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    • 4. 发明授权
    • Glycosylated FGF
    • 糖基化FGF
    • US5360896A
    • 1994-11-01
    • US7089
    • 1993-01-19
    • Masaharu SenooReiko SasadaKoichi Igarashi
    • Masaharu SenooReiko SasadaKoichi Igarashi
    • G06F1/28A61K38/00C07K14/50C07K13/00
    • C07K14/50A61K38/00C07K2319/036C07K2319/75
    • Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.
    • 公开了(1)成纤维细胞生长因子(FGF)的突变蛋白,其中引入了至少一个编码糖基化位点的核苷酸序列的DNA,(2)编码(1),(3)的突变蛋白的DNA 含有(2)的DNA的载体,(4)用(3)的载体转化的转化体,和(5)一种产生突变蛋白的方法,其包括在培养基中培养转化了酵母或动物细胞的转化体 (3)的载体,并且在培养基中产生和积累(1)的突变蛋白,从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力,稳定性和活性,并且有利地用作药物 。
    • 10. 发明申请
    • OIL-FLOODED SCREW COMPRESSOR, MOTOR DRIVE SYSTEM, AND MOTOR CONTROL DEVICE
    • 油压螺杆压缩机,电机驱动系统和电动机控制装置
    • US20100028165A1
    • 2010-02-04
    • US12533097
    • 2009-07-31
    • Hirotaka KAMEYAMasaru YamasakiToshiyuki AjimaMasaharu SenooHideharu TanakaNorinaga Suzuki
    • Hirotaka KAMEYAMasaru YamasakiToshiyuki AjimaMasaharu SenooHideharu TanakaNorinaga Suzuki
    • F04B49/00F04B35/04F04C29/04H02P1/04
    • F04B17/03F04C18/16F04C28/06F04C28/08F04C2270/051F04C2270/19F04C2270/701
    • When an oil-flooded screw compressor is started up in a cold environment after a long halt, start-up torque increases due to the increased viscosity of the oil that has long stayed inside the working chambers of the compressor. This has necessitated drive means with a larger capacity than that required for normal operation.An oil-flooded screw compressor according to the invention comprises: a casing; a pair of rotors each having screw-thread-shaped groove and being housed in the casing; an electric motor for rotationally driving the pair of rotors; a control device for controlling the electric motor; an oil feeding mechanism for feeding oil into working chambers formed by being enclosed by the casing and the pair of rotors in which teeth thereof are meshed to each other; and an oil separating mechanism for separating the oil from compressed gas discharged from the working chambers. The oil-flooded screw compressor drives the pair of rotors at a rotational speed which is low enough not to increase torque for a short amount of time after start-up and accelerates the pair of rotors up to a normal-operation rotational speed after oil discharge. Alternatively, the oil-flooded screw compressor rotates the pair of rotors for a short amount of time after the remaining compressed gas is discharged after a halt, thereby allowing the oil accumulated inside the working chambers to be discharged and ensuring smooth start-up after the halt.
    • 当在长时间停止之后,在冷空气环境中启动一个充油螺杆压缩机时,由于长时间停留在压缩机的工作室内的油的粘度增加,启动扭矩增加。 这需要比正常操作所需的更大的容量的驱动装置。 根据本发明的一种充油螺杆式压缩机包括:壳体; 一对转子,每个转子都具有螺纹形槽并容纳在壳体中; 用于旋转地驱动所述一对转子的电动机; 用于控制电动机的控制装置; 供油机构,用于将油输送到由壳体和由其彼此啮合的一对转子形成的工作室; 以及用于将油与从工作室排出的压缩气体分离的油分离机构。 充油螺杆式压缩机以一定的转速驱动一对转子,旋转速度足够低,在启动后不会在短时间内增加扭矩,并且在排油后将一对转子加速至正常操作转速 。 或者,油压螺杆式压缩机在停止后剩余的压缩气体排出之后使一对转子旋转一段时间,从而允许积聚在工作室内的油排出,并确保顺利启动 停。