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1. 发明申请

US20140207220A1 Implantable Neurostimulator with Integral Hermetic Electronic Enclosure, Circuit Substrate, Monolithic Feed-Through, Lead Assembly and Anchoring Mechanism 审中-公开
标题翻译：具有整体密封电子外壳，电路基板，整体馈通，引线组装和锚定机构的植入式神经刺激器
公开(公告)号：US20140207220A1
公开(公告)日：2014-07-24
申请号：US14223765
申请日：2014-03-24
申请人： Carl Lance BOLING , Benjamin David PLESS , Ryan POWELL , Anthony V. CAPARSO
发明人： Carl Lance BOLING , Benjamin David PLESS , Ryan POWELL , Anthony V. CAPARSO
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫症，脑血管疾病，自身免疫疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板成一体的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

2. 发明授权

US08190270B2 Refillable reservoir lead systems 有权
标题翻译：可补充油箱引导系统
公开(公告)号：US08190270B2
公开(公告)日：2012-05-29
申请号：US13347675
申请日：2012-01-10
申请人： Brett M. Wingeier , Martha Morrell , Carl Lance Boling
发明人： Brett M. Wingeier , Martha Morrell , Carl Lance Boling
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0536 , A61N1/0568
摘要： Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.
摘要翻译：描述医用电引线系统及相关方法。医疗电引线系统可以被配置为至少部分地植入受试者的身体。医疗电引线系统的一些变型可以包括引线主体，引线主体包括近端和远端以及至少部分延伸到其间的内腔，在引线主体的远端附近的至少一个电极和与内腔流体连通，其中储存器位于从引线主体的远端移除的位置。医疗电引线系统的某些变型可以包括引线本体，该引线主体包括近端和远端以及至少部分地延伸的第一和第二内腔以及在引线主体的远端附近的至少一个电极。

3. 发明申请

US20160008608A1 IMPLANTABLE NEUROSTIMULATOR WITH INTEGRAL HERMETIC ELECTRONIC ENCLOSURE, CIRCUIT SUBSTRATE, MONOLITHIC FEED-THROUGH, LEAD ASSEMBLY AND ANCHORING MECHANISM 审中-公开
标题翻译：具有集成电磁外壳，电路基板，单片式馈电，导线组装和锚固机构的可植入神经元
公开(公告)号：US20160008608A1
公开(公告)日：2016-01-14
申请号：US14858904
申请日：2015-09-18
申请人： Carl Lance BOLING , Benjamin David PLESS , Ryan POWELL , Anthony V. CAPARSO
发明人： Carl Lance BOLING , Benjamin David PLESS , Ryan POWELL , Anthony V. CAPARSO
IPC分类号： A61N1/375 , A61N1/378 , A61N1/372 , A61N1/05 , A61N1/36
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫症，脑血管疾病，自身免疫疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板成一体的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

4. 发明申请

US20130296993A1 Implantable Neurostimulator with Integral Hermetic Electronic Enclosure, Circuit Substrate, Monolithic Feed-Through, Lead Assembly and Anchoring Mechanism 有权
标题翻译：具有整体密封电子外壳，电路基板，整体馈通，引线组装和锚定机构的植入式神经刺激器
公开(公告)号：US20130296993A1
公开(公告)日：2013-11-07
申请号：US13939068
申请日：2013-07-10
申请人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
发明人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
IPC分类号： A61N1/05
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫症，脑血管疾病，自身免疫疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板成一体的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

5. 发明申请

US20130178701A1 Integrated Delivery and Visualization Tool for a Neuromodulation System 有权
标题翻译：用于神经调节系统的综合交付和可视化工具
公开(公告)号：US20130178701A1
公开(公告)日：2013-07-11
申请号：US13784452
申请日：2013-03-04
申请人： Benjamin David Pless , Carl Lance Boling , Anthony V. Caparso
发明人： Benjamin David Pless , Carl Lance Boling , Anthony V. Caparso
IPC分类号： A61B1/018
CPC分类号： A61B1/07 , A61B1/00135 , A61B1/00154 , A61B1/00165 , A61B1/015 , A61B1/018 , A61B1/042 , A61B1/313 , A61N1/36071 , A61N1/36082 , A61N1/36114 , A61N1/37205
摘要： Methods and apparatus for delivering a neurostimulator to a target tissue are provided which may include any number of features. One feature is a delivery tool comprising a handle portion, an elongate shaft comprising a contoured distal portion, a visualization system embedded in the elongate shaft, and an insertion groove on the elongate shaft configured to deploy the neurostimulator. The contoured distal portion can be shaped and configured to maintain contact with a posterior maxilla and elevate a periosteum off of the posterior maxilla to avoid soft tissue dissection. In some embodiments, the neurostimulator is implanted in close proximity to or touching the sphenopalatine ganglion.
摘要翻译：提供了将神经刺激器递送到目标组织的方法和装置，其可以包括任何数量的特征。一个特征是递送工具，其包括手柄部分，细长轴，其包括轮廓远端部分，嵌入在细长轴中的可视化系统，以及细长轴上的插入槽，其构造成展开神经刺激器。轮廓远端部分可以被成形和构造成保持与后上颌骨的接触并且将骨膜从后上颌骨上提升以避免软组织解剖。在一些实施例中，将神经刺激器植入到邻近或接触蝶腭神经节。

6. 发明授权

US08311632B2 Devices, methods, and systems for harvesting energy in the body 有权
标题翻译：用于在体内收获能量的装置，方法和系统
公开(公告)号：US08311632B2
公开(公告)日：2012-11-13
申请号：US12392938
申请日：2009-02-25
申请人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
发明人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
IPC分类号： A61N1/00
CPC分类号： A61N1/3785 , H02N2/18 , H02N11/002
摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.
摘要翻译：在一些实施例中，描述了用于将机械能转换成电能的功率发生器可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩通过从两个相邻组织层施加到可压缩元件的力。

7. 发明申请

US20120277761A1 SURGICAL TOOLS TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA 有权
标题翻译：手术工具，以便将神经调节剂输送到PASGGALALATINE FOSSA
公开(公告)号：US20120277761A1
公开(公告)日：2012-11-01
申请号：US13470480
申请日：2012-05-14
申请人： Carl Lance Boling , Anthony V. Caparso , Francis A. Papay , Ryan Powell , Jennifer Teng , Morgan Clyburn
发明人： Carl Lance Boling , Anthony V. Caparso , Francis A. Papay , Ryan Powell , Jennifer Teng , Morgan Clyburn
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61B17/3468 , A61B17/02 , A61B17/0218 , A61B17/24 , A61B17/3211 , A61B2017/320052 , A61N1/0526 , A61N1/0548 , A61N1/0551 , A61N1/36075 , A61N1/37205 , A61N1/375
摘要： A surgical tool configured to facilitate delivery of a neurostimulator to a craniofacial region of a subject includes a handle portion, an elongate shaft having a contoured distal portion, and an insertion groove on the elongate shaft. The elongate shaft is configured to be advanced under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa. The distal portion includes a distal dissecting tip. The insertion groove is configured to receive, support, and guide a medical device or instrument.
摘要翻译：构造成便于将神经刺激器递送到受试者的颅面区域的手术工具包括手柄部分，具有轮廓远侧部分的细长轴和细长轴上的插入槽。细长轴构造成沿着上颌骨结节朝向翼腭窝向下延伸到z骨下方。远侧部分包括远端解剖尖端。插入槽被构造成接收，支撑和引导医疗装置或器械。

8. 发明申请

US20110041382A1 Fly-safe, fly patch 审中-公开
标题翻译：飞安全，飞贴
公开(公告)号：US20110041382A1
公开(公告)日：2011-02-24
申请号：US12806789
申请日：2010-08-20
申请人： Carl Lance Boling
发明人： Carl Lance Boling
IPC分类号： A01K97/06
CPC分类号： A01K97/06
摘要： A fly-safe fly patch for containing and drying fishing flies having an outer injection molded cover, an inner injection molded telescoping capsule, and a gate when actuated provides access to an internal storage chamber within the fly patch's capsule. The fly patch is sized such that the fly patch may be actuated with a single hand, the thumb and forefingers. The fly patch is constructed such that the described means for actuating exposes a gate in the sidewall accessing the inner storage chamber and when manual compression is removed the gate in the sidewall automatically shuts providing a safe, loss free environment for the fishing flies. The fly patch is shaped to avoid entanglement with brush and other accessories used during angling as well as include a fixation apparatus for attaching the fly-patch to a fly-fishing vest or other articles during angling.
摘要翻译：用于容纳和干燥具有外部注射成型盖，内部注射成型伸缩胶囊和门的捕蝇蝇的飞行安全飞行补片提供对飞斑胶囊内的内部储存室的通路。尺寸使得飞行补片的尺寸可以用单手，拇指和食指来致动。飞行补片被构造成使得所描述的用于致动的装置暴露出进入内部存储室的侧壁中的门，并且当手动压缩被去除时，侧壁中的门自动关闭，为钓鱼提供安全，无损的环境。飞片的形状是为了避免在钓鱼期间使用的刷子和其他附件的缠结，并且包括用于在钓鱼时将飞行补片附接到飞钓背心或其他物品的固定装置。

9. 发明申请

US20090216292A1 DEVICES, METHODS, AND SYSTEMS FOR HARVESTING ENERGY IN THE BODY 有权
标题翻译：用于收集身体能量的装置，方法和系统
公开(公告)号：US20090216292A1
公开(公告)日：2009-08-27
申请号：US12392938
申请日：2009-02-25
申请人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
发明人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
IPC分类号： A61N1/378 , H02K7/18 , H02N11/00 , H02N2/18
CPC分类号： A61N1/3785 , H02N2/18 , H02N11/002
摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.
摘要翻译：在一些实施例中，描述了用于将机械能转换成电能的功率发生器可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩通过从两个相邻组织层施加到可压缩元件的力。

10. 发明授权

US09550057B2 Surgical guide and method for guiding a therapy delivery device into the pterygopalatine fossa 有权
标题翻译：用于将治疗输送装置引导到翼腭窝的手术指南和方法
公开(公告)号：US09550057B2
公开(公告)日：2017-01-24
申请号：US13397060
申请日：2012-02-15
申请人： Francis A. Papay , Carl Lance Boling
发明人： Francis A. Papay , Carl Lance Boling
IPC分类号： A61N1/05 , A61B17/24 , A61N1/36 , A61B17/02 , A61B17/3211 , A61B17/32
CPC分类号： A61N1/0548 , A61B17/02 , A61B17/24 , A61B17/3211 , A61B2017/320052 , A61N1/0526 , A61N1/0558 , A61N1/36057 , A61N1/3606
摘要： A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces.
摘要翻译：用于促进将治疗递送装置递送到受试者的翼腭窝的手术引导件包括具有远端部分，近端部分和在远端部分和近端部分之间延伸的中间部分的曲线体。近端部分由相对设置的第一和第二表面限定。近端部分和中间部分限定在近端部分和远端部分之间延伸的纵向平面。远端部分具有相对于纵向平面的弧形构造，并且由相对设置的第三和第四表面限定。

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