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1. 发明申请

US20100105952A1 PROCESS FOR THE SYNTHESIS OF DMAPA 有权
标题翻译：合成DMAPA的方法
公开(公告)号：US20100105952A1
公开(公告)日：2010-04-29
申请号：US12683015
申请日：2010-01-06
申请人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roß , Roland Deeg , Johann-Peter Melder
发明人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roß , Roland Deeg , Johann-Peter Melder
IPC分类号： C07C209/02 , B01J19/00
CPC分类号： C07C209/48 , B01J2219/00006 , C07C253/30 , C07C211/11 , C07C255/24
摘要： The present invention relates to a process for the industrial preparation of a diamine starting from a corresponding alkenyl nitrile comprising at least one C—C double bond, which comprises the steps (a) reaction of the alkenyl nitrile with a corresponding monoamine in a first reactor so that the monoamine adds exothermically onto the at least one double bond to form an aminoalkyl nitrile, with the monoamine and water being charged initially and the alkenyl nitrile being fed in; (b) evaporation of unreacted alkenyl nitrile and monoamine to increase the concentration of the aminoalkyl nitrile product in the bottoms of the first reactor; (c) transfer of the aminoalkyl nitrile bottom product from step (b) to a second reactor; (d) batchwise catalytic hydrogenation of the aminoalkyl nitrile transferred in step (c) to the diamine in the second reactor, with each batch being obtained by initially charging a catalyst suitable for the hydrogenation of nitriles to amines and also water, the desired diamine and a base, introducing hydrogen into the second reactor and feeding in the aminoalkyl nitrile transferred in step (c); and (e) isolation of the diamine and, if appropriate, repetition of the steps (a) to (e). The invention further relates to an apparatus for preparing these diamines and the use of the apparatuses. A preferred diamine is 3-dimethylaminopropylamine (DMAPA).
摘要翻译：本发明涉及从包含至少一个C-C双键的相应链烯基腈开始工业制备二胺的方法，其包括步骤（a）在第一反应器中烯基腈与相应的单胺反应使得单胺在至少一个双键上放热添加以形成氨基烷基腈，最初加入单胺和水，并加入链烯基腈; （b）蒸发未反应的烯基腈和单胺以增加第一反应器底部氨基烷基腈产物的浓度; （c）将氨基烷基腈底部产物从步骤（b）转移至第二反应器; （d）将步骤（c）中转移的氨基烷基腈分批催化氢化为第二反应器中的二胺，每个批次通过首先将适合于将腈氢化成的催化剂加入到胺中而得到，并且还需要水，所需的二胺和碱，将氢气引入第二反应器并进料步骤（c）中转移的氨基烷基腈; 和（e）分离二胺，如果合适，重复步骤（a）至（e）。本发明还涉及一种用于制备这些二胺的装置和该装置的用途。优选的二胺是3-二甲基氨基丙胺（DMAPA）。

2. 发明授权

US07939027B2 Process for the synthesis of DMAPA 有权
标题翻译：合成DMAPA的方法
公开(公告)号：US07939027B2
公开(公告)日：2011-05-10
申请号：US12683015
申请日：2010-01-06
申请人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roβ , Roland Deeg , Johann-Peter Melder
发明人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roβ , Roland Deeg , Johann-Peter Melder
IPC分类号： B01J10/00 , C07C209/00 , B01J35/02 , B01J19/00 , B01J8/00
CPC分类号： C07C209/48 , B01J2219/00006 , C07C253/30 , C07C211/11 , C07C255/24
摘要： The present invention relates to a process for the industrial preparation of a diamine starting from a corresponding alkenyl nitrile comprising at least one C—C double bond, which comprises the steps (a) reaction of the alkenyl nitrile with a corresponding monoamine in a first reactor so that the monoamine adds exothermically onto the at least one double bond to form an aminoalkyl nitrile, with the monoamine and water being charged initially and the alkenyl nitrile being fed in; (b) evaporation of unreacted alkenyl nitrile and monoamine to increase the concentration of the aminoalkyl nitrile product in the bottoms of the first reactor; (c) transfer of the aminoalkyl nitrile bottom product from step (b) to a second reactor; (d) batchwise catalytic hydrogenation of the aminoalkyl nitrile transferred in step (c) to the diamine in the second reactor, with each batch being obtained by initially charging a catalyst suitable for the hydrogenation of nitriles to amines and also water, the desired diamine and a base, introducing hydrogen into the second reactor and feeding in the aminoalkyl nitrile transferred in step (c); and (e) isolation of the diamine and, if appropriate, repetition of the steps (a) to (e). The invention further relates to an apparatus for preparing these diamines and the use of the apparatuses. A preferred diamine is 3-dimethylaminopropylamine (DMAPA).
摘要翻译：本发明涉及从包含至少一个C-C双键的相应链烯基腈开始工业制备二胺的方法，其包括步骤（a）在第一反应器中烯基腈与相应的单胺反应使得单胺在至少一个双键上放热添加以形成氨基烷基腈，最初加入单胺和水，并加入链烯基腈; （b）蒸发未反应的烯基腈和单胺以增加第一反应器底部氨基烷基腈产物的浓度; （c）将氨基烷基腈底部产物从步骤（b）转移至第二反应器; （d）将步骤（c）中转移的氨基烷基腈分批催化氢化为第二反应器中的二胺，每个批次通过首先将适合于将腈氢化成的催化剂加入到胺中而得到，并且还需要水，所需的二胺和碱，将氢气引入第二反应器并进料步骤（c）中转移的氨基烷基腈; 和（e）分离二胺，如果合适，重复步骤（a）至（e）。本发明还涉及一种用于制备这些二胺的装置和该装置的用途。优选的二胺是3-二甲基氨基丙胺（DMAPA）。

3. 发明授权

US07723547B2 Process for the synthesis of DMAPA 有权
标题翻译：合成DMAPA的方法
公开(公告)号：US07723547B2
公开(公告)日：2010-05-25
申请号：US12092684
申请日：2006-10-31
申请人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roβ , Ronald Deeg , Johann-Peter Melder
发明人： Martin Ernst , Steffen Oehlenschläger , Frank Kuhnke , Karl-Heinz Roβ , Ronald Deeg , Johann-Peter Melder
IPC分类号： C07C209/48
CPC分类号： B01J8/20 , B01D3/14 , B01J2219/00006 , B01J2219/00029 , B01J2219/0004 , C07C209/48 , C07C211/11
摘要： The present invention relates to a process for the industrial preparation of a diamine starting from a corresponding alkenyl nitrile comprising at least one C—C double bond, which comprises the steps (a) reaction of the alkenyl nitrile with a corresponding monoamine in a first reactor so that the monoamine adds exothermically onto the at least one double bond to form an aminoalkyl nitrile, with the monoamine and water being charged initially and the alkenyl nitrile being fed in; (b) evaporation of unreacted alkenyl nitrile and monoamine to increase the concentration of the aminoalkyl nitrile product in the bottoms of the first reactor; (c) transfer of the aminoalkyl nitrile bottom product from step (b) to a second reactor; (d) batchwise catalytic hydrogenation of the aminoalkyl nitrile transferred in step (c) to the diamine in the second reactor, with each batch being obtained by initially charging a catalyst suitable for the hydrogenation of nitriles to amines and also water, the desired diamine and a base, introducing hydrogen into the second reactor and feeding in the aminoalkyl nitrile transferred in step (c); and (e) isolation of the diamine and, if appropriate, repetition of the steps (a) to (e). The invention further relates to an apparatus for preparing these diamines and the use of the apparatuses. A preferred diamine is 3-dimethylaminopropylamine (DMAPA).
摘要翻译：本发明涉及从包含至少一个C-C双键的相应链烯基腈开始工业制备二胺的方法，其包括步骤（a）在第一反应器中烯基腈与相应的单胺反应使得单胺在至少一个双键上放热添加以形成氨基烷基腈，最初加入单胺和水，并加入链烯基腈; （b）蒸发未反应的烯基腈和单胺以增加第一反应器底部氨基烷基腈产物的浓度; （c）将氨基烷基腈底部产物从步骤（b）转移至第二反应器; （d）将步骤（c）中转移的氨基烷基腈分批催化氢化为第二反应器中的二胺，每个批次通过首先将适合于将腈氢化成的催化剂加入到胺中而得到，并且还需要水，所需的二胺和碱，将氢气引入第二反应器并进料步骤（c）中转移的氨基烷基腈; 和（e）分离二胺，如果合适，重复步骤（a）至（e）。本发明还涉及一种用于制备这些二胺的装置和该装置的用途。优选的二胺是3-二甲基氨基丙胺（DMAPA）。

4. 发明申请

US20080293973A1 Process for the Synthesis of Dmapa 有权
标题翻译：合成Dmapa的过程
公开(公告)号：US20080293973A1
公开(公告)日：2008-11-27
申请号：US12092684
申请日：2006-10-31
申请人： Martin Ernst , Steffen Oehlenschlager , Frank Kuhnke , Karl-Heinz Ross , Roland Deeg , Johann-Peter Melder
发明人： Martin Ernst , Steffen Oehlenschlager , Frank Kuhnke , Karl-Heinz Ross , Roland Deeg , Johann-Peter Melder
IPC分类号： C07C209/48 , B01J19/00
CPC分类号： B01J8/20 , B01D3/14 , B01J2219/00006 , B01J2219/00029 , B01J2219/0004 , C07C209/48 , C07C211/11
摘要： The present invention relates to a process for the industrial preparation of a diamine starting from a corresponding alkenyl nitrile comprising at least one C-C double bond, which comprises the steps (a) reaction of the alkenyl nitrile with a corresponding monoamine in a first reactor so that the monoamine adds exothermically onto the at least one double bond to form an aminoalkyl nitrile, with the monoamine and water being charged initially and the alkenyl nitrile being fed in; (b) evaporation of unreacted alkenyl nitrile and monoamine to increase the concentration of the aminoalkyl nitrile product in the bottoms of the first reactor; (c) transfer of the aminoalkyl nitrile bottom product from step (b) to a second reactor; (d) batchwise catalytic hydrogenation of the aminoalkyl nitrile transferred in step (c) to the diamine in the second reactor, with each batch being obtained by initially charging a catalyst suitable for the hydrogenation of nitriles to amines and also water, the desired diamine and a base, introducing hydrogen into the second reactor and feeding in the aminoalkyl nitrile transferred in step (c); and (e) isolation of the diamine and, if appropriate, repetition of the steps (a) to (e). The invention further relates to an apparatus for preparing these diamines and the use of the apparatuses. A preferred diamine is 3-dimethylaminopropylamine (DMAPA).
摘要翻译：本发明涉及从包含至少一个CC双键的相应烯基腈开始工业制备二胺的方法，其包括步骤（a）在第一反应器中使链烯基腈与相应的单胺反应，使得单胺在至少一个双键上放热添加以形成氨基烷基腈，最初加入单胺和水，并加入链烯基腈; （b）蒸发未反应的烯基腈和单胺以增加第一反应器底部氨基烷基腈产物的浓度; （c）将氨基烷基腈底部产物从步骤（b）转移至第二反应器; （d）将步骤（c）中转移的氨基烷基腈分批催化氢化为第二反应器中的二胺，每个批次通过首先将适合于将腈氢化成的催化剂加入到胺中而得到，并且还需要水，所需的二胺和碱，将氢气引入第二反应器并进料步骤（c）中转移的氨基烷基腈; 和（e）分离二胺，如果合适，重复步骤（a）至（e）。本发明还涉及一种用于制备这些二胺的装置和该装置的用途。优选的二胺是3-二甲基氨基丙胺（DMAPA）。

5. 发明授权

US08536377B2 Method for producing N,N-substituted-3-aminopropan-1-ols 有权
标题翻译：制备N，N-取代-3-氨基丙-1-醇的方法
公开(公告)号：US08536377B2
公开(公告)日：2013-09-17
申请号：US13127828
申请日：2009-11-02
申请人： Christof Wilhelm Wigbers , Johann-Peter Melder , Martin Ernst
发明人： Christof Wilhelm Wigbers , Johann-Peter Melder , Martin Ernst
IPC分类号： C07C213/00
CPC分类号： C07C213/02 , C07C227/08 , Y02P20/582 , C07C215/08 , C07C229/12
摘要： The present invention relates to a process for preparing N,N-substituted 3-aminopropan-1-ols by a) reacting secondary amine with acrolein at a temperature of (−50) to 100° C. and a pressure of 0.01 to 300 bar, and b) reacting the reaction mixture obtained in stage a) with hydrogen and ammonia in the presence of a hydrogenation catalyst at a pressure of 1 to 400 bar, wherein the molar ratio of secondary amine to acrolein in stage a) is 1:1 or more and the temperature in stage b) is in the range from (−50) to 70° C. In a preferred embodiment, acrolein which has been obtained from glycerol based on renewable raw materials is used. The invention further relates to the use of an N,N-dimethyl-3-aminopropan-1-ol (DMAPOL) based on renewable raw materials as a catalyst for polyurethane preparation, as a scrubbing fluid in gas scrubbing, in the electronics chemicals and electroplating sectors, as a feedstock in organic synthesis, and as an intermediate in the production of pharmaceuticals and crop protection compositions.
摘要翻译：本发明涉及一种通过以下步骤制备N，N-取代的3-氨基丙-1-醇的方法：a）在（-50）至100℃的温度和0.01至300巴的压力下使仲胺与丙烯醛反应，和b）在加氢催化剂存在下，在1至400巴的压力下，将a）中获得的反应混合物与氢气和氨反应，其中a）步中仲胺与丙烯醛的摩尔比为1:1 或更高，步骤b）中的温度在（-50）至70℃的范围内。在优选的实施方案中，使用了基于可再生原料从甘油获得的丙烯醛。本发明还涉及使用基于可再生原料的N，N-二甲基-3-氨基丙-1-醇（DMAPOL）作为聚氨酯制备的催化剂，在电气化学品中用作气体洗涤中的洗涤液，电镀部门，作为有机合成中的原料，以及作为药物和作物保护组合物生产中的中间体。

6. 发明授权

US08461391B2 Method for producing N,N-substituted-1,3-propandiamines 有权
标题翻译：制备N，N-取代-1,3-丙二胺的方法
公开(公告)号：US08461391B2
公开(公告)日：2013-06-11
申请号：US12991767
申请日：2009-05-11
申请人： Martin Ernst , Johann-Peter Melder , Christof Wilhelm Wigbers
发明人： Martin Ernst , Johann-Peter Melder , Christof Wilhelm Wigbers
IPC分类号： C07C209/60
CPC分类号： C07C211/11 , C07C209/60 , Y02P20/582
摘要： The present invention relates to a process for preparing N,N-substituted 1,3-propanediamine by a) reacting secondary amine with acrolein at a temperature of from (−50) to 100° C. and a pressure of from 0.01 to 300 bar, and b) reacting the reaction mixture obtained in stage a) with hydrogen and ammonia in the presence of a hydrogenation catalyst at a temperature of from 40 to 400° C. and a pressure of from 1 to 400 bar, wherein the molar ratio of secondary amine to acrolein in stage a) is 2:1 or more and the hydrogenation catalyst used in stage b) comprises cobalt. In a preferred embodiment, acrolein which has been obtained from glycerol based on renewable raw materials is used. The invention further relates to the use of N,N-dimethyl-1,3-propanediamine (DMAPA) based on renewable raw materials as a feedstock for lubricant soaps and other detergents, coagulants, polymers and comb polymers. In a further preferred embodiment, stage b) is performed in the presence of water.
摘要翻译：本发明涉及一种通过以下步骤制备N，N-取代的1,3-丙二胺的方法：a）在（-50）至100℃的温度和0.01至300巴的压力下使仲胺与丙烯醛反应和b）在加氢催化剂存在下，在40〜400℃，压力为1〜400巴下，使a）中获得的反应混合物与氢气和氨反应，其中摩尔比阶段a）中的仲胺与丙烯醛的比例为2:1或更高，而阶段b）中使用的氢化催化剂包括钴。在优选的实施方式中，使用从基于可再生原料的甘油获得的丙烯醛。本发明还涉及基于可再生原料的N，N-二甲基-1,3-丙二胺（DMAPA）作为润滑剂皂和其它洗涤剂，凝结剂，聚合物和梳状聚合物的原料的用途。在另一优选实施方案中，步骤b）在水的存在下进行。

7. 发明申请

US20120071692A1 PROCESS FOR THE PREPARATION OF AROMATIC AMINES 审中-公开
标题翻译：制备芳香胺的方法
公开(公告)号：US20120071692A1
公开(公告)日：2012-03-22
申请号：US13234328
申请日：2011-09-16
申请人： SEBASTIAN AHRENS , Christoph Mueller , Axel Paul , Martin Ernst , Nadja Pollmer , Johann-Peter Melder , Thomas Heidemann , Joachim-Thierry Anders , Bram Willem Hoffer
发明人： SEBASTIAN AHRENS , Christoph Mueller , Axel Paul , Martin Ernst , Nadja Pollmer , Johann-Peter Melder , Thomas Heidemann , Joachim-Thierry Anders , Bram Willem Hoffer
IPC分类号： C07C209/18 , B01J21/06
CPC分类号： C07C209/18 , B01J21/066 , B01J23/44 , B01J35/002 , B01J35/026 , B01J35/08 , B01J35/1014 , B01J35/1038 , B01J37/0063 , B01J37/0072 , B01J37/0201 , Y02P20/582 , C07C211/45
摘要： A process for preparing an aromatic amine by reacting a corresponding aromatic alcohol with an aminating agent selected from the group consisting of ammonia, primary amines and secondary amines, in the presence of hydrogen and a catalyst molding, at a temperature of from 60-300°. The catalyst molding comprises Zr, Pd and Pt and has an annular tablet form with an external diameter in the range from 2-6 mm, a height in the range from 1-4 mm and an internal diameter of from 1-5 mm or a topologically equivalent form with the same volume. Catalyst moldings comprising Zr, Pd and Pt are also provided. The catalyst molding has an annular tablet form with an external diameter in the range from 3-6 mm, a height in the range from 1-4 mm and an internal diameter of from 2-5 mm or a topologically equivalent form.
摘要翻译：通过使相应的芳族醇与选自氨，伯胺和仲胺的胺化剂在氢和催化剂模塑的存在下，在60-300℃的温度下反应制备芳族胺的方法。催化剂成型包括Zr，Pd和Pt，并且具有环形片形式，其外径为2-6mm，高度为1-4mm，内径为1-5mm，或具有相同体积的拓扑等效形式。还提供了包含Zr，Pd和Pt的催化剂模制品。催化剂成型具有环形片形式，其外径为3-6mm，高度为1-4mm，内径为2-5mm或拓扑等效形式。

8. 发明申请

US20080214871A1 Method For Producing A Xylylene Diamine 审中-公开
标题翻译：生产二甲苯二胺的方法
公开(公告)号：US20080214871A1
公开(公告)日：2008-09-04
申请号：US11814390
申请日：2006-01-19
申请人： Martin Ernst , Thilo Hahn , Kirsten Wenz , Randolf Hugo , Johann-Peter Melder
发明人： Martin Ernst , Thilo Hahn , Kirsten Wenz , Randolf Hugo , Johann-Peter Melder
IPC分类号： C07C211/27
CPC分类号： C07C209/48 , C07C211/27
摘要： A process for preparing a xylylenediamine by heterogeneously catalyzed hydrogenation of a phthalonitrile, wherein the hydrogenation is carried out in the presence of a cobalt skeletal catalyst, of an alkali metal hydroxide and of an alcohol and/or ether as the solvent, at an absolute pressure in the range from 1 to 100 bar and a temperature in the range from 40 to 150° C.
摘要翻译：通过邻苯二甲腈的非均相催化氢化制备苯二甲胺的方法，其中氢化是在钴骨架催化剂存在下，碱金属氢氧化物和醇和/或醚作为溶剂在绝对压力下进行的在1至100巴的范围内，温度在40至150℃的范围内。

9. 发明申请

US20080154061A1 Method For Producing a Xylylenediamine 审中-公开
标题翻译：生产甲苯二胺的方法
公开(公告)号：US20080154061A1
公开(公告)日：2008-06-26
申请号：US11816878
申请日：2006-02-23
申请人： Martin Ernst , Kirsten Wenz , Randolf Hugo , Johann-Peter Melder , Thilo Hahn
发明人： Martin Ernst , Kirsten Wenz , Randolf Hugo , Johann-Peter Melder , Thilo Hahn
IPC分类号： C07C211/07
CPC分类号： C07C209/48 , C07C211/27
摘要： A process for preparing a xylylenediamine by heterogeneously catalyzed hydrogenation of a phthalonitrile, wherein the hydrogenation is carried out in the presence of a nickel catalyst, of water, of an alkali metal hydroxide and of an ether as a solvent, at an absolute pressure in the range from 1 to 100 bar, at a temperature in the range from 40 to 150° C. and without addition of ammonia.
摘要翻译：通过邻苯二甲腈的非均相催化氢化制备苯二甲胺的方法，其中氢化在镍催化剂存在下，水，碱金属氢氧化物和作为溶剂的醚作为溶剂在绝对压力下进行范围为1至100巴，温度范围为40至150℃，不加氨。

10. 发明申请

US20120245389A1 PROCESS FOR HYDROGENATING NITRILES 审中-公开
标题翻译：加氢处理方法
公开(公告)号：US20120245389A1
公开(公告)日：2012-09-27
申请号：US13427308
申请日：2012-03-22
申请人： Christof Wilhelm Wigbers , Christoph Müller , Wolfgang Mägerlein , Martin Ernst , Thomas Heidemann , Johann-Peter Melder , Lucia Königsmann , Milind Joshi , Oliver Bey , Bernd Stein
发明人： Christof Wilhelm Wigbers , Christoph Müller , Wolfgang Mägerlein , Martin Ernst , Thomas Heidemann , Johann-Peter Melder , Lucia Königsmann , Milind Joshi , Oliver Bey , Bernd Stein
IPC分类号： C07C209/48
CPC分类号： C07C209/48 , C07C2601/14 , C07C211/36 , C07C211/09
摘要： The present invention relates to a process for hydrogenating organic nitriles by means of hydrogen in the presence of a catalyst in a reactor, where the shaped body catalyst is arranged in a fixed bed, wherein the shaped body in the shape of spheres or rods has in each case a diameter 3 mm or less, in the shape of tablets a height of 4 mm or less, and in the case of all other geometries in each case has an equivalent diameter L=1/a′ of 0.70 mm or less, where a′ is the external surface area per unit volume (mms2/mmp3), where: a ′ = A p V p , where Ap is the external surface area of the catalyst particle (mms2) and Vp is the volume of the catalyst particle (mmp3). The present invention further relates to a process for preparing downstream products of isophoronediamine (IPDA) or N,N-dimethylaminopropylamine (DMAPA) from amines prepared according to the invention.
摘要翻译：本发明涉及一种在反应器中催化剂存在下通过氢气氢化有机腈的方法，其中成形体催化剂布置在固定床中，其中球体或棒状的成形体具有每个壳体的直径为3mm以下，片状形状为4mm以下，在各种情况下，所有其他几何形状的等效直径L = 1 / a'为0.70mm以下，其中 a'是每单位体积的外表面积（mms2 / mmp3），其中：a'= A p V p，其中Ap是催化剂颗粒的外表面积（mms2），Vp是催化剂颗粒的体积 mmp3）。本发明还涉及由根据本发明制备的胺制备异佛尔酮二胺（IPDA）或N，N-二甲基氨基丙胺（DMAPA）的下游产物的方法。

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