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1. 发明授权

US08427653B2 Optical coherence tomography methods and systems 有权
标题翻译：光学相干断层扫描方法和系统
公开(公告)号：US08427653B2
公开(公告)日：2013-04-23
申请号：US13007470
申请日：2011-01-14
申请人： Martin Hacker , Christoph Hauger , Keith O'Hara , Scott Meyer
发明人： Martin Hacker , Christoph Hauger , Keith O'Hara , Scott Meyer
IPC分类号： G01B11/02
CPC分类号： A61B3/102 , A61B3/1225 , A61B5/0066 , A61B5/0073 , G01B9/02004 , G01B9/02007 , G01B9/02009 , G01B9/02044 , G01B9/02091 , G01N21/4795
摘要： Frequency domain optical coherence tomography (FD-OCT) systems and methods are provided. Thereby, a first measurement and a second measurement is performed, wherein in the first measurement an object region is illuminated by measuring light having a spectrum with a first spectral width and in the second measurement the object region is illuminated with measuring light having a spectrum with a second spectral width, wherein the first spectral width is at least 10% greater than the second spectral width. Further, during the first measurement intensities of spectral ranges of light having interacted with the object and being superimposed with reference light are detected, wherein a width of these spectral ranges is greater than a corresponding width during the second measurement. Thus, switching an axial field of view of structural information of the object across a depth direction is enabled upon minimizing radiation damage at the object.
摘要翻译：提供了频域光学相干断层扫描（FD-OCT）系统和方法。由此，执行第一测量和第二测量，其中在第一测量中，通过测量具有第一光谱宽度的光谱的光照射对象区域，并且在第二测量中，用具有光谱的测量光照射对象区域第二光谱宽度，其中所述第一光谱宽度比所述第二光谱宽度大至少10％。此外，在第一测量期间，检测到与对象相互作用并与参考光叠加的光的光谱范围的强度，其中这些光谱范围的宽度大于第二测量期间的对应宽度。因此，在最小化物体的辐射损伤的情况下，能够在深度方向上切换物体的结构信息的轴向视场。

2. 发明授权

US08922882B2 Imaging system 有权
标题翻译：成像系统
公开(公告)号：US08922882B2
公开(公告)日：2014-12-30
申请号：US13116358
申请日：2011-05-26
申请人： Christoph Hauger , Markus Seesselberg , Martin Hacker , Keith O'Hara
发明人： Christoph Hauger , Markus Seesselberg , Martin Hacker , Keith O'Hara
IPC分类号： G02B23/12 , G02B21/06 , G01B9/02 , G01J3/45 , A61B3/10 , A61B3/13
CPC分类号： A61B3/102 , A61B3/005 , A61B3/117 , A61B3/12 , A61B3/1225 , A61B3/13 , A61B3/14 , G01B9/02004 , G01B9/0203 , G01B9/02035 , G01B9/02044 , G01B9/02091 , G02B7/14 , G02B27/0955
摘要： Imaging systems are provided allowing examination of different object regions spaced apart in a depth direction by visual microscopy and by optical coherence tomography. An axial field of view and a lateral resolution is varied depending on which object region is examined by the imaging system. The proposed imaging systems are in particular applicable for thorough examination of the human eye.
摘要翻译：提供成像系统，允许通过视觉显微镜和光学相干断层摄影检查在深度方向上间隔开的不同物体区域。取决于由成像系统检查的对象区域来改变轴向视场和横向分辨率。所提出的成像系统特别适用于人眼的彻底检查。

3. 发明申请

US20110228218A1 IMAGING SYSTEM 有权
标题翻译：成像系统
公开(公告)号：US20110228218A1
公开(公告)日：2011-09-22
申请号：US13116358
申请日：2011-05-26
申请人： Christoph Hauger , Markus Seesselberg , Martin Hacker , Keith O'Hara
发明人： Christoph Hauger , Markus Seesselberg , Martin Hacker , Keith O'Hara
IPC分类号： A61B3/18 , G01B9/02 , A61B3/13
CPC分类号： A61B3/102 , A61B3/005 , A61B3/117 , A61B3/12 , A61B3/1225 , A61B3/13 , A61B3/14 , G01B9/02004 , G01B9/0203 , G01B9/02035 , G01B9/02044 , G01B9/02091 , G02B7/14 , G02B27/0955
摘要： Imaging systems are provided allowing examination of different object regions spaced apart in a depth direction by visual microscopy and by optical coherence tomography. An axial field of view and a lateral resolution is varied depending on which object region is examined by the imaging system. The proposed imaging systems are in particular applicable for thorough examination of the human eye.
摘要翻译：提供成像系统，允许通过视觉显微镜和光学相干断层摄影检查在深度方向上间隔开的不同物体区域。取决于由成像系统检查的对象区域来改变轴向视场和横向分辨率。所提出的成像系统特别适用于人眼的彻底检查。

4. 发明申请

US20060228011A1 Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权
公开(公告)号：US20060228011A1
公开(公告)日：2006-10-12
申请号：US11389351
申请日：2006-03-24
申请人： Matthew Everett , Claus Flachenecker , Martin Hacker , Scott Meyer , Keith O'Hara , Rick Williams
发明人： Matthew Everett , Claus Flachenecker , Martin Hacker , Scott Meyer , Keith O'Hara , Rick Williams
IPC分类号： G09G5/00 , G06K9/00
CPC分类号： A61B3/102 , A61B3/113
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

5. 发明授权

US08230866B2 Systems and methods for treating glaucoma and systems and methods for imaging a portion of an eye 有权
标题翻译：用于治疗青光眼的系统和方法以及用于对眼睛的一部分进行成像的系统和方法
公开(公告)号：US08230866B2
公开(公告)日：2012-07-31
申请号：US12000477
申请日：2007-12-13
申请人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
发明人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
IPC分类号： A61B19/00
CPC分类号： A61B3/13 , A61B3/102 , A61B3/14 , A61F9/008 , A61F2009/00868
摘要： Systems and methods are described for imaging an eye portion or for treating glaucoma in an eye of a patient. In a first step an optical microscopic image of a portion of the eye is acquired. In the optical microscopic image a distinguishable anatomical structure is identified to predict a location of a volume portion to be imaged three-dimensionally. Three-dimensional imaging of the located volume portion is performed by acquiring an optical coherence tomography image of the located volume portion. The volume portion is treated by either directing a laser beam to the volume portion or inserting an implant based on the OCT-image.
摘要翻译：描述了用于对眼部进行成像或用于治疗患者眼睛中的青光眼的系统和方法。在第一步骤中，获取眼睛的一部分的光学显微镜图像。在光学显微镜图像中，识别出可区分的解剖结构以预测待三维成像的体积部分的位置。通过获取定位体积部分的光学相干断层摄影图像来执行定位体积部分的三维成像。通过将激光束引导到体积部分或基于OCT图像插入植入物来处理体积部分。

6. 发明申请

US20090157062A1 Systems and methods for treating glaucoma and systems and methods for imaging a portion of an eye 有权
标题翻译：用于治疗青光眼的系统和方法以及用于对眼睛的一部分进行成像的系统和方法
公开(公告)号：US20090157062A1
公开(公告)日：2009-06-18
申请号：US12000477
申请日：2007-12-13
申请人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
发明人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
IPC分类号： A61F9/008 , A61B18/20 , A61M27/00 , A61B3/13 , A61B3/14
CPC分类号： A61B3/13 , A61B3/102 , A61B3/14 , A61F9/008 , A61F2009/00868
摘要： Systems and methods are described for imaging an eye portion or for treating glaucoma in an eye of a patient. In a first step an optical microscopic image of a portion of the eye is acquired. In the optical microscopic image a distinguishable anatomical structure is identified to predict a location of a volume portion to be imaged three-dimensionally. Three-dimensional imaging of the located volume portion is performed by acquiring an optical coherence tomography image of the located volume portion. The volume portion is treated by either directing a laser beam to the volume portion or inserting an implant based on the OCT-image.
摘要翻译：描述了用于对眼部进行成像或用于治疗患者眼睛中的青光眼的系统和方法。在第一步骤中，获取眼睛的一部分的光学显微镜图像。在光学显微镜图像中，识别出可区分的解剖结构以预测待三维成像的体积部分的位置。通过获取定位体积部分的光学相干断层摄影图像来执行定位体积部分的三维成像。通过将激光束引导到体积部分或基于OCT图像插入植入物来处理体积部分。

7. 发明申请

US20110181702A1 METHOD AND SYSTEM FOR GENERATING A REPRESENTATION OF AN OCT DATA SET 审中-公开
标题翻译：用于产生OCT数据集的表示的方法和系统
公开(公告)号：US20110181702A1
公开(公告)日：2011-07-28
申请号：US12844696
申请日：2010-07-27
申请人： Christoph Hauger , Martin Hacker
发明人： Christoph Hauger , Martin Hacker
IPC分类号： H04N13/02 , G06K9/00 , H04N15/00
CPC分类号： G01B9/02087 , A61B3/102 , A61B3/1225 , G01B9/0203 , G01B9/02091
摘要： A method of generating a representation of an OCT data set includes obtaining the OCT data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a value of a scattering intensity, obtaining a color image data set representing a plurality of tuples, each of which comprises values of two spatial coordinates and a color value, and generating an image data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a color value. Generating the image data set is performed depending on an analysis of the OCT data set and an analysis of the color image data set.
摘要翻译：一种产生OCT数据集的表示的方法包括获得表示多个元组的OCT数据集，每个元组包括三个空间坐标值和散射强度的值，获得表示多个的彩色图像数据集每个元组包括两个空间坐标和颜色值的值，并且生成表示多个元组的图像数据集，每个元组包括三个空间坐标和颜色值的值。根据OCT数据集的分析和彩色图像数据集的分析来执行图像数据集的生成。

8. 发明申请

US20110199577A1 ARTICLE FOR USE IN AN OCT-METHOD AND INTRAOCULAR LENS 有权
标题翻译：用于OCT方法和内镜镜片的文章
公开(公告)号：US20110199577A1
公开(公告)日：2011-08-18
申请号：US12858216
申请日：2010-08-17
申请人： Marco Wilzbach , Martin Hacker , Christoph Hauger
发明人： Marco Wilzbach , Martin Hacker , Christoph Hauger
IPC分类号： A61B3/14 , G02B5/22 , G02B5/08 , G01B9/02 , A61F2/16 , B82Y20/00
CPC分类号： A61B3/102 , A61B5/0066 , A61B17/30 , A61B90/30 , A61F2/16 , A61F2/1613 , A61F2250/0096 , B29D11/023 , B82Y20/00 , G01B9/02091 , G02B5/08 , G02B5/22
摘要： An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.
摘要翻译：一种用于OCT方法的制品，所述制品包含固体基质和纳米颗粒，其分散在所述制品的至少一个透光部分中或所述基底中或基底上，使得所述纳米颗粒导致所述透光部分沿着透射的消光增加光透射部分的方向与衬底相比没有纳米颗粒。沿透射方向的光透射部分的消光小于6，其中消光被定义为通过透光部分透射的光的强度与入射光的强度之比的负十进制对数在所述光透射部分上，其中所述光处于可见光和近红外波长范围中的至少一个。

9. 发明授权

US08740380B2 Article for use in an OCT-method and intraocular lens 有权
标题翻译：用于OCT方法和眼内镜的文章
公开(公告)号：US08740380B2
公开(公告)日：2014-06-03
申请号：US12858216
申请日：2010-08-17
申请人： Marco Wilzbach , Martin Hacker , Christoph Hauger
发明人： Marco Wilzbach , Martin Hacker , Christoph Hauger
IPC分类号： A61B3/00 , A61B3/14 , A61F2/16
CPC分类号： A61B3/102 , A61B5/0066 , A61B17/30 , A61B90/30 , A61F2/16 , A61F2/1613 , A61F2250/0096 , B29D11/023 , B82Y20/00 , G01B9/02091 , G02B5/08 , G02B5/22
摘要： An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.
摘要翻译：一种用于OCT方法的制品，所述制品包含固体基质和纳米颗粒，其分散在所述制品的至少一个透光部分中或所述基底中或基底上，使得所述纳米颗粒导致所述透光部分沿着透射的消光增加光透射部分的方向与衬底相比没有纳米颗粒。沿透射方向的光透射部分的消光小于6，其中消光被定义为通过透光部分透射的光的强度与入射光的强度之比的负十进制对数在所述光透射部分上，其中所述光处于可见光和近红外波长范围中的至少一个。

10. 发明申请

US20060171503A1 Method to suppress artifacts in frequency-domain optical coherence tomography 有权
标题翻译：抑制频域光学相干断层扫描中伪像的方法
公开(公告)号：US20060171503A1
公开(公告)日：2006-08-03
申请号：US11334964
申请日：2006-01-19
申请人： Keith O'Hara , Martin Hacker
发明人： Keith O'Hara , Martin Hacker
IPC分类号： H05G1/60
CPC分类号： A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/0201 , G01B9/02058 , G01B9/02078 , G01B9/02083 , G01B9/02091
摘要： One embodiment of the present invention is a method for suppressing artifacts in frequency-domain OCT images, which method includes (a) providing sample and reference paths with a significant difference in their chromatic dispersion (b) correcting for the effects of the mismatch in chromatic dispersion, for the purpose of making artifacts in the OCT image readily distinguishable from the desired image.
摘要翻译：本发明的一个实施例是一种用于抑制频域OCT图像中的伪影的方法，该方法包括（a）提供其色散中显着差异的样本和参考路径（b）校正色差中的不匹配的影响分散体，用于使OCT图像中的人造物与期望的图像容易地区分开。

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