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1. 发明授权

US5858345A In vivo polymerizable ophthalmic compositions 失效
标题翻译：体内聚合性眼用组合物
公开(公告)号：US5858345A
公开(公告)日：1999-01-12
申请号：US833635
申请日：1997-04-08
申请人： Steven T. Charles , Mark E. Hammer , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
发明人： Steven T. Charles , Mark E. Hammer , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
IPC分类号： A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F20/22 , C08F22/10 , A61K31/74 , A61K47/30
CPC分类号： C08F20/22 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F22/105 , Y10S514/919
摘要： Ophthalmic compositions containing biocompatible, bioadhesive polymerizable amphipathic mesophase materials useful for repairing retinal tissue tears or retinal detachments are disclosed. In one embodiment, the polymerizable materials, which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends, are polymerized in vivo to provide effective, long-lasting repair of torn, ruptured or detached retinal tissue. Ophthalmic applications of these materials are not limited to retinal repair.
摘要翻译：公开了含有用于修复视网膜组织撕裂或视网膜脱离的生物相容性，生物粘附性可聚合两亲中间相材料的眼用组合物。在一个实施方案中，包含在不饱和氟疏离末端具有阴离子，阳离子和/或非离子表面活性官能团的取代的氟代烷基或全氟烷基单体的可聚合材料在体内聚合，以提供有效的，持久的修复撕裂，破裂或分离的视网膜组织。这些材料的眼科应用不限于视网膜修复。

2. 发明授权

US06180687B2 In vivo polymerizable ophthalmic compositions and methods of using 失效
标题翻译：体内可聚合眼用组合物和使用方法
公开(公告)号：US06180687B2
公开(公告)日：2001-01-30
申请号：US09313226
申请日：1999-05-17
申请人： Mark E. Hammer , Steven T. Charles , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
发明人： Mark E. Hammer , Steven T. Charles , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
IPC分类号： C08F2210
CPC分类号： C09K19/3842 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F20/22 , C08F22/105 , Y10S514/912 , Y10S623/905
摘要： In vivo polymerizable intraocular lens compositions which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends. The compositions are preferably cured by UV photoinitiation and are useful in repairing torn or detached retinal tissue or forming intraocular lenses in situ.
摘要翻译：包含在不饱和氟疏离末端具有阴离子，阳离子和/或非离子表面活性官能团的取代氟烷基或全氟烷基单体的体内可聚合眼内透镜组合物。组合物优选通过UV光引发固化，并且可用于修复撕裂或分离的视网膜组织或原位形成眼内透镜。

3. 发明授权

US6124037A Articles coated with in vivo polymerizable ophthalmic compositions 失效
标题翻译：涂有体内可聚合眼用组合物的制品
公开(公告)号：US6124037A
公开(公告)日：2000-09-26
申请号：US12836
申请日：1998-01-23
申请人： Mark E. Hammer , Steven T. Charles , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
发明人： Mark E. Hammer , Steven T. Charles , John C. Lang , Robert Y. Lochhead , Lon J. Mathias
IPC分类号： A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , A61P27/02 , C08F20/04 , C08F20/22 , C08F22/10 , C08F214/18 , A61B17/00 , A61F2/14 , C08F236/16
CPC分类号： C08F20/04 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/22 , C08F22/105 , Y10S514/839 , Y10S514/912 , Y10S514/915
摘要： Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.
摘要翻译：用于外科器械的涂层，其包含在不饱和氟疏离末端中具有阴离子，阳离子和/或非离子表面活性官能团的取代的氟代烷基或全氟烷基单体。

4. 发明申请

US20130267988A1 Devices, Systems, and Methods For Pupil Expansion 有权
标题翻译：用于学生扩张的设备，系统和方法
公开(公告)号：US20130267988A1
公开(公告)日：2013-10-10
申请号：US13438881
申请日：2012-04-04
申请人： Glenn R. Sussman , Steven T. Charles , Hsin S. Chin
发明人： Glenn R. Sussman , Steven T. Charles , Hsin S. Chin
IPC分类号： A61M29/00
CPC分类号： A61B17/0231 , A61B17/0293 , A61B2017/00902 , A61F9/007
摘要： A pupil expander is disclosed. The pupil expander comprises a support member sized to expand a pupil and a plurality of engaging portions. The plurality of engaging portions are coupled to and spaced about the support member. The engaging portions have a recess and are shaped and sized to receive an inner margin of an iris.
摘要翻译：公开了一种瞳孔扩张器。瞳孔扩张器包括尺寸适于扩大瞳孔和多个接合部分的支撑构件。多个接合部分联接到支撑构件上并与支撑构件间隔开。接合部分具有凹部，并且其形状和尺寸适于接纳虹膜的内缘。

5. 发明授权

US07824089B2 Gradient index surgical illuminator 有权
标题翻译：渐变指数手术照明器
公开(公告)号：US07824089B2
公开(公告)日：2010-11-02
申请号：US11865381
申请日：2007-10-01
申请人： Steven T. Charles
发明人： Steven T. Charles
IPC分类号： A61B1/06
CPC分类号： A61B90/36 , A61B2090/306
摘要： A gradient index wide-angle illuminator is disclosed, one embodiment comprising: a light source for providing a light beam; an optical cable, optically coupled to the light source for receiving and transmitting the light beam; a handpiece, operably coupled to the optical cable to receive the light beam; an optical fiber, operably coupled to the handpiece, wherein the optical fiber is optically coupled to the optical cable to receive and transmit the light beam; an optical element, optically coupled to a distal end of the optical fiber, for receiving the light beam and transmitting the light beam to illuminate a surgical field, wherein the optical element comprises a gradient index lens; and a cannula, operably coupled to the handpiece, for housing and directing the optical fiber and the optical element. The optical element can be a small-gauge, divergent gradient index lens having a distal surface co-incident with the distal end of the cannula. For example, the optical element can be a 19, 20 or 25 gauge optical element. Further, the cannula and the handpiece can be fabricated from biocompatible materials.
摘要翻译：公开了一种梯度折射率广角照明器，一个实施例包括：用于提供光束的光源; 光缆，光学耦合到光源，用于接收和传输光束; 可操作地耦合到光缆以接收光束的手持件; 光纤，其可操作地耦合到所述手持件，其中所述光纤光耦合到所述光缆以接收和传输所述光束; 光学元件，其光学耦合到所述光纤的远端，用于接收所述光束并透射所述光束以照射手术区域，其中所述光学元件包括渐变折射率透镜; 以及可操作地联接到所述手持件的套管，用于容纳和引导所述光纤和所述光学元件。光学元件可以是具有与插管的远端共同入射的远端表面的小规格发散梯度折射率透镜。例如，光学元件可以是19,20或25号光学元件。此外，插管和手持件可以由生物相容性材料制成。

6. 发明申请

US20080097346A1 Trocar cannula 审中-公开
标题翻译：套管套管
公开(公告)号：US20080097346A1
公开(公告)日：2008-04-24
申请号：US11523765
申请日：2006-09-19
申请人： Steven T. Charles
发明人： Steven T. Charles
IPC分类号： A61M5/00
CPC分类号： A61B17/3421 , A61B2017/00345 , A61B2017/3492 , A61F9/007
摘要： A trocar cannula having a tube and a hub. The hub is attached to the proximal end of the tube so that the tube may be inserted into an incision. The proximal side of the hub is rounded, curved or slanted so as to minimize contact with the tissue surrounding the incision.
摘要翻译：具有管和毂的套管针插管。轮毂连接到管的近端，使得管可插入切口。轮毂的近侧是圆形的，弯曲的或倾斜的，以便最小化与切口周围的组织的接触。

7. 发明申请

US20080080206A1 GRADIENT INDEX SURGICAL ILLUMINATOR 有权
标题翻译：梯度指数外科照明器
公开(公告)号：US20080080206A1
公开(公告)日：2008-04-03
申请号：US11865381
申请日：2007-10-01
申请人： Steven T. Charles
发明人： Steven T. Charles
IPC分类号： A61B1/06
CPC分类号： A61B90/36 , A61B2090/306
摘要： A gradient index wide-angle illuminator is disclosed, one embodiment comprising: a light source for providing a light beam; an optical cable, optically coupled to the light source for receiving and transmitting the light beam; a handpiece, operably coupled to the optical cable to receive the light beam; an optical fiber, operably coupled to the handpiece, wherein the optical fiber is optically coupled to the optical cable to receive and transmit the light beam; an optical element, optically coupled to a distal end of the optical fiber, for receiving the light beam and transmitting the light beam to illuminate a surgical field, wherein the optical element comprises a gradient index lens; and a cannula, operably coupled to the handpiece, for housing and directing the optical fiber and the optical element. The optical element can be a small-gauge, divergent gradient index lens having a distal surface co-incident with the distal end of the cannula. For example, the optical element can be a 19, 20 or 25 gauge optical element. Further, the cannula and the handpiece can be fabricated from biocompatible materials.
摘要翻译：公开了一种梯度折射率广角照明器，一个实施例包括：用于提供光束的光源; 光缆，光学耦合到光源，用于接收和传输光束; 可操作地耦合到光缆以接收光束的手持件; 光纤，其可操作地耦合到所述手持件，其中所述光纤光耦合到所述光缆以接收和传输所述光束; 光学元件，其光学耦合到所述光纤的远端，用于接收所述光束并透射所述光束以照射手术区域，其中所述光学元件包括渐变折射率透镜; 以及可操作地联接到所述手持件的套管，用于容纳和引导所述光纤和所述光学元件。光学元件可以是具有与插管的远端共同入射的远端表面的小规格发散梯度折射率透镜。例如，光学元件可以是19,20或25光学元件。此外，插管和手持件可以由生物相容性材料制成。

8. 发明授权

US07285107B1 Vitreoretinal instrument 有权
标题翻译：玻璃体视网膜仪
公开(公告)号：US07285107B1
公开(公告)日：2007-10-23
申请号：US10672188
申请日：2003-09-26
申请人： Steven T. Charles
发明人： Steven T. Charles
IPC分类号： A61M1/00
CPC分类号： A61M1/0064 , A61F9/00736 , A61M1/0045
摘要： An improved instrument for removing subretinal fluid and performing fluid exchanges in vitreoretinal surgery is disclosed. The instrument includes a cannula with a curved distal portion and a side port on the curved distal portion for aspirating subretinal fluid. The instrument also includes a second port for aspirating a second fluid from the vitreous cavity during a fluid exchange.
摘要翻译：公开了一种用于去除视网膜下液体并进行玻璃体视网膜手术中的液体交换的改进仪器。该仪器包括具有弯曲远端部分的插管和弯曲远端部分上的用于吸入视网膜下液体的侧端口。仪器还包括用于在流体交换期间从玻璃体腔吸入第二流体的第二端口。

9. 发明授权

US5464025A Self-contained surgical tubing management system 失效
标题翻译：独立外科管理系统
公开(公告)号：US5464025A
公开(公告)日：1995-11-07
申请号：US395403
申请日：1995-02-27
申请人： Steven T. Charles , John A. Ripley , John C. Huculak
发明人： Steven T. Charles , John A. Ripley , John C. Huculak
IPC分类号： A61B19/00 , A61B19/02 , A61B19/08 , A61B19/10
CPC分类号： A61B46/23 , A61B2050/002 , A61B2050/318 , A61B50/36
摘要： A self-contained surgical tubing management system whereby all of the required surgical handpiece(s) and power and fluid tubings, cables and connections are incorporated in a single disposable package. The tubing management system includes a sterile sheet or substrate that may cover either all or only a portion of the patient's body. Pockets may be formed in either end of the sheet to hold, at one end, any number or variety of surgical instruments, such as vitreous probes, infusion cannulas, aspiration lines, coagulating probes, etc., and, at the end opposite the instruments, a small coils of power and fluid lines. The various power and fluid lines needed to operated these instruments may be permanently or temporarily connected to the respective instruments and extend down the length of the sheet. These lines are attached to the sheet either continuously or at various points by any number of methods.
摘要翻译：一种独立的手术管理系统，其中所有所需的外科手持件以及动力和流体管道，电缆和连接件并入单个一次性包装中。管道管理系统包括可以覆盖患者身体的全部或仅一部分的无菌片材或基底。口袋可以形成在片材的任一端，在一端保持任何数量或种类的手术器械，例如玻璃体探针，输注插管，抽吸管线，凝固探针等，并且在与仪器相对的末端，一个小线圈的动力和流体线。操作这些仪器所需的各种动力和流体管线可以永久地或临时地连接到相应的仪器并且沿着纸张的长度延伸。这些线通过任何数量的方法连续地或在各个点附接到片材。

10. 发明授权

US09549849B2 Systems and methods for reinjection of processed vitreous humor 有权
标题翻译：加工玻璃体液注射系统和方法
公开(公告)号：US09549849B2
公开(公告)日：2017-01-24
申请号：US13614483
申请日：2012-09-13
申请人： Steven T. Charles
发明人： Steven T. Charles
IPC分类号： A61K9/22 , A61F9/007
CPC分类号： A61F9/00745 , A61F9/00736
摘要： A system for the removal of vitreous humor and other fluids from an eye and the reinjection of filtered vitreous humor into the eye is provided. The system comprises a hollow removal device, a filter, and an infusion device. The removal device includes an element configured to cut the vitreous humor and is configured to aspirate the vitreous humor from the eye. The filter is configured to create a filtered form of vitreous humor by separating the vitreous humor from undesired components in the vitreous humor. The infusion device is fluidly coupled to the filter and is configured to return the filtered form of vitreous humor into the eye.
摘要翻译：提供了一种用于从眼睛中去除玻璃体液和其他液体并将过滤的玻璃体液注入眼睛的系统。该系统包括中空移除装置，过滤器和输注装置。去除装置包括被配置为切割玻璃体液并被配置为从眼睛吸出玻璃体液的元件。过滤器被配置为通过将玻璃体液与玻璃体液中的不期望的成分分开来产生玻璃体液的过滤形式。输注装置流体地联接到过滤器并且被配置为将过滤形式的玻璃体液返回到眼睛中。

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