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1. 发明授权

US5849764A Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US5849764A
公开(公告)日：1998-12-15
申请号：US760817
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号： C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号： C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

2. 发明授权

US5780437A Antagonists of gonadotropin releasing hormone 失效
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：US5780437A
公开(公告)日：1998-07-14
申请号：US760816
申请日：1996-12-05
申请人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
发明人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
IPC分类号： C07D20060101 , C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08 , A61K38/00 , A61K31/40 , A61K31/54
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗两种男性中各种性激素相关和其他病症和妇女。

3. 发明授权

US06200957B1 Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US06200957B1
公开(公告)日：2001-03-13
申请号：US09115497
申请日：1998-07-14
申请人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
发明人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
IPC分类号： C07D20910
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

4. 发明授权

US5756507A Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US5756507A
公开(公告)日：1998-05-26
申请号：US760851
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
发明人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
IPC分类号： C07D209/14 , C07D209/16 , A61K31/405 , A61K31/495 , C07D209/10 , C07D403/06
CPC分类号： C07D209/14 , C07D209/16
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

5. 发明授权

US6156767A Antagonists of gonadotropin releasing hormone 失效
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：US6156767A
公开(公告)日：2000-12-05
申请号：US83477
申请日：1998-05-22
申请人： Mark Goulet , Matthew J. Wyvratt, Jr. , Peter Lin , Lin Chu , Narindar N. Girotra
发明人： Mark Goulet , Matthew J. Wyvratt, Jr. , Peter Lin , Lin Chu , Narindar N. Girotra
IPC分类号： C07D401/12 , C07D401/14 , C07D487/08 , C07D217/00 , A61K31/56 , C07D215/12 , C07D401/00
CPC分类号： C07D401/14 , C07D401/12 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。

6. 发明授权

US5726319A Biphenyl substituted dipeptide analogs promote release of growth hormone 失效
标题翻译：联苯取代的二肽类似物促进生长激素的释放
公开(公告)号：US5726319A
公开(公告)日：1998-03-10
申请号：US510026
申请日：1995-08-01
申请人： Peter Lin , William R. Schoen , Judith M. Pisano , Matthew J. Wyvratt
发明人： Peter Lin , William R. Schoen , Judith M. Pisano , Matthew J. Wyvratt
IPC分类号： A61K38/00 , C07C275/24 , C07D257/04 , C07K5/06 , C07D257/00
CPC分类号： C07D257/04 , C07C275/24 , C07K5/06026 , C07K5/06191 , A61K38/00
摘要： There are disclosed certain compounds identified as substituted dipeptide analogs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such substituted dipeptide analogs as the active ingredient thereof are also disclosed.
摘要翻译：公开了鉴定为取代的二肽类似物的某些化合物，其促进人和动物中生长激素的释放。该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。还公开了含有这种取代的二肽类似物作为其活性成分的生长促进组合物。

7. 发明申请

US20090253655A1 QUINOLINONE FARNESYL TRANSFERASE INHIBITORS FOR THE TREATMENT OF SYNUCLEINOPATHIES AND OTHER INDICATIONS 失效
标题翻译：喹诺酮转运酶抑制剂治疗综合征及其他症状
公开(公告)号：US20090253655A1
公开(公告)日：2009-10-08
申请号：US12402910
申请日：2009-03-12
申请人： Peter T. Lansbury, JR. , Craig J. Justman , Ross A. Fredenburg , Robin Kate Meray , Mark E. Duggan , Peter Lin
发明人： Peter T. Lansbury, JR. , Craig J. Justman , Ross A. Fredenburg , Robin Kate Meray , Mark E. Duggan , Peter Lin
IPC分类号： A61K31/675 , C12N5/02 , A61K31/47 , C07F9/06 , C07D215/00 , C07D401/02 , C07D409/04 , C07D401/14
CPC分类号： C07F9/65583 , C07D215/36 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/14
摘要： Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety.The treatment including administering to a subject a therapeutically effective amount of an inventive farnesyl transferase inhibitor compound.
摘要翻译：提供了新的喹啉酮法呢基转移酶抑制剂。这些新化合物可用于治疗或预防突触核蛋白病，如帕金森病，弥漫性路易体病，多系统萎缩，脑铁浓度紊乱，包括泛酸激酶相关神经变性（如PANK1）或其他神经变性/神经系统疾病疾病提供的化合物也可用于治疗增殖性疾病如癌症，以及治疗诸如认知障碍，抑郁和焦虑的神经疾病。治疗包括向受试者施用治疗有效量的本发明的法呢基转移酶抑制剂化合物。

8. 发明申请

US20090171903A1 Business Rules Externalization System 审中-公开
标题翻译：业务规则外部化系统
公开(公告)号：US20090171903A1
公开(公告)日：2009-07-02
申请号：US11966993
申请日：2007-12-29
申请人： Peter Lin , Eric Gelman
发明人： Peter Lin , Eric Gelman
IPC分类号： G06F17/30 , G06F21/00
CPC分类号： G06F21/604
摘要： A business rules externalization system is provided for centrally storing, compiling, and distributing computer readable business rules employed by a plurality of multi-tiered applications executing the rules in native application code. The system includes a rule database for centrally storing the rules in a standardized format, including multiple versions of a given rule or set of rules. The rule externalization system employs a rule object module to declare and store the rules in a standardized format. When an application encounters a trigger point, it interfaces with a rule object module to request the desired rules. The rule object module queries the rule database for the appropriate version of the requested rules and passes the standardized rules to a compiler module. The rule compiler module translates each rule into application-specific computer executable code or format and returns native code-based rules to the rule object module for transmission to the calling application.
摘要翻译：提供业务规则外部化系统用于集中存储，编译和分发由本机应用程序代码执行规则的多个多层应用程序采用的计算机可读业务规则。该系统包括用于以规范格式集中存储规则的规则数据库，包括给定规则或一组规则的多个版本。规则外部化系统采用规则对象模块以规范格式声明和存储规则。当应用程序遇到触发点时，它与规则对象模块接口以请求所需的规则。规则对象模块向规则数据库查询所请求规则的适当版本，并将标准化规则传递给编译器模块。规则编译器模块将每个规则转换为应用程序特定的计算机可执行代码或格式，并将原生的基于代码的规则返回给规则对象模块以传输到调用应用程序。

9. 发明申请

US20080157580A1 BODY-SUPPORTING DEVICE 有权
标题翻译：身体支持装置
公开(公告)号：US20080157580A1
公开(公告)日：2008-07-03
申请号：US11618322
申请日：2006-12-29
申请人： Peter Lin
发明人： Peter Lin
IPC分类号： A47C7/02 , A47C7/36
CPC分类号： A47C7/282 , A47C31/023
摘要： A body-supporting device includes a tray, a net and a frame. The tray includes a margin and a groove in the margin. The groove gets narrower downwardly. The net includes a margin. The frame includes a first rib for inserting the margin of the net into the groove of the tray and a second rib for pressing the margin of the net against the margin of the tray. The first rib gets narrower downwardly. Fasteners are driven into the first rib of the frame through the margin of the tray. The sandwiching of the margin of the net between the first rib of the frame and the margin of the tray gets firmer as the fasteners get tighter in the first rib of the frame.
摘要翻译：身体支撑装置包括托盘，网和框架。托盘包括边缘和边缘中的凹槽。凹槽向下变窄。净额包括利润。框架包括用于将网的边缘插入托盘的凹槽中的第一肋和用于将网的边缘压靠在托盘的边缘上的第二肋。第一肋骨向下变窄。紧固件通过托盘的边缘被驱动到框架的第一肋中。当框架的第一肋处的紧固件变得更紧时，将框架的边缘夹在框架的第一肋和托盘的边缘之间变得更坚固。

10. 发明申请

US20070078098A1 Anti-hypercholesterolemic compounds 失效
标题翻译：抗高胆固醇血症化合物
公开(公告)号：US20070078098A1
公开(公告)日：2007-04-05
申请号：US11542966
申请日：2006-10-04
申请人： Robert DeVita , Gregori Morriello , Peter Lin
发明人： Robert DeVita , Gregori Morriello , Peter Lin
IPC分类号： A61K31/7052 , A61K31/397 , C07D205/02 , C07D205/00
CPC分类号： C07D205/08 , C07D405/10
摘要： This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译：本发明提供式I的胆固醇吸收抑制剂及其药学上可接受的盐和酯。该化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。

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