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1. 发明授权

US07949409B2 Dual spiral lead configurations 有权
标题翻译：双螺旋引线配置
公开(公告)号：US07949409B2
公开(公告)日：2011-05-24
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil, Jr. , Brendan E. Koop
IPC分类号： A61N1/00 , A61B18/04
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

2. 发明申请

US20080183254A1 DUAL SPIRAL LEAD CONFIGURATIONS 有权
标题翻译：双螺旋引导配置
公开(公告)号：US20080183254A1
公开(公告)日：2008-07-31
申请号：US11668887
申请日：2007-01-30
申请人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
发明人： Mark J. Bly , Anthony V. Caparso , Randy W. Westlund , Ronald W. Heil , Brendan Koop
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0558 , A61N1/36114
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes a bifurcated distal portion including a first elongate member forming a first spiral and a second elongate member forming a second spiral. The spirals can be in parallel or serial alignment with one another.
摘要翻译：描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。引线包括分叉的远端部分，其包括形成第一螺旋的第一细长构件和形成第二螺旋的第二细长构件。螺旋可以彼此平行或串联对准。

3. 发明申请

US20080228194A1 METHOD AND APPARATUS FOR ENDOSCOPIC ACCESS TO THE VAGUS NERVE 有权
标题翻译： VAGUS神经内窥镜获取的方法和装置
公开(公告)号：US20080228194A1
公开(公告)日：2008-09-18
申请号：US11685476
申请日：2007-03-13
申请人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
发明人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
IPC分类号： A61N1/02
CPC分类号： A61N1/0556 , A61B17/3468
摘要： An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described.
摘要翻译：用于在迷走神经区域中执行微创外科手术的装置包括套管，内窥镜解剖工具和可滑动地设置在套管腔中的支架组件。支架组件包括C形环，设置在C形环的外表面上的电极套，以及展开装置。当使用展开装置从C形环展开时，电极套套适于围绕目标神经区域或神经分支进行包围。还描述了执行微创外科手术的方法。

4. 发明授权

US07819883B2 Method and apparatus for endoscopic access to the vagus nerve 有权
标题翻译：用于内窥镜进入迷走神经的方法和装置
公开(公告)号：US07819883B2
公开(公告)日：2010-10-26
申请号：US11685476
申请日：2007-03-13
申请人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
发明人： Randy W. Westlund , David J. Smith , Mark J. Bly , Anthony V. Caparso
IPC分类号： A61N1/02
CPC分类号： A61N1/0556 , A61B17/3468
摘要： An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described.
摘要翻译：用于在迷走神经区域中执行微创外科手术的装置包括套管，内窥镜解剖工具和可滑动地设置在套管腔中的支架组件。支架组件包括C形环，设置在C形环的外表面上的电极套，以及展开装置。当使用展开装置从C形环展开时，电极套套适于围绕目标神经区域或神经分支进行包围。还描述了执行微创外科手术的方法。

5. 发明授权

US07966076B2 Lead and apparatus for stimulation of the cardiac plexus 失效
标题翻译：用于刺激心脏丛的铅和器械
公开(公告)号：US07966076B2
公开(公告)日：2011-06-21
申请号：US11685511
申请日：2007-03-13
申请人： Randy W. Westlund , Anthony V. Caparso
发明人： Randy W. Westlund , Anthony V. Caparso
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A medical electrical lead adapted to stimulate a patient's cardiac plexus includes a flexible distal portion having a surface adapted to conform to an outer surface of an aortic region generally associated with the cardiac plexus. The distal portion can have one or more elongate members. Alternatively, the distal portion can have a generally planar portion. The distal portion is flexible such that it can be furled or otherwise compacted such that it can be delivered to a target stimulation site using a guide catheter or other delivery tool, such as a cannula.
摘要翻译：适于刺激患者心脏丛的医用电线包括柔性远端部分，其具有适于与通常与心脏神经丛相关的主动脉瓣区域的外表面的表面。远端部分可以具有一个或多个细长构件。或者，远端部分可以具有大致平坦的部分。远侧部分是柔性的，使得其可以被卷曲或以其他方式压实，使得其可以使用导管或其它输送工具（例如套管）被输送到目标刺激部位。

6. 发明申请

US20080228252A1 LEAD AND APPARATUS FOR STIMULATION OF THE CARDIAC PLEXUS 失效
标题翻译：用于刺激心脏病的铅和装置
公开(公告)号：US20080228252A1
公开(公告)日：2008-09-18
申请号：US11685511
申请日：2007-03-13
申请人： Randy W. Westlund , Anthony V. Caparso
发明人： Randy W. Westlund , Anthony V. Caparso
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A medical electrical lead adapted to stimulate a patient's cardiac plexus includes a flexible distal portion having a surface adapted to conform to an outer surface of an aortic region generally associated with the cardiac plexus. The distal portion can have one or more elongate members. Alternatively, the distal portion can have a generally planar portion. The distal portion is flexible such that it can be furled or otherwise compacted such that it can be delivered to a target stimulation site using a guide catheter or other delivery tool, such as a cannula.
摘要翻译：适于刺激患者心脏丛的医用电线包括柔性远端部分，其具有适于与通常与心脏神经丛相关的主动脉瓣区域的外表面的表面。远端部分可以具有一个或多个细长构件。或者，远端部分可以具有大致平坦的部分。远侧部分是柔性的，使得其可以被卷曲或以其他方式压实，使得其可以使用导管或其它输送工具（例如套管）被输送到目标刺激部位。

7. 发明授权

US08630716B2 Systems and methods for providing neural stimulation transitions 有权
标题翻译：用于提供神经刺激过渡的系统和方法
公开(公告)号：US08630716B2
公开(公告)日：2014-01-14
申请号：US13587654
申请日：2012-08-16
申请人： Marina V. Brockway , Paul A. Haefner , Anthony V. Caparso , Wondimeneh Tesfayesus
发明人： Marina V. Brockway , Paul A. Haefner , Anthony V. Caparso , Wondimeneh Tesfayesus
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.
摘要翻译：方法实施例包括产生用于神经刺激治疗的神经刺激信号。在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现了升温协议和斜降协议两者。加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

8. 发明授权

US08509906B2 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 有权
标题翻译：用于产生用于治疗疼痛和/或其他患者病症的异步神经反应的系统和方法
公开(公告)号：US08509906B2
公开(公告)日：2013-08-13
申请号：US13544727
申请日：2012-07-09
申请人： Andre B. Walker , Zi-Ping Fang , Anthony V. Caparso
发明人： Andre B. Walker , Zi-Ping Fang , Anthony V. Caparso
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译：公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致对电信号的异步感觉神经元响应。

9. 发明授权

US08494641B2 Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism 有权
标题翻译：可植入神经刺激器，具有整体密封电子外壳，电路基板，单片馈通，引线组件和锚定机构
公开(公告)号：US08494641B2
公开(公告)日：2013-07-23
申请号：US12765712
申请日：2010-04-22
申请人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
发明人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
IPC分类号： A61N1/34
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫，脑血管疾病，自身免疫性疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板一体化的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

10. 发明授权

US08457734B2 System and method for neural stimulation 有权
公开(公告)号：US08457734B2
公开(公告)日：2013-06-04
申请号：US11468135
申请日：2006-08-29
申请人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
发明人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

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