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    • 3. 发明申请
    • METHOD OF READING ENCODED PARTICLES
    • 读取编码颗粒的方法
    • US20110033948A9
    • 2011-02-10
    • US11544309
    • 2006-10-06
    • John A. MoonMartin A. Putnam
    • John A. MoonMartin A. Putnam
    • G01N21/00
    • G01N21/6428G01N21/645Y10T436/143333
    • Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The code may be digital binary or may be other numerical bases. The micro-particles 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The micro-particles 8 are functionalized by coating them with a material/substance of interest, which are then used to perform multiplexed experiments involving chemical processes, e.g., DNA testing and combinatorial chemistry.
    • 微粒8包括其中设置有至少一个衍射光栅12的光学基板10。 光栅12具有多个共同定位的间距Λ,其表示当被入射光24照射时检测到的唯一识别数字码。入射光24可以从基底10的侧面以窄带(单波长)横向地引导, 或多个波长源,在这种情况下,代码分别由光或波长光谱的空间分布表示。 代码可以是数字二进制的,也可以是其他的数字基础。 微粒子8可以提供大量唯一的代码,例如大于6700万个代码,并且可以承受恶劣的环境。 通过用感兴趣的材料/物质涂覆微粒8来进行官能化,然后将其用于进行涉及化学过程(例如DNA测试和组合化学)的复合实验。
    • 8. 发明申请
    • Method of reading encoded particles
    • 读取编码粒子的方法
    • US20080085565A1
    • 2008-04-10
    • US11544309
    • 2006-10-06
    • John A. MoonMartin A. Putnam
    • John A. MoonMartin A. Putnam
    • G01N21/00
    • G01N21/6428G01N21/645Y10T436/143333
    • Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The code may be digital binary or may be other numerical bases. The micro-particles 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The micro-particles 8 are functionalized by coating them with a material/substance of interest, which are then used to perform multiplexed experiments involving chemical processes, e.g., DNA testing and combinatorial chemistry.
    • 微粒8包括其中设置有至少一个衍射光栅12的光学基板10。 光栅12具有多个共同定位的间距λ,它们表示当被入射光24照射时检测到的唯一识别数字码。 入射光24可以以窄带(单波长)或多个波长源从基板10的侧面横向地引导,在这种情况下,代码分别由光或波长光谱的空间分布表示。 代码可以是数字二进制的,也可以是其他的数字基础。 微粒子8可以提供大量唯一的代码,例如大于6700万个代码,并且可以承受恶劣的环境。 通过用感兴趣的材料/物质涂覆微粒8来进行官能化,然后将其用于进行涉及化学过程(例如DNA测试和组合化学)的复合实验。