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1. 发明授权

US5972886A Megakaryocyte differentiation factor 失效
公开(公告)号：US5972886A
公开(公告)日：1999-10-26
申请号：US611977
申请日：1996-03-06
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91 , C07K14/52 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host.The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.

2. 发明授权

US5831030A Antibodies specific for megakaryocyte differentiation factor 失效
标题翻译：特异于巨核细胞分化因子的抗体
公开(公告)号：US5831030A
公开(公告)日：1998-11-03
申请号：US472659
申请日：1995-06-07
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/475 , A61K38/00
摘要： The present invention provides novel megakaryocyte differentiation factors, which are useful as therapeutic agents due to their accelerating effects on the differentiation of megakaryocytes and their thrombopoietic effects. The megakaryocyte differentiation factors of the present invention include the megakaryocyte differentiation factor having the amino acid sequence shown in SEQ ID NO: 34. The present invention also provides DNA coding for the megakaryocyte differentiation factors of the present invention, expression vectors containing the DNA, hosts transformed with the expression vectors, and processes for production of the megakaryocyte differentiation factors using transformed hosts. The present invention further provides specific antibodies to the megakaryocyte differentiation factors of the present invention.
摘要翻译：本发明提供了新的巨核细胞分化因子，由于它们对巨核细胞的分化及其血小板生成作用的加速作用，它们可用作治疗剂。本发明的巨核细胞分化因子包括具有SEQ ID NO：34所示的氨基酸序列的巨核细胞分化因子。本发明还提供编码本发明的巨核细胞分化因子的DNA，含有该DNA的表达载体，宿主用表达载体转化，以及使用转化宿主生产巨核细胞分化因子的过程。本发明还提供了针对本发明的巨核细胞分化因子的特异性抗体。

3. 发明授权

US5874253A DNA encoding megakaryocyte differentiation factor 失效
标题翻译：编码巨核细胞分化因子的DNA
公开(公告)号：US5874253A
公开(公告)日：1999-02-23
申请号：US474661
申请日：1995-06-07
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host. The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.
摘要翻译：一种新型巨核细胞分化因子，例如基本上由SEQ ID NO：30组成; 编码巨核细胞分化因子的DNA，包含DNA的表达载体，用表达载体转化的宿主以及使用该宿主产生巨核细胞分化因子的方法。巨核细胞分化因子加速了在IL-3存在下巨核细胞的分化，并且作为血小板生成素，因此是涉及减少血小板的各种疾病的有效药物。

4. 发明授权

US5151349A Method for expressing polypeptide having anti-tumor activity 失效
标题翻译：表达具有抗肿瘤活性的多肽的方法
公开(公告)号：US5151349A
公开(公告)日：1992-09-29
申请号：US473168
申请日：1990-01-31
申请人： Shoji Tanaka , Masafumi Tsujimoto , Yayoi Wada , Nobuo Tsuruoka , Hiroshi Nakazato
发明人： Shoji Tanaka , Masafumi Tsujimoto , Yayoi Wada , Nobuo Tsuruoka , Hiroshi Nakazato
IPC分类号： C07K14/525 , C12N15/70
CPC分类号： C07K14/525 , C12N15/70
摘要： Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
摘要翻译：公开了通过用可能引起严重不良反应的人TNF的氨基酸序列的N-末端替代第31位和32位精氨酸残基而导致副作用降低的趋势的人TNF衍生物，分别使用天冬酰胺残基和苏氨酸残基，以及利用重组DNA技术制备其的方法。

5. 发明授权

US4948875A Novel polypeptide having an anti-tumor activity and a method of preparation thereof 失效
标题翻译：具有抗肿瘤活性的新型多肽及其制备方法
公开(公告)号：US4948875A
公开(公告)日：1990-08-14
申请号：US123316
申请日：1987-11-20
申请人： Shoji Tanaka , Masafumi Tsujimoto , Yayoi Wada , Nobuo Tsuruoka , Hiroshi Nakazato
发明人： Shoji Tanaka , Masafumi Tsujimoto , Yayoi Wada , Nobuo Tsuruoka , Hiroshi Nakazato
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C12N15/00 , C12N15/70 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , C12N15/70
摘要： Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
摘要翻译：公开了通过用可能引起严重不良反应的人TNF的氨基酸序列的N-末端替代第31位和32位精氨酸残基而导致副作用降低的趋势的人TNF衍生物，分别使用天冬酰胺残基和苏氨酸残基，以及利用重组DNA技术制备其的方法。

6. 发明授权

US4820641A Monoclonal antibody capable of specifically distinguishing human hepato-carcinoma cells 失效
标题翻译：能够特异性区分人肝癌细胞的单克隆抗体
公开(公告)号：US4820641A
公开(公告)日：1989-04-11
申请号：US749564
申请日：1985-06-27
申请人： Toshihiro Nakanishi , Yoshiaki Fukuda , Kenju Miura , Hiroshi Nakazato
发明人： Toshihiro Nakanishi , Yoshiaki Fukuda , Kenju Miura , Hiroshi Nakazato
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/02 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/00 , C07K15/04
CPC分类号： C07K16/3038 , A61K38/00 , C07K2317/732
摘要： The specification discloses a monoclonal antibody capable of distinguishing human hepato-carcinoma cells, a hybridoma producing said monoclonal antibody and a process for preparing the monoclonal antibody using said hybridoma. The monoclonal antibody of the invention specifically attackes hepato-carcinoma cells in vivo.
摘要翻译：该说明书公开了能够区分人肝癌细胞的单克隆抗体，产生所述单克隆抗体的杂交瘤和使用所述杂交瘤制备单克隆抗体的方法。本发明的单克隆抗体体内特异性侵袭肝癌细胞。

7. 发明授权

US07753634B2 Parts attaching structure 有权
标题翻译：零件附件结构
公开(公告)号：US07753634B2
公开(公告)日：2010-07-13
申请号：US11790006
申请日：2007-04-23
申请人： Hiroshi Nakazato
发明人： Hiroshi Nakazato
IPC分类号： F16B21/02
CPC分类号： F16B21/02 , F16B5/065 , F16B21/086 , Y10T24/4578
摘要： This attaching structure includes: a first part having a slot; a second part having an attaching hole; and a clip for connecting those parts, the clip including a first flange portion, a shank portion, a second flange portion for coming into elastic abutment against the back side of the slot, a third flange portion, and a leg portion to be retained in the attaching hole, wherein: the shank portion has sliding portions of a large arcuate shape, and stopper portions of a small arcuate shape; protrusions are disposed on the first part in the periphery of the side portions close to the stopper portions when the first flange portion intersects at a right angle with respect to the slot; and the protrusions engage with the first flange portion to stop the turning motion thereby to prevent the clip from coming out from the first part.
摘要翻译：该连接结构包括：具有槽的第一部分; 具有安装孔的第二部分; 以及用于连接这些部件的夹子，夹子包括第一凸缘部分，柄部分，用于与槽的背面弹性抵接的第二凸缘部分，第三凸缘部分和待保持的腿部分所述安装孔，其中：所述柄部具有大弓形形状的滑动部分和小弓形形状的止动部分; 当第一凸缘部分相对于狭槽以直角相交时，突出物设置在靠近止动部分的侧部的周边的第一部分上; 并且突起与第一凸缘部接合以停止转动运动，从而防止夹子从第一部件脱出。

8. 发明授权

US07680425B2 Image forming apparatus and method for controlling tone characteristics based on tone-control patch image 失效
标题翻译：用于基于色调控制补片图像来控制色调特征的图像形成装置和方法
公开(公告)号：US07680425B2
公开(公告)日：2010-03-16
申请号：US10893743
申请日：2004-07-16
申请人： Takashi Hama , Hidetsugu Shimura , Keiichi Taguchi , Hiroshi Nakazato , Ken Ikuma , Hidenori Kin
发明人： Takashi Hama , Hidetsugu Shimura , Keiichi Taguchi , Hiroshi Nakazato , Ken Ikuma , Hidenori Kin
IPC分类号： G03G15/00
CPC分类号： G03G15/5058 , G03G15/0131 , G03G2215/00059 , G03G2215/00063 , G03G2215/0177 , H04N1/4078
摘要： An image It is formed as a patch image which includes a header image portion Ih of a solid image having a length of a circumferential length of a developing roller or more, and a gradation image portion Ig progressively varied in the tone level thereof from the maximum level to the minimum level. The densities of the patch image on an intermediate transfer belt are sampled. However, the sampling results contain errors resulting from noises or variations and hence, are subjected to a noise removal process, a periodical variation correction process and a reverse correction process. The results detected on the intermediate transfer belt do not always coincide with image densities (OD values) on a recording material. Therefore, the detection results are converted into the OD values, based on which tone characteristics of an apparatus is estimated. Then a tone correction table is updated in a manner to compensate for the tone characteristics. This approach is taken to improve image quality on the recording material.
摘要翻译：图像形成为补片图像，其包括具有显影辊或其以上的周长的长度的实心图像的标题图像部分Ih，并且其色调级别中的渐变图像部分Ig从最大值逐渐变化水平达到最低水平。对中间转印带上的贴片图像的密度进行采样。然而，采样结果包含由噪声或变化引起的误差，因此，进行噪声去除处理，周期性变化校正处理和反向校正处理。在中间转印带上检测到的结果并不总是与记录材料上的图像密度（OD值）重合。因此，根据估计装置的音调特性，将检测结果转换成OD值。然后以补偿色调特性的方式更新色调校正表。采取这种方法来改善记录材料上的图像质量。

9. 发明授权

US07570892B2 Image forming apparatus and control method of that apparatus 失效
标题翻译：该装置的图像形成装置和控制方法
公开(公告)号：US07570892B2
公开(公告)日：2009-08-04
申请号：US12269729
申请日：2008-11-12
申请人： Hiroshi Nakazato , Ken Ikuma , Keiichi Taguchi
发明人： Hiroshi Nakazato , Ken Ikuma , Keiichi Taguchi
IPC分类号： G03G15/00 , G03G21/00
CPC分类号： G03G21/1839 , G03G15/0121 , G03G15/0173 , G03G15/5004 , G03G2215/0177 , G03G2221/169 , G03G2221/183
摘要： An image forming apparatus adapted for a smooth mounting/dismounting of a process unit and for the reduction of wasteful power consumption is provided.Unless a new image signal is applied after completion of an image forming operation, the apparatus starts a clocking operation by an internal timer (Step S101). If the apparatus is left standstill for a predetermined length of time (Step S102), a sleep process (Step S103) is executed to shift the apparatus to a power save mode to consume less power. When an outside cover is opened (Step S105), on the other hand, the apparatus is shifted to a replacement operation mode (Step S106) in which only the rotation of a development rotary is permitted. However, if the apparatus is left with the outside cover opened (Step S108), the sleep process is executed.
摘要翻译：提供了适于平滑地安装/拆卸处理单元并且减少浪费的功率消耗的图像形成装置。除非在完成图像形成操作之后施加新的图像信号，否则该装置通过内部定时器开始计时操作（步骤S101）。如果设备停留预定时间长度（步骤S102），则执行睡眠处理（步骤S103），以将设备移动到省电模式以消耗更少的功率。另一方面，当打开外盖（步骤S105）时，将装置转移到仅允许显影旋转的旋转的替换操作模式（步骤S106）。然而，如果在打开外盖的情况下留下装置（步骤S108），则执行睡眠处理。

10. 外观设计

USD589333S1 Fixing article for automobile parts 有权
标题翻译：汽车零件固定件
公开(公告)号：USD589333S1
公开(公告)日：2009-03-31
申请号：US29300363
申请日：2008-03-19
申请人： Hiroshi Nakazato
设计人： Hiroshi Nakazato

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