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1. 发明申请

US20100228307A1 Responding to Partial Lead Failure in an Implantable Cardioverter Defibrillator 有权
标题翻译：在植入式心律转复除颤器中应对局部引导失败
公开(公告)号：US20100228307A1
公开(公告)日：2010-09-09
申请号：US12781716
申请日：2010-05-17
申请人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
发明人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
IPC分类号： A61N1/39
CPC分类号： A61N1/3931 , A61N1/3621 , A61N2001/083
摘要： An implanted cardioverter defibrillator (ICD) delivers an electrical therapy signal to the heart of a patient. When ventricular fibrillation or another condition of the heart requiring high voltage therapy is sensed, the therapy signal is delivered to the heart. When a partial short-circuit or other low impedance condition occurs, an over-current protection circuit will stop delivery of a shocking pulse. The ICD will then reduce the voltage of the shocking pulse and try again to deliver electrical therapy. This process is repeated until a voltage level is found that is able to deliver the electrical therapy without causing an over-voltage condition. Alternate lead configurations may also be tried in an attempt to find a signal path that is not affected by the low impedance or short-circuit condition.
摘要翻译：植入式心律转复除颤器（ICD）向患者的心脏递送电疗治疗信号。当心室纤维性颤动或需要高压治疗的心脏的另一种情况被感测时，治疗信号传递到心脏。当发生部分短路或其他低阻抗情况时，过电流保护电路将停止输送震动脉冲。然后，ICD将降低冲击脉冲的电压，然后再次进行电疗治疗。重复该过程，直到发现能够递送电疗而不引起过电压状况的电压电平。也可以尝试替代引线配置来尝试找到不受低阻抗或短路条件影响的信号路径。

2. 发明授权

US07747320B1 Responding a partial lead failure in an implantable cardioverter defibrillator 有权
标题翻译：在植入式心律转复除颤器中应对部分导致失败
公开(公告)号：US07747320B1
公开(公告)日：2010-06-29
申请号：US11433541
申请日：2006-05-12
申请人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
发明人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
IPC分类号： A61N1/00
CPC分类号： A61N1/3931 , A61N1/3621 , A61N2001/083
摘要： An implanted cardioverter defibrillator (ICD) delivers an electrical therapy signal to the heart of a patient. When ventricular fibrillation or another condition of the heart requiring high voltage therapy is sensed, the therapy signal is delivered to the heart. When a partial short-circuit or other low impedance condition occurs, an over-current protection circuit will stop delivery of a shocking pulse. The ICD will then reduce the voltage of the shocking pulse and try again to deliver electrical therapy. This process is repeated until a voltage level is found that is able to deliver the electrical therapy without causing an over-voltage condition. Alternate lead configurations may also be tried in an attempt to find a signal path that is not affected by the low impedance or short-circuit condition.
摘要翻译：植入式心律转复除颤器（ICD）向患者的心脏递送电疗治疗信号。当心室纤维性颤动或需要高压治疗的心脏的另一种情况被感测时，治疗信号传递到心脏。当发生部分短路或其他低阻抗情况时，过电流保护电路将停止输送震动脉冲。然后，ICD将降低冲击脉冲的电压，然后再次进行电疗治疗。重复该过程，直到发现能够递送电疗而不引起过电压状况的电压电平。也可以尝试替代引线配置来尝试找到不受低阻抗或短路条件影响的信号路径。

3. 发明授权

US07684870B1 Direct current fibrillator 失效
标题翻译：直流纤颤器
公开(公告)号：US07684870B1
公开(公告)日：2010-03-23
申请号：US11282172
申请日：2005-11-18
申请人： Mark W. Kroll , J. Christopher Moulder , Gabriel A. Mouchawar
发明人： Mark W. Kroll , J. Christopher Moulder , Gabriel A. Mouchawar
IPC分类号： A61N1/39
CPC分类号： A61N1/385
摘要： An implantable cardiac device to induce fibrillation in the heart of a patient to allow testing of the defibrillation capability of the device. The device induces fibrillation using a direct current across the heart. The shock to the heart may be applied in a method to minimize discomfort to the patient. The heart is monitored during application of the shock. The voltage of shock at the heart is gradually increased until fibrillation is induced. Once the fibrillation is detected the shock may be stopped. This results in a minimized voltage level and duration for the shock to the heart, thereby diminishing pain and discomfort to the patient.
摘要翻译：一种植入式心脏装置，用于在患者的心脏中诱导原纤维化，以允许测试该装置的除颤能力。该装置使用穿过心脏的直流电导致纤维颤动。心脏的震荡可以用于最小化患者不适的方法。在应用冲击期间监测心脏。心脏的休克电压逐渐增加，直到引发颤动。一旦检测到颤动，可能会停止休克。这导致对心脏的休克的最小电压电平和持续时间，从而减轻患者的疼痛和不适。

4. 发明授权

US07450995B2 Implantable cardiac stimulation device including an output circuit that provides arbitrarily shaped defibrillation waveforms 有权
标题翻译：可植入心脏刺激装置，包括提供任意形状除颤波形的输出电路
公开(公告)号：US07450995B2
公开(公告)日：2008-11-11
申请号：US10687386
申请日：2003-10-15
申请人： J. Christopher Moulder , Gabriel A. Mouchawar , Steven W. Badelt , Mark W. Kroll
发明人： J. Christopher Moulder , Gabriel A. Mouchawar , Steven W. Badelt , Mark W. Kroll
IPC分类号： A61N1/40
CPC分类号： H03F3/217 , A61N1/3975 , A61N1/3981
摘要： An output circuit for use in an implantable cardiac defibrillation provides an output pulse having a waveform of virtually any desired shape. The device includes a sensing circuit that senses cardiac activity. An arrhythmia detector detects fibrillation responsive to the cardiac activity signal. The device further includes an output circuit that provides a stimulation output pulse when the arrhythmia detector detects a cardiac arrhythmia. The output circuit includes an H-bridge having a pair of switching devices which control the output pulse waveform with pulse-width modulation and a second pair of switching devices that control the output pulse polarity.
摘要翻译：用于可植入心脏除颤的输出电路提供具有几乎任何期望形状的波形的输出脉冲。该装置包括感测心脏活动的感测电路。心律失常检测器响应于心脏活动信号检测原纤维。该装置还包括输出电路，其在心律不齐检测器检测到心律不齐时提供刺激输出脉冲。输出电路包括H桥，其具有控制脉冲宽度调制的输出脉冲波形的一对开关器件和控制输出脉冲极性的第二对开关器件。

5. 发明授权

US08676317B1 System and method for estimating defibrillation impedance based on low-voltage resistance measurements using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的低电压电阻测量来估计除颤阻抗的系统和方法
公开(公告)号：US08676317B1
公开(公告)日：2014-03-18
申请号：US11186741
申请日：2005-07-20
申请人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder
发明人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder
IPC分类号： A61N1/00 , G01R27/00 , A61B5/02
CPC分类号： A61N1/3937 , A61B5/046 , A61B5/0538 , A61B5/686 , A61B5/6869 , A61B2560/0276 , A61N1/3706
摘要： Techniques are provided for estimating defibrillation impedance of an implantable cardioverter/defibrillator (ICD). Briefly, at least two low-voltage resistance values are measured at different voltages using a pair of stimulation electrodes connected to the ICD. High-voltage defibrillation impedance is then estimated by the ICD based on a weighted combination of the measured resistance values. In one example, a set of weight coefficients, calculated during an initial calibration procedure, are applied to the measured resistance values to produce the estimate of the high-voltage defibrillation impedance. The weight coefficients are updated whenever a defibrillation shock is delivered, based on actual defibrillation impedance values measured during the shock.
摘要翻译：提供了用于估计植入式心律转复除颤器（ICD）的除颤阻抗的技术。简言之，使用连接到ICD的一对刺激电极，在不同的电压下测量至少两个低电压电阻值。然后，基于所测量的电阻值的加权组合，由ICD估计高电压除颤阻抗。在一个示例中，在初始校准过程期间计算的一组权重系数被施加到测量的电阻值，以产生高电压除颤阻抗的估计。根据在休克期间测量的实际除颤阻抗值，每当递送除颤电击时，权重系数都被更新。

6. 发明授权

US08170689B2 Implantable cardiac defibrillation system with defibrillation electrode entrapment prevention and method 有权
标题翻译：植入心脏除颤系统除颤电极夹带预防及方法
公开(公告)号：US08170689B2
公开(公告)日：2012-05-01
申请号：US11779158
申请日：2007-07-17
申请人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder
发明人： Mark W. Kroll , Gabriel A. Mouchawar , J. Christopher Moulder
IPC分类号： A61N1/08
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/378 , A61N1/3975
摘要： An implantable cardiac defibrillation device diminishes fibrosis of a defibrillation electrode. The device includes an implantable lead having a defibrillation electrode adapted for implant in one of the superior vena cava and right ventricle of a heart, a pulse generator adapted to be coupled to the defibrillation electrode that provides defibrillation energy to the defibrillation electrode, and a power supply that maintains a negative voltage on the defibrillation electrode in the absence of defibrillating energy being provided to the defibrillation electrode.
摘要翻译：植入式心脏除颤装置减少除颤电极的纤维化。该装置包括可植入引线，其具有适于植入在心脏的上腔静脉和右心室中的一个中的除颤电极，脉冲发生器适于耦合到除颤电极，该除颤电极向去纤维性颤动电极提供除颤能量，在除颤能量不存在的情况下，在除颤电极上保持负电压的电源。

7. 发明授权

US08200330B2 Responding to partial lead failure in an implantable cardioverter defibrillator 有权
标题翻译：响应植入式心律转复除颤器部分导致失败
公开(公告)号：US08200330B2
公开(公告)日：2012-06-12
申请号：US12781716
申请日：2010-05-17
申请人： Mark Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
发明人： Mark Kroll , Gabriel A. Mouchawar , J. Christopher Moulder , Andre Walker
IPC分类号： A61N1/39
CPC分类号： A61N1/3931 , A61N1/3621 , A61N2001/083
摘要： An implanted cardioverter defibrillator (ICD) delivers an electrical therapy signal to the heart of a patient. When ventricular fibrillation or another condition of the heart requiring high voltage therapy is sensed, the therapy signal is delivered to the heart. When a partial short-circuit or other low impedance condition occurs, an over-current protection circuit will stop delivery of a shocking pulse. The ICD will then reduce the voltage of the shocking pulse and try again to deliver electrical therapy. This process is repeated until a voltage level is found that is able to deliver the electrical therapy without causing an over-voltage condition. Alternate lead configurations may also be tried in an attempt to find a signal path that is not affected by the low impedance or short-circuit condition.
摘要翻译：植入式心律转复除颤器（ICD）向患者的心脏递送电疗治疗信号。当心室纤维性颤动或需要高压治疗的心脏的另一种情况被感测时，治疗信号传递到心脏。当发生部分短路或其他低阻抗情况时，过电流保护电路将停止输送震动脉冲。然后，ICD将降低冲击脉冲的电压，然后再次进行电疗治疗。重复该过程，直到发现能够递送电疗而不引起过电压状况的电压电平。也可以尝试替代引线配置来尝试找到不受低阻抗或短路条件影响的信号路径。

8. 发明授权

US08886319B2 MRI signal filtering for implantable medical device 有权
标题翻译：可植入医疗器械的MRI信号滤波
公开(公告)号：US08886319B2
公开(公告)日：2014-11-11
申请号：US12617532
申请日：2009-11-12
申请人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08 , G01R33/28 , A61N1/37 , A61N1/375 , A61N1/365 , G01R33/36
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

9. 发明申请

US20110112599A1 MRI SIGNAL FILTERING FOR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于可植入医疗器械的MRI信号滤波
公开(公告)号：US20110112599A1
公开(公告)日：2011-05-12
申请号：US12617532
申请日：2009-11-12
申请人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Zin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

10. 发明授权

US06862476B2 Implantable cardiac stimulation device having automatic sensitivity control and method 有权
标题翻译：具有自动灵敏度控制和方法的植入式心脏刺激装置
公开(公告)号：US06862476B2
公开(公告)日：2005-03-01
申请号：US10081709
申请日：2002-02-20
申请人： Gabriel A. Mouchawar , James D. Causey, III , Kelly H. McClure , J. Christopher Moulder , Paul A. Levine
发明人： Gabriel A. Mouchawar , James D. Causey, III , Kelly H. McClure , J. Christopher Moulder , Paul A. Levine
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3704 , A61N1/3962
摘要： An implantable cardiac stimulation device and method provides reliable sensing of cardiac events to support cardiac pacing or fibrillation detection. The device comprises a sensing circuit that senses the cardiac events in accordance with a plurality of threshold characterizing parameters. A parameter control adjusts the threshold parameters responsive to the rate of the sensed cardiac events in a manner which precludes positive feedback to prevent continued oversensing, undersensing, or noise sensing.
摘要翻译：可植入心脏刺激装置和方法提供心脏事件的可靠感测以支持心脏起搏或原纤维化检测。该装置包括感测电路，其根据多个阈值特性参数来感测心脏事件。参数控制以响应于感测到的心脏事件的速率的方式调整阈值参数，排除正反馈以防止持续的过度感测，欠感测或噪声感测。

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