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1. 发明申请

US20090281166A1 Treatment of Cancer by Inhibition of HSP27 审中-公开
标题翻译：通过抑制HSP27治疗癌症
公开(公告)号：US20090281166A1
公开(公告)日：2009-11-12
申请号：US12423359
申请日：2009-04-14
申请人： Martin Gleave , Christopher Ong , Norihiro Hayashi
发明人： Martin Gleave , Christopher Ong , Norihiro Hayashi
IPC分类号： A61K31/7088 , C12Q1/68 , C12Q1/42 , A61K31/519 , A61K31/435 , A61K31/4355 , A61K31/05
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： A cancer is evaluated for selection of appropriate therapy by evaluating a sample of cancerous tissue to determine an expression of level of phosphatase and tensin homologue deleted from chromosome 10 (PTEN); and in the case where the expression level of functional PTEN is below a threshold level, identifying the cancer as susceptible to an active agent that inhibits the expression of heat shock protein 27 (hsp27). The evaluation may be included as part of a method of treatment, in which an hsp27 inhibitor is selected as a therapeutic agent when the PTEN level is below the threshold.
摘要翻译：通过评估癌组织样品来评估癌症的选择以确定从10号染色体（PTEN）缺失的磷酸酶和张力蛋白同源物的水平的表达; 并且在功能性PTEN的表达水平低于阈值水平的情况下，鉴定对抑制热休克蛋白27（hsp27）表达的活性剂敏感的癌症。评价可以作为治疗方法的一部分被包括，其中当PTEN水平低于阈值时，选择hsp27抑制剂作为治疗剂。

2. 发明授权

US08808693B2 Semaphorin 3C (Sema3C) inhibitor therapeutics, methods, and uses 有权
标题翻译： Semaphorin 3C（Sema3C）抑制剂治疗，方法和用途
公开(公告)号：US08808693B2
公开(公告)日：2014-08-19
申请号：US13262196
申请日：2010-04-01
申请人： Christopher J. Ong , Martin E. Gleave , Norihiro Hayashi , James Peacock
发明人： Christopher J. Ong , Martin E. Gleave , Norihiro Hayashi , James Peacock
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/22 , A61K31/167 , A61K31/713 , A61K33/30 , A61K38/09 , A61K38/1709 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K14/4703 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/61 , C12N15/113 , C12N2310/11 , A61K2300/00
摘要： Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.
摘要翻译：提供了用足以引起前列腺癌细胞的细胞死亡或抑制前列腺癌细胞增殖的生物有效量的用SEMA3C抑制剂治疗前列腺癌的方法，用途和药物组合物。前列腺癌可以是雄激素受体（AR）阳性前列腺癌，SEMA3C抑制剂可以选自以下一种或多种：抗体，SEMA3C肽，反义RNA，siRNA，shRNA或小分子。

3. 发明申请

US20130028896A1 Semaphorin 3C (Sema3C) Inhibitor Therapeutics, Methods, and Uses 有权
公开(公告)号：US20130028896A1
公开(公告)日：2013-01-31
申请号：US13262196
申请日：2010-04-01
申请人： Christopher J. Ong , Martin E. Gleave , Norihiro Hayashi , James Peacock
发明人： Christopher J. Ong , Martin E. Gleave , Norihiro Hayashi , James Peacock
IPC分类号： A61K39/395 , A61P35/00 , A61K31/16 , A61K38/00 , A61K31/713
CPC分类号： C07K16/22 , A61K31/167 , A61K31/713 , A61K33/30 , A61K38/09 , A61K38/1709 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K14/4703 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/61 , C12N15/113 , C12N2310/11 , A61K2300/00
摘要： Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

4. 发明申请

US20110132328A1 PASSIVE AND SEMI-ACTIVE DIESEL AND GASOLINE FUEL MODULE 有权
标题翻译：被动和半主动柴油和汽油燃料模块
公开(公告)号：US20110132328A1
公开(公告)日：2011-06-09
申请号：US12632175
申请日：2009-12-07
申请人： William E. Attwood , Norihiro Hayashi
发明人： William E. Attwood , Norihiro Hayashi
IPC分类号： F02M69/46 , F02M37/04
CPC分类号： F02M37/106 , F02M37/0023 , F02M37/0052 , F02M37/0082 , F02M37/0094
摘要： A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.
摘要翻译：车辆燃料系统可以使用具有在燃料箱内的储存器的燃料泵模块。该系统还可以使用燃料喷射共轨，从燃料泵模块储存器引导到燃料喷射共轨的燃料供应管线和从燃料喷射共轨通过燃料泵模块凸缘的燃料返回管线。另外，该系统可以采用第一返回燃料止回阀来将燃料仅释放到储存器喷射泵和/或转移喷射泵中，而第二返回燃料止回阀可以仅将燃料直接释放到燃料泵模块储存器中。储存器内的电动燃料泵可以具有燃料泵止回阀，并且仅当燃料返回管线中的压力传感器启动时才向燃料喷射泵和/或转移喷射泵供给燃料，而不向发动机供应燃料。

5. 发明授权

US07713997B2 Pyridonecarboxylic acid derivatives or salts thereof 失效
标题翻译：吡啶并羧酸衍生物或其盐
公开(公告)号：US07713997B2
公开(公告)日：2010-05-11
申请号：US11719547
申请日：2005-11-17
申请人： Akira Yazaki , Yasuhiro Kuramoto , Kenji Itoh , Kazusa Yoshikai , Yuzo Hirao , Yoshihiro Ohshita , Norihiro Hayashi , Hirotaka Amano , Takayuki Amago , Hitomi Takenaka
发明人： Akira Yazaki , Yasuhiro Kuramoto , Kenji Itoh , Kazusa Yoshikai , Yuzo Hirao , Yoshihiro Ohshita , Norihiro Hayashi , Hirotaka Amano , Takayuki Amago , Hitomi Takenaka
IPC分类号： C07D215/38 , A61K38/02
CPC分类号： C07D401/14
摘要： The present invention provides an agent which exhibits excellent antibacterial activity, low toxicity, improved bioavailability, and low binding rate to serum proteins. The present invention is directed to a pyridonecarboxylic acid derivative represented by formula (1): or a salt thereof, wherein R1 represents a methyl group, a fluorine atom, or a chlorine atom; R2 represents a hydrogen atom or a lower alkyl group; R3 represents an isopropyl group or a tert-butyl group; R4 represents a methyl group or a halogen atom; and R5 represents a fluorine atom or a chlorine atom. The present invention is also directed to an antibacterial agent and a medicament containing the derivative or the salt thereof as an active ingredient.
摘要翻译：本发明提供了具有优异的抗菌活性，低毒性，改善的生物利用度和与血清蛋白的低结合速率的试剂。本发明涉及由式（1）表示的吡啶酮羧酸衍生物或其盐，其中R1表示甲基，氟原子或氯原子; R2表示氢原子或低级烷基; R3表示异丙基或叔丁基; R4表示甲基或卤原子; R 5表示氟原子或氯原子。本发明还涉及一种抗菌剂和含有其衍生物或其盐作为活性成分的药物。

6. 发明申请

US20090241912A1 Fuel supply system 有权
标题翻译：燃油供应系统
公开(公告)号：US20090241912A1
公开(公告)日：2009-10-01
申请号：US12382397
申请日：2009-03-16
申请人： Shin Iwaoka , Norihiro Hayashi , Masakazu Suzuki
发明人： Shin Iwaoka , Norihiro Hayashi , Masakazu Suzuki
IPC分类号： F02M37/04
CPC分类号： F02M37/0017 , Y10T137/86131
摘要： A fuel supply system includes a plurality of fuel pumps, and one suction filter. The suction filter includes connection portions that are connected to pump inlets of the fuel pumps, and an interval adjusting member that adjusts the interval between the connection portions in accordance with the interval between the fuel pumps. Thus, it is possible to fit the suction filter to the fuel pumps without changing the interval between the fuel pumps. Because the interval between pump outlets is not changed, it is possible to minimize the problems that are likely to occur when the suction filter is fitted to the fuel pumps.
摘要翻译：燃料供给系统包括多个燃料泵和一个吸入过滤器。吸入过滤器包括连接到燃料泵的泵入口的连接部分，以及间隔调节部件，其根据燃料泵之间的间隔来调节连接部分之间的间隔。因此，可以将抽吸过滤器装配到燃料泵上而不改变燃料泵之间的间隔。因为泵出口之间的间隔没有改变，所以可以将吸入过滤器安装到燃油泵时可能发生的问题最小化。

7. 发明授权

US07159574B2 Fuel feed apparatus having opening in sub-tank 失效
标题翻译：燃料进料装置在副罐中有开口
公开(公告)号：US07159574B2
公开(公告)日：2007-01-09
申请号：US11041984
申请日：2005-01-26
申请人： Norihiro Hayashi , Tetsuro Okazono
发明人： Norihiro Hayashi , Tetsuro Okazono
IPC分类号： F02M37/04
CPC分类号： F02M37/106 , F02M37/025 , Y10T137/86187 , Y10T137/86212
摘要： A fuel feed apparatus includes a sub-tank and a fuel pump that are received in the fuel tank. The sub-tank has an inner space that is partitioned into at least a first chamber and a second chamber. The fuel pump is arranged in the first chamber to discharge fuel received in the sub-tank to the outside of the fuel tank. The second chamber has an opening, through which the second chamber communicates with the outside of the sub-tank such that fuel accumulated in the second chamber is exhausted to the outside of the sub-tank through the opening. The fuel tank has a first tank space and a second tank space. The sub-tank is received in the first tank space. A first jet pump is disposed in the second chamber of the sub-tank. The first jet pump draws fuel accumulated in the second tank space into the first tank space.
摘要翻译：燃料供给装置包括容纳在燃料箱中的副罐和燃料泵。副容器具有至少分隔成第一室和第二室的内部空间。燃料泵布置在第一室中以将容纳在副罐中的燃料排放到燃料箱的外部。第二室具有开口，第二室通过该开口与副罐的外部连通，使得积聚在第二室中的燃料通过开口排出到副罐的外部。燃料箱具有第一储罐空间和第二储罐空间。副坦克被接收在第一个坦克空间。第一喷射泵设置在副罐的第二室中。第一喷射泵将在第二罐空间中积聚的燃料吸入第一罐空间。

8. 发明授权

US08820298B2 Passive and semi-active diesel and gasoline fuel module 有权
标题翻译：被动和半主动柴油和汽油燃油模块
公开(公告)号：US08820298B2
公开(公告)日：2014-09-02
申请号：US12632175
申请日：2009-12-07
申请人： William E. Attwood , Norihiro Hayashi
发明人： William E. Attwood , Norihiro Hayashi
IPC分类号： F02M37/04 , F02M69/46 , F02M37/10 , F02M37/00
CPC分类号： F02M37/106 , F02M37/0023 , F02M37/0052 , F02M37/0082 , F02M37/0094
摘要： A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.
摘要翻译：车辆燃料系统可以使用具有在燃料箱内的储存器的燃料泵模块。该系统还可以使用燃料喷射共轨，从燃料泵模块储存器引导到燃料喷射共轨的燃料供应管线和从燃料喷射共轨通过燃料泵模块凸缘的燃料返回管线。另外，该系统可以采用第一返回燃料止回阀来将燃料仅释放到储存器喷射泵和/或转移喷射泵中，而第二返回燃料止回阀可以仅将燃料直接释放到燃料泵模块储存器中。储存器内的电动燃料泵可以具有燃料泵止回阀，并且仅当燃料返回管线中的压力传感器启动时才向燃料喷射泵和/或转移喷射泵供给燃料，而不向发动机供应燃料。

9. 发明授权

US08689827B2 Fuel supply apparatus 有权
标题翻译：燃油供应装置
公开(公告)号：US08689827B2
公开(公告)日：2014-04-08
申请号：US13230027
申请日：2011-09-12
申请人： Tetsuro Okazono , Shinobu Oikawa , Kiyomori Kobayashi , Norihiro Hayashi , Shinji Noda , Hiroshi Morishita , Kazuki Matsubara , Kouji Maruyama , Masato Inoue , Hironobu Oki
发明人： Tetsuro Okazono , Shinobu Oikawa , Kiyomori Kobayashi , Norihiro Hayashi , Shinji Noda , Hiroshi Morishita , Kazuki Matsubara , Kouji Maruyama , Masato Inoue , Hironobu Oki
IPC分类号： F04B17/03 , B67D7/68 , F02M37/10
CPC分类号： F02M37/106 , B01D35/027 , B01D35/26 , B60K15/077 , F02M37/0017 , F02M37/025 , F02M37/103 , F04B23/021 , Y10T29/49826 , Y10T137/86035 , Y10T137/86043 , Y10T137/86067 , Y10T137/86091
摘要： A support shaft connects between a flange and a pump unit. An intermediate member, which connects between the support shaft and pump unit, enables a relative positional change between the support shaft and the pump unit in an axial direction of the support shaft. The intermediate member limits a relative positional change between the support shaft and the pump unit in a circumferential direction of the support shaft. A resilient member is received in the support shaft and exerts a restoring force in an axial direction of the support shaft to urge the pump unit, which is movable relative to the support shaft in the axial direction, toward a bottom portion of the fuel tank.
摘要翻译：支撑轴连接在法兰和泵单元之间。连接在支撑轴和泵单元之间的中间构件能够在支撑轴的轴向方向上支撑轴和泵单元之间的相对位置变化。中间构件在支撑轴的圆周方向上限制支撑轴和泵单元之间的相对位置变化。弹性构件被容纳在支撑轴中并且沿着支撑轴的轴向方向施加恢复力，以将相对于支撑轴在轴向方向上移动的泵单元推向燃料箱的底部。

10. 发明授权

US06211375B1 Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient 失效
标题翻译：吡啶酮羧酸衍生物或其盐和含有该活性成分的抗菌剂
公开(公告)号：US06211375B1
公开(公告)日：2001-04-03
申请号：US09171411
申请日：1999-01-20
申请人： Akira Yazaki , Yoshiko Niino , Yoshihiro Ohshita , Norihiro Hayashi , Hirotaka Amano , Yuzo Hirao , Tamae Yamane
发明人： Akira Yazaki , Yoshiko Niino , Yoshihiro Ohshita , Norihiro Hayashi , Hirotaka Amano , Yuzo Hirao , Tamae Yamane
IPC分类号： C07D21556
CPC分类号： C07D401/04
摘要： A novel pyridonecarboxylic acid derivative or its salt exhibiting satisfactory antibacterial activities, intestinal absorption, metabolic stability, and reduced side effects, in particular, phototoxicity and cytotoxicity, as well as an antibacterial agent containing such pyridonecarboxylic acid derivative or its salt are provided. For such an object, a pyridonecarboxylic acid derivative represented by the following formula (1): (wherein R1 represents hydrogen atom, a halogen atom or a lower alkyl group; R2 represents hydrogen atom or a lower alkyl group; R3 represents substituted or unsubstituted amino group or hydroxyl group; and R4 represents hydrogen atom, a lower alkyl group, amino group or nitro group) or its salt is provided.
摘要翻译：提供了具有令人满意的抗菌活性，肠吸收，代谢稳定性和副作用特别是光毒性和细胞毒性的新型吡啶酮羧酸衍生物或其盐，以及含有这种吡啶酮羧酸衍生物或其盐的抗菌剂。目的，下述式（1）表示的吡啶酮羧酸衍生物:(其中，R1表示氢原子，卤素原子或低级烷基; R2表示氢原子或低级烷基; R3表示取代或未取代的氨基或羟基，R4表示氢原子，低级烷基，氨基或硝基）或其盐。

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