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1. 发明申请

US20080317821A1 Lipase Inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US20080317821A1
公开(公告)日：2008-12-25
申请号：US11631507
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： A61K31/353 , A61P1/00
CPC分类号： A61K36/82 , A23F3/163 , A23L33/105 , A23V2002/00 , A61K31/352 , A23V2200/332 , A23V2250/21 , A23V2250/214
摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula:
摘要翻译：本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由以下公式表示的茶黄素：

2. 发明申请

US20080207747A1 Lipase Inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US20080207747A1
公开(公告)日：2008-08-28
申请号：US11631506
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： C07D311/04 , C07D493/12 , A61K31/365 , A61K31/352 , A61P3/06
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K31/353 , C07D311/62 , C07D493/14 , A23V2250/21 , A23V2250/214 , A23V2200/332 , A23V2200/326
摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula: wherein R1 and R3 independently represent H or OH, R2 represents H, R4 represents H, G, 3MeG or p-cou, R5 represents H or G, R4′ and R5′ independently represent H or G, R4″ represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae: or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供了含有衍生自茶的黄烷-3-醇单体或其酰化物以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式所示的黄烷-3-醇单体中的至少一种的脂肪酶抑制剂：其中R 1和R 3独立地表示H或OH R 2代表H，R 4代表H，G，3MeG或对 - 可可，R 5代表H或G，R _{4 <＆gt;和R 5'独立地表示H或G，R 4'表示H或G，并且G，3MeG和p-cou分别表示下式的基团：或其酰化物; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。}

3. 发明授权

US08668921B2 Lipase inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US08668921B2
公开(公告)日：2014-03-11
申请号：US11631507
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： A61K31/353 , A61P1/00 , A61K31/7048 , A61K31/355 , A61K31/375 , A61K31/202 , A61K31/195 , A61K31/015
CPC分类号： A61K36/82 , A23F3/163 , A23L33/105 , A23V2002/00 , A61K31/352 , A23V2200/332 , A23V2250/21 , A23V2250/214
摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula: wherein R1 and R2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由下式表示的茶黄素：其中R1和R2独立地表示G或H; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

4. 发明申请

US20080306284A1 Lipase Inhibitors 审中-公开
标题翻译：脂肪酶抑制剂
公开(公告)号：US20080306284A1
公开(公告)日：2008-12-11
申请号：US11631486
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： C07D493/18 , C07D407/10
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A61K31/353 , C07D311/62
摘要： The present invention provides lipase inhibitors containing dimers having an epigallocatechin gallate (EGCG) unit derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of proanthocyanidins represented by the formula: wherein R1 and R2 independently represent H or OH, and R3 and R4 independently represent H or a galloyl group; as well as foods and beverages and pharmaceutical compositions containing said lipase inhibitors.
摘要翻译：本发明提供含有来自茶叶的表没食子儿茶素没食子酸酯（EGCG）单元的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地说，本发明提供含有至少一种由下式表示的原花色素的脂肪酶抑制剂：其中R1和R2独立地表示H或OH，R3和R4独立地表示H或加成酯基; 以及含有所述脂肪酶抑制剂的食品和饮料和药物组合物。

5. 发明授权

US07939559B2 Lipase inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US07939559B2
公开(公告)日：2011-05-10
申请号：US11631506
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： A61K31/353
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K31/353 , C07D311/62 , C07D493/14 , A23V2250/21 , A23V2250/214 , A23V2200/332 , A23V2200/326
摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula: wherein R1 and R3 independently represent H or OH, R2 represents H, R4 represents H, G, 3MeG or p-cou, R5 represents H or G, R4′ and R5′ independently represent H or G, R4″ represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae: or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供了含有衍生自茶的黄烷-3-醇单体或其酰化物以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式所示的黄烷-3-醇单体中的至少一种的脂肪酶抑制剂：其中R1和R3独立地表示H或OH，R2表示H，R4表示H，G，3MeG或p-cou R5代表H或G，R4'和R5'独立地表示H或G，R4“表示H或G，G，3MeG和p-cou分别表示下式的基团：或其酰化物; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

6. 发明申请

US20070254948A1 Lipase Inhibitors 审中-公开
标题翻译：脂肪酶抑制剂
公开(公告)号：US20070254948A1
公开(公告)日：2007-11-01
申请号：US11660784
申请日：2005-08-22
申请人： Yuko Fukui , Masaaki Nakai , Sumio Asami
发明人： Yuko Fukui , Masaaki Nakai , Sumio Asami
IPC分类号： A61K31/351 , A23L2/00 , A61P3/00 , C07D309/10
CPC分类号： A61K31/7024 , A23F3/16 , A23F3/18 , A23F3/34 , A23L33/105 , A23V2002/00 , A23V2250/214 , A23V2250/21 , A23V2200/02 , A23V2200/30
摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents. The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.
摘要翻译：本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。本发明提供脂肪酶抑制剂，其包含至少一种由下式I表示的化合物：其中R 1，R 2和R 3独立地为表示H或没食子酸的残基，R 4和R 5表示H或没食子酸残基，或R 4和R 3 > 5＆gt;一起形成由下式表示的HHDP基团：条件是R 1至R 5中的至少两个表示没食子酸残基或全部 R 1，R 2和R 3均为H，R 4和R 5，共同组成HHDP组; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

7. 发明授权

US08309745B2 Epigallocatechin dimers or trimers having lipase inhibitory activity and/or antioxidant activity 有权
标题翻译：具有脂肪酶抑制活性和/或抗氧化活性的表没食子儿茶素二聚体或三聚体
公开(公告)号：US08309745B2
公开(公告)日：2012-11-13
申请号：US12872872
申请日：2010-08-31
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami
IPC分类号： C07D311/62
CPC分类号： C07D311/62 , A23L33/105
摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有掺入其中的这种脂肪酶活性抑制剂。本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。本发明的另一个目的是提供抗氧化剂。为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

8. 发明申请

US20080275258A1 Epigallocatechin Dimers or Trimers Having Lipase Inhibitory Activity and/or Antioxidant Activity 有权
标题翻译：具有脂肪酶抑制活性和/或抗氧化活性的表没食子儿茶素二聚体或三聚体
公开(公告)号：US20080275258A1
公开(公告)日：2008-11-06
申请号：US11597291
申请日：2005-05-26
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami
IPC分类号： C07D311/04
CPC分类号： C07D311/62 , A23L33/105
摘要： It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：旨在提供对胰脂肪酶具有高抑制活性的脂肪酶活性抑制剂，调节从膳食中吸收脂肪和/或有助于调节或预防肥胖症的食物和饮料，以及茶 - 原料脂肪酶抑制剂是非常优选的，而不是恶化味道。还旨在提供一种生产脂肪酶抑制剂的方法。还旨在提供抗氧化剂。为了克服这些问题，向食物或饮料中加入表没食子儿茶素二聚体（乌龙同双双黄烷）或三聚体。因此，可以调节从膳食中吸收脂肪，并且可以获得抗氧化作用。上述化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

9. 发明授权

US07754695B2 Lipase inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US07754695B2
公开(公告)日：2010-07-13
申请号：US12285144
申请日：2008-09-30
申请人： Yuko Fukui , Masaaki Nakai , Sumio Asami
发明人： Yuko Fukui , Masaaki Nakai , Sumio Asami
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61K31/7024 , A23F3/16 , A23F3/18 , A23F3/34 , A23L33/105 , A23V2002/00 , A23V2250/214 , A23V2250/21 , A23V2200/02 , A23V2200/30
摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents.The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.
摘要翻译：本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。本发明提供脂肪酶抑制剂，其包含至少一种以下式I表示的化合物：其中R1，R2和R3独立地表示H或没食子酸残基，R4和R5表示H或没食子酸残基，或R4和R5 一起形成由下式表示的HHDP基团：条件是R 1至R 5中至少两个表示没食子酸残基，或者当R1，R2和R3全部为H时，R4和R5一起形成HHDP基团; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

10. 发明授权

US07989492B2 Epigallocatechin dimers or trimers having lipase inhibitory activity and/or antioxidant activity 有权
标题翻译：具有脂肪酶抑制活性和/或抗氧化活性的表没食子儿茶素二聚体或三聚体
公开(公告)号：US07989492B2
公开(公告)日：2011-08-02
申请号：US11597291
申请日：2005-05-26
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami
IPC分类号： A61K31/353
CPC分类号： C07D311/62 , A23L33/105
摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有掺入其中的这种脂肪酶活性抑制剂。本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。本发明的另一个目的是提供抗氧化剂。为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

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