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1. 发明申请

US20050102178A1 Systems and methods for generating multiple revenue streams involving the use of an integrated appliance 审中-公开
标题翻译：用于生成涉及使用集成设备的多个收入流的系统和方法
公开(公告)号：US20050102178A1
公开(公告)日：2005-05-12
申请号：US10703967
申请日：2003-11-07
申请人： Daniel Phillips , Mark Goodman , David Hostetter , Donny McDonald
发明人： Daniel Phillips , Mark Goodman , David Hostetter , Donny McDonald
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q30/0233 , G06Q30/0251
摘要： Systems for generating multiple revenue streams are provided. One such system includes an integrated appliance that incorporates a display. The integrated appliance is operative to display content to a user via the display and provide the user with passthrough communication connectivity so that the user can interconnect a computing device to the integrated appliance and be provided with at least one of passthrough telephone network access and passthrough Internet access. Methods also are provided.
摘要翻译：提供了生成多个收入流的系统。一个这样的系统包括集成显示器的集成设备。集成设备可操作以经由显示器向用户显示内容，并向用户提供直通通信连接性，使得用户可以将计算设备互连到集成设备，并且提供至少一个通过电话网络接入和直通式互联网访问。还提供了方法。

2. 发明授权

US6122966A Ultrasonic leak detecting lubrication apparatus and method of use 失效
标题翻译：超声波泄漏检测润滑装置及其使用方法
公开(公告)号：US6122966A
公开(公告)日：2000-09-26
申请号：US28554
申请日：1998-02-24
申请人： Mark Goodman , John R. Zeno, deceased , by Lynda J. Mabb-Zeno, executrix
发明人： Mark Goodman , John R. Zeno, deceased , by Lynda J. Mabb-Zeno, executrix
IPC分类号： G01N29/04 , F16C17/24 , F16N3/12 , F16N21/00 , F16N29/02 , G01H1/08 , G01M3/24 , G01N29/032 , G01N29/14 , G01N29/36 , H04B1/26 , G01N29/12
CPC分类号： F16C33/6625 , F16N29/02 , G01H1/08 , G01N29/032 , G01N29/14 , G01N29/36 , G01N2291/015 , G01N2291/0226 , H04B1/26
摘要： An apparatus for detecting ultrasonic energy generated by a mechanical device and for applying lubricant to the device is presented. The apparatus includes a lubrication tool, such as a grease gun, which has a lubrication delivery element for delivering lubrication to the mechanical device. An ultrasonic transducer is contained in a housing which is removably attached to the outside of the lubrication delivery element such that the transducer makes acoustical contact with the lubrication tool. An electrical circuit, which may be attached to the lubrication device, produces an output signal which indicates the magnitude of detected ultrasonic energy. A method using such an ultrasonic energy detector in conjunction with a lubrication tool to detect the condition of a sealed mechanical rotating device and to determine when sufficient lubricant has been applied is also presented.
摘要翻译：本发明提供了一种用于检测机械装置产生的超声波能量和用于向装置施加润滑剂的装置。该装置包括润滑工具，例如油脂枪，其具有用于将润滑输送到机械装置的润滑输送元件。超声换能器被容纳在壳体中，壳体可移除地附接到润滑输送元件的外部，使得换能器与润滑工具进行声学接触。可以附接到润滑装置的电路产生指示检测到的超声能量的大小的输出信号。还提出了一种使用这种超声波能量检测器与润滑工具结合以检测密封的机械旋转装置的状况并确定什么时候已经施加足够的润滑剂的方法。

3. 发明授权

US4823600A Ultrasonic transducer and current loop transmitter 失效
标题翻译：超声波换能器和电流回路变送器
公开(公告)号：US4823600A
公开(公告)日：1989-04-25
申请号：US118221
申请日：1987-11-05
申请人： Michael Biegel , Mark Goodman
发明人： Michael Biegel , Mark Goodman
IPC分类号： G01D3/024 , G01H3/10 , G01H17/00 , G01M3/24 , H01H9/50 , H01H33/26 , H03G3/20 , H04B17/00 , G01N29/04
CPC分类号： G01M3/243
摘要： Ultrasonic vibrations indicating trouble at remote locations are detected by sensors spaced in the vinicity of expected trouble. These sensors have weather resistant transducers that convert ultrasonic vibrations from a leak in a conduit, electrical arc, bearing vibration or the like, into an electrical signal. In the sensor there are circuits that amplify the electrical signal and transmit it with a current loop transmission system over a twisted pair of wires to a central control and analysis computer. The amplification of the signal at the sensor is controlled by a signal from the center computer which changes the gain increments until the sensor circuits are not saturated by the ultrasonic signal. This gain control signal is also delivered to the sensors over a twisted pair of wires by current loop transmission system.

4. 发明授权

US09931017B2 Washing apparatus and method with spiral air flow for drying 有权
公开(公告)号：US09931017B2
公开(公告)日：2018-04-03
申请号：US13885227
申请日：2011-11-16
申请人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
发明人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
IPC分类号： A47L15/48 , A47K10/48 , A47L15/00 , A47L15/42 , B08B3/02 , B08B5/02
CPC分类号： A47L15/48 , A47K10/48 , A47K2210/00 , A47L15/0089 , A47L15/4242 , A47L15/486 , B08B3/024 , B08B5/02
摘要： An apparatus and method for washing and drying objects includes a rotating washing fluid sprayer having several nozzles to direct washing fluid, e.g., water, at an object being washed in a chamber. A drying fluid is directed at the object in the chamber to dry the object. The drying fluid, e.g., air, is directed in a spiral pattern against the object to urge washing liquid away from the object to dry the object and to push the drying liquid away from edges of the object. The air may be directed at the object simultaneously with the water to increase the energy with which the water impinges on the object and to urge dirt from the object being washed.

5. 发明申请

US20070082879A1 Imaging Agents 有权
标题翻译：成像剂
公开(公告)号：US20070082879A1
公开(公告)日：2007-04-12
申请号：US11425078
申请日：2006-06-19
申请人： Mark Goodman
发明人： Mark Goodman
IPC分类号： A61K31/397 , A61K31/337 , A61K31/38 , A61K31/335
CPC分类号： C07C229/48 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07C2601/04 , C07D291/04 , C07D345/00 , C07F13/005
摘要： The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled with halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. These compounds can also be labeled with technetium and rhenium isotopes using known chelation complexes. The compounds disclosed herein bind tumor tissues in vivo with high specificity and selectivity when administered to a subject. Preferred compounds show a target to non-target ratio of at least 2:1, are stable in vivo and substantially localized to target within 1 hour after administration. Preferred compounds include 1-amino-2-[18F]fluorocyclobutyl-1-carboxylic acid (2-[18F]FACBC) and 1-amino-2-[18F]fluoromethylcyclobutyl-1-carboxylic acid (2-[18F]FMACBC). The labeled amino acid compounds of the invention are useful as imaging agents in detecting and/or monitoring tumors in a subject by PET or SPECT.
摘要翻译：本发明提供了可用于检测和评估脑和体肿瘤的新型氨基酸化合物。这些化合物具有在肿瘤中快速吸收和延长保留的有利特性，并可用卤素同位素如氟-18，碘-123，碘-124，碘-125，碘-131，溴-75，溴-76 ，溴-77，溴-82，ast ine -21，ast ine -211和其他ast同位素。这些化合物也可以使用已知的螯合络合物用锝和铼同位素标记。当给予受试者时，本文所公开的化合物以高特异性和选择性在体内结合肿瘤组织。优选的化合物显示至少2:1的目标与非目标比例，在给药后1小时内在体内是稳定的并且基本上定位于靶标上。优选的化合物包括1-氨基-2 - [[18 F]氟代环丁基-1-羧酸（2 - [（18 F）FACBC））和1-氨基-2- [ F]氟甲基环丁基-1-羧酸（2- [叔丁基] FMACBC））。本发明的标记氨基酸化合物可用作通过PET或SPECT检测和/或监测受试者的肿瘤的成像剂。

6. 发明授权

US5955670A Ultrasonic leak detecting apparatus 失效
标题翻译：超声波检漏仪
公开(公告)号：US5955670A
公开(公告)日：1999-09-21
申请号：US749910
申请日：1996-11-15
申请人： Mark Goodman , John R. Zeno, deceased , Linda Mabbs, executrix
发明人： Mark Goodman , John R. Zeno, deceased , Linda Mabbs, executrix
IPC分类号： G01N29/04 , F16C17/24 , F16N3/12 , F16N21/00 , F16N29/02 , G01H1/08 , G01M3/24 , G01N29/032 , G01N29/14 , G01N29/36 , H04B1/26 , G01H17/00 , G01N29/12
CPC分类号： F16C33/6625 , F16N29/02 , G01H1/08 , G01N29/032 , G01N29/14 , G01N29/36 , G01N2291/015 , G01N2291/0226 , H04B1/26
摘要： An ultrasonic leak detector with a wide dynamic bandwidth and repeatable fixed attenuation reference points includes a transducer which receives ultrasonic energy and converts it into an electrical output signal related in intensity and frequency to the received ultrasonic energy. A high gain charge preamplifier is connected to the transducer and generates an amplified version of the transducer's electrical output signal. The amplified signal is then passed through a multi-level logarithmic attenuator having at least one fixed attenuation reference point to create an attenuated version of the detected and amplified ultrasonic signal. The output of the logarithmic attenuator is connected to a frequency shift circuit which converts the ultrasonic frequency signal into an audio frequency signal related in magnitude and frequency to the attenuated signal. The audio frequency signal is then amplified by an audio amplifier and used to drive a signal level indicator which provides an indication of the magnitude of the amplified output signal. The detector may be used with a lubrication tool to determine the amount of lubrication applied to a sealed mechanical device, such as a bearing, by detecting the decrease in received ultrasonic energy as the lubrication reaches the device. The detector may also be used to detect the increase in ultrasonic energy associated with pending mechanical failure.
摘要翻译：具有宽动态带宽和可重复的固定衰减参考点的超声波泄漏检测器包括接收超声能量并将其转换为与所接收的超声波能量相关的电输出信号的换能器。高增益电荷前置放大器连接到换能器，并产生传感器的电气输出信号的放大版本。放大的信号然后通过具有至少一个固定衰减参考点的多电平对数衰减器，以产生检测和放大的超声波信号的衰减版本。对数衰减器的输出连接到频移电路，该频移电路将超声波频率信号转换成与衰减信号相关的音频和频率的音频信号。音频信号然后被音频放大器放大，并用于驱动提供放大的输出信号幅度的指示的信号电平指示器。检测器可以与润滑工具一起使用，以通过检测在润滑到达设备时接收到的超声能量的减少来确定施加到密封的机械装置（例如轴承）上的润滑量。检测器也可用于检测与待机械故障相关联的超声能量的增加。

7. 再颁专利

USRE33977E Ultrasonic leak detecting method and apparatus 失效
公开(公告)号：USRE33977E
公开(公告)日：1992-06-30
申请号：US349180
申请日：1989-05-09
申请人： Mark Goodman , John R. Zeno , Marty Borruso
发明人： Mark Goodman , John R. Zeno , Marty Borruso
IPC分类号： G01M3/24 , G01N29/22 , G01N29/34 , G01N29/36
CPC分类号： G01N29/34 , G01M3/24 , G01N29/22 , G01N29/36 , G01N2291/02433
摘要： Leaks or thin spots in containers, as well as mechanical faults, e.g. worn bearings, are detected by an ultrasonic energy indicator that includes a modulator that heterodynes ultrasonic signals received by a transducer and creates an audio signal related thereto. The transducer includes a series arrangement of piezoelectric crystals feeding a field-effect transistor amplifier and the modulator operates in an amplitude modulation, suppressed-carrier mode which can be stabilized by a feedback loop. For indicating the presence of the audio signal, either headphones or a meter or both are employed. When leaks in a container are being detected, an ultrasonic generator is used which varies its output frequency slowly over a band of frequencies. The leak detection technique can be improved by applying a thin layer of a liquid to the container surface so that pressure introduced into the container causes the formation and bursting of bubbles in the liquid that results in the production of ultrasonic energy.

8. 发明申请

US20130233355A1 WASHING APPARATUS AND METHOD WITH SPIRAL AIR FLOW FOR DRYING 有权
标题翻译：用于干燥的螺旋空气流的洗涤装置和方法
公开(公告)号：US20130233355A1
公开(公告)日：2013-09-12
申请号：US13885227
申请日：2011-11-16
申请人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
发明人： Martin A. Alpert , Mark Goodman , Charles H. Smoot
IPC分类号： A47L15/48
CPC分类号： A47L15/48 , A47K10/48 , A47K2210/00 , A47L15/0089 , A47L15/4242 , A47L15/486 , B08B3/024 , B08B5/02
摘要： An apparatus and method for washing and drying objects includes a rotating washing fluid sprayer having several nozzles to direct washing fluid, e.g., water, at an object being washed in a chamber. A drying fluid is directed at the object in the chamber to dry the object. The drying fluid, e.g., air, is directed in a spiral pattern against the object to urge washing liquid away from the object to dry the object and to push the drying liquid away from edges of the object. The air may be directed at the object simultaneously with the water to increase the energy with which the water impinges on the object and to urge dirt from the object being washed.
摘要翻译：用于洗涤和干燥物体的装置和方法包括旋转的洗涤液喷雾器，其具有若干喷嘴，以在待洗涤的物体在室中引导洗涤流体，例如水。将干燥流体引导到室中的物体以干燥物体。干燥流体例如空气以螺旋图案被引导到物体上以将清洗液体从物体推出以干燥物体并将干燥液体推离物体的边缘。空气可以与水同时地引导到物体上，以增加水撞击在物体上的能量，并且促使来自被洗涤物体的污物。

9. 发明申请

US20060292073A1 Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging 审中-公开
标题翻译：用于肿瘤成像的氨基酸类似物的立体选择性合成
公开(公告)号：US20060292073A1
公开(公告)日：2006-12-28
申请号：US11425051
申请日：2006-06-19
申请人： Mark Goodman , Weiping Yu
发明人： Mark Goodman , Weiping Yu
IPC分类号： A61K51/00 , C07F13/00 , C07D345/00 , C07C61/04
CPC分类号： C07D235/02 , A61K51/04 , A61K51/0402 , C07C61/04 , C07C227/20 , C07C233/81 , C07C233/84 , C07C271/24 , C07C303/28 , C07C2601/04 , C07C2601/14 , C07C309/73 , C07C229/48 , C07C309/65
摘要： The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.
摘要翻译：放射性标记的非天然氨基酸1-氨基-3-环丁烷-1-羧酸（ACBC）及其类似物是用于正电子发射断层扫描和单光子发射计算机断层摄影的候选肿瘤成像剂，由于它们对肿瘤细胞的选择性亲和力。本发明提供了立体选择性合成syn-ACBC类似物的方法。所公开的合成策略是可靠和有效的，并且可以用于合成一定数量的ACBC类似物，特别是顺式 - [F 18 F] -1-氨基-3-氟环丁烷的各种顺式异构体 -1-羧酸（FACBC）和顺式 - [123 I] -1-氨基-3-碘代环丁烷-1-羧酸（IACBC）酸类似物。

10. 发明申请

US20050192458A1 Tumor imaging compounds 有权
标题翻译：肿瘤成像化合物
公开(公告)号：US20050192458A1
公开(公告)日：2005-09-01
申请号：US10507221
申请日：2003-04-24
申请人： Mark Goodman , Jonathan McConathy
发明人： Mark Goodman , Jonathan McConathy
IPC分类号： G01T1/161 , A61K51/00 , A61K51/04 , C07C229/20 , C07C229/22 , C07F13/00 , C07C61/00 , C07C61/08
CPC分类号： C07F13/005 , A61K51/04 , A61K51/0478 , A61K51/0487 , C07B2200/05 , C07C229/20 , C07C229/22
摘要： The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen sustituents, including certain useful halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. In addition the compounds can be labeled with technetium and rhenium isotopes using known chelation complexes. The amino acid compounds disclosed herein have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds include [18F] FAMP, ([18F]5a) and [18F]N-MeFAMP, ([18F]5b). The invention further features pharmaceutical compositions comprised of an α-amino acid moiety attached to eiher a four, five or a six member carbon-chain ring. The labeled amino acid compounds are useful as imaging agents in detecting and/or monitoring tumors in a subject by Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT).
摘要翻译：本发明提供了用于检测和评价脑和体肿瘤的新型氨基酸化合物。这些化合物结合了α-氨基异丁酸（AIB）类似物的有利性质，即它们在肿瘤中的快速摄取和延长的保留性，其具有卤素支持物质的性质，包括某些有用的卤素同位素如氟-18，碘-123，碘-124 ，碘-125，碘-131，溴-75，溴-76，溴-77，溴-82，ast ine -21，ast ine -211和其他ast同位素。此外，化合物可以使用已知的螯合络合物用锝和铼同位素标记。当在体内施用于受试者时，本文公开的氨基酸化合物对靶位点具有高特异性。优选的氨基酸化合物包括[[SUP] 18F] FAMP，（[[18 F] 5a）和[ - 18 F] N-MeFAMP，（[ F）5b）。本发明进一步包括由连接四个，五个或六个碳链环的更多的α-氨基酸部分组成的药物组合物。标记的氨基酸化合物可用作通过正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）检测和/或监测受试者的肿瘤的成像剂。

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