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1. 发明授权

US4332875A Polymeric electrically active conductive layer for electrically activatable recording element and process 失效
标题翻译：用于电可激活记录元件和工艺的聚合物电活性导电层
公开(公告)号：US4332875A
公开(公告)日：1982-06-01
申请号：US229701
申请日：1981-01-29
申请人： Mark Lelental , Richard C. Sutton
发明人： Mark Lelental , Richard C. Sutton
IPC分类号： G03C1/498 , G03G17/00 , G03G5/026 , G03G5/04
CPC分类号： G03G17/00 , G03C1/49872 , G03C1/4989
摘要： In an electrically activatable recording element, such as one comprising an electrically conductive support having thereon, in sequence: (a) a polymeric electrically active conductive (EAC) layer, (b) an electrically activatable recording layer comprising (A) a dye-forming coupler, and (B) an oxidation-reduction combination comprising (i) an organic silver salt oxidizing agent consisting essentially of a silver salt of a 1,2,4-mercaptotriazole derivative, with (ii) a reducing agent which, in its oxidized form, forms a dye with the dye-forming coupler, (c) a photoconductive layer separated from (b) by an air gap of up to 20 microns, and (d) an electrically conductive layer; improvements are provided by means of a polymeric EAC layer (a) consisting essentially of a vinyl addition polymer, such as poly(methyl acrylate-co-vinylidene chloride). The recording element is room light handleable and provides a dye image and silver image by dry development processing.
摘要翻译：在可激活的记录元件中，例如包括其上的导电载体的顺序：（a）聚合物电活性导电（EAC）层，（b）可电激活的记录层，其包含（A）成染染色剂成色剂和（B）氧化还原组合，其包含（i）基本上由1,2,4-巯基三唑衍生物的银盐组成的有机银盐氧化剂与（ii）还原剂，其在其氧化形成染料，与染料形成成色剂形成染料，（c）通过高达20微米的气隙与（b）分离的光电导层，和（d）导电层; 通过基本上由乙烯基加成聚合物如聚（丙烯酸甲酯 - 共 - 偏二氯乙烯）组成的聚合物EAC层（a）提供改进。记录元件是室内光线处理，通过干式显影处理提供染色图像和银色图像。

2. 发明授权

US5374516A Avidin-and biotin immobilized reagents and methods of use 失效
标题翻译：抗生物素蛋白和生物素固定化试剂及使用方法
公开(公告)号：US5374516A
公开(公告)日：1994-12-20
申请号：US315086
申请日：1989-02-24
申请人： Richard C. Sutton , Brent A. Burdick , Susan J. Danielson , Harold C. Warren, III , Brian A. Snyder , Gregory J. McClune , Annie L. Wu
发明人： Richard C. Sutton , Brent A. Burdick , Susan J. Danielson , Harold C. Warren, III , Brian A. Snyder , Gregory J. McClune , Annie L. Wu
IPC分类号： G01N33/543 , G01N33/545 , G01N33/546
CPC分类号： G01N33/54306 , G01N33/54313 , G01N33/545 , Y10T428/2991 , Y10T428/2998
摘要： Reagents have been prepared from water-insoluble polymeric particles to which are covalently attached avidin, biotin or an avidin or biotin derivative. The polymeric particles comprise a polymer on at least the outer surface which is derived from at least one ethylenically unsaturated monomer having a reactive activated 2-substituted ethylsulfonyl, vinylsulfonyl or active halogen atom. Covalent attachment of avidin, biotin or an avidin or biotin derivative is effected either directly or indirectly through these reactive groups. The resulting reagent is useful in analytical elements and various analytical methods including agglutination and sandwich assays. The immobilized avidin, biotin or derivative can be used to complex with the corresponding biotin or avidin molecule which may be conjugated to a compound of biological interest.
摘要翻译：试剂由水不溶性聚合物颗粒制备，共价连接的抗生物素蛋白，生物素或抗生物素蛋白或生物素衍生物。聚合物颗粒在至少外表面上包含衍生自至少一种具有反应性活化的2-取代的乙基磺酰基，乙烯基磺酰基或活性卤素原子的烯属不饱和单体的聚合物。亲和素，生物素或抗生物素蛋白或生物素衍生物的共价连接通过这些反应性基团直接或间接地实现。所得试剂可用于分析元件和各种分析方法，包括凝集和夹心测定。固定的抗生物素蛋白，生物素或衍生物可用于与可能与生物学兴趣的化合物缀合的相应生物素或抗生物素蛋白分子复合。

3. 发明授权

US5262297A Specific binding analytical and separation methods using carboxy containing polymers 失效
标题翻译：使用含羧基聚合物的特异性结合分析和分离方法
公开(公告)号：US5262297A
公开(公告)日：1993-11-16
申请号：US876672
申请日：1992-04-30
申请人： Richard C. Sutton , Susan J. Danielson , John B. Findlay , Fred. T. Oakes , Marsha D. B. Oenick , Ignazio S. Ponticello , Harold C. Warren, III
发明人： Richard C. Sutton , Susan J. Danielson , John B. Findlay , Fred. T. Oakes , Marsha D. B. Oenick , Ignazio S. Ponticello , Harold C. Warren, III
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/543 , G01N33/545 , G01N83/545 , G01N33/546 , G01N33/547
CPC分类号： G01N33/54313 , C12Q1/6876 , C12Q1/701 , C12Q1/703 , G01N33/545 , Y10S436/804 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/824
摘要： Specific binding methods are used for diagnostic assays and purification separations whereby the specific binding capture reagent is prepared from copolymers having highly reactive carboxy groups. These groups are extended from the polymer surface with a linking group having from 8 to 50 atoms in the chain and two or more alkylene, arylene, alkylenearylene or arylenealkylene groups. To these reactive groups is attached a biologically active substance such as a protein or oligonucleotide which then participates in the diagnostic assays or purification separation methods.
摘要翻译：特异性结合方法用于诊断测定和纯化分离，由此特异性结合捕获试剂由具有高反应性羧基的共聚物制备。这些基团从聚合物表面延伸，在链中具有8至50个原子的连接基团和两个或更多个亚烷基，亚芳基，亚烷基亚芳基或亚芳基亚烷基。将这些反应性基团连接到生物活性物质如蛋白质或寡核苷酸上，然后参与诊断测定或纯化分离方法。

4. 发明授权

US5149737A Carboxy containing monomers and polymers and latices prepared from same 失效
标题翻译：含羧基的单体和聚合物以及由其制备的胶乳
公开(公告)号：US5149737A
公开(公告)日：1992-09-22
申请号：US654112
申请日：1991-02-12
申请人： Ignazio S. Ponticello , Richard C. Sutton
发明人： Ignazio S. Ponticello , Richard C. Sutton
IPC分类号： C07C69/40 , C07C69/007 , C07C69/42 , C07C233/05 , C07C233/49 , C07C251/24 , C07C275/38 , C07C323/12 , C07C323/41 , C07C323/50 , C07C323/52 , C07C323/56 , C08F12/00 , C08F12/04 , C08F12/14 , C08F20/02 , C08F20/64 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： C07C69/007 , C07C323/12 , C07C323/52 , C07C323/56 , C08F12/14 , G01N33/54313
摘要： Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl or 1 to 3 carbon atoms,M is hydrogen, an alkali metal ion or an ammonium ion, andL is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

5. 发明授权

US5043062A High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material 失效
标题翻译：高性能亲和色谱柱包括无孔，非分散的聚合物包装材料
公开(公告)号：US5043062A
公开(公告)日：1991-08-27
申请号：US601106
申请日：1990-10-18
申请人： Marsha D. Bale , Richard C. Sutton
发明人： Marsha D. Bale , Richard C. Sutton
IPC分类号： B01D15/08 , B01J20/32
CPC分类号： B01D15/3804 , B01J20/261 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/286 , B01J20/3092 , B01J20/321 , B01J20/3217 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J20/3293 , B01D15/3809 , B01D15/3823 , B01J2220/445 , B01J2220/54 , B01J2220/58
摘要： A high performance affinity chromatography separation device comprising:A) a chromatographic column containing:B) a packing material;wherein the packing material is a plurality of non-porous, nonodisperse polymeric particles having i) a particle size in the range of 0.01 to about 5 micrometers and ii) surface reactive groups which are directly or indirectly reactive with free amino groups, sulfhydryl groups, carboxy groups or aldehyde groups of biological ligands is disclosed.
摘要翻译：一种高性能亲和层析分离装置，包括：A）色谱柱，其含有：B）包装材料; 其中所述包装材料是多个非多孔非分散聚合物颗粒，其具有i）在0.01至约5微米范围内的粒度，和ii）与游离氨基直接或间接反应的表面反应性基团，巯基，公开了生物配体的羧基或醛基。

6. 发明授权

US5622822A Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same 失效
标题翻译：使用聚乙烯亚胺和阴离子磷酸酯表面活性剂捕获和选择性释放核酸的方法及其扩增
公开(公告)号：US5622822A
公开(公告)日：1997-04-22
申请号：US305769
申请日：1994-09-13
申请人： Tobias E. Ekeze , John W. Backus , David J. Sharkey , Richard C. Sutton , JoAnne H. Kerschner
发明人： Tobias E. Ekeze , John W. Backus , David J. Sharkey , Richard C. Sutton , JoAnne H. Kerschner
IPC分类号： C12N15/09 , C07H21/04 , C12N15/10 , C12Q1/68 , C12P19/34 , C12Q1/70
CPC分类号： C12N15/1003 , C12Q1/6806
摘要： Nucleic acids can be made available for amplification or other treatment after lysis by contacting the lysate with polyethyleneimine to form a precipitate with the nucleic acids. The nucleic acids are then released from the precipitate by contact with a strong base, and the released nucleic acids are kept in solution with an anionic phosphate ester surfactant. This method for preparing specimen samples is simple and quite rapid.
摘要翻译：通过使裂解物与聚乙烯亚胺接触以与核酸形成沉淀，可将核酸用于扩增或裂解后的其它处理。然后通过与强碱接触将核酸从沉淀物中释放，并将释放的核酸与阴离子磷酸酯表面活性剂一起保持在溶液中。这种制备样品样品的方法简单而且相当迅速。

7. 发明授权

US5308749A Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use 失效
标题翻译：从含琥珀酰亚胺的聚合物制备生物活性试剂的方法，分析元件和使用方法
公开(公告)号：US5308749A
公开(公告)日：1994-05-03
申请号：US646303
申请日：1991-01-25
申请人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson , Marsha D. B. Oenick
发明人： Richard C. Sutton , Ignazio S. Ponticello , Susan J. Danielson , Marsha D. B. Oenick
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/545 , G01N33/531 , G01N33/546
CPC分类号： G01N33/54313 , G01N33/54386 , Y10S524/90 , Y10T428/2991 , Y10T428/2998
摘要： Biologically active reagents are prepared from particles of copolymers having highly active succinimid groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through amide groups by displacement of highly active succinimid groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods such as affinity chromatography.
摘要翻译：生物活性试剂由具有高活性琥珀酰亚胺基团的共聚物颗粒制备。试剂通过将颗粒表面上的高活性琥珀酰亚胺基团置换而直接或间接地通过酰胺基团将生物活性物质例如抗体共价连接而制备。这些试剂用于分析元件，检测特异性结合配体（例如免疫物质）和免疫测定的方法以及纯化方法如亲和层析中。

8. 发明授权

US5210289A Carboxy containing monomers 失效
标题翻译：含羧基的单体
公开(公告)号：US5210289A
公开(公告)日：1993-05-11
申请号：US856279
申请日：1992-03-23
申请人： Ignazio S. Ponticello , Richard C. Sutton
发明人： Ignazio S. Ponticello , Richard C. Sutton
IPC分类号： C07C69/007 , C07C323/12 , C07C323/52 , C07C323/56 , C08F12/14 , G01N33/543
CPC分类号： C07C69/007 , C07C323/12 , C07C323/52 , C07C323/56 , C08F12/14 , G01N33/54313
摘要： Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl of 1 to 3 carbon atoms,M is hydrogen, an alkali metal ion or an ammonium ion, andL is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## group, and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.
摘要翻译：某些具有活性羧基的烯键式不饱和可聚合单体可用于制备各种用途的均聚物和共聚物，包括诊断测定法。聚合物可以作为水性组合物中的胶乳颗粒提供。单体由以下结构表示：其中：R是氢，卤素或1至3个碳原子的烷基，M是氢，碱金属离子或铵离子，L是具有8至其连接链中包含50个原子，并且包含两个或多个与一个或多个氮，氧或硫原子连接或封端的二价烃基，或者在连接链中与一个或多个含有该原子的基团连接，条件是L具有至少一个亚芳基其不直接连接到终端基团，并且进一步提供没有一个烃基具有非芳族不饱和键。

9. 发明授权

US5086143A Copolymers containing polyoxyalkylene side chains 失效
标题翻译：含有聚氧亚基链的共聚物
公开(公告)号：US5086143A
公开(公告)日：1992-02-04
申请号：US557338
申请日：1990-07-25
申请人： Richard C. Sutton , Marsha B. Oenick
发明人： Richard C. Sutton , Marsha B. Oenick
IPC分类号： C08F212/02 , C08F12/00 , C08F220/28 , C08F246/00 , C08L25/00 , G01N33/543 , G01N33/545
CPC分类号： G01N33/545 , C08F220/28 , C08F246/00 , G01N33/54313
摘要： Copolymers are prepared from (a) at least about 0.5 mole % of monomers having reactive groups which are, directly or indirectly, capable of reaction with free amine or sulfhydryl groups of biologically active substances, (b) from about 0.1 to about 20 mole % of monomers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88, and (c) up to about 99.4 mole % of oleophilic monomers which provide hydrophobicity to the copolymers. The copolymers can be supplied as latex particles in aqueous compositions.

10. 发明授权

US5053443A Methods of preparing a polymeric latex composition and water-insoluble biological reagent 失效
标题翻译：制备聚合物胶乳组合物和水不溶性生物试剂的方法
公开(公告)号：US5053443A
公开(公告)日：1991-10-01
申请号：US347537
申请日：1989-05-04
申请人： Richard C. Sutton
发明人： Richard C. Sutton
IPC分类号： C08J3/215 , G01N33/543 , G01N33/569 , G01N33/58
CPC分类号： C08J3/215 , G01N33/54313 , G01N33/54386 , G01N33/56911 , G01N33/585
摘要： A polymeric latex composition having a hydrophobe incorporated therein can be prepared using a novel latex "loading" method. This method includes providing a loadable latex, providing a hydrophobe dissolved in a water-miscible organic solvent, heating the loadable latex to about 30.degree. to about 90.degree. C. and gradually adding the hydrophobe solution to the heated loadable latex under conditions to keep the hydrophobe in solution and to "load" it into the latex particles. In preferred embodiments, the latex is surfactant-free and has particles which have outer reactive groups which are capable of reacting with free amine or sulfhydryl groups of a biological compound. Such latices can be used to prepare water-insoluble biological reagents having a biological compound attached to the particles.
摘要翻译：可以使用新的胶乳“加载”方法制备其中掺入疏水物的聚合物胶乳组合物。该方法包括提供可加载的胶乳，提供溶解在水可混溶的有机溶剂中的疏水物，将可加载的胶乳加热到约30℃至约90℃，并且在保持该可加载胶乳的条件下逐渐将该疏水物溶液加入到加热的可加载胶乳中在溶液中疏水，并将其“负载”到胶乳颗粒中。在优选的实施方案中，胶乳是无表面活性剂的，并且具有能够与生物化合物的游离胺或巯基反应的外部反应性基团的颗粒。这种胶乳可以用于制备具有附着到颗粒上的生物化合物的水不溶性生物试剂。

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