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1. 发明申请

US20060040903A1 Methods of use related to xerostomia 审中-公开
标题翻译：使用方法与口腔干燥有关
公开(公告)号：US20060040903A1
公开(公告)日：2006-02-23
申请号：US11258335
申请日：2005-10-25
申请人： Martin Stogniew , David Alberts , Edward Kaplan
发明人： Martin Stogniew , David Alberts , Edward Kaplan
IPC分类号： A61K31/13 , A61K31/66
CPC分类号： A61K31/661 , A61K31/13 , A61K31/135 , A61K31/145 , A61K31/16 , A61K31/195 , A61K31/426 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new uses of thermally stable, crystalline S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by radiation treatment. In particular, the invention provides a method for treating or preventing xerostomia associated with the administration of radiation treatment of head and neck cancer.
摘要翻译：本发明涉及热稳定的结晶S-2-（3-氨基丙基氨基）乙基二硫代磷酸酯（氨磷汀）和其它氨基硫醇化合物治疗和逆转放射治疗引起的毒性的新用途。特别地，本发明提供了治疗或预防与头颈癌的放射治疗相关的口腔干燥症的方法。

2. 发明申请

US20060270636A1 Methods for treatment of neuro- and nephro- disorders and therapeutic toxicities using aminothiol compounds 审中-公开
公开(公告)号：US20060270636A1
公开(公告)日：2006-11-30
申请号：US11501949
申请日：2006-08-09
申请人： Martin Stogniew , David Alberts , Edward Kaplan
发明人： Martin Stogniew , David Alberts , Edward Kaplan
IPC分类号： A61K31/66 , A61K31/13
CPC分类号： A61K31/661 , A61K31/13 , A61K31/135 , A61K31/145 , A61K31/16 , A61K31/195 , A61K31/426 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.

3. 发明授权

US06592508B1 Fiberoptic-guided interstitial seed manual applicator and seed cartridge 失效
标题翻译：光纤导向间质种子手动施放器和种子筒
公开(公告)号：US06592508B1
公开(公告)日：2003-07-15
申请号：US09512468
申请日：2000-02-24
申请人： Steven S. Ravins , Edward Kaplan
发明人： Steven S. Ravins , Edward Kaplan
IPC分类号： A61N500
CPC分类号： A61M37/0069 , A61B90/36 , A61B2090/306 , A61N5/1007 , A61N5/1027 , A61N2005/101 , A61N2005/1011
摘要： A method and apparatus for implanting seeds in or about a target area, such as a tumor, within a patient. The implantation device includes an implantation needle having a bore extending a longitudinally therethrough from a proximal end to a distal end of the needle, the needle bore being adapted to permit at least one seed to pass therethrough. An elongated plunger extends longitudinally through the implantation device in aligned relation to the needle bore and is selectively movable in the longitudinal direction relative the needle from a retracted position spaced apart from the needle to an extended position wherein the plunger is advanced through the needle bore to eject at least one of the seeds through the bore, out of the distal end of needle and into the target area. An optical device is carried by and operatively connected to the plunger to provide visual assistance to an operator of the implantation device to guide and verify implantation of the ejected seed into the target area. A seed cartridge is releasably connected to the implantation device to store unused seeds and to load the seeds into the implantation device.
摘要翻译：用于在患者体内或周围的靶区域（例如肿瘤）内植入种子的方法和装置。所述植入装置包括具有从所述针的近端至远端纵向延伸穿过的孔的注射针，所述针孔适于允许至少一个种子通过。细长的柱塞沿对准的针孔延伸穿过注入装置，并且可以相对于针从相对于针间隔开的缩回位置的长度方向可移动到延伸位置，其中柱塞前进穿过针孔，通过孔将至少一个种子排出针的远端并进入目标区域。光学装置被携带并且可操作地连接到柱塞，以向植入装置的操作者提供视觉辅助以引导和验证将喷射的种子植入到目标区域中。种子筒可释放地连接到植入装置以存储未使用的种子并将种子加载到植入装置中。

4. 发明授权

US06508755B1 Fiberoptic-guided interstitial seed manual applicator and seed cartridge 失效
标题翻译：光纤导向间质种子手动施放器和种子筒
公开(公告)号：US06508755B1
公开(公告)日：2003-01-21
申请号：US09512450
申请日：2000-02-24
申请人： Steven S. Ravins , Edward Kaplan , Ernest A. Elgin, III
发明人： Steven S. Ravins , Edward Kaplan , Ernest A. Elgin, III
IPC分类号： A61N500
CPC分类号： A61M37/0069 , A61B90/36 , A61B2090/306 , A61N5/1007 , A61N5/1027 , A61N2005/101 , A61N2005/1011
摘要： A method and apparatus for implanting seeds in or about a target area, such as a tumor, within a patient. The implantation device includes an implantation needle having a bore extending longitudinally therethrough from a proximal and to a distal end of the needle, the needle bore being adapted to permit at least one seed to pass therethrough. An elongated plunger extends longitudinally through the implantation device in aligned relation to the needle bore and is selectively movable in the longitudinal direction relative the needle from a retracted position spaced apart from the needle to an extended position wherein the plunger is advanced through the needle bore to eject at least one of the seeds through the bore, out of the distal end of needle and into the target area. An optical device is carried by and operatively connected to the plunger to provide visual assistance to an operator of the implantation device to guide and verify implantation of the ejected seed into the target area. A seed cartridge is releasably connected to the implantation device to store unused seeds and to load the seeds into the implantation device.
摘要翻译：用于在患者体内或周围的靶区域（例如肿瘤）内植入种子的方法和装置。植入装置包括具有从针的近端和远端纵向穿过的孔的注射针，所述针孔适于允许至少一个种子通过。细长的柱塞沿对准的针孔延伸穿过注入装置，并且可以相对于针从相对于针间隔开的缩回位置的长度方向可移动到延伸位置，其中柱塞前进穿过针孔，通过孔将至少一个种子排出针的远端并进入目标区域。光学装置被携带并且可操作地连接到柱塞，以向植入装置的操作者提供视觉辅助以引导和验证将喷射的种子植入到目标区域中。种子筒可释放地连接到植入装置以存储未使用的种子并将种子加载到植入装置中。

5. 发明申请

US20150041612A1 ToweLock 审中-公开
公开(公告)号：US20150041612A1
公开(公告)日：2015-02-12
申请号：US14492023
申请日：2014-09-21
申请人： Edward Kaplan
发明人： Edward Kaplan
IPC分类号： E04H15/62 , A47G9/06
CPC分类号： E04H15/62 , A47G9/062 , E04H15/64
摘要： This invention provides for a new and improved apparatus to secure the corners or edges of fabric or material that is used for covering ground surfaces. The apparatus incorporates a clip for gripping the fabric or material thereby enabling the corners or edges to be anchored buy a stake with an extendable spike into porous ground surfaces. Opening the clip via compressing the rear clip handles, the foldable spring-loaded releasing stake and spike attached to the clip body, extends and locks the stake and spike onto the clip base to be inserted into the ground matter for the secure anchoring of the article that is attached.
摘要翻译：本发明提供了一种新的和改进的装置，用于固定用于覆盖地面的织物或材料的角部或边缘。该装置包括用于夹紧织物或材料的夹子，从而使得拐角或边缘能够被锚定，将具有可延伸尖端的桩材购买到多孔地面中。通过压缩后夹子手柄打开夹子，附接到夹子主体的可折叠的弹簧释放支架和钉钉延伸并锁定扎带和钉子到夹子基座上以插入到地面物质中，以固定锚固物品这是附件。

6. 发明申请

US20110093412A1 SYSTEM AND METHOD FOR PROMOTING CHARITABLE CONTRIBUTIONS 审中-公开
标题翻译：促进会费捐赠的制度和方法
公开(公告)号：US20110093412A1
公开(公告)日：2011-04-21
申请号：US12820465
申请日：2010-06-22
申请人： Edward Kaplan , Marilyn L. Soffer
发明人： Edward Kaplan , Marilyn L. Soffer
IPC分类号： G06Q90/00
CPC分类号： G06Q30/02 , G06Q99/00
摘要： An organization TGS is formed to be dedicated, for example, to raise funds for a particular charitable, religious or health cause or to a predefined group of causes, members of TGS dedicating themselves to contributing to TGS on an ongoing basis, for example, annually. Upon making an initial contribution, a member of TGS receives a token, a unique and attractive piece of jewelry, for example a brooch, pendant, or lapel pin. The jewelry piece is constructed to be enhanced, for example, by the addition of a jewelry stone every time a periodic contribution is made.
摘要翻译：组织TGS的形成是为了特定的慈善，宗教或健康事业或预定义的一系列原因而筹集资金，TGS成员致力于持续为TGS提供支持，例如每年。在作出初步贡献时，TGS的成员将收到一个令牌，一个独特而有吸引力的首饰，例如胸针，吊坠或翻领针。首饰的构造要加强，例如，每当定期捐款时，都加入珠宝石。

7. 发明申请

US20080091056A1 DEFLECTABLE IMPLANTATION DEVICE AND METHOD FOR USE 有权
标题翻译：可植入植入装置及其使用方法
公开(公告)号：US20080091056A1
公开(公告)日：2008-04-17
申请号：US11873295
申请日：2007-10-16
申请人： Edward Kaplan
发明人： Edward Kaplan
IPC分类号： A61M36/12
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00867 , A61M25/0662 , A61M2205/0266 , A61N5/1007 , A61N2005/1011
摘要： Systems, apparatus, components and methods are disclosed that allow the clinician to circumvent the pubic arch in instances where it interferes with insertion of instrumentation into the prostate or periprostatic tissue. The systems, apparatus and components disclosed herein employ structures, such as needles and trocars, of shape memory alloys, such as nickel-titanium (Ni—Ti) for the purpose of avoiding the pubic arch when accessing the prostate from the perineum.
摘要翻译：公开了允许临床医生在妨碍仪器插入前列腺或静脉周围组织的情况下绕过耻骨弓的系统，装置，部件和方法。本文公开的系统，装置和组件采用诸如镍 - 钛（Ni-Ti）的形状记忆合金的结构，例如针和套管针，用于在从会阴访问前列腺时避免耻骨弓。

8. 发明授权

US09382725B2 ToweLock 有权
公开(公告)号：US09382725B2
公开(公告)日：2016-07-05
申请号：US14492023
申请日：2014-09-21
申请人： Edward Kaplan
发明人： Edward Kaplan
IPC分类号： E04H15/62 , A47G9/06 , E04H15/64
CPC分类号： E04H15/62 , A47G9/062 , E04H15/64
摘要： This invention provides for an apparatus for securing corners or edges of a piece of fabric that is used for covering ground surfaces. The apparatus includes a clip for gripping the piece of fabric and a stake with a spike for anchoring the apparatus into the ground surfaces. When a user presses rear ends of the clip, the stake and the spike would be released such that the apparatus could be anchored to the ground surfaces.
摘要翻译：本发明提供一种用于固定用于覆盖地面的织物片的角部或边缘的装置。该装置包括用于夹持该织物片的夹子和具有用于将该装置固定到地面中的钉的桩。当使用者按压夹子的后端时，松脱和钉将被释放，使得该装置可以锚定到地面。

9. 发明申请

US20060033034A1 Real-time self-networking radiation detector apparatus 失效
标题翻译：实时自组网辐射检测仪
公开(公告)号：US20060033034A1
公开(公告)日：2006-02-16
申请号：US10918795
申请日：2004-08-16
申请人： Edward Kaplan , James Lemley , Thomas Tsang , Laurence Milian
发明人： Edward Kaplan , James Lemley , Thomas Tsang , Laurence Milian
IPC分类号： G01T3/00
CPC分类号： G01T1/167 , G01T3/00
摘要： The present invention is for a radiation detector apparatus for detecting radiation sources present in cargo shipments. The invention includes the features of integrating a bubble detector sensitive to neutrons and a GPS system into a miniaturized package that can wirelessly signal the presence of radioactive material in shipping containers. The bubble density would be read out if such indicated a harmful source.
摘要翻译：本发明是用于检测货物中存在的辐射源的辐射检测装置。本发明包括将对中子敏感的气泡检测器和GPS系统集成到可以无线地发送运输容器中放射性物质的存在的小型化封装的特征。如果这样表示有害的来源，则会读出气泡密度。

10. 发明授权

US06432035B1 Fiberoptic-guided interstitial seed manual applicator and cartridge 失效
标题翻译：光纤引导的间质种子手动施放器和药筒
公开(公告)号：US06432035B1
公开(公告)日：2002-08-13
申请号：US09512452
申请日：2000-02-24
申请人： Steven S. Ravins , Edward Kaplan , Ernest A. Elgin, III
发明人： Steven S. Ravins , Edward Kaplan , Ernest A. Elgin, III
IPC分类号： A61N500
CPC分类号： A61M37/0069 , A61B90/36 , A61B2090/306 , A61N5/1007 , A61N5/1027 , A61N2005/101 , A61N2005/1011
摘要： A method for implanting seeds in or about a target area, such as a tumor, within a patient. The implantation device includes an implantation needle having a bore extending longitudinally therethrough from a proximal end to a distal end of the needle, the needle bore being adapted to permit at least one seed to pass therethrough. An elongated plunger extends longitudinally through the implantation device in aligned relation to the needle bore. An optical device is carried by and operatively connected to the plunger to provide visual assistance to an operator of the implantation device to guide and verify implantation of the ejected seed into the target area.
摘要翻译：将种子植入患者体内的目标区域（例如肿瘤）周围的方法。植入装置包括具有从针的近端到远端纵向延伸的孔的注射针，所述针孔适于允许至少一个种子通过。细长柱塞沿对准的针孔延伸穿过植入装置。光学装置被携带并且可操作地连接到柱塞，以向植入装置的操作者提供视觉辅助以引导和验证将喷射的种子植入到目标区域中。

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