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1. 发明授权

US08129560B2 Process for the synthesis of mandipropamid and derivatives thereof 有权
标题翻译：槲寄生及其衍生物的合成方法
公开(公告)号：US08129560B2
公开(公告)日：2012-03-06
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).
摘要翻译：一种制备式（I）化合物的方法，该方法包括：（i）式（III）化合物与式（IV）化合物的反应，得到式（II）化合物，和（ii）式（II）化合物与离去基团的反应，得到式（I）化合物。

2. 发明申请

US20090118532A1 Process for the Synthesis of Mandipropamid and Derivatives Thereof 有权
公开(公告)号：US20090118532A1
公开(公告)日：2009-05-07
申请号：US12063907
申请日：2006-08-08
申请人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
发明人： Martin Charles Bowden , Thomas Aitcheson Clark , Fanny Giordano , Beat Jau , Hans-Dieter Schneider , Gottfried Seifert , Martin Zeller , Dominik Faber , Juerg Wiss
IPC分类号： C07C255/37 , C07C231/02 , C07C231/06 , C07C43/23 , C07C213/02
CPC分类号： C07C231/12 , C07C33/46 , C07C59/70 , C07C69/734 , C07C213/02 , C07C235/34 , C07C251/16 , C07C255/37 , C07C315/04 , C07C319/20 , C07C317/46 , C07C323/62
摘要： A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m′ are independently 0 or 1; when m and m′ are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m′ is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m′ are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with, wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

3. 发明授权

US07994341B2 Process for the production of amides 有权
标题翻译：酰胺生产工艺
公开(公告)号：US07994341B2
公开(公告)日：2011-08-09
申请号：US12066683
申请日：2006-09-14
申请人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
发明人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
IPC分类号： C07D231/14
CPC分类号： C07C211/61 , A01N43/56 , C07C205/06 , C07C209/325 , C07C209/70 , C07C2603/66 , C07D231/14
摘要： The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1和R 2各自独立地为氢或C 1 -C 5烷基，R 3为CF 3或CF 2 H，通过a）式（Ⅱ）化合物）其中R1和R2如式（I）所定义，与至少一种还原剂形成式（III）化合物，其中R 1和R 2如式（I）所定义，和b）该化合物与至少一种还原剂形成式（Ⅳ）化合物，其中R1和R2如式（Ⅰ）所定义，和（c）该化合物与式（Ⅴ）化合物的反应其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式（I）所定义，形成式（I）化合物; 以及用于该过程的新型中间体。

4. 发明申请

US20090163569A1 PROCESS FOR THE PRODUCTION OF AMIDES 有权
标题翻译：生产助剂的方法
公开(公告)号：US20090163569A1
公开(公告)日：2009-06-25
申请号：US12066683
申请日：2006-09-14
申请人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
发明人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
IPC分类号： A01N43/56 , C07D231/14 , C07C211/45 , C07C205/11 , C07D403/12 , A01P7/00
CPC分类号： C07C211/61 , A01N43/56 , C07C205/06 , C07C209/325 , C07C209/70 , C07C2603/66 , C07D231/14
摘要： The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1和R 2各自独立地为氢或C 1 -C 5烷基，R 3为CF 3或CF 2 H，通过a）式（Ⅱ）化合物）其中R1和R2如式（I）所定义，与至少一种还原剂形成式（III）化合物，其中R 1和R 2如式（I）所定义，和b）该化合物与至少一种还原剂形成式（Ⅳ）化合物，其中R1和R2如式（Ⅰ）所定义，和（c）该化合物与式（Ⅴ）化合物的反应其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式（I）所定义，形成式（I）化合物; 以及用于该过程的新型中间体。

5. 发明授权

US08436037B2 Process for the production of amides 有权
标题翻译：酰胺生产工艺
公开(公告)号：US08436037B2
公开(公告)日：2013-05-07
申请号：US13198739
申请日：2011-08-05
申请人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Jones , Paul Bonnett
发明人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Jones , Paul Bonnett
IPC分类号： A01N43/56 , C07D231/14
CPC分类号： C07C211/61 , A01N43/56 , C07C205/06 , C07C209/325 , C07C209/70 , C07C2603/66 , C07D231/14
摘要： The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.
摘要翻译：本发明涉及一种制备式Ⅰ化合物的方法，其中R1和R2分别独立地为氢或C1-C5烷基，R3为CF3或CF2H，通过a）式II化合物与式 R 2如式I所定义，与至少一种还原剂形成式III化合物，其中R 1和R 2如式I所定义，和b）该化合物与至少一种还原剂的反应形成式式IV其中R1和R2如式I所定义，和（c）该化合物与式V化合物的反应，其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式 I，形成式I化合物; 以及用于该过程的新型中间体。

6. 发明申请

US20120065239A1 PROCESS FOR THE PRODUCTION OF AMIDES 有权
标题翻译：生产助剂的方法
公开(公告)号：US20120065239A1
公开(公告)日：2012-03-15
申请号：US13198739
申请日：2011-08-05
申请人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
发明人： Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
IPC分类号： A01N43/56 , A01P3/00 , C07D231/14
CPC分类号： C07C211/61 , A01N43/56 , C07C205/06 , C07C209/325 , C07C209/70 , C07C2603/66 , C07D231/14
摘要： The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.
摘要翻译：本发明涉及一种制备式Ⅰ化合物的方法，其中R1和R2分别独立地为氢或C1-C5烷基，R3为CF3或CF2H，通过a）式II化合物的反应其中R 1和 R 2如式I所定义，与至少一种还原剂形成下式化合物，其中R 1和R 2如式I所定义，和b）该化合物与至少一种还原剂的反应形成式 IV其中R1和R2如式I所定义，和（c）该化合物与式V化合物的反应，其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式I所定义，形成式I化合物; 以及用于该过程的新型中间体。

7. 发明授权

US4332939A Process for the preparation of fluorinated s-triazines 失效
标题翻译：制备氟化s-三嗪的方法
公开(公告)号：US4332939A
公开(公告)日：1982-06-01
申请号：US246968
申请日：1981-03-24
申请人： Gottfried Seifert , Sebastian Staubli
发明人： Gottfried Seifert , Sebastian Staubli
IPC分类号： B01J21/00 , B01J21/18 , C07B61/00 , C07D251/28
CPC分类号： C07D251/28
摘要： A process for the preparation of a fluorinated s-triazine, which comprises reacting a cyanuric halide, which contains at least one halogen other than fluorine, with hydrogen fluoride in the presence of active charcoal.
摘要翻译：一种制备氟化均三嗪的方法，其包括在活性炭存在下使包含至少一种氟以外的卤素的氰尿酰卤与氟化氢反应。

8. 发明授权

US06861522B2 Process for the manufacture of thiazole derivatives with pesticidal activity 有权
标题翻译：用于制造具有杀虫活性的噻唑衍生物的方法
公开(公告)号：US06861522B2
公开(公告)日：2005-03-01
申请号：US10415259
申请日：2001-10-25
申请人： Thomas Rapold , Gottfried Seifert , Marcel Senn
发明人： Thomas Rapold , Gottfried Seifert , Marcel Senn
IPC分类号： C07D277/28 , C07D277/30 , C07D277/32 , C07D417/06
CPC分类号： C07D277/32 , C07D417/06
摘要： A process for the preparation of a compound of the formula in which Q is CH or N; Y is NO2 or CN; Z is CHR3, O, NR3 or S; R1 and R2 are, for example, together an alkylene bridge which optionally contains an O; R3 is H or unsubstituted or R4-substituted C1-C12alkyl, R4 is unsubstituted or substituted aryl or heteroaryl; wherein said compound has pesticidal activity.
摘要翻译：制备Q为CH或N的甲醛化合物的方法; Y是NO2或CN; Z是CHR 3，O，NR 3或S; R 1和R 2例如可以包含任选地含有O的亚烷基桥; R3是H或未取代的或R4取代的C1-C12烷基，R4是未取代或取代的芳基或杂芳基; 其中所述化合物具有杀虫活性。

9. 发明授权

US06175018B1 Process for preparation of propionic acid derivatives 有权
标题翻译：丙酸衍生物的制备方法
公开(公告)号：US06175018B1
公开(公告)日：2001-01-16
申请号：US09270925
申请日：1999-03-16
申请人： Gottfried Seifert , Andrea Rolf Sting , Bernhard Urwyler
发明人： Gottfried Seifert , Andrea Rolf Sting , Bernhard Urwyler
IPC分类号： C07D21364
CPC分类号： C07D213/643
摘要： (R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II in an inert organic solvent, without isolation of the intermediate products, with M2CO3, in which M is sodium or potassium, into the compound of formula III reacting this with the compound of formula IV to form the compound of formula V and converting this with a compound of formula VI wherein Z signifies phenylsulphonyl, tosyl, methylsulphonyl, nosyl, bromophenyl, Cl-, Br- or CICO-, into the compound of formula I.
摘要翻译：（R）（+） - 2- [4-（5-氯-3-氟吡啶-2-基氧基） - 苯氧基] - 丙酸丙酯通过在惰性有机溶剂中转化式II化合物而不分离中间产物，其中M为钠或钾的M 2 C 3与式IV化合物反应，形成式V化合物，并与式VI化合物反应，其中Z表示苯基磺酰基，甲苯磺酰基，甲基磺酰基，，溴苯基，Cl-，Br-或CICO-转化成式I的化合物。

10. 发明授权

US06747146B2 Method of producing nitroguanidine- and nitroenamine derivatives 有权
标题翻译：制备硝基胍和硝基胺衍生物的方法
公开(公告)号：US06747146B2
公开(公告)日：2004-06-08
申请号：US10325559
申请日：2002-12-20
申请人： Gottfried Seifert , Thomas Rapold , Verena Gisin
发明人： Gottfried Seifert , Thomas Rapold , Verena Gisin
IPC分类号： C07D27304
CPC分类号： C07D213/40 , C07C257/22 , C07C261/00 , C07C277/08 , C07D213/38 , C07D277/28 , C07D307/14 , C07D401/06 , C07D417/06 , C07C279/36
摘要： Method of producing compounds of formula wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical —N(R3)R4; or R2 and R6 together are —CH2—CH2—S—; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a radical —CH2B; R6 is hydrogen, C1-C8-alkyl, aryl or benzyl; or R3 and R6 together are —CH2—CH2—, —CH2—CH2—CH2—, —CH2—O—CH2—, —CH2—S—CH2— or —CH2—N(R5)—CH2—; X is CH—CN; CH—NO2 or N—NO2; A is an optionally substituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is optionally substituted phenyl, 3-pyridyl or thiazolyl; characterised in that a compound of formula wherein R2, R6 and X have the same significance as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of formula wherein A and R1 have the same significance as given above in formula (I) and Q is a leaving group.
摘要翻译：制备糠醛的化合物的方法是氢或C 1 -C 4烷基; R 2是氢，C 1 -C 8烷基，C 3 -C 6环烷基或-N（R 3）R 4基团; 或R 2和R 6一起是-CH 2 -CH 2 -S-; R 3和R 4是氢，C 1 -C 4 - 烷基，C 3 -C 6环烷基或基团-CH 2 B; R 6是氢，C 1 -C 8 - 烷基，芳基或苄基 ;或R 3和R 6一起是-CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -O-CH 2 - ， - CH 2 -S-CH 2 - 或-CH 2 -N（R 5）-CH 2 - ; X是 CH-CN; CH-NO 2或N-NO 2; A是任选取代的芳族或非芳族单环或双环杂环基; 和B是任选取代的苯基，3-吡啶基或噻唑基;其特征在于，式（I）化合物与式（I）中所给出的具有相同意义的化合物在相转移催化剂和碱的存在下反应与式（I）中的上述式相同，Q为离去基团。

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