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1. 发明申请

US20130345408A1 ANTIBODY AGAINST AMYLOID PRECURSOR PROTEIN SIGNAL PEPTIDE 有权
标题翻译：抗体蛋白前体蛋白信号肽抗体
公开(公告)号：US20130345408A1
公开(公告)日：2013-12-26
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

2. 发明申请

US20140072592A1 METHOD OF PREPARING ANTIGEN FOR ACQUIRING ANTI-HYDROPHOBIC PEPTIDE ANTIBODY 有权
标题翻译：制备用于获得抗血栓肽抗体的抗原的方法
公开(公告)号：US20140072592A1
公开(公告)日：2014-03-13
申请号：US13978419
申请日：2012-01-06
申请人： Masaji Okamoto , Masato Hanamura , Hitoshi Fukushima , Tetsuhiko Yoshida
发明人： Masaji Okamoto , Masato Hanamura , Hitoshi Fukushima , Tetsuhiko Yoshida
IPC分类号： G01N33/68 , C07K16/18 , C07K14/705 , C07K14/47 , C07K14/245 , C07K16/12 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/245 , C07K14/4711 , C07K14/70596 , C07K16/1232 , C07K16/18 , C07K16/2896
摘要： The object of the present invention is to provide a method to obtain an antibody for a hydrophobic peptide, which can be used for general purposes easily and with great reliability. Also provided is a method for preparing an antigen characterized in that a hydrophobic peptide, which is unbound to carrier protein, is used as high-molecular-weight aggregates in an aqueous solution containing a nonionic surfactant.
摘要翻译：本发明的目的是提供一种获得疏水性肽抗体的方法，其可以容易且高可靠性地用于一般目的。还提供了制备抗原的方法，其特征在于将未结合载体蛋白的疏水性肽用作含有非离子表面活性剂的水溶液中的高分子量聚集体。

3. 发明授权

US09506933B2 Method of preparing antigen for acquiring anti-hydrophobic peptide antibody 有权
标题翻译：制备用于获得抗疏水肽抗体的抗原的方法
公开(公告)号：US09506933B2
公开(公告)日：2016-11-29
申请号：US13978419
申请日：2012-01-06
申请人： Masaji Okamoto , Masato Hanamura , Hitoshi Fukushima , Tetsuhiko Yoshida
发明人： Masaji Okamoto , Masato Hanamura , Hitoshi Fukushima , Tetsuhiko Yoshida
IPC分类号： C07K16/18 , G01N33/68 , C07K14/245 , C07K14/47 , C07K14/705 , C07K16/12 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/245 , C07K14/4711 , C07K14/70596 , C07K16/1232 , C07K16/18 , C07K16/2896
摘要： The object of the present invention is to provide a method to obtain an antibody for a hydrophobic peptide, which can be used for general purposes easily and with great reliability. Also provided is a method for preparing an antigen characterized in that a hydrophobic peptide, which is unbound to carrier protein, is used as high-molecular-weight aggregates in an aqueous solution containing a nonionic surfactant.
摘要翻译：本发明的目的是提供一种获得疏水性肽抗体的方法，其可以容易且高可靠性地用于一般目的。还提供了制备抗原的方法，其特征在于将未结合载体蛋白的疏水性肽用作含有非离子表面活性剂的水溶液中的高分子量聚集体。

4. 发明授权

US09309307B2 Antibody against amyloid precursor protein signal peptide 有权
标题翻译：抗淀粉样前体蛋白信号肽抗体
公开(公告)号：US09309307B2
公开(公告)日：2016-04-12
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C12N5/12 , C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

5. 发明授权

US08603967B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08603967B2
公开(公告)日：2013-12-10
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： A61K38/04 , C07K7/00
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

6. 发明申请

US20130142812A1 ANTIBODY AND USE THEREOF 有权
标题翻译：抗体及其用途
公开(公告)号：US20130142812A1
公开(公告)日：2013-06-06
申请号：US13701947
申请日：2011-06-03
申请人： Nobuyoshi Shimizu , Atsushi Takayanagi , Tetsuhiko Yoshida
发明人： Nobuyoshi Shimizu , Atsushi Takayanagi , Tetsuhiko Yoshida
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , C07K16/2863 , C07K2317/73
摘要： A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.
摘要翻译：作为抗体成分的细胞生长抑制剂，其特征在于，其表位为富含半胱氨酸的亚结构域2（C2结构域）和/或配体结合域1（L1结构域）在包含在EGFR细胞外结构域的四个子结构域之间。

7. 发明申请

US20090253618A1 NEURONAL DIFFERENTIATION-INDUCING PEPTIDE AND USE THEREOF 审中-公开
标题翻译：神经元差异诱导肽及其用途
公开(公告)号：US20090253618A1
公开(公告)日：2009-10-08
申请号：US11996207
申请日：2006-07-20
申请人： Hiroshi Kanno , Tetsuhiko Yoshida , Nahoko Kobayashi
发明人： Hiroshi Kanno , Tetsuhiko Yoshida , Nahoko Kobayashi
IPC分类号： A61K38/16 , C12N5/08 , C07K14/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： A neuronal differentiation inducer comprising at least one peptide which can induce the differentiation of at least one cell into a neurocyte. The peptide is an artificially synthesized peptide comprising an amino acid sequence derived from a BC-box of at least one protein belonging to the SOCS protein family or an amino acid sequence having a partial modification in the BC-box-derived amino acid sequence, wherein the BC-box-derived amino acid sequence is composed of at least 10 contiguous amino acid residues selected in the amino acid sequence constituting the BC-box.
摘要翻译：一种神经元分化诱导剂，其包含至少一种能诱导至少一种细胞分化为神经细胞的肽。肽是人造合成的肽，其包含衍生自属于SOCS蛋白家族的至少一种蛋白质的BC盒的氨基酸序列或在BC-盒衍生的氨基酸序列中具有部分修饰的氨基酸序列，其中 BC盒衍生的氨基酸序列由在构成BC盒的氨基酸序列中选择的至少10个连续氨基酸残基组成。

8. 发明申请

US20060089488A1 Antimicrobial peptides and use thereof 有权
标题翻译：抗微生物肽及其用途
公开(公告)号：US20060089488A1
公开(公告)日：2006-04-27
申请号：US11247376
申请日：2005-10-11
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.
摘要翻译：人造合成的天然不发生的抗微生物肽由本发明提供。抗微生物肽包括由以下8个氨基酸残基组成的一个单元，两个单元或更多个氨基酸序列单元：<？in-line-formula description =“In-line Formulas”end =“lead”？>（R或 Q） - （L或F或I）-IK-（L或F或I或V）-LYQ; 和/或由所述序列组成的经修改的修改序列。

9. 发明授权

US09029513B2 Anti-EGFR antibody and use thereof 有权
标题翻译：抗EGFR抗体及其用途
公开(公告)号：US09029513B2
公开(公告)日：2015-05-12
申请号：US13701947
申请日：2011-06-03
申请人： Nobuyoshi Shimizu , Atsushi Takayanagi , Tetsuhiko Yoshida
发明人： Nobuyoshi Shimizu , Atsushi Takayanagi , Tetsuhiko Yoshida
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： C07K16/30 , A61K39/39558 , C07K16/2863 , C07K2317/73
摘要： A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.
摘要翻译：作为抗体成分的细胞生长抑制剂，其特征在于，其表位为富含半胱氨酸的亚结构域2（C2结构域）和/或配体结合域1（L1结构域）在包含在EGFR细胞外结构域的四个子结构域之间。

10. 发明授权

US08710005B2 Neuronal differentiation-inducing peptide and use thereof 有权
标题翻译：神经元分化诱导肽及其用途
公开(公告)号：US08710005B2
公开(公告)日：2014-04-29
申请号：US13258788
申请日：2010-04-12
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： C07K14/4756 , A61K38/00
摘要： A neuronal differentiation inducer provided by the present invention contains an artificially synthesized peptide which includes an amino acid sequence constituting a signal peptide in amyloid precursor protein (APP), or a partial sequence of the amino acid sequence constituting this signal peptide.
摘要翻译：本发明提供的神经元分化诱导剂含有人造合成的肽，其包含构成该淀粉状蛋白前体蛋白（APP）中的信号肽的氨基酸序列或构成该信号肽的氨基酸序列的部分序列。

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