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1. 发明授权

US06420577B1 Method for commercial preparation of conjugated linoleic acid 失效
标题翻译：共轭亚油酸的商业制备方法
公开(公告)号：US06420577B1
公开(公告)日：2002-07-16
申请号：US09451710
申请日：1999-12-01
申请人： Martin J. Reaney , Ya-Dong Liu , Neil D Westcott
发明人： Martin J. Reaney , Ya-Dong Liu , Neil D Westcott
IPC分类号： C07C51347
CPC分类号： C11C1/007 , C11C1/025 , C11C1/10 , C11C3/14
摘要： Methods for simultaneous saponification and quantitative isomerization of glyceride oils containing interrupted double bond systems, with alkali in water to yield soaps with conjugated double bond systems are disclosed. Novel methods of hydrolysis of the soap product with acid to form fatty acid-water emulsions and the breaking of those emulsions are also disclosed. The preferred embodiment uses a vegetable oil rich in linoleic acid such as sunflower or safflower oil, potassium hydroxide, phosphoric acid to neutralize the soaps, and an emulsion breaking compound which can include ethanol or other monohydric alcohol, tannins (either hydrolysable or condensed tannin) or polyethylene glycol. The reaction forms positional and geometric isomers of conjugated linoleic acid and the preferred isomer mixture is controlled by a combination of agitation, precisely controlled heating and rapid initiation and termination of the reaction. The reaction product composition may be enriched by crystallization.
摘要翻译：公开了含有间断双键体系的甘油酯油同时皂化和定量异构化的方法，其中碱在水中产生具有共轭双键体系的皂。还公开了用酸水解皂产物以形成脂肪酸 - 水乳液和这些乳液的断裂的新方法。优选的实施方案使用富含亚油酸的植物油，例如向日葵或红花油，氢氧化钾，磷酸中和皂，以及可包括乙醇或其它一元醇的破乳化合物，单宁（可水解或缩合的单宁）或聚乙二醇。该反应形成共轭亚油酸的位置和几何异构体，优选的异构体混合物通过搅拌，精确控制加热和快速引发和终止反应的组合来控制。反应产物组合物可以通过结晶富集。

2. 发明申请

US20050159393A1 Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents 审中-公开
标题翻译：脂肪族氨基羧酸和氨基膦酸，氨基腈和氨基四唑作为细胞拯救剂
公开(公告)号：US20050159393A1
公开(公告)日：2005-07-21
申请号：US11077124
申请日：2005-03-11
申请人： Lillian Dyck , Bruce Davis , Ya-Dong Liu , David Durden , Alan Boulton , I. Paterson , Brenda Kennedy , Kevin Rogers
发明人： Lillian Dyck , Bruce Davis , Ya-Dong Liu , David Durden , Alan Boulton , I. Paterson , Brenda Kennedy , Kevin Rogers
IPC分类号： C07C229/12 , C07C255/24 , C07C255/25 , C07F9/38 , C07F9/40 , C07F9/28 , A61K31/195 , A61K31/275 , A61K31/41 , A61K31/66
CPC分类号： C07F9/3808 , C07C229/12 , C07C255/24 , C07C255/25 , C07F9/4006
摘要： Novel compounds of the formula I are described: wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms, R2=H, CH3 or CH2CH3 R3=H or CH3 R4=H or CH3 R5=lower alkyl having from 1 to 5 carbon atoms n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C≡N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.
摘要翻译：描述了新的式I化合物：其中：R 1 =（CH 2 CH 2）m CH 3其中 m为0或1至16的整数，或具有2至17个碳原子的烯基，炔基，烷氧基，烷硫基或烷基亚磺酰基，R 2 = H，CH 2， 3> 3或CH 2 CH 3 3 R 3 = H或CH 3 R＆lt; SUB＆lt; 3＆gt; > 4 = H或CH 3 R 5 =具有1至5个碳原子的低级烷基n是1至3的整数，并且 X是羧基（COOH）或烷氧基（COOR 5），氰基（C≡N），膦酸（PO 3 H 2 H 2）膦酸酯（PO 3/3 [R 5/2] 2）或5-四唑及其药学上可接受的盐。优选地，化合物是其中R 3 = R 4 = R 5 = H的R-或S-构型的光学纯对映异构体， R 2 = CH 3和R 1是1至5个碳原子的饱和脂族链。这些化合物可用作细胞拯救剂。

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