COMPUTER PROGRAM, AND COMPUTER SYSTEM 有权
标题翻译：判断癌症复发风险的方法，计算机程序和计算机系统
公开(公告)号：US20110246413A1
公开(公告)日：2011-10-06
申请号：US13074745
申请日：2011-03-29
申请人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
发明人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
IPC分类号： G06N5/04 , C12Q1/48
CPC分类号： G06F19/18 , G01N33/57496 , G01N2800/54
摘要： A method for judging a risk of cancer recurrence comprising: acquiring an activity value and expression level of a first cyclin dependent kinase (CDK) of a cell contained in tissues extracted from cancer patients, an activity value and expression level of a second CDK, and a number of Ki67-expressing cells or an expression level of Ki67; and judging a risk of cancer recurrence based on the acquired activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and a percentage of Ki67-expressing cells or the expression level of Ki67. A computer program product and a computer system are also disclosed.
摘要翻译：一种判断癌症复发风险的方法，包括：获得癌症患者提取的组织中含有的细胞的第一细胞周期蛋白依赖性激酶（CDK）的活性值和表达水平，第二CDK的活性值和表达水平，以及多个Ki67表达细胞或Ki67表达水平; 根据获得的第一CDK的活性值和表达水平，第二CDK的活性值和表达量以及Ki67表达细胞的百分比或Ki67的表达水平来判断癌症复发的风险。还公开了一种计算机程序产品和计算机系统。

2. 发明授权

US08583588B2 Method for judging risk of cancer recurrence, computer program, and computer system 有权
标题翻译：判断癌症复发风险的方法，计算机程序和计算机系统
公开(公告)号：US08583588B2
公开(公告)日：2013-11-12
申请号：US13074745
申请日：2011-03-29
申请人： Masaki Shibayama , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
发明人： Masaki Shibayama , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
IPC分类号： G06F17/00 , C12Q1/68 , G06F19/18
CPC分类号： G06F19/18 , G01N33/57496 , G01N2800/54
摘要： A method for judging a risk of cancer recurrence comprising: acquiring an activity value and expression level of a first cyclin dependent kinase (CDK) of a cell contained in tissues extracted from cancer patients, an activity value and expression level of a second CDK, and a number of Ki67-expressing cells or an expression level of Ki67; and judging a risk of cancer recurrence based on the acquired activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and a percentage of Ki67-expressing cells or the expression level of Ki67. A computer program product and a computer system are also disclosed.
摘要翻译：一种判断癌症复发风险的方法，包括：获得癌症患者提取的组织中含有的细胞的第一细胞周期蛋白依赖性激酶（CDK）的活性值和表达水平，第二CDK的活性值和表达水平，以及多个Ki67表达细胞或Ki67表达水平; 根据获得的第一CDK的活性值和表达水平，第二CDK的活性值和表达量以及Ki67表达细胞的百分比或Ki67的表达水平来判断癌症复发的风险。还公开了一种计算机程序产品和计算机系统。

3. 发明申请

US20100250483A1 EFFECT PREDICTING APPARATUS, COMPUTER PROGRAM PRODUCT, AND METHOD FOR PREDICTING AN EFFECT 审中-公开
标题翻译：效果预测装置，计算机程序产品和预测效果的方法
公开(公告)号：US20100250483A1
公开(公告)日：2010-09-30
申请号：US12569130
申请日：2009-09-29
申请人： Tomoko Ohyama , Masaki Shibayama , Hideki Ishihara , Tomokazu Yoshida , Keigo Gohda
发明人： Tomoko Ohyama , Masaki Shibayama , Hideki Ishihara , Tomokazu Yoshida , Keigo Gohda
IPC分类号： G06N5/02
CPC分类号： G16C20/30 , G16B25/00
摘要： An effect predicting apparatus for predicting an effect of anthracycline anticancer drugs, comprising: a display, a processor, and a memory, under control of said processor, including software instructions adapted to enable the processor to perform operations, comprising: acquiring a CDK parameter based on a first CDK parameter and a second CDK parameter; acquiring an expression level of glutathione; comparing the CDK parameter with a CDK threshold value, and the expression level of glutathione with a glutathione threshold value; predicting an effect of anthracycline anticancer drugs based on the result of the comparison; and displaying the result of the prediction. A computer program product and a method for predicting an effect are also disclosed.
摘要翻译：一种用于预测蒽环类抗癌药物的效果的效果预测装置，包括：在所述处理器的控制下的显示器，处理器和存储器，包括适于使处理器执行操作的软件指令，包括：基于CDK参数获取第一个CDK参数和第二个CDK参数; 获得谷胱甘肽的表达水平; 将CDK参数与CDK阈值进行比较，以及谷胱甘肽阈值的谷胱甘肽的表达水平; 基于比较结果预测蒽环类抗癌药物的作用; 并显示预测结果。还公开了一种用于预测效果的计算机程序产品和方法。

4. 发明申请

US20110244497A1 METHOD FOR JUDGING SUSCEPTIBILITY OF CANCER CELLS TO ANTHRACYCLINE ANTICANCER AGENT AND COMPUTER PROGRAM 审中-公开
标题翻译：判断癌细胞对抗癌药物和计算机程序的可靠性的方法
公开(公告)号：US20110244497A1
公开(公告)日：2011-10-06
申请号：US13075673
申请日：2011-03-30
申请人： Tomoko Ohyama , Masaki Shibayama , Hideki Ishihara , Tomokazu Yoshida , Keigo Gohda
发明人： Tomoko Ohyama , Masaki Shibayama , Hideki Ishihara , Tomokazu Yoshida , Keigo Gohda
IPC分类号： C12Q1/48
CPC分类号： G01N33/57415 , G01N2333/91177 , G01N2333/9121 , G01N2800/44 , G01N2800/52
摘要： The present invention provides a method for judging susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent comprising steps of: measuring expression levels of GST-π of cancer cells contained in a biological sample; and judging the susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent as high when the expression level of GST-π obtained by the measuring process is high, and a computer program which makes a computer execute the method.
摘要翻译：本发明提供了一种用于判断生物样品中包含的癌细胞对蒽环类抗癌剂的敏感性的方法，包括以下步骤：测量GST-和pgr的表达水平; 包含在生物样品中的癌细胞; 并且当GST-＆pgr的表达水平，判断生物样品中包含的癌细胞对蒽环类抗癌剂的敏感性高。通过测量过程获得的计算机程序高，并且使计算机执行该方法。

5. 发明申请

US20090248316A1 METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS 失效
标题翻译：通过使用蒽环类抗生素药物来治疗治疗效果的诊断方法和用于支持通过使用安非他酮类抗生素治疗药物治疗效果的装置的方法
公开(公告)号：US20090248316A1
公开(公告)日：2009-10-01
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

6. 发明授权

US08921114B2 Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product 有权
标题翻译：癌症诊断支持系统，癌症诊断支持信息提供方法和计算机程序产品
公开(公告)号：US08921114B2
公开(公告)日：2014-12-30
申请号：US12197714
申请日：2008-08-25
申请人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
发明人： Hideki Ishihara , Tomoko Matsushima , Masaki Shibayama
IPC分类号： G06F19/24 , G06F19/20 , G06F19/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A diagnosis support system for cancer is disclosed that comprises: a measurement value acquiring section for acquiring a measurement value of a first cancer patient; a sample data memory for storing sample data of a plurality of cancer patients different from the first patient; a reference range determination section for determining a reference range based on the measurement value of the first cancer patient; a display unit; and a display controller for controlling the display unit to display a diagnosis support screen showing the clinical information included in the sample data having measurement value within the reference range. A method of providing cancer diagnosis support information and a computer program product are also disclosed.
摘要翻译：公开了一种用于癌症的诊断支持系统，包括：测量值获取部分，用于获取第一癌症患者的测量值; 用于存储与第一患者不同的多个癌症患者的样本数据的样本数据存储器; 参考范围确定部分，用于基于第一癌症患者的测量值来确定参考范围; 显示单元; 以及显示控制器，用于控制显示单元显示诊断支持屏幕，其显示包含在具有参考范围内的测量值的样本数据中的临床信息。还公开了提供癌症诊断支持信息的方法和计算机程序产品。

7. 发明授权

US08160821B2 Method for supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs and a device for supporting a diagnosis for an effect of a treatment by using anthracycline anticancer drugs 失效
标题翻译：支持通过使用蒽环类抗癌药物治疗效果的诊断的方法和通过使用蒽环类抗癌药物进行治疗效果的支持诊断的装置
公开(公告)号：US08160821B2
公开(公告)日：2012-04-17
申请号：US12242500
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G06F19/00 , G06F15/00 , C12Q1/25
CPC分类号： G01N33/57484 , G01N2333/912 , G01N2800/52
摘要： A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.
摘要翻译：公开了一种通过使用蒽环类抗癌药来支持治疗效果的诊断方法。该方法提供了用于判断效果的新值，根据两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算出的判断评分。通过将判断分数与预定阈值水平进行比较来判断使用蒽环类抗癌药物的治疗效果。

8. 发明授权

US08014960B2 Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US08014960B2
公开(公告)日：2011-09-06
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： G01N33/50
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

9. 发明授权

US08041514B2 Method for judging feature of malignant tumor 失效
标题翻译：判断恶性肿瘤特征的方法
公开(公告)号：US08041514B2
公开(公告)日：2011-10-18
申请号：US11711053
申请日：2007-02-27
申请人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
发明人： Satoshi Tanaka , Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Aya Katayama , Yuko Kawasaki
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57415 , C12Q1/485 , G01N2333/4739 , G01N2333/9121 , G06F19/24
摘要： A method for judging feature of malignant tumor is described. The method comprises obtaining step, first comparing step, second comparing step and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell. The first comparing step comprises comparing a first threshold value with the third parameter. The second comparing comprises comparing a second threshold value with the fourth parameter. The judging step comprises judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.
摘要翻译：描述了判断恶性肿瘤特征的方法。该方法包括获得步骤，第一比较步骤，第二比较步骤和判断步骤。获得步骤包括基于包含在恶性肿瘤的肿瘤细胞中的第一细胞周期依赖性激酶（第一CDK）的活性和表达水平获得第一参数，第二参数基于第二细胞周期蛋白依赖性激酶的活性和表达水平（第二CDK），基于第一参数和第二参数的第三参数，以及基于包含在肿瘤细胞中的细胞周期蛋白的表达水平的第四参数。第一比较步骤包括将第一阈值与第三参数进行比较。第二比较包括将第二阈值与第四参数进行比较。判断步骤包括基于第一比较步骤和第二比较步骤的比较结果判断恶性肿瘤的特征。

10. 发明申请

US20090246809A1 METHOD OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE, AND A DEVICE OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE 有权
标题翻译：支持诊断癌症复发风险的方法，以及支持诊断癌症复发风险的手段
公开(公告)号：US20090246809A1
公开(公告)日：2009-10-01
申请号：US12242817
申请日：2008-09-30
申请人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
发明人： Masaki Shibayama , Hideki Ishihara , Tomoko Matsushima , Shigehiro Numada
IPC分类号： C12Q1/48 , C12M1/34 , C12M1/36
CPC分类号： G01N33/574 , C12Q1/485 , G01N33/5302 , G01N2800/54 , G01N2800/56
摘要： A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS.
摘要翻译：公开了一种支持癌症复发风险诊断的方法。该方法提供了基于两种细胞周期蛋白依赖性激酶（CDK）的表达水平和活性值计算的复发风险评分（RRS）的新的确定值。通过将RRS与RRS的预定阈值水平进行比较来判断癌症复发的风险。

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