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1. 发明申请

US20100144866A1 ANTI-FATIGUE AGENTS AND ORAL COMPOSITIONS CONTAINING ANDROGRAPHOLIDE AS ACTIVE INGREDIENT 有权
标题翻译：含有作为活性成分的异佛尔酰胺的抗疲劳剂和口服组合物
公开(公告)号：US20100144866A1
公开(公告)日：2010-06-10
申请号：US12602006
申请日：2008-05-30
申请人： Sumio Asami , Kayo Saito , Akifumi Maeda , Norifumi Tateishi
发明人： Sumio Asami , Kayo Saito , Akifumi Maeda , Norifumi Tateishi
IPC分类号： A61K31/341 , C07D307/20 , A61P43/00
CPC分类号： C07D307/58 , A23K20/105 , A23K20/121 , A23K20/158 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K36/18 , A23V2200/31 , A23V2250/21
摘要： Disclosed is a composition which is safe for a human body and an animal, can be ingested continuously on a daily basis, has an anti-fatigue activity, and is effective for the prevention or treatment of a disease or condition associated with fatigue. Specifically disclosed is an anti-fatigue agent comprising andrographolide optionally together with an α-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide and an α-lipoic acid. The anti-fatigue agent and the oral composition are useful for the prevention or treatment of chronic fatigue syndrome, overfatigue, physical fatigue, mental fatigue and organ fatigue.
摘要翻译：公开了对人体和动物安全的组合物，可以每天连续摄取，具有抗疲劳活性，对预防或治疗与疲劳有关的疾病或病症有效。具体公开了包含穿心莲内酯任选与α-硫辛酸作为活性成分一起的抗疲劳剂。还公开了包含穿心莲内酯和α-硫辛酸的新型口服组合物。抗疲劳剂和口服组合物可用于预防或治疗慢性疲劳综合征，过度疲劳，身体疲劳，精神疲劳和器官疲劳。

2. 发明申请

US20080317821A1 Lipase Inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US20080317821A1
公开(公告)日：2008-12-25
申请号：US11631507
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： A61K31/353 , A61P1/00
CPC分类号： A61K36/82 , A23F3/163 , A23L33/105 , A23V2002/00 , A61K31/352 , A23V2200/332 , A23V2250/21 , A23V2250/214
摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula:
摘要翻译：本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由以下公式表示的茶黄素：

3. 发明申请

US20080207747A1 Lipase Inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US20080207747A1
公开(公告)日：2008-08-28
申请号：US11631506
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： C07D311/04 , C07D493/12 , A61K31/365 , A61K31/352 , A61P3/06
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K31/353 , C07D311/62 , C07D493/14 , A23V2250/21 , A23V2250/214 , A23V2200/332 , A23V2200/326
摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula: wherein R1 and R3 independently represent H or OH, R2 represents H, R4 represents H, G, 3MeG or p-cou, R5 represents H or G, R4′ and R5′ independently represent H or G, R4″ represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae: or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供了含有衍生自茶的黄烷-3-醇单体或其酰化物以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式所示的黄烷-3-醇单体中的至少一种的脂肪酶抑制剂：其中R 1和R 3独立地表示H或OH R 2代表H，R 4代表H，G，3MeG或对 - 可可，R 5代表H或G，R _{4 <＆gt;和R 5'独立地表示H或G，R 4'表示H或G，并且G，3MeG和p-cou分别表示下式的基团：或其酰化物; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。}

4. 发明申请

US20070254948A1 Lipase Inhibitors 审中-公开
标题翻译：脂肪酶抑制剂
公开(公告)号：US20070254948A1
公开(公告)日：2007-11-01
申请号：US11660784
申请日：2005-08-22
申请人： Yuko Fukui , Masaaki Nakai , Sumio Asami
发明人： Yuko Fukui , Masaaki Nakai , Sumio Asami
IPC分类号： A61K31/351 , A23L2/00 , A61P3/00 , C07D309/10
CPC分类号： A61K31/7024 , A23F3/16 , A23F3/18 , A23F3/34 , A23L33/105 , A23V2002/00 , A23V2250/214 , A23V2250/21 , A23V2200/02 , A23V2200/30
摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents. The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.
摘要翻译：本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。本发明提供脂肪酶抑制剂，其包含至少一种由下式I表示的化合物：其中R 1，R 2和R 3独立地为表示H或没食子酸的残基，R 4和R 5表示H或没食子酸残基，或R 4和R 3 > 5＆gt;一起形成由下式表示的HHDP基团：条件是R 1至R 5中的至少两个表示没食子酸残基或全部 R 1，R 2和R 3均为H，R 4和R 5，共同组成HHDP组; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

5. 发明授权

US5211953A Liver function improver 失效
标题翻译：肝功能改善剂
公开(公告)号：US5211953A
公开(公告)日：1993-05-18
申请号：US902854
申请日：1992-06-23
申请人： Yoshifumi Shinmen , Kengo Akimoto , Sumio Asami , Yoshihide Suwa , Yoshinori Kitagawa , Michihiro Sugano , Hideaki Yamada , Sakayu Shimizu
发明人： Yoshifumi Shinmen , Kengo Akimoto , Sumio Asami , Yoshihide Suwa , Yoshinori Kitagawa , Michihiro Sugano , Hideaki Yamada , Sakayu Shimizu
IPC分类号： A23D7/005 , A23L1/24 , A23L1/30 , A61K31/335 , A61K31/34
CPC分类号： A23D7/0056 , A23L27/60 , A23L33/10 , A61K31/335 , A61K31/34 , A23V2002/00 , Y10S514/811 , Y10S514/893 , Y10S514/894
摘要： A liver function improver, food, or drink comprising, as an effective ingredient, a dioxabicyclo[3.3.0]octane derivative, such as sesamin, sesaminol espisesamin, episesaminol, sesamolin, 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane or 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenoxy)-3,7-dioxabicyclo[3.3.0]octane.
摘要翻译：作为有效成分的二氧杂二环[3.3.0]辛烷衍生物，如芝麻素，芝麻素西塞米松，异芝麻酚，芝麻素，2-（3,4-亚甲二氧基苯基）-6-（ 3-甲氧基-4-羟基苯基）-3,7-二氧杂环环[3.3.0]辛烷，2,6-双 - （3-甲氧基-4-羟基苯基）-3,7-二氧杂双环[3.3.0]辛烷或 2-（3,4-亚甲二氧基苯基）-6-（3-甲氧基-4-羟基苯氧基）-3,7-二氧杂环己烯并[3.3.0]辛烷。

6. 发明授权

US5116751A Process for producing peroxidase 失效
标题翻译：生产过氧化物的方法
公开(公告)号：US5116751A
公开(公告)日：1992-05-26
申请号：US643166
申请日：1991-01-22
申请人： Yoshifumi Shinmen , Sumio Asami , Norihide Amano , Teruo Amachi , Hajime Yoshizumi
发明人： Yoshifumi Shinmen , Sumio Asami , Norihide Amano , Teruo Amachi , Hajime Yoshizumi
IPC分类号： C12N9/08 , C12Q1/28 , C12R1/645
CPC分类号： C12N9/0065 , C12Q1/28 , Y10S435/911
摘要： A novel peroxidase was obtained from a fast growing microorganism of the genus Coprinus cinereus. The fungal peroxidase is comparable to the conventional peroxidase derived from horseradish or Japanese radish in that it can be used either as a clinical or diagnostic reagent or as a marker enzyme in enzyme immunoassay.
摘要翻译：一种新型过氧化物酶是从快速生长的灰霉菌属微生物获得的。真菌过氧化物酶与来自辣根或日本萝卜的常规过氧化物酶相当，因为它可以作为临床或诊断试剂或作为酶免疫测定中的标记酶使用。

7. 发明授权

US08680301B2 Lipase activity inhibitors containing high-molecular weight polyphenol fractions, tea extracts, and processes for producing the same 有权
$Lipase activity inhibitors containing high-molecular weight polyphenol fractions, tea extracts, and processes for producing the same$
标题翻译：含有高分子量多酚馏分的脂肪酶活性抑制剂，茶提取物及其制备方法
公开(公告)号：US08680301B2
公开(公告)日：2014-03-25
申请号：US10589607
申请日：2005-02-17
申请人： Hitoshi Matsubara , Yoshiyuki Ishikura , Hiroaki Sasaki , Keiichi Abe , Sumio Asami , Masaaki Nakai , Aki Kusumoto
发明人： Hitoshi Matsubara , Yoshiyuki Ishikura , Hiroaki Sasaki , Keiichi Abe , Sumio Asami , Masaaki Nakai , Aki Kusumoto
IPC分类号： C07D403/00 , C07D311/62
CPC分类号： C07D403/00 , A23F3/18 , A23L33/20 , A61K31/765 , A61K36/82 , C07D311/62
摘要： There are provided foods and beverages that will suppress the absorption of dietary lipids, thereby suppressing the rise of triglyceride in blood. High-molecular weight polyphenol fractions recovered from oolong tea are added to foods or beverages as an active ingredient for inhibiting lipase activity. The foods and beverages of the present invention are safe and their inherent flavor has not been impaired; hence, they may be taken in routinely so that the lipase inhibitory action of the high-molecular weight polyphenol fractions will suppress the rise of triglyceride in blood and prevent obesity.
摘要翻译：提供的食品和饮料将抑制膳食脂质的吸收，从而抑制血液中甘油三酯的升高。将从乌龙茶回收的高分子量多酚馏分作为抑制脂肪酶活性的活性成分添加到食品或饮料中。本发明的食品和饮料是安全的，其固有的味道没有被削弱; 因此，它们可以常规摄取，使得高分子量多酚馏分的脂肪酶抑制作用将抑制血液中甘油三酯的升高并防止肥胖。

8. 发明授权

US08668921B2 Lipase inhibitors 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：US08668921B2
公开(公告)日：2014-03-11
申请号：US11631507
申请日：2005-07-05
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami , Fumio Hashimoto
IPC分类号： A61K31/353 , A61P1/00 , A61K31/7048 , A61K31/355 , A61K31/375 , A61K31/202 , A61K31/195 , A61K31/015
CPC分类号： A61K36/82 , A23F3/163 , A23L33/105 , A23V2002/00 , A61K31/352 , A23V2200/332 , A23V2250/21 , A23V2250/214
摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula: wherein R1 and R2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由下式表示的茶黄素：其中R1和R2独立地表示G或H; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

9. 发明申请

US20120329862A1 NOVEL COMPOUND HAVING INHIBITORY EFFECT ON LIPASE 审中-公开
标题翻译：对化合物有抑制作用的新化合物
公开(公告)号：US20120329862A1
公开(公告)日：2012-12-27
申请号：US13336070
申请日：2011-12-23
申请人： Masaaki NAKAI , Yuko Fukui , Sumio Asami
发明人： Masaaki NAKAI , Yuko Fukui , Sumio Asami
IPC分类号： A61K31/353 , A61P3/06
CPC分类号： C07D407/14 , A23F3/163 , A23F5/243 , A23L2/52 , A23L33/105
摘要： This invention provides, a novel polyphenol compound having lipase inhibitory activity derived from tealeaves, a process for the preparation of the compound, and foods and/or beverages and pharmaceutical drugs containing the compound.Particularly, this invention provides a novel dimer compound of formula: obtained by oxidative polymerization of epigallocatechin-3-O-gallate, a main catechin component of oolong tea, with a tealeaf enzyme (polyphenol oxidase), as well as foods and/or beverages and pharmaceutical compositions containing said novel compound which suppress absorption of dietary lipids and suppresses increase of blood triglyceride.
摘要翻译：本发明提供一种新型的具有来源于茶叶的脂肪酶抑制活性的多酚化合物，制备该化合物的方法，以及含有该化合物的食品和/或饮料和药物。特别地，本发明提供了一种新型的二聚体化合物，其通过用茶叶酶（多酚氧化酶）以及食品和/或饮料的乌龙茶的主要儿茶素组分氧化聚合得到。以及含有抑制饮食脂质吸收并抑制血液甘油三酯增加的新化合物的药物组合物。

10. 发明申请

US20110124887A1 EPIGALLOCATECHIN DIMERS OR TRIMERS HAVING LIPASE INHIBITORY ACTIVITY AND/OR ANTIOXIDANT ACTIVITY 有权
标题翻译：具有脂蛋白抑制活性和/或抗氧化活性的二磷酸二酯或二聚体
公开(公告)号：US20110124887A1
公开(公告)日：2011-05-26
申请号：US12872872
申请日：2010-08-31
申请人： Masaaki NAKAI , Yuko Fukui , Sumio Asami
发明人： Masaaki NAKAI , Yuko Fukui , Sumio Asami
IPC分类号： C07D407/14
CPC分类号： C07D311/62 , A23L33/105
摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有掺入其中的这种脂肪酶活性抑制剂。本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。本发明的另一个目的是提供抗氧化剂。为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

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