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1. 发明授权

US5637315A Treatment of disease states induced by oxidative stress 失效
标题翻译：治疗由氧化应激引起的疾病状态
公开(公告)号：US5637315A
公开(公告)日：1997-06-10
申请号：US349129
申请日：1994-12-02
申请人： Mark Zern , Leaf Huang , Tony Yoa
发明人： Mark Zern , Leaf Huang , Tony Yoa
IPC分类号： A61K9/127 , A61K9/133 , A61K31/05 , A61K31/19 , A61K31/355 , A61K31/375
CPC分类号： A61K31/19 , A61K31/05 , A61K31/355 , A61K31/375 , A61K9/127 , Y10S436/829
摘要： Liposome carrier systems, methods and pharmaceutical compositions that target an organ preferentially with high concentrations of at least one therapeutic agent utilize a liposome carrier having a lipid membrane and an aqueous space to deliver pharmacologically active agents, such as free radical scavengers and antioxidants, to a target organ such as the liver. At least one free radical scavenger and/or antioxidant and a liposome carrier may be provided to a liver donor prior to harvesting to preserve the liver for transplantation.
摘要翻译：优选以高浓度的至少一种治疗剂靶向器官的脂质体载体系统，方法和药物组合物利用具有脂质膜和水性空间的脂质体载体将药理活性剂（例如自由基清除剂和抗氧化剂）递送至目标器官如肝脏。可以在收获之前将至少一种自由基清除剂和/或抗氧化剂和脂质体载体提供给肝供体以保留用于移植的肝脏。

2. 发明申请

US20050170502A1 Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage 审中-公开
标题翻译：维持肝细胞培养和沿肝细胞谱系分化胚胎干细胞的方法
公开(公告)号：US20050170502A1
公开(公告)日：2005-08-04
申请号：US10956169
申请日：2004-09-30
申请人： Mark Zern , Hitoshi Shirahashi
发明人： Mark Zern , Hitoshi Shirahashi
IPC分类号： C12N20060101 , C12N5/071 , C12N5/08
CPC分类号： C12N5/067 , C12N2500/32 , C12N2501/113 , C12N2501/115 , C12N2501/235 , C12N2501/237 , C12N2501/33 , C12N2501/39 , C12N2502/13 , C12N2506/02
摘要： The invention provides methods and media for culturing embryonic stem (ES) cells, such as human ES cells, and directing them along the hepatic lineage. It further provides methods for maintaining hepatocytes in culture for extended periods. The invention further provides cells cultured by the methods of the invention. Additionally, the invention provides methods of transducing cells with marker proteins that will be expressed only in hepatocyte-like cells and selecting for cells expressing the marker protein.
摘要翻译：本发明提供用于培养胚胎干细胞（ES）细胞如人类ES细胞的方法和培养基，并将其引导沿着肝脏谱系。它进一步提供了长时间维持培养中的肝细胞的方法。本发明还提供通过本发明的方法培养的细胞。此外，本发明提供了用仅在肝细胞样细胞中表达的标志物蛋白转导细胞的方法，并选择表达标志物蛋白的细胞。

3. 发明申请

US20120164913A1 MAGNETIC TOY PIECES 审中-公开
标题翻译：磁性玩具
公开(公告)号：US20120164913A1
公开(公告)日：2012-06-28
申请号：US13332197
申请日：2011-12-20
申请人： Gregory E. Pomeroy , Paul Karapetian , Mark Zern
发明人： Gregory E. Pomeroy , Paul Karapetian , Mark Zern
IPC分类号： A63H33/26 , B23P19/00
CPC分类号： A63H33/046 , Y10T29/49826
摘要： A first toy includes a housing having an elongate shape and a length. The housing includes two surfaces extending along the length that are substantially opposite one another. Two or more chambers are formed within the housing and situated at different positions along the length of the housing. Two or more permanent magnets are each situated within one of the two or more chambers. Each permanent magnet is free to assume a plurality of different orientations. Each permanent magnet is positioned sufficiently close to each one of the two surfaces to enable magnetic interaction with an adjacent permanent magnet contained in a second toy that is contacting the first toy at that one of the two surfaces of the first toy.
摘要翻译：第一玩具包括具有细长形状和长度的壳体。壳体包括沿着基本上彼此相对的长度延伸的两个表面。在壳体内形成两个或更多个腔室，并且位于沿壳体长度的不同位置。两个或更多个永磁体分别位于两个或多个腔室的一个内。每个永磁体可以自由地呈现多个不同的取向。每个永磁体被定位成足够接近两个表面中的每一个，以使得能够与包含在第一玩具中的相邻的永磁体磁化相互作用，该第二玩具在第一玩具的两个表面之一处接触第一玩具。

4. 发明申请

US20050123521A1 Immortalization of human cells by the ectopic expression of human telomerase reverse transcriptase 审中-公开
标题翻译：人类细胞通过人端粒酶逆转录酶的异位表达而永生化
公开(公告)号：US20050123521A1
公开(公告)日：2005-06-09
申请号：US10481191
申请日：2002-06-21
申请人： Mark Zern , Henning Wege
发明人： Mark Zern , Henning Wege
IPC分类号： A01K67/027 , A61K35/12 , A61K48/00 , C12N5/071 , C12N9/12 , C12N15/867 , C12N5/08
CPC分类号： C12N9/1241 , A01K67/0271 , A61K35/12 , C12N5/067 , C12N5/0676 , C12N2510/04 , C12N2799/027
摘要： Immortalized primary adult and fetal human cells are provided that express a functional telomerase catalytic subunit from a nucleic acid sequence encoding the hTERT gene. The telomerase-immortalized human cells can be maintained in culture for at least 35 population doublings without developing a transformed phenotype, and while continuing to express proteins associated with the primary differentiated cell type. The invention is also directed to immortalized, non-transformed cell lines derived from primary human cells that express a functional telomerase catalytic subunit and to their use for transplantation to patients with hepatic disease. The invention also is directed to an improved biologic extracorporeal liver support device wherein the improvement is the use of telomerase-immortalized hepatocytes incorporated onto the scaffolding of the cell colonization chamber and use of the improved device for treating symptoms of patients with hepatic disease.
摘要翻译：提供永生化的初级成人和胎儿人细胞，其从编码hTERT基因的核酸序列表达功能性端粒酶催化亚基。端粒酶永生化的人细胞可以在培养物中维持至少35个群体倍增，而不发展转化的表型，并且在继续表达与初级分化细胞类型相关的蛋白质的同时。本发明还涉及来自表达功能性端粒酶催化亚单位的原代人细胞的永生化，未转化的细胞系，以及它们用于肝病患者移植的用途。本发明还涉及改进的生物体外肝支持装置，其中改进是使用结合到细胞定植室的支架上的端粒酶永生化肝细胞，并使用改进的装置来治疗肝病患者的症状。

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