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1. 发明申请

US20100028330A1 METHODS OF UPMODULATING ADAPTIVE IMMUNE RESPONSE USING ANTI-PD1 ANTIBODIES 有权
标题翻译：使用抗PD1抗体进行适应性免疫应答的方法
公开(公告)号：US20100028330A1
公开(公告)日：2010-02-04
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/07 , C12P21/00 , A61P37/04
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

2. 发明授权

US07521051B2 Methods of upmodulating adaptive immune response using anti-PD-1 antibodies 失效
标题翻译：使用抗PD-1抗体上调适应性免疫应答的方法
公开(公告)号：US07521051B2
公开(公告)日：2009-04-21
申请号：US10540084
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

3. 发明申请

US20080311117A1 Antibodies against PD-1 and uses therefor 审中-公开
标题翻译：抗PD-1抗体及其用途
公开(公告)号：US20080311117A1
公开(公告)日：2008-12-18
申请号：US11893989
申请日：2007-08-17
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

4. 发明授权

US08088905B2 Nucleic acids encoding antibodies against PD-1 有权
标题翻译：编码抗PD-1抗体的核酸
公开(公告)号：US08088905B2
公开(公告)日：2012-01-03
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C12N15/11
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

5. 发明授权

US07488802B2 Antibodies against PD-1 失效
标题翻译：抗PD-1抗体
公开(公告)号：US07488802B2
公开(公告)日：2009-02-10
申请号：US10741481
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可以用于例如治疗自身免疫疾病，炎性疾病，过敏，移植排斥，癌症和其他免疫系统疾病。

6. 发明申请

US20050285901A1 Ink jet nozzle geometry selection by laser ablation of thin walls 审中-公开
标题翻译：通过激光消融薄壁喷墨喷嘴几何选择
公开(公告)号：US20050285901A1
公开(公告)日：2005-12-29
申请号：US10880069
申请日：2004-06-29
申请人： Shelby Nelson , Eduardo Freire , John Andrews
发明人： Shelby Nelson , Eduardo Freire , John Andrews
IPC分类号： B41J2/04 , B41J2/16
CPC分类号： B41J2/1634 , B41J2/1606 , B41J2/162 , B41J2/1631 , B41J2002/14475
摘要： A novel method of fabricating the channel ends of an ink jet printhead: lithographically fabricating channels in photopolymer having the channel end blocked by a thin layer of photopolymer; sandwiching the photopolymer between two parallel substrates, one of which has an actuator for each channel; dicing through the substrates on a line perpendicular to the channels and leaving the channels and solid wall at the end of the channels intact; optionally coating the diced face including the polymer wall blocking the channel ends with a hydrophobic material; and forming nozzles in the end of the channels by laser ablating through the polymer layer at the end of the channel. Forming the nozzles after dicing and the optional coating prevents contamination of the interior of the printhead. The nozzles can be recessed from the diced edges of the substrate. Photolithographic formation of the end of the channel insures an accurate distance is maintained between the nozzle and the actuator. Improved jetting stability, directionality of the ejected drops, and drop size result from this novel fabrication method.
摘要翻译：一种制造喷墨打印头的通道端的新颖方法：光刻制造光聚合物中的通道，其通道端被光聚合物薄层阻挡; 将光聚合物夹在两个平行的基板之间，其中一个具有用于每个通道的致动器; 在垂直于通道的线上通过基底切割，并保留通道末端的通道和实心壁; 任选地将包含聚合物壁的切割面涂覆用疏水材料阻挡通道末端; 并且在通道的末端通过在通道末端的聚合物层激光烧蚀而在通道的末端形成喷嘴。在切割之后形成喷嘴，并且可选的涂层防止了打印头内部的污染。喷嘴可以从基板的切割边缘凹进。通道端部的光刻形成确保喷嘴和致动器之间保持精确的距离。改进的喷射稳定性，喷射液滴的方向性和液滴尺寸是由这种新颖的制造方法产生的。

7. 发明申请

US20050234178A1 Metal peroxide films 有权
标题翻译：金属过氧化物膜
公开(公告)号：US20050234178A1
公开(公告)日：2005-10-20
申请号：US10826565
申请日：2004-04-16
申请人： John Andrews
发明人： John Andrews
IPC分类号： C08K3/08
CPC分类号： C01B15/04 , C01B15/043 , C01B15/047 , Y10S428/917 , Y10S977/773 , Y10S977/774 , Y10S977/775 , Y10S977/776 , Y10S977/777 , Y10S977/81 , Y10S977/811 , Y10S977/896 , Y10T428/26 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/315
摘要： Disclosed are adhesive coating compositions containing a metal peroxide for producing clear colorless adhesive coatings on substrates, particularly micro particulate substrates. In one preferred embodiment the nanoparticle coatings are chemically active and function at a high level of efficiency due to the high total surface area of the micro particulate substrate. Also disclosed are coated substrates and compositions having nanoparticles bound to a substrate by the coating compositions.
摘要翻译：公开了含有金属过氧化物的粘合剂涂料组合物，用于在基材，特别是微颗粒基材上产生透明的无色粘合剂涂料。在一个优选实施方案中，纳米颗粒涂层具有化学活性并且由于微粒基质的高总表面积而以高效率的水平起作用。还公开了具有通过涂料组合物结合到基材上的纳米颗粒的涂布基材和组合物。

8. 发明申请

US20050205480A1 Portable ultraviolet water purification system 有权
标题翻译：便携式紫外线净水系统
公开(公告)号：US20050205480A1
公开(公告)日：2005-09-22
申请号：US11003536
申请日：2004-12-03
申请人： Kurt Kuhlmann , John Andrews
发明人： Kurt Kuhlmann , John Andrews
IPC分类号： C02F1/00 , C02F1/32 , C02F9/00
CPC分类号： C02F1/325 , C02F1/001 , C02F1/002 , C02F2201/009 , C02F2201/326 , C02F2209/006 , Y02A20/212
摘要： A portable water-purification system includes a container for holding a liquid and an ultraviolet light source configured for immersion in the liquid. The ultraviolet light source is a straight low-cost tube controlled by electronic circuitry for providing hot-cathode striking at a relatively low voltage using a fly-back inductor. The operation of the water purification system is controlled by a micro-controller within the electronic circuitry.
摘要翻译：便携式水净化系统包括用于保持液体的容器和被配置为浸没在液体中的紫外光源。紫外光源是由电子电路控制的直接低成本管，用于使用回扫电感器以相对较低的电压提供热阴极击打。水净化系统的操作由电子电路内的微控制器控制。

9. 发明授权

US08173813B2 Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity 有权
标题翻译：喹诺酮和四氢喹诺酮及具有NOS抑制活性的相关化合物
公开(公告)号：US08173813B2
公开(公告)日：2012-05-08
申请号：US12054083
申请日：2008-03-24
申请人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Subhash C. Annedi , John Andrews , Peter Dove , Sarah Silverman , Paul Renton
发明人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Subhash C. Annedi , John Andrews , Peter Dove , Sarah Silverman , Paul Renton
IPC分类号： C07D215/00 , C07D487/00
CPC分类号： C07D409/14 , C07D409/12 , C07D413/14
摘要： The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.
摘要翻译：本发明的特征在于抑制一氧化氮合酶（NOS）的喹诺酮类，四氢喹啉类和相关化合物，特别是选择性地抑制神经元一氧化氮合酶（nNOS）优先于其它NOS同种型的化合物。本发明的NOS抑制剂单独或与其它药物活性剂组合可用于治疗或预防各种医学病症。

10. 发明申请

US20080214613A1 Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity 失效
标题翻译：具有双重NOS抑制活性和μ阿片样物质激动剂活性的取代的苯并咪唑化合物
公开(公告)号：US20080214613A1
公开(公告)日：2008-09-04
申请号：US11436393
申请日：2006-05-18
申请人： Paul Renton , Shawn Maddaford , Suman Rakhit , John Andrews
发明人： Paul Renton , Shawn Maddaford , Suman Rakhit , John Andrews
IPC分类号： A61K31/454 , C07D235/06 , A61K31/4184 , A61P25/24 , A61P25/16 , A61P25/28 , A61P25/00 , C07D403/06 , C07D401/04
CPC分类号： C07D409/12 , C07D235/12 , C07D405/12
摘要： The present invention relates to benzimidazole compounds having dual nitric oxide synthase (NOS) inhibitory activity and agonist activity at the mu-opioid receptor, to pharmaceutical and diagnostic compositions containing them, and to their medical use, particularly as compounds for the treatment or prevention of chronic pain, acute pain, migraine, and neuropathic pain.
摘要翻译：本发明涉及具有双重一氧化氮合酶（NOS）抑制活性和在μ-阿片受体上的激动剂活性的苯并咪唑化合物，含有它们的药物和诊断组合物及其医疗用途，特别是作为治疗或预防慢性疼痛，急性疼痛，偏头痛和神经性疼痛。

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