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1. 发明申请

US20090318846A1 METHODS AND APPARATUS FOR SURFACE ABLATION 审中-公开
标题翻译：表面消除的方法和装置
公开(公告)号：US20090318846A1
公开(公告)日：2009-12-24
申请号：US12130728
申请日：2008-05-30
申请人： Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Jeong Woo Lee , Priya D. Gadiraju
发明人： Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Jeong Woo Lee , Priya D. Gadiraju
IPC分类号： A61N1/30 , A61B18/18
CPC分类号： A61B17/3203 , A61B2017/00765 , A61B2018/00613 , A61N1/0412 , A61N1/0428 , A61N1/30 , A61N1/325 , A61N1/327 , A61N1/328
摘要： The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability.
摘要翻译：本发明的各种实施例一般涉及用于表面消融的方法和装置。更具体地，本发明的各种实施例涉及用于消除阻挡表面（例如皮肤）的方法和装置，以增加阻挡表面的渗透性。本发明的实施例包括通过由电弧放电产生的微流体射流对皮肤进行快速热机械消融，以产生定位于角质层的微米级孔，这增加了皮肤渗透性。

2. 发明授权

US08690865B2 Methods and devices for thermal treatment 有权
标题翻译：热处理方法和装置
公开(公告)号：US08690865B2
公开(公告)日：2014-04-08
申请号：US11597969
申请日：2005-05-31
申请人： Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Yong-Kyu Yoon , Jin-Woo Park
发明人： Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Yong-Kyu Yoon , Jin-Woo Park
IPC分类号： A61B18/08 , A61N1/30
CPC分类号： A61K9/0004 , A61B5/14514 , A61B18/082 , A61B18/10 , A61B2018/00005 , A61B2018/00613 , A61K9/7023 , A61K41/0047 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0046 , A61N1/0412 , A61N1/0476 , A61N1/0492 , A61N1/327
摘要： The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.
摘要翻译：本发明包括用于热处理屏障以增加屏障的渗透性的方法和装置。增加屏障渗透性的一种形式包括形成微孔，该微孔可用于通过阻挡层施用活性剂，或可用于取样或收集流体，或可用于检测，测量或确定分析物，或者可以是用于监测生理或其他条件。本发明的装置可以包括由电感或欧姆加热电源部件激活的微热电。

3. 发明申请

US20100048744A1 Particle Based Molding 有权
标题翻译：基于粒子的成型
公开(公告)号：US20100048744A1
公开(公告)日：2010-02-25
申请号：US12299092
申请日：2007-04-30
申请人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
发明人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
IPC分类号： C08J9/35 , B29C35/08 , B29C35/02
CPC分类号： B29C35/0261 , A61M37/0015 , B29C35/0805 , B29C67/205 , B29C2035/0827 , B29K2105/251 , B29K2995/006 , B29L2031/7544
摘要： Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.
摘要翻译：提供各种装置，布置和方法来产生包括微结构的各种结构。在一个实施例中，提供了一种用于产生微结构的方法，包括将多个颗粒包裹在微胶片中，然后将能量施加到微镜中的颗粒。作为施加能量的结果，在微粒中形成微结构。此后，将微观结构从微型金属中除去。

4. 发明授权

US08101114B2 Particle based molding 有权
标题翻译：基于粒子的成型
公开(公告)号：US08101114B2
公开(公告)日：2012-01-24
申请号：US12299092
申请日：2007-04-30
申请人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
发明人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
IPC分类号： A61K9/14
CPC分类号： B29C35/0261 , A61M37/0015 , B29C35/0805 , B29C67/205 , B29C2035/0827 , B29K2105/251 , B29K2995/006 , B29L2031/7544
摘要： Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.
摘要翻译：提供各种装置，布置和方法来产生包括微结构的各种结构。在一个实施例中，提供了一种用于产生微结构的方法，包括将多个颗粒包裹在微胶片中，然后将能量施加到微镜中的颗粒。作为施加能量的结果，在微粒中形成微结构。此后，将微观结构从微型金属中除去。

5. 发明授权

US09302903B2 Microneedle devices and production thereof 有权
公开(公告)号：US09302903B2
公开(公告)日：2016-04-05
申请号：US10023259
申请日：2001-12-14
申请人： Jung-Hwan Park , Mark R. Prausnitz
发明人： Jung-Hwan Park , Mark R. Prausnitz
IPC分类号： A61N1/30 , B81C1/00 , A61B5/15 , A61M37/00 , A61B5/145
CPC分类号： B81C1/00111 , A61B5/1411 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/30 , B81B2201/055
摘要： Microneedle devices and methods of manufacture are provided for transport of molecules or energy across or into biological barriers, such as skin. The device can comprise one or more microneedles formed of a first material and a second material, wherein the second material is dispersed throughout the first material or forms a portion of the microneedle. The first material preferably is a polymer. The second material can be pore forming agents, structural components, biosensor, or molecules for release, such as drug. The device also can comprise a substrate and a plurality of microneedles extending from the substrate, wherein the microneedles have a beveled or tapered tip portion, a longitudinally extending exterior channel, or both. Methods of making these devices include providing a mold having a plurality of microdepressions which define the surface of a microneedle; filling the microdepressions with a first molding material; and molding the material, thereby forming microneedles.

6. 发明申请

US20090182306A1 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal 审中-公开
标题翻译：微针装置和药物递送或液体抽出方法
公开(公告)号：US20090182306A1
公开(公告)日：2009-07-16
申请号：US12357195
申请日：2009-01-21
申请人： Jeong Woo Lee , Mark R. Prausnitz
发明人： Jeong Woo Lee , Mark R. Prausnitz
IPC分类号： A61M5/00 , B29C39/42
CPC分类号： B29C41/04 , A61K9/0021 , A61M37/0015 , A61M2037/0053 , B29L2031/7544 , B29L2031/756
摘要： Microneedle devices and methods of manufacture and use thereof are provided. The devices may be used in controlled delivery of drug across or into a biological barrier, such as skin, or fluid withdrawal from a biological barrier. In one case, the device includes a base substrate which comprises a drug dispersed in a swellable matrix material; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellable material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.
摘要翻译：提供微针装置及其制造和使用方法。这些装置可以用于药物横跨或进入生物屏障（例如皮肤）或从生物屏障排出液体的受控递送。在一种情况下，该装置包括基底，其包含分散在可溶胀基质材料中的药物; 和一个或多个从所述基底基底延伸的微针，其中所述一个或多个微针包含水溶性或水溶胀性材料，其中所述一个或多个微针在插入所述生物屏障之后会溶解或溶胀，从而提供用于该药物从基底层传递到生物屏障。

7. 发明申请

US20090131905A1 Microneedle devices and methods of manufacture and use thereof 审中-公开
公开(公告)号：US20090131905A1
公开(公告)日：2009-05-21
申请号：US12150945
申请日：2008-05-01
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/32 , A61N1/32 , B29C45/00 , G03F7/20 , B22D23/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

8. 发明授权

US07226439B2 Microneedle drug delivery device 有权
标题翻译：微针药物输送装置
公开(公告)号：US07226439B2
公开(公告)日：2007-06-05
申请号：US10454973
申请日：2003-06-04
申请人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
发明人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61B2090/0814 , A61M5/422 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles. In one embodiment, the reservoir is a syringe or pump connected to the substrate.
摘要翻译：提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。储存器可以由可变形的，优选弹性的材料形成。该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

9. 发明授权

US06743211B1 Devices and methods for enhanced microneedle penetration of biological barriers 有权
标题翻译：增强生物屏障微针穿透的装置和方法
公开(公告)号：US06743211B1
公开(公告)日：2004-06-01
申请号：US09448107
申请日：1999-11-23
申请人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
发明人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译：提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔或（4）这些方法的任何组合。在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。

10. 发明授权

US06611707B1 Microneedle drug delivery device 有权
标题翻译：微针药物输送装置
公开(公告)号：US06611707B1
公开(公告)日：2003-08-26
申请号：US09452979
申请日：1999-12-02
申请人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
发明人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
IPC分类号： A61N130
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61B2090/0814 , A61M5/422 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles. In one embodiment, the reservoir is a syringe or pump connected to the substrate.
摘要翻译：提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。储存器可以由可变形的，优选弹性的材料形成。该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

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