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1. 发明授权

US08637455B2 Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces 有权
标题翻译：用于将糖肽抗生素递送到医疗器械表面的组合物和方法
公开(公告)号：US08637455B2
公开(公告)日：2014-01-28
申请号：US12739353
申请日：2008-10-17
申请人： Martyn K. Darby , Isaac G. Sanford , R. Edward Benson , Hanne Gron , Paul T. Hamilton , Shrikumar A. Nair , Doug Buechter , Elliott Gruskin
发明人： Martyn K. Darby , Isaac G. Sanford , R. Edward Benson , Hanne Gron , Paul T. Hamilton , Shrikumar A. Nair , Doug Buechter , Elliott Gruskin
IPC分类号： A61K38/04 , A01N37/18
CPC分类号： C07K17/00 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/406 , A61L2300/606 , C07K9/00 , C07K14/00 , C07K2319/00 , C08L89/00
摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
摘要翻译：目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。此外，提供了包含肽组合物的试剂盒。

2. 发明申请

US20110038912A1 COMPOSITIONS AND METHODS FOR DELIVERY OF GLYCOPEPTIDE ANTIBIOTICS TO MEDICAL DEVICE SURFACES 有权
标题翻译：用于向医疗装置表面递送糖尿病抗生素的组合物和方法
公开(公告)号：US20110038912A1
公开(公告)日：2011-02-17
申请号：US12739353
申请日：2008-10-17
申请人： Martyn K. Darby , Isaac G. Sanford , R. Edward Benson , Hanne Gron , Paul T. Hamilton , Shrikumar A. Nair , Doug Buechter , Elliott Gruskin
发明人： Martyn K. Darby , Isaac G. Sanford , R. Edward Benson , Hanne Gron , Paul T. Hamilton , Shrikumar A. Nair , Doug Buechter , Elliott Gruskin
IPC分类号： A61F2/02 , A61K38/14 , A61K38/16 , A61K9/00 , C07K19/00 , C07K7/08 , C07K14/00 , C07H21/00 , C12N15/63 , A61F2/32 , A61F2/30 , A61F2/08 , A61P31/00
CPC分类号： C07K17/00 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/406 , A61L2300/606 , C07K9/00 , C07K14/00 , C07K2319/00 , C08L89/00
摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
摘要翻译：目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。此外，提供了包含肽组合物的试剂盒。

3. 发明授权

US07977313B2 Methods and compositions for promoting localization of pharmaceutically active agents to bone 有权
标题翻译：用于促进药物活性剂定位于骨骼的方法和组合物
公开(公告)号：US07977313B2
公开(公告)日：2011-07-12
申请号：US12107098
申请日：2008-04-22
申请人： Hanne Gron , David Duffin , Doug Buechter , Elliott Gruskin , Michael Lehmicke
发明人： Hanne Gron , David Duffin , Doug Buechter , Elliott Gruskin , Michael Lehmicke
IPC分类号： A61K38/00
CPC分类号： C07K14/001 , A61F2002/2817 , A61K38/00 , A61K47/66 , B82Y5/00 , C07K7/08 , C12N15/62
摘要： Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.
摘要翻译：提供了包含对骨具有结合特异性的肽家族及其用于生产涂料组合物的组合物。涂层组合物用于将药物活性剂递送至骨骼，并且用于与骨植入物，骨修复和骨相关疾病相关的方法。

4. 发明申请

US20110117167A1 METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR 失效
公开(公告)号：US20110117167A1
公开(公告)日：2011-05-19
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K9/00 , C07K14/00 , C07K7/08 , C07K14/78 , C12N5/071 , C12N5/078 , A61K35/12 , A61K35/32 , A61K35/28 , A61K35/14 , A61K35/16 , A61K35/48 , A61K35/50 , C07K19/00 , A61K38/16 , A61K38/10 , A61K38/39 , A61P17/02 , A61P19/04 , A61P21/00 , A61P19/00 , A61P9/00 , C07K9/00 , C08G63/91 , A61K38/14 , A61K31/765 , C12N5/077
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

5. 发明申请

US20060263357A1 Anti-CD19 antibody therapy for autoimmune disease 审中-公开
标题翻译：抗CD19抗体治疗自身免疫性疾病
公开(公告)号：US20060263357A1
公开(公告)日：2006-11-23
申请号：US11429545
申请日：2006-05-05
申请人： Thomas Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K2039/505 , A61K2039/507 , C07K16/2803 , C07K16/2896 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of autoimmune diseases and disorders in human subjects using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原并优选介导人ADCC的治疗性抗体治疗人受试者自身免疫性疾病和病症的免疫治疗组合物和方法。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

6. 发明申请

US20130084294A1 ANTI-CD19 ANTIBODIES AND USES IN B CELL DISORDERS 审中-公开
标题翻译：抗CD19抗体和B细胞病症中的用途
公开(公告)号：US20130084294A1
公开(公告)日：2013-04-04
申请号：US13603154
申请日：2012-09-04
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K38/13 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/73 , C07K2317/732 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原的治疗性抗体来治疗人受试者中B细胞疾病和病症的免疫治疗组合物和方法，例如但不限于B细胞恶性肿瘤和自身免疫疾病和病症，优选介导人ADCC。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

7. 发明申请

US20110104150A1 ANTI-CD19 ANTIBODIES AND USES IN B CELL DISORDERS 有权
标题翻译：抗CD19抗体和B细胞病症中的用途
公开(公告)号：US20110104150A1
公开(公告)日：2011-05-05
申请号：US12885341
申请日：2010-09-17
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K38/13 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/73 , C07K2317/732 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原的治疗性抗体来治疗人受试者中B细胞疾病和病症的免疫治疗组合物和方法，例如但不限于B细胞恶性肿瘤和自身免疫疾病和病症，优选介导人ADCC。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

8. 发明申请

US20090285808A1 ANTI-CD19 ANTIBODIES AND USES IN ONCOLOGY 审中-公开
标题翻译：抗CD19抗体及其在肿瘤学中的应用
公开(公告)号：US20090285808A1
公开(公告)日：2009-11-19
申请号：US12401310
申请日：2009-03-10
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/54 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原并优选介导人ADCC的治疗性抗体来治疗人受试者中B细胞疾病和障碍的免疫治疗组合物和方法，所述B细胞疾病和病症例如但不限于B细胞恶性肿瘤。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

9. 发明授权

US08779089B2 Methods and compositions for soft tissue repair 失效
公开(公告)号：US08779089B2
公开(公告)日：2014-07-15
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K38/10 , C07K17/00 , C07K17/12 , C07K7/08 , C07K17/08 , C07K17/10 , A61K47/48 , A61K47/02 , A61K9/00 , A61L27/54 , A61L27/58 , A61K47/42 , A61L27/42
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

10. 发明授权

US08444973B2 Anti-CD19 antibodies and uses in B cell disorders 有权
标题翻译：抗CD19抗体和用于B细胞疾病
公开(公告)号：US08444973B2
公开(公告)日：2013-05-21
申请号：US12885341
申请日：2010-09-17
申请人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
发明人： Thomas F. Tedder , Yasuhito Hamaguchi , Hanne Gron , Norihito Yazawa
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K38/13 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/54 , C07K16/2803 , C07K16/2887 , C07K2317/73 , C07K2317/732 , C07K2317/77
摘要： The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG1 or IgG3 human isotype. The present invention relates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate human ADCC. The present invention also relates to pharmaceutical compositions comprising chimerized anti-CD19 antibodies of the IgG1, IgG2, IgG3, or IgG4 isotype that mediate human ADCC. In preferred embodiments, the present invention relates to pharmaceutical compositions comprising monoclonal human, humanized, or chimeric anti-CD19 antibodies.
摘要翻译：本发明涉及使用结合人CD19抗原的治疗性抗体来治疗人受试者中B细胞疾病和病症的免疫治疗组合物和方法，所述方法例如但不限于B细胞恶性肿瘤和自身免疫性疾病和病症，优选介导人ADCC。本发明涉及包含IgG1或IgG3人同种型的人或人源化抗CD19抗体的药物组合物。本发明涉及药物组合物，其包含优选介导人ADCC的IgG2或IgG4人同种型人或人源化抗CD19抗体。本发明还涉及包含介导人ADCC的IgG1，IgG2，IgG3或IgG4同种型的嵌合抗CD19抗体的药物组合物。在优选的实施方案中，本发明涉及包含单克隆人，人源化或嵌合抗-CD19抗体的药物组合物。

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