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1. 发明授权

US06740662B1 Naphthyridine derivatives 失效
标题翻译：萘啶衍生物
公开(公告)号：US06740662B1
公开(公告)日：2004-05-25
申请号：US10111077
申请日：2002-04-19
申请人： Masahiro Iwata , Noriyuki Kawano , Tomofumi Takuwa , Ryota Shiraki , Miki Kobayashi , Makoto Takeuchi
发明人： Masahiro Iwata , Noriyuki Kawano , Tomofumi Takuwa , Ryota Shiraki , Miki Kobayashi , Makoto Takeuchi
IPC分类号： A61K31435
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377
摘要： 2-Oxo-1,2-dihydro-1,8-naphthyridine derivatives characterized by bearing a specific substituent, —X—R6, at the 3-position and a cyclic substituent, R5, at the 4-position; or salts thereof. The derivatives and the salts are useful as drugs, particularly preventive or therapeutic agents for respiratory diseases related to PDE IV.
摘要翻译： 2-氧代-1,2-二氢-1,8-二氮杂萘衍生物，其特征在于在3-位具有特定取代基-X-R 6，在4-位具有环取代基R 5; 或其盐。衍生物和盐可用作药物，特别是与PDE IV相关的呼吸道疾病的预防或治疗剂。

2. 发明授权

US07196080B2 Phenylpyridinecarbonylpiperazinederivative 失效
标题翻译：苯基吡啶羰基哌嗪基化
公开(公告)号：US07196080B2
公开(公告)日：2007-03-27
申请号：US10480543
申请日：2002-06-13
申请人： Masahiro Iwata , Noriyuki Kawano , Hiroyuki Kaizawa , Tomofumi Takuwa , Issei Tsukamoto , Ryushi Seo , Kiyoshi Yahiro , Miki Kobayashi , Makoto Takeuchi
发明人： Masahiro Iwata , Noriyuki Kawano , Hiroyuki Kaizawa , Tomofumi Takuwa , Issei Tsukamoto , Ryushi Seo , Kiyoshi Yahiro , Miki Kobayashi , Makoto Takeuchi
IPC分类号： A61K31/496 , C07D401/06 , C07D401/14 , C07D413/14 , C07D213/79
CPC分类号： C07D213/79 , A61K31/439 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/55 , C07D213/81 , C07D213/89 , C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08
摘要： The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein R1, R2: hydrogen, a halogen, a lower alkyl, a lower alkoxy, or the like, R3, R4: hydrogen, a (substituted) lower alkyl, a halogen, or the like, R5: hydrogen, a lower alkyl, a lower alkoxycarbonyl, or the like, and n: 0 or 1).
摘要翻译：本发明涉及由以下通式表示的具有4型磷酸二酯酶抑制作用的化合物及其用途及其中间体化合物。

3. 发明授权

US07173033B2 Nitrogen-containing heterocyclic compound 失效
标题翻译：含氮杂环化合物
公开(公告)号：US07173033B2
公开(公告)日：2007-02-06
申请号：US11190859
申请日：2005-07-28
申请人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
发明人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
IPC分类号： C07D487/04 , A61K31/5025 , A61P19/08
CPC分类号： C07D487/04
摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention.Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.
摘要翻译：本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物，特别是骨形成剂。

4. 发明申请

US20050261297A1 Nitrogen-containing heterocyclic compound 失效
公开(公告)号：US20050261297A1
公开(公告)日：2005-11-24
申请号：US11190859
申请日：2005-07-28
申请人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
发明人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
IPC分类号： A61P19/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07D487/04 , A61K31/503 , A61K31/55
CPC分类号： C07D487/04
摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

5. 发明申请

US20050096322A1 Nitrogen-containing heterocyclic compound 审中-公开
标题翻译：含氮杂环化合物
公开(公告)号：US20050096322A1
公开(公告)日：2005-05-05
申请号：US10505939
申请日：2003-02-27
申请人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
发明人： Susumu Igarashi , Ryo Naito , Yoshinori Okamoto , Noriyuki Kawano , Issei Tsukamoto , Ippei Sato , Makoto Takeuchi , Hiroyuki Kanoh , Masato Kobori
IPC分类号： A61P19/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07D487/04 , A61K31/503
CPC分类号： C07D487/04
摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.
摘要翻译：本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物，特别是骨形成剂。

6. 发明授权

US07054236B2 Optical disk drive apparatus, optical pickup, manufacturing method therefor and adjusting method therefor 失效
标题翻译：光盘驱动装置，光拾取器及其制造方法及其调整方法
公开(公告)号：US07054236B2
公开(公告)日：2006-05-30
申请号：US10327110
申请日：2002-12-24
申请人： Noriyuki Kawano
发明人： Noriyuki Kawano
IPC分类号： G11B7/095
CPC分类号： G11B17/056 , G11B7/08582 , G11B7/0932 , G11B7/0933 , G11B7/0935 , G11B7/0956 , G11B7/22
摘要： An optical disk drive apparatus has an objective lens which converges a light beam to direct it to an optical disk, an objective lens support, an elastic support member which movably supports the objective lens on the objective lens support portion, and a coil and a magnet. The coil and magnet are capable of moving the objective lens against an elastic force of the elastic support member relative to the objective lens support portion so as to vary an angle of incidence of the light beam emitted from the objective lens with respect to an irradiated surface of the optical disk. The angle of incidence is adjusted by an electric power supplied to the coil.
摘要翻译：光盘驱动装置具有会聚光束以将其引导到光盘的物镜，物镜支架，可移动地将物镜支撑在物镜支撑部上的弹性支撑部件，以及线圈和磁铁。线圈和磁体能够抵抗弹性支撑构件相对于物镜支撑部分的弹力移动物镜，以便改变从物镜发射的光束相对于照射表面的入射角的光盘。通过供给线圈的电力来调节入射角。

7. 发明授权

US6160771A Objective lens drive device and method of manufacturing the same 失效
标题翻译：物镜驱动装置及其制造方法
公开(公告)号：US6160771A
公开(公告)日：2000-12-12
申请号：US21820
申请日：1998-02-11
申请人： Noriyuki Kawano , Nobuo Uekusa , Yasuhiro Terasaki
发明人： Noriyuki Kawano , Nobuo Uekusa , Yasuhiro Terasaki
IPC分类号： G11B7/09 , G11B7/22
CPC分类号： G11B7/0932 , G11B7/22
摘要： An objective lens drive device has a movable section which has an objective lens and is supported by wires extended from a stationary section, and the wires which are positioned by guide holes formed in the movable section or stationary section. In the device, the wires are fixedly positioned in such a manner that the wires are in contact with the inner walls of the guide holes.
摘要翻译：物镜驱动装置具有可动部，该可动部具有物镜，并且由从固定部延伸的线支撑，并且由形成在可动部或静止部的引导孔定位的线。在该装置中，电线被固定地定位成使得电线与引导孔的内壁接触。

8. 发明授权

US08399663B2 Salt of 1,3,5-triazine-2,4,6-triamine derivative 失效
标题翻译： 1,3,5-三嗪-2,4,6-三胺衍生物的盐
公开(公告)号：US08399663B2
公开(公告)日：2013-03-19
申请号：US12753415
申请日：2010-04-02
申请人： Junya Ohmori , Makoto Kasai , Takenori Kimura , Noritaka Hamada , Ryo Mizoguchi , Satoshi Miyamoto , Noriyuki Kawano
发明人： Junya Ohmori , Makoto Kasai , Takenori Kimura , Noritaka Hamada , Ryo Mizoguchi , Satoshi Miyamoto , Noriyuki Kawano
IPC分类号： C07D403/12 , A61K31/53 , A61P25/28
CPC分类号： A61K31/53 , C07D403/12
摘要： Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.
摘要翻译：得到的N-（4-氟苯基）-N'-苯基-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物A）和 /或N，N'-二（4-氟苯基）-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物B）作为药物或起始物用于制备药物的材料，并且提供具有优异的稳定性和新颖结晶的化合物A和/或化合物B的富马酸盐。化合物A和/或化合物B与富马酸的盐能够随时获得均匀的结晶，因此，作为制备具有优异稳定性的药物的药物或原料非常有用的化合物。

9. 发明授权

US07790884B2 Acylaminopiperidine compound 失效
标题翻译：酰胺基哌啶化合物
公开(公告)号：US07790884B2
公开(公告)日：2010-09-07
申请号：US12294145
申请日：2007-03-23
申请人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
发明人： Toru Kontani , Noriyuki Kawano , Naoyuki Masuda , Koji Kato , Hiroshi Nagata , Hiroshi Inami , Tadashi Terasaka , Kazuhiro Yokoyama , Takahiro Miyazaki
IPC分类号： C07D473/34
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like.An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].
摘要翻译：提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

10. 发明授权

US06463019B2 Optical pickup 有权
标题翻译：光学拾音
公开(公告)号：US06463019B2
公开(公告)日：2002-10-08
申请号：US09905870
申请日：2001-07-17
申请人： Noriyuki Kawano , Kouichi Ogura , Yoshio Saito , Mitsuru Kinouchi , Nobuo Uekusa , Hiroyuki Matsuura
发明人： Noriyuki Kawano , Kouichi Ogura , Yoshio Saito , Mitsuru Kinouchi , Nobuo Uekusa , Hiroyuki Matsuura
IPC分类号： G11B700
CPC分类号： G11B17/04 , G11B7/082 , G11B7/093 , G11B7/0932 , G11B7/0933 , G11B7/0935 , G11B7/0956 , G11B7/22
摘要： An optical pickup comprises an objective-lens driving device including a movable section provided with an objective lens, a focusing coil, and tracking coils, and a fixed section provided with a single magnetic circuit having a magnetic gap, the focusing coil and the tracking coils being disposed in the magnetic gap. The point of application of a tracking-driving force, the point of application of a result force of focusing-driving forces occurring in and outside the magnetic gap, and the position of the center of gravity of the movable section are made to substantially coincide with each other. In addition, the objective lens and the magnetic circuit are disposed within an area of a window in a lower shell of a optical disk. Further, a through hole for accommodating a lower portion of a yoke of the magnetic circuit is provided in a mounting base on which the objective-lens driving device is mounted. An inclining fulcrum and a height adjusting means for inclining the objective-lens driving device about the inclining fulcrum are provided in the vicinities of the through hole.
摘要翻译：光拾取器包括物镜驱动装置，该物镜驱动装置包括设置有物镜的可移动部分，聚焦线圈和跟踪线圈，以及设置有具有磁隙的单个磁路的固定部分，聚焦线圈和跟踪线圈设置在磁隙中。跟踪驱动力的应用点，发生在磁隙内外的聚焦驱动力的结果力的施加点和可移动部分的重心位置基本上与彼此。此外，物镜和磁路设置在光盘的下壳体内的窗口的区域内。此外，用于容纳磁路的磁轭的下部的通孔设置在安装有物镜驱动装置的安装基座中。在通孔附近设置倾斜支点和用于使物镜驱动装置围绕倾斜支点倾斜的高度调节装置。

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