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1. 发明申请

US20070054538A1 Releasable Cord Coupler 审中-公开
标题翻译：可释放电缆耦合器
公开(公告)号：US20070054538A1
公开(公告)日：2007-03-08
申请号：US11162053
申请日：2005-08-26
申请人： Mark Smith , Robert Hasler
发明人： Mark Smith , Robert Hasler
IPC分类号： H01R13/62
CPC分类号： H01R13/6392 , H01R13/60
摘要： A releasable cord coupler in a single embodiment consisting of an enlongated linear strap with a tapered tail, two apertures and a slot through the planar surface of the strap, a plurality of ratcheted teeth affixed to the bottom side of the strap, a slide located around the strap, and a head with a pawl inserted therein that receives the tail and engages the ratcheted teeth. The cord coupler prevents the accidental uncoupling of an electrical appliance from an electrical extension cord. The cord coupler may also be used to bind two extension cords. When storing a hand tool or extension cord equipped with the cord coupler, the cord coupler may be used to secure the power tool cord to the tool or to secure a coiled extension cord for storage.
摘要翻译：在单个实施例中的可释放的线耦合器，包括具有锥形尾部的伸长线性带，两个孔和通过带的平面表面的狭槽，固定到带的底侧的多个棘齿，位于带的底侧的滑块带子，以及插入其中的棘爪的头部，其接纳尾部并与棘齿啮合。电缆耦合器防止电器从电气延长线意外断开。线缆耦合器也可用于绑定两个延伸线。当存储配备有电缆耦合器的手动工具或延长线时，电缆耦合器可用于将电动工具线固定到工具上或固定用于存放的线圈延长线。

2. 发明授权

US11951746B2 Device for controlling access to containers for dispensing printing material 有权
公开(公告)号：US11951746B2
公开(公告)日：2024-04-09
申请号：US17429748
申请日：2020-03-06
申请人： James R. Pryde , Mark Smith , Robert Hargreaves
发明人： James R. Pryde , Mark Smith , Robert Hargreaves
IPC分类号： B41J2/175 , G03G15/08
CPC分类号： B41J2/17523 , G03G15/0877
摘要： A device (1) for controlling user access to at least one container (4) for dispensing printing material housed by a printing apparatus (5), the device (1) comprising an openable and closable barrier (2) corresponding to the container (4) and a lock for locking the barrier (2) in a closed position. The lock is overlapped by at least a portion of the barrier (2) both when the barrier (2) is in the closed position and when the barrier (2) is in an open position.

3. 发明申请

US20170206608A1 HORIZONTALLY-LINKED REINSURANCE NETWORK 审中-公开
公开(公告)号：US20170206608A1
公开(公告)日：2017-07-20
申请号：US15403374
申请日：2017-01-11
申请人： Mark Smith
发明人： Mark Smith
IPC分类号： G06Q40/08 , G06Q40/00 , G06Q40/06
CPC分类号： G06Q40/08 , G06Q40/06 , G06Q40/10
摘要： A Horizontally-Linked Reinsurance Network (HLRN) formed of a plurality of small insurance companies (as defined by applicable law, e.g. U.S.C. §831(b)) that is established and managed by a network administrator presents a new approach to harnessing the benefits of small insurance companies while mitigating the drawbacks of small insurance companies. This system uses a rules-based approach and algorithm to select, allocate, optimize and manage the individual risk portfolio of independent small insurance companies so as to preserve their status as a small insurance company while diversifying risk. Further, network administrator will perform the management functions if the HLRN. This allows investors or persons who would not otherwise own an insurance company to invest in a new asset class which by its nature demonstrates a non-correlation to traditional investment markets and carries both unique return and tax properties.

4. 外观设计

USD729041S1 Terminal of a holder system for supporting mobile electronic devices and external articles 有权
标题翻译：支持移动电子设备和外部物品的支架系统的终端
公开(公告)号：USD729041S1
公开(公告)日：2015-05-12
申请号：US29433547
申请日：2012-10-01
申请人： Mark Smith
设计人： Mark Smith

5. 发明申请

US20150038409A1 Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta 审中-公开
标题翻译：瘦素组合物和方法治疗由神经原纤维缠结和淀粉样蛋白β积累引起的进行性认知功能障碍
公开(公告)号：US20150038409A1
公开(公告)日：2015-02-05
申请号：US14097818
申请日：2013-12-05
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22 , A61K31/7056
CPC分类号： A61K38/22 , A61K31/7056 , A61K38/2264 , A61K45/06 , C12Q1/485 , G01N33/5058 , G01N2800/2821 , G01N2800/2828 , A61K2300/00
摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.
摘要翻译：本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。根据一个方面，所述发明提供了治疗进行性认知障碍的方法。根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

6. 发明授权

US08795194B2 Tissue harvesting 有权
标题翻译：组织收获
公开(公告)号：US08795194B2
公开(公告)日：2014-08-05
申请号：US12058910
申请日：2008-03-31
申请人： Mark Howard , Mark Smith
发明人： Mark Howard , Mark Smith
IPC分类号： A61B10/02 , A61M1/00 , B01D25/00
CPC分类号： C12N5/0653 , A61B10/025 , A61B10/0283 , A61B17/1635 , A61B17/32002 , A61B17/3205 , A61B2017/00969 , A61B2217/005 , A61M1/00 , A61M1/0056 , A61M2202/0014 , A61M2202/08
摘要： The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed.
摘要翻译：本公开涉及一种组织收集装置。所述组织收集装置包括限定入口和出口的壳体，设置在所述壳体内的第一过滤器，设置在所述壳体内的第二过滤器，所述第二过滤器被配置为将通过所述第一过滤器的所需尺寸的组织颗粒隔开，施加通过壳体施加的抽吸力。还公开了收获组织的方法。

7. 发明授权

US08642543B2 Methods for treating progressive cognitive disorders related to neurofibrillary tangles 有权
标题翻译：治疗与神经原纤维缠结相关的进行性认知障碍的方法
公开(公告)号：US08642543B2
公开(公告)日：2014-02-04
申请号：US12470427
申请日：2009-05-21
申请人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
发明人： Nikolaos Tezapsidis , Steven Greco , Mark Smith
IPC分类号： A61K38/22
CPC分类号： A61K38/2264 , A61K38/22 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof.
摘要翻译：所述发明提供了用于治疗或预防进行性认知疾病，病症或病症进展的方法，以及用于在有需要的受试者中提高认知功能的弹性的方法。

8. 发明授权

US08312562B2 Impact and/or vibration absorbent material and protective articles making use thereof 有权
标题翻译：冲击和/或吸震材料及其使用的保护制品
公开(公告)号：US08312562B2
公开(公告)日：2012-11-20
申请号：US12715263
申请日：2010-03-01
申请人： Gary Hammons , Roger W. Kramer , Charles Marks , Kevin Porter , Robert Bogard , Traci Skahill , Mark Smith
发明人： Gary Hammons , Roger W. Kramer , Charles Marks , Kevin Porter , Robert Bogard , Traci Skahill , Mark Smith
IPC分类号： A41D19/00
CPC分类号： A41D31/005 , A41D19/01523 , A43B13/187 , A43B13/189 , A47C7/021 , B60N2/522 , B60N2/525 , B60N2/70 , F16F3/093 , F16F2230/36
摘要： An impact and/or vibration absorbent material and protective articles making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of different materials, or of the same material with the composition of the material of one layer adjusted to be of dissimilar hardness to an adjacent layer. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. Through use of a protective article of the present invention, the effects of impact and/or vibration forces on a user of the protective article can be minimized.
摘要翻译：使用所述材料的冲击和/或振动吸收材料和保护制品。本发明的冲击和/或振动吸收材料具有至少两个材料层。冲击和/或振动吸收材料的各个层可以是不同的材料，或者具有相同材料的材料，其中一层材料的组成被调整为与相邻层具有不同的硬度。每个材料层优选地包含许多孔。一层中的孔位于并布置成偏离相邻层中的孔。材料性质的组合和孔的包含和排列使得这种材料具有高度冲击和/或吸振性。通过使用本发明的保护制品，能够使冲击力和/或振动力对保护用品的使用者的影响最小化。

9. 发明申请

US20120251639A1 Mole Eliminating Ointment 审中-公开
标题翻译：摩尔消除软膏
公开(公告)号：US20120251639A1
公开(公告)日：2012-10-04
申请号：US13079133
申请日：2011-04-04
申请人： Mark Smith
发明人： Mark Smith
IPC分类号： A61K36/752 , A61P17/00 , A61K36/81
CPC分类号： A61K36/8962 , A61K8/97 , A61K36/752 , A61K36/81 , A61Q19/02 , A61K2300/00
摘要： A topical treatment, and a method for making and using, for eliminating moles comprising, a mixture of natural extracts, where said extracts include garlic, white potatoes, onions and grapefruit.
摘要翻译：一种局部治疗，以及用于消除摩尔的制造和使用方法，包括天然提取物的混合物，其中所述提取物包括大蒜，白土豆，洋葱和葡萄柚。

10. 发明申请

US20120190124A1 Reversible Covalent Linkage of Functional Molecules 有权
标题翻译：功能分子的可逆共价连接
公开(公告)号：US20120190124A1
公开(公告)日：2012-07-26
申请号：US13389625
申请日：2010-08-09
申请人： Mark Smith , Stephen Caddick , James Baker
发明人： Mark Smith , Stephen Caddick , James Baker
IPC分类号： C07K1/00 , C07D207/456 , C07K1/14 , C07D237/04 , G01N21/75 , C07K14/655 , C07D495/04
CPC分类号： C07K14/655 , A61K47/551 , A61K47/60 , A61K47/62 , A61K49/0017 , C07D207/416 , C07D207/456 , C07D209/52 , C07K14/435 , G01N33/58 , Y02P20/55
摘要： The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
摘要翻译：本发明涉及含有式（I）部分的化合物作为将包含式F1的第一功能部分的式R 1 -H的化合物与式F2的第二功能部分连接的试剂的用途，其中X， X'，Y，R1，F1和F2如本文所定义。本发明还提供了相关的方法和产品。本发明可用于产生功能性缀合化合物，特别是缀合物，其中至少一种构成分子携带巯基。

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