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1. 发明申请

US20100028330A1 METHODS OF UPMODULATING ADAPTIVE IMMUNE RESPONSE USING ANTI-PD1 ANTIBODIES 有权
标题翻译：使用抗PD1抗体进行适应性免疫应答的方法
公开(公告)号：US20100028330A1
公开(公告)日：2010-02-04
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/07 , C12P21/00 , A61P37/04
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

2. 发明授权

US07521051B2 Methods of upmodulating adaptive immune response using anti-PD-1 antibodies 失效
标题翻译：使用抗PD-1抗体上调适应性免疫应答的方法
公开(公告)号：US07521051B2
公开(公告)日：2009-04-21
申请号：US10540084
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

3. 发明申请

US20080311117A1 Antibodies against PD-1 and uses therefor 审中-公开
标题翻译：抗PD-1抗体及其用途
公开(公告)号：US20080311117A1
公开(公告)日：2008-12-18
申请号：US11893989
申请日：2007-08-17
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

4. 发明授权

US08088905B2 Nucleic acids encoding antibodies against PD-1 有权
标题翻译：编码抗PD-1抗体的核酸
公开(公告)号：US08088905B2
公开(公告)日：2012-01-03
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C12N15/11
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。

5. 发明授权

US07488802B2 Antibodies against PD-1 失效
标题翻译：抗PD-1抗体
公开(公告)号：US07488802B2
公开(公告)日：2009-02-10
申请号：US10741481
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。所公开的组合物和方法可以用于例如治疗自身免疫疾病，炎性疾病，过敏，移植排斥，癌症和其他免疫系统疾病。

6. 发明申请

US20080241130A1 METHODS AND COMPOSITIONS FOR MODULATING IL-17F/IL-17A BIOLOGICAL ACTIVITY 审中-公开
公开(公告)号：US20080241130A1
公开(公告)日：2008-10-02
申请号：US12057778
申请日：2008-03-28
申请人： Jill F. Wright , Spencer C. Liang , Frances K. Bennett , Mary Collins , Beatriz M. Carreno
发明人： Jill F. Wright , Spencer C. Liang , Frances K. Bennett , Mary Collins , Beatriz M. Carreno
IPC分类号： A61K39/395 , G01N33/557 , A61K38/17 , A61P11/06
CPC分类号： G01N33/6869 , G01N2333/54 , G01N2500/02
摘要： The invention provides a novel mouse IL-17F/IL-17A, and further provides uses of such mouse IL-17F/IL-17A in the characterization of the IL-17F/IL-17A heterodimer. The present invention is also related to polynucleotides and polypeptides of the IL-17F/IL-17A signaling pathway, and targeting of the IL-17F/IL-17A signaling pathway in methods of treating IL-17F/IL-17A-associated disorders. The invention thus provides methods of using isolated IL-17F/IL-17A heterodimer, e.g., in a mouse model of airway inflammation, and specific or selective IL-17F/IL-17A modulators (e.g., signaling agonists or signaling antagonists (e.g., specific or selective antagonistic antibodies, specific or selective antagonistic small molecules, etc.)). The invention also provides methods of screening for compounds capable of modulating IL-17F/IL-17A biological activity, e.g., IL-17F/IL-17A signaling antagonists (e.g., using the mouse model of airway inflammation), as well as methods of identifying whether the IL-17F/IL-17A modulator is a specific IL-17F/IL-17A modulator. The invention is also directed to novel methods for diagnosing, prognosing, monitoring, preventing, and/or treating IL-17F/IL-17A-associated disorders, including, but not limited to, inflammatory disorders (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., airway inflammation, chronic obstructive pulmonary disease, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets identified by methods of screening of the invention, and uses of such identified therapeutics in methods of treatment and prevention of IL-17F/IL-17A-associated disorders.

7. 发明授权

US5700664A Mammalian cytokine, IL-11 失效
标题翻译：哺乳动物细胞因子，IL-11
公开(公告)号：US5700664A
公开(公告)日：1997-12-23
申请号：US949516
申请日：1992-11-19
申请人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
发明人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
IPC分类号： A61K38/00 , A61K38/20 , A61K38/21 , A61P7/00 , A61P37/04 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/24 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： A61K38/2073 , C07K14/5431 , Y10S514/885 , Y10S514/887
摘要： A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
摘要翻译： PCT No.PCT / US90 / 06803 Sec。 371日期：1992年11月19日 102（e）1992年11月19日PCT PCT 1990年11月20日PCT公布。出版物WO91 / 07495 日期1991年5月30日公开了一种新型哺乳动物细胞因子IL-11及其生产方法。 IL-11可用于刺激和/或增强涉及免疫应答的细胞和参与造血系统正常功能的细胞的药物制剂中。

8. 发明授权

US6066317A Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells 失效
标题翻译：使用IL-11治疗造血祖细胞或干细胞缺陷的方法
公开(公告)号：US6066317A
公开(公告)日：2000-05-23
申请号：US122525
申请日：1998-07-24
申请人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
发明人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
IPC分类号： A61K38/00 , A61K38/20 , A61K38/21 , A61P7/00 , A61P37/04 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/24 , C12P21/02 , C12R1/19 , C12R1/91 , A61K38/19
CPC分类号： A61K38/2073 , C07K14/5431 , Y10S514/885 , Y10S514/887
摘要： A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
摘要翻译：公开了一种新型哺乳动物细胞因子IL-11及其生产方法。 IL-11可用于刺激和/或增强涉及免疫应答的细胞和参与造血系统正常功能的细胞的药物制剂中。

9. 发明授权

US5371193A Mammalian cytokine, IL-11 失效
标题翻译：哺乳动物细胞因子，IL-11
公开(公告)号：US5371193A
公开(公告)日：1994-12-06
申请号：US17522
申请日：1993-02-12
申请人： Frances K. Bennett , Stephen R. Paul , Yu-Chung Yang
发明人： Frances K. Bennett , Stephen R. Paul , Yu-Chung Yang
IPC分类号： A61K38/00 , C07K14/54 , C07K13/00
CPC分类号： C07K14/5431 , A61K38/00 , Y10S930/141
摘要： A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
摘要翻译：公开了一种新型哺乳动物细胞因子IL-11及其生产方法。 IL-11可用于刺激和/或增强涉及免疫应答的细胞和参与造血系统正常功能的细胞的药物制剂中。

10. 发明授权

US5854028A Compositions comprising IL-11 and methods of making and using IL-11 失效
标题翻译：包含IL-11的组合物和制备和使用IL-11的方法
公开(公告)号：US5854028A
公开(公告)日：1998-12-29
申请号：US814459
申请日：1997-03-10
申请人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
发明人： Yu-Chung Yang , Frances K. Bennett , Stephan R. Paul
IPC分类号： A61K38/00 , A61K38/20 , A61K38/21 , A61P7/00 , A61P37/04 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/52 , C07K14/54 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/24 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： A61K38/2073 , C07K14/5431 , Y10S514/885 , Y10S514/887
摘要： A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
摘要翻译：公开了一种新型哺乳动物细胞因子IL-11及其生产方法。 IL-11可用于刺激和/或增强涉及免疫应答的细胞和参与造血系统正常功能的细胞的药物制剂中。

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