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1. 发明申请

US20090247475A1 METHODS AND COMPOSITIONS RELATING TO PHARMACOGENETICS OF DIFFERENT GENE VARIANTS IN THE CONTEXT OF IRINOTECAN-BASED THERAPIES 审中-公开
标题翻译：不同基因组变异基因在不同基因型治疗中的药代动力学方法与组成
公开(公告)号：US20090247475A1
公开(公告)日：2009-10-01
申请号：US11913150
申请日：2006-05-12
申请人： Mark J. Ratain , Federico Innocenti , Deanna L. Kroetz , Samir Undevia , Tan D. Nguyen , Wanqing Liu
发明人： Mark J. Ratain , Federico Innocenti , Deanna L. Kroetz , Samir Undevia , Tan D. Nguyen , Wanqing Liu
IPC分类号： C12Q1/68 , A61K31/4545
CPC分类号： A61K31/4545 , C12Q1/6827
摘要： The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs. In addition, there are methods and compositions of evaluating the risk of an individual for developing toxicity or adverse event(s) to an ABCC2, UGT1A1, and/or SLCO1B1 substrate. In some embodiments, the invention concerns methods and compositions for determining the presence or absence of ABCC2 3972C>T variant and predicting or anticipating the level of activity of ABCC2 and determining dosages of an ABCC2 drug substrate, such as irinotecan, in a patient. Such methods and compositions can be used to evaluate whether irinotecan-based therapy, or therapy involving other ABCC2 substrates, may pose toxicity problems if given to a particular patient or predicting their efficacy. Alterations in suggested therapy may ensue based on genotyping results.
摘要翻译：本发明涉及用于确定ABCC2，UGT1A1和/或SLCO1B1基因内存在或不存在多态性的方法和组合物，并将这些多态性与其基因产物的活性水平相关联并且对其底物的影响进行评估，特别是那些底物是药物。此外，还有一些方法和组成来评估个体对ABCC2，UGT1A1和/或SLCO1B1底物的毒性或不良事件的风险。在一些实施方案中，本发明涉及用于确定ABCC23972C> T变体的存在或不存在以及预测或预测ABCC2的活性水平并确定患者体内ABCC2药物底物（例如伊立替康）的剂量的方法和组合物。这样的方法和组合物可用于评估依托替替治疗或涉及其他ABCC2底物的治疗如果给予特定患者或预测其功效，可能引起毒性问题。建议治疗的改变可能是基于基因分型结果。

2. 发明申请

US20090017452A1 METHODS AND COMPOSITIONS RELATING TO THE PHARMACOGENETICS OF DIFFERENT GENE VARIANTS 审中-公开
标题翻译：与不同基因变异体药物相关的方法和组合物
公开(公告)号：US20090017452A1
公开(公告)日：2009-01-15
申请号：US10591484
申请日：2005-03-07
申请人： Mark J. Ratain , Federico Innoceti , Deanna L. Kroetz , Samir Undevia , Tan D. Nguyen , Wanqing Liu
发明人： Mark J. Ratain , Federico Innoceti , Deanna L. Kroetz , Samir Undevia , Tan D. Nguyen , Wanqing Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/142 , C12Q2600/172
摘要： The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs. In addition, there are methods and compositions of evaluating the risk of an individual for developing toxicity or adverse event(s) to an ABCC2, UGT1A1, and/or SLCO1B1 substrate. In some embodiments, the invention concerns methods and compositions for determining the presence or absence of ABCC2 3972C>T variant and predicting or anticipating the level of activity of ABCC2 and determining dosages of an ABCC2 drug substrate, such as irinotecan, in a patient. Such methods and compositions can be used to evaluate whether irinotecan-based therapy, or therapy involving other ABCC2 substrates, may pose toxicity problems if given to a particular patient or predicting their efficacy. Alterations in suggested therapy may ensue based on genotyping results.
摘要翻译：本发明涉及用于确定ABCC2，UGT1A1和/或SLCO1B1基因内存在或不存在多态性的方法和组合物，并将这些多态性与其基因产物的活性水平相关联并且对其底物的影响进行评估，特别是那些底物是药物。此外，还有一些方法和组成来评估个体对ABCC2，UGT1A1和/或SLCO1B1底物的毒性或不良事件的风险。在一些实施方案中，本发明涉及用于确定ABCC23972C> T变体的存在或不存在以及预测或预测ABCC2的活性水平并确定患者体内ABCC2药物底物（例如伊立替康）的剂量的方法和组合物。这样的方法和组合物可用于评估依托替替治疗或涉及其他ABCC2底物的治疗如果给予特定患者或预测其功效，可能引起毒性问题。建议治疗的改变可能是基于基因分型结果。

3. 发明申请

US20080217594A1 TAIL SECTION FOR CARPET STRETCHING TOOL 有权
公开(公告)号：US20080217594A1
公开(公告)日：2008-09-11
申请号：US11684429
申请日：2007-03-09
申请人： William Kirker , Tan D. Nguyen
发明人： William Kirker , Tan D. Nguyen
IPC分类号： A47G27/04
CPC分类号： A47G27/0493
摘要： A tail section for a carpet stretching tool. The carpet stretching tool is the type having a carpet engaging head, an elongate body, a tail section and a lever mechanism allowing extension of the elongate body. The tail section includes a first leg and a second leg, each leg having a wall running face. The legs may be selectively positioned between at least two positions. In one positions the wall running faces form a substantially flat surface allowing use of the tool down a wall section. In a second position the wall running faces on the first and second leg of the tool may be positioned at an angle to allow the tool to be used on corner locations within a room or on a post.

4. 发明授权

US06718166B2 Multiple carrier adaptive notch filter 有权
标题翻译：多载波自适应陷波滤波器
公开(公告)号：US06718166B2
公开(公告)日：2004-04-06
申请号：US10151648
申请日：2002-05-17
申请人： Sean S. Cordone , Tan D. Nguyen
发明人： Sean S. Cordone , Tan D. Nguyen
IPC分类号： H04B110
CPC分类号： H04B1/1036 , H04B1/1027 , H04B1/123 , H04B1/71
摘要： A multiple carrier adaptive notch filter (ANF) module selectively filters a received wideband communication signal to eliminate narrowband interference that lies within the frequency spectrum of the wideband communication signal. To determine the presence of narrowband interference, the multiple carrier ANF module scans various known narrowband channels that lie within the frequency spectrum of the wideband communication signal and determines signal strengths for each of the narrowband channels. The signal strengths from the narrowband channels are compared to a threshold that is derived from a statistical combination of the narrowband signal strengths. Narrowband channels having signal strengths that are greater than the threshold are determined to have interference.
摘要翻译：多载波自适应陷波滤波器（ANF）模块选择性地对接收到的宽带通信信号进行滤波，以消除位于宽带通信信号的频谱范围内的窄带干扰。为了确定窄带干扰的存在，多载波ANF模块扫描位于宽带通信信号的频谱内的各种已知窄带信道，并确定每个窄带信道的信号强度。将来自窄带信道的信号强度与从窄带信号强度的统计组合导出的阈值进行比较。具有大于阈值的信号强度的窄带信道被确定为具有干扰。

5. 发明授权

US08671581B2 Undercut saw height adjustment, handle, blade guard improvements 有权
标题翻译：底切锯高度调节，手柄，刀片防护罩改进
公开(公告)号：US08671581B2
公开(公告)日：2014-03-18
申请号：US13455495
申请日：2012-04-25
申请人： Lance D. Crain , Tan D. Nguyen
发明人： Lance D. Crain , Tan D. Nguyen
IPC分类号： B23D45/16
CPC分类号： B27B9/02 , B27B5/08 , Y10T83/546
摘要： An undercut saw including a motor, a drive shaft rotated by the motor, a blade mount mechanically linked to the drive shaft, the blade mount allowing a saw blade to be mounted and a fixed blade guard circumscribing a portion of the saw blade. The fixed blade guard includes a top plate and a height adjustment skirt in telescoping attachment joined by fasteners. A guide washer with a fastener assembly is configured to move up and down in a slot on the height adjustment skirt. Turning a lead threaded member raises and lowers the top plate.
摘要翻译：包括马达的底切锯，由马达旋转的驱动轴，与驱动轴机械连接的刀片安装件，允许锯片安装的刀片安装件和围绕锯片的一部分的固定刀片防护罩。固定刀片防护罩包括顶板和通过紧固件连接的伸缩附件中的高度调节裙部。具有紧固件组件的导向垫圈构造成在高度调节裙部的槽中上下移动。转动导线螺纹部件会升高并降低顶板。

6. 发明授权

US07788812B2 Carpet trimmer 有权
标题翻译：地毯修剪器
公开(公告)号：US07788812B2
公开(公告)日：2010-09-07
申请号：US12030710
申请日：2008-02-13
申请人： Tan D. Nguyen , Lance D. Crain
发明人： Tan D. Nguyen , Lance D. Crain
IPC分类号： B26B5/00 , B26B29/00
CPC分类号： B26B5/005 , B26B29/06
摘要： A carpet trimmer including a base, a pair of posts mounted on said base and a handle mounted on said base. A number of spacers are inserted over the posts and secured by fasteners. A blade holder holding a pair of blades and including a blade holding face and a wall runner is inserted between two of the spacers, such that the posts fit into groove on the blade holding face. Throat adjustment holes on said spacers receive dimples on the blade holder to allow throat adjustment.
摘要翻译：一种地毯修剪器，包括基座，安装在所述基座上的一对柱和安装在所述基座上的手柄。多个间隔件插入柱上并用紧固件固定。保持一对刀片并且包括刀片保持面和壁流道的刀片保持器插入在两个间隔件之间，使得柱安装在刀片保持面上的槽中。所述间隔物上的喉部调节孔接收刀片保持器上的凹坑以允许喉部调节。

7. 发明申请

US20090229436A1 UNDERCUT SAW HEIGHT ADJUSTMENT, HANDLE, BLADE GUARD IMPROVEMENTS 审中-公开
标题翻译：底切高度调节，手柄，刀片保护改进
公开(公告)号：US20090229436A1
公开(公告)日：2009-09-17
申请号：US12401839
申请日：2009-03-11
申请人： Lance D. Crain , Tan D. Nguyen
发明人： Lance D. Crain , Tan D. Nguyen
IPC分类号： B26D5/00 , B23D51/01 , B27B9/04
CPC分类号： B27B9/02 , B27B5/08 , Y10T83/546
摘要： An undercut saw including a motor, a drive shaft rotated by the motor, a blade mount mechanically linked to the drive shaft, the blade mount allowing a saw blade to be mounted and a fixed blade guard circumscribing a portion of the saw blade. The fixed blade guard includes a top plate and a height adjustment skirt in telescoping attachment joined by fasteners. A guide washer including a guide washer slot runner is configured to move up and down in a slot on the height adjustment skirt.
摘要翻译：包括马达的底切锯，由马达旋转的驱动轴，与驱动轴机械连接的刀片安装件，允许锯片安装的刀片安装件和围绕锯片的一部分的固定刀片防护罩。固定刀片防护罩包括顶板和通过紧固件连接的伸缩附件中的高度调节裙部。包括导向垫圈槽流道的导向垫圈构造成在高度调节裙部的槽中上下移动。

8. 发明授权

US07722012B2 Tail section for carpet stretching tool 有权
标题翻译：地毯拉伸工具尾部
公开(公告)号：US07722012B2
公开(公告)日：2010-05-25
申请号：US12030727
申请日：2008-02-13
申请人： William Kirker , Tan D. Nguyen
发明人： William Kirker , Tan D. Nguyen
IPC分类号： B65H77/00
CPC分类号： A47G27/0493
摘要： A tail section for a carpet stretching tool. The carpet stretching tool is the type having a carpet engaging head, an elongate body, a tail section and a lever mechanism allowing extension of the elongate body. The tail section includes a first leg and a second leg, each leg having a wall running face. The legs may be selectively positioned between at least two positions. In one positions the wall running faces form a substantially flat surface allowing use of the tool down a wall section. In a second position the wall running faces on the first and second leg of the tool may be positioned at an angle to allow the tool to be used on corner locations within a room or on a post.
摘要翻译：地毯拉伸工具的尾部。地毯拉伸工具是具有地毯接合头，细长主体，尾部和允许细长主体延伸的杠杆机构的类型。尾部包括第一腿部和第二腿部，每个腿部具有壁面运动面。腿可以选择性地定位在至少两个位置之间。在一个位置中，壁面运行面形成基本平坦的表面，允许将工具沿壁部分使用。在第二位置，工具的第一和第二腿上的壁面可以以一定角度定位，以允许工具在房间或柱子的角落位置上使用。

9. 发明授权

US07571806B2 Case for vinyl roller tool 有权
标题翻译：乙烯基辊道工具箱
公开(公告)号：US07571806B2
公开(公告)日：2009-08-11
申请号：US11679662
申请日：2007-02-27
申请人： Lance D. Crain , Tan D. Nguyen
发明人： Lance D. Crain , Tan D. Nguyen
IPC分类号： B65D85/20
CPC分类号： B25H3/006
摘要： A rolling tool case for holding and transporting a tool. The case includes two sections which are joined to enclose the tool body in an interior cavity. The handle of the tool extends through an opening hole in the top of the case. The tool's handle may be gripped to roll the tool over a surface, reducing the needed size of the tool case. Wheels on the bottom of one of the two sections allow the case to roll.
摘要翻译：用于保持和运输工具的滚动工具箱。壳体包括两个部分，其连接以将工具主体包围在内部空腔中。工具的手柄延伸穿过外壳顶部的开孔。可以抓住工具的手柄以将工具滚动在表面上，从而减少工具箱的所需尺寸。两个部分之一的底部上的轮子允许情况滚动。

10. 发明授权

US07356932B1 Carpet trimmer 有权
标题翻译：地毯修剪器
公开(公告)号：US07356932B1
公开(公告)日：2008-04-15
申请号：US11106419
申请日：2005-04-14
申请人： Tan D. Nguyen , Lance D. Crain
发明人： Tan D. Nguyen , Lance D. Crain
IPC分类号： B26B5/00 , B26B29/00
CPC分类号： B26B5/005 , B26B29/06
摘要： A carpet trimmer including a base, a pair of posts mounted on said base and a handle mounted on said base. A number of spacers are inserted over the posts and secured by fasteners. A blade holder holding a pair of blades and including a blade holding face and a wall runner is inserted between two of the spacers, such that the posts fit into groove on the blade holding face. Throat adjustment holes on said spacers receive dimples on the blade holder to allow throat adjustment.
摘要翻译：一种地毯修剪器，包括基座，安装在所述基座上的一对柱和安装在所述基座上的手柄。多个间隔件插入柱上并用紧固件固定。保持一对刀片并且包括刀片保持面和壁流道的刀片保持器插入在两个间隔件之间，使得柱安装在刀片保持面上的槽中。所述间隔物上的喉部调节孔接收刀片保持器上的凹坑以允许喉部调节。

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