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1. 发明授权

US5602244A Polynucleotide phosphorodithioate compounds 失效
标题翻译：多核苷酸二硫代磷酸酯化合物
公开(公告)号：US5602244A
公开(公告)日：1997-02-11
申请号：US436714
申请日：1995-05-08
申请人： Marvin H. Caruthers , Wolfgang K.-D. Brill , Eric Yau , Michael Ma , John Nielsen
发明人： Marvin H. Caruthers , Wolfgang K.-D. Brill , Eric Yau , Michael Ma , John Nielsen
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： Dinucleoside phosphorodithioate phosphoramidite precursors useful in the synthesis of oligonucleotide phosphorodithioate which can be used as antisense inhibitors of translation.
摘要翻译：用于合成寡核苷酸二硫代磷酸酯的二核苷酸二硫代磷酸亚磷酸酯前体，其可用作翻译的反义抑制剂。

2. 发明授权

US5684148A Nucleoside thiophosphoramidites 失效
标题翻译：核苷硫代亚磷酰胺
公开(公告)号：US5684148A
公开(公告)日：1997-11-04
申请号：US442705
申请日：1995-05-17
申请人： Marvin H. Caruthers , Wolfgang K. D. Brill , Eric Yau , Michael Ma , John Nielsen
发明人： Marvin H. Caruthers , Wolfgang K. D. Brill , Eric Yau , Michael Ma , John Nielsen
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.
摘要翻译：本发明涉及新的和有用的核苷硫代亚磷酰胺和多核苷酸二硫代磷酸酯化合物以及这些化合物可用于合成新的单核苷酸和具有硫代磷酸酯和二硫代磷酸酯核苷酸间键的多核苷酸的方法。

3. 发明授权

US5750666A Polynucleotide phosphorodithioate compounds 失效
标题翻译：多核苷酸二硫代磷酸酯化合物
公开(公告)号：US5750666A
公开(公告)日：1998-05-12
申请号：US332829
申请日：1994-10-31
申请人： Marvin H. Caruthers , Wolfgang K.-D Brill , Eric Yau , Michael Ma , John Nielsen
发明人： Marvin H. Caruthers , Wolfgang K.-D Brill , Eric Yau , Michael Ma , John Nielsen
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04 , C12N5/10 , C12N9/99 , C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.
摘要翻译：本发明涉及新的和有用的核苷硫代亚磷酰胺和多核苷酸二硫代磷酸酯化合物以及这些化合物可用于合成新的单核苷酸和具有硫代磷酸酯和二硫代磷酸酯核苷酸间键的多核苷酸的方法。

4. 发明授权

US5218103A Nucleoside thiophosphoramidites 失效
标题翻译：核苷硫代亚磷酰胺
公开(公告)号：US5218103A
公开(公告)日：1993-06-08
申请号：US643381
申请日：1991-01-22
申请人： Marvin H. Caruthers , Yun-Xi Ma , Eric K. Yau , John Nielsen , Wolfgang Brill
发明人： Marvin H. Caruthers , Yun-Xi Ma , Eric K. Yau , John Nielsen , Wolfgang Brill
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthesizing new monoucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters and phosphorothioate internucleotide linkages.
摘要翻译：本发明涉及新的和有用的核苷酸硫代亚磷酰胺，二硫代亚磷酸多核苷酸和多核苷酸硫代酰胺酯亚磷酰胺化合物，以及这些化合物可用于合成新的二核苷酸和具有二硫代磷酸酯，硫代酰胺酯，硫代磷酸酯和硫代磷酸酯核苷酸间键的多核苷酸的方法。

5. 发明授权

US5695979A Inhibition of reverse transcriptase by phosphorodithioates 失效
标题翻译：通过二硫代磷酸酯抑制逆转录酶
公开(公告)号：US5695979A
公开(公告)日：1997-12-09
申请号：US411474
申请日：1995-03-28
申请人： Marvin H. Caruthers , William S. Marshall , Wolfgang Brill , John Nielsen
发明人： Marvin H. Caruthers , William S. Marshall , Wolfgang Brill , John Nielsen
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04 , C12N9/99 , C12N5/10 , C12Q1/68
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： The present invention describes a method for the inhibition of reverse transcriptase by contacting said reverse transcriptase with oligonucleotides having have at least one phosphorodithioate internucleotide linkage of the formula ##STR1## within the phosphorus backbone of the oligonucleotide.
摘要翻译：本发明描述了通过使所述逆转录酶与寡核苷酸的磷骨架中具有式“IMAGE”的至少一个二硫代磷酸核苷酸间键的寡核苷酸接触来抑制逆转录酶的方法。

6. 发明授权

US5453496A Polynucleotide phosphorodithioate 失效
标题翻译：多核苷酸二硫代磷酸酯
公开(公告)号：US5453496A
公开(公告)日：1995-09-26
申请号：US138140
申请日：1993-10-15
申请人： Marvin H. Caruthers , William S. Marshall , Wolfgang Brill , John Nielsen
发明人： Marvin H. Caruthers , William S. Marshall , Wolfgang Brill , John Nielsen
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
摘要： Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.
摘要翻译：具有至少一个二硫代磷酸核苷酸核苷酸键的寡核苷酸。磷酸二核苷酸寡核苷酸表现出比相应的硫代硫酸酯衍生物更强的抗病毒活性。

7. 发明申请

US20110070840A1 Handheld synthetic antenna array 失效
标题翻译：手持式合成天线阵列
公开(公告)号：US20110070840A1
公开(公告)日：2011-03-24
申请号：US12585605
申请日：2009-09-18
申请人： John Nielsen , Gerard Lachapelle , Ali Broumandan
发明人： John Nielsen , Gerard Lachapelle , Ali Broumandan
IPC分类号： H04B17/00
CPC分类号： H04B7/0891 , H04B7/028 , H04B7/086
摘要： A system for estimating parameters of an incoming signal is provided. At least one antenna is coupled to at least one suitable receiver. The antenna(s) are spatially translated in an arbitrary trajectory. As the antenna(s) is being spatially translated, a data processing means samples the incoming signal at set intervals based on a clock signal provided by a system clock. By sampling the incoming signal at different times at different spatial locations on the arbitrary trajectory, the system acts as a synthetic antenna array. The different samplings of the incoming signal at different times and positions provide signal diversity gain as well as different readings which can be used to estimate and/or calculate various parameters of the incoming signal. The different samplings can be used to detect the incoming signal, estimate its angle of arrival, estimate its time of arrival, as well as other parameters.
摘要翻译：提供了一种用于估计输入信号的参数的系统。至少一个天线耦合到至少一个合适的接收机。天线在任意轨迹上空间转换。当天线被空间转换时，数据处理装置基于由系统时钟提供的时钟信号以设定的时间间隔对输入信号进行采样。通过在任意轨迹上的不同空间位置的不同时间采样输入信号，该系统充当合成天线阵列。在不同时间和位置处的输入信号的不同采样提供信号分集增益以及可用于估计和/或计算输入信号的各种参数的不同读数。不同的采样可用于检测输入信号，估计其到达角度，估计其到达时间以及其他参数。

8. 发明申请

US20050261691A1 Surgical screw dispenser 有权
标题翻译：手术螺丝机
公开(公告)号：US20050261691A1
公开(公告)日：2005-11-24
申请号：US11159987
申请日：2005-06-23
申请人： Peter Hester , John Nielsen , Rhett Kentwell
发明人： Peter Hester , John Nielsen , Rhett Kentwell
IPC分类号： A61B17/86 , A61B19/00 , B25B23/00 , A61B17/56
CPC分类号： B25B23/00 , A61B17/865 , A61B90/90
摘要： The present invention provides a surgical screw container including: at least one recess which is adapted to receive therein a screw having a head and a threaded shank, said recess having an opening at one end to allow said screw to pass into or out of said recess, said recess being such that said screw lies within said recess with said head of said screw facing said opening; and retaining means for retaining said screw within said container, said retaining means being disposed within said recess and being releasable by insertion of a screwdriver shaft into said recess through said opening to allow withdrawal of said screw through said opening after said screw engages said screwdriver.
摘要翻译：本发明提供了一种手术螺钉容器，其包括：至少一个凹部，其适于在其中容纳具有头部和螺纹柄的螺钉，所述凹部在一端具有开口，以允许所述螺钉进入或离开所述凹部所述凹部使得所述螺钉位于所述凹部内，所述螺钉的头部面向所述开口; 以及用于将所述螺钉保持在所述容器内的保持装置，所述保持装置设置在所述凹部内，并且通过将所述螺丝刀插入所述凹槽中并通过所述开口可释放，以在所述螺钉接合所述螺丝刀之后允许所述螺钉通过所述开口。

9. 发明申请

US20050217939A1 Lifting system 审中-公开
标题翻译：起重系统
公开(公告)号：US20050217939A1
公开(公告)日：2005-10-06
申请号：US10981763
申请日：2004-11-05
申请人： John Nielsen , Erik Kristiansen , Flemming Eriksen
发明人： John Nielsen , Erik Kristiansen , Flemming Eriksen
IPC分类号： B66B9/08
CPC分类号： B66B9/0869
摘要： A lifting system for a stairway provides steps that remain horizontal at all times. Thus the system may be used for lifting a person who is in a wheelchair or who in other ways is physically disabled, together with functioning as an ordinary stairway; hence, it also can be usable for walking-enabled persons.
摘要翻译：楼梯提升系统提供了始终保持水平的步骤。因此，该系统可用于解除轮椅上的人或以其他方式身体残疾的人，以及作为普通楼梯的功能; 因此，它也可以用于支持步行者。

10. 发明申请

US20050137121A1 Inhibition of invasive remodelling 审中-公开
标题翻译：抑制侵袭性重塑
公开(公告)号：US20050137121A1
公开(公告)日：2005-06-23
申请号：US10952160
申请日：2004-09-29
申请人： Leif Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Nielsen
发明人： Leif Lund , Keld Dano , Ross Stephens , Nils Brunner , Helene Solberg , Claus Holst-Hansen , John Nielsen
IPC分类号： A61K31/40 , A61K38/57 , A61K45/06 , A01N37/18
CPC分类号： A61K31/404 , A61K31/40 , A61K38/57 , A61K45/06 , A61K2300/00
摘要： Invasive remodelling in a mammal may be inhibited by (1) inhibiting or abolishing the protein cleaving action of plasmin and (2) inhibiting or abolishing the protein cleaving action of at least one additional proteolytic enzyme active in invasive remodelling, such as a metalloprotease.
摘要翻译：可通过（1）抑制或消除纤溶酶的蛋白质切割作用和（2）抑制或消除至少一种在侵袭性重塑中活化的另外的蛋白水解酶（例如金属蛋白酶）的蛋白质切割作用来抑制哺乳动物的侵袭性重塑。

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