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1. 发明授权

US06893650B1 N2-phenylamidine derivatives 有权
标题翻译： N2-苯基脒衍生物
公开(公告)号：US06893650B1
公开(公告)日：2005-05-17
申请号：US09890775
申请日：2000-02-04
申请人： Mark David Charles , Wilfried Franke , David Eric Green , Thomas Lawley Hough , Dale Robert Mitchell , Donald James Simpson , John Frederick Atherall
发明人： Mark David Charles , Wilfried Franke , David Eric Green , Thomas Lawley Hough , Dale Robert Mitchell , Donald James Simpson , John Frederick Atherall
IPC分类号： C07D249/08 , A01N25/02 , A01N37/52 , A01N41/10 , A01N43/06 , A01N43/18 , A01N43/40 , A01N43/54 , A01N43/74 , A01N43/76 , A01N43/80 , A01N43/82 , A01N43/836 , A01N43/84 , A01N43/88 , A01N43/90 , A01N47/42 , A01P3/00 , C07C233/37 , C07C251/04 , C07C257/12 , C07C257/14 , C07C317/40 , C07C323/20 , C07C323/41 , C07D207/325 , C07D207/50 , C07D209/48 , C07D213/64 , C07D213/68 , C07D215/22 , C07D237/14 , C07D237/16 , C07D239/34 , C07D239/46 , C07D239/88 , C07D241/24 , C07D251/30 , C07D251/34 , C07D257/04 , C07D261/08 , C07D261/14 , C07D263/38 , C07D263/46 , C07D263/58 , C07D271/06 , C07D271/10 , C07D273/00 , C07D277/20 , C07D277/34 , C07D277/68 , C07D285/00 , C07D285/08 , C07D285/10 , C07D285/12 , C07D285/13 , C07D295/12 , C07D295/125 , C07D307/12 , C07D307/81 , C07D307/83 , C07D311/22 , C07D311/56 , C07D317/64 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/54 , C07D333/58 , C07D333/64 , C07D487/04 , C07D495/04 , C07F7/08 , A61K31/155 , C07D237/00 , C07D261/20 , C07D233/37
CPC分类号： C07D209/48 , A01N37/52 , A01N43/06 , A01N43/40 , A01N43/54 , A01N43/74 , A01N43/82 , A01N43/90 , A01N47/42 , C07C257/12 , C07C257/14 , C07D207/50 , C07D239/88 , C07D251/34 , C07D261/08 , C07D263/38 , C07D263/46 , C07D263/58 , C07D271/06 , C07D271/10 , C07D285/08 , C07D285/13 , C07D295/125 , C07D311/22 , C07D333/54 , C07D487/04 , C07D495/04 , C07F7/0812
摘要： The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or different, are any group defined for R1; cyano; acyl; —ORa or —SRa, where Ra is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; or R2 and R3, or R2 and R1, together with their interconnecting atoms may form a ring, which may be substituted; R4 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; hydroxy; mercapto; azido; nitro; halogen; cyano; acyl; optionally substituted amino; cyanato; thiocyanato; —SF5; —ORa; —SRa or —Si(Ra)3; m is 0 to 3; when present R5, which may be the same or different to any other R5, is any group defined for R4; R6 is optionally substituted carbo- or heterocylclyl; and A is a defined linking group, or —A—R6 and R5 together with benzene ring M form an optionally substituted fused ring system.
摘要翻译：本发明提供式（I）的杀真菌化合物及其盐，其中：R 1是烷基，烯基，炔基，碳环基或杂环基，其各自可以被取代，或氢; R 2和R 3可以相同或不同，为R 1定义的任何基团; 氰基酰基; 其中R a是烷基，烯基，炔基，碳环基或杂环基，其各自可以被取代;或者其中R a，或R 2和R 3，或R 2和R 1以及它们的互连原子可以形成环，其可以被取代; R 4是烷基，烯基，炔基，碳环基或杂环基，其各自可以被取代; 羟基; 巯基叠氮硝基卤素; 氰基酰基; 任选取代的氨基; 青色硫氰酸 -SF 5; -OR ^{a ; -SR ^{a或-Si（R a a）3 3; m为0〜3; 当存在R 5可以与任何其它R 5相同或不同时，R 5为限定的任何基团。 R 6是任选取代的碳 - 或杂环基; 并且A是限定的连接基团，或者-A-R 6和R 5和苯环M一起形成任选取代的稠环体系。}}

2. 发明授权

US06541630B1 Fungicides 失效
标题翻译：杀菌剂
公开(公告)号：US06541630B1
公开(公告)日：2003-04-01
申请号：US10172891
申请日：2002-06-13
申请人： John Frederick Atherall , Thomas Lawley Hough , Stephen David Lindell , Mary Josephine O'Mahony , John Henry Parsons , Elizabeth Anne Saville-Stones
发明人： John Frederick Atherall , Thomas Lawley Hough , Stephen David Lindell , Mary Josephine O'Mahony , John Henry Parsons , Elizabeth Anne Saville-Stones
IPC分类号： C07D49504
CPC分类号： C07D495/04 , A01N43/90
摘要： The invention provides the use in combating fungi of compounds of general formula I wherein R1 is hydrogen, hydroxy, acyl, acyloxy, optionally substituted amino, Ra, Ra3Si, RaS or RaO, where Ra is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; Z is oxygen or sulfur; M is a thiophene ring; and R3 and R4, which may be the same or different, have the same meaning as Ra or can be optionally substituted amino, hydrogen, halogen, cyano, nitro or a group ORc or S(O)mRc, where Rc has the same meaning as Ra or is hydrogen or acyl and m is 0, 1 or 2; or R3 and R4 together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; together with tautomers of compounds where R1 is hydrogen.
摘要翻译：本发明提供了用于对抗通式I化合物的用途，其中R 1是氢，羟基，酰基，酰氧基，任选取代的氨基，R a，R 3 Si，RaS或RaO，其中R a是任选取代的烷基，任选取代的链烯基，炔基，任选取代的环烷基，任选取代的环烯基，任选取代的芳基或任选取代的杂环基; Z是氧或硫; M是噻吩环; 和R 3和R 4可以相同或不同，具有与R a相同的含义或可以是任选取代的氨基，氢，卤素，氰基，硝基或基团OR c或S（O）m R c，其中R c具有相同的含义为Ra或为氢或酰基，m为0,1或2; 或R 3和R 4与它们所连接的原子一起形成任选取代的碳环或杂环; 以及R1为氢的化合物的互变异构体。

3. 发明授权

US06432964B1 Fungicides 失效
标题翻译：杀菌剂
公开(公告)号：US06432964B1
公开(公告)日：2002-08-13
申请号：US09423135
申请日：1999-11-05
申请人： John Frederick Atherall , Thomas Lawley Hough , Stephen David Lindell , Mary Josephine O'Mahony , John Henry Parsons , Elizabeth Anne Saville-Stones
发明人： John Frederick Atherall , Thomas Lawley Hough , Stephen David Lindell , Mary Josephine O'Mahony , John Henry Parsons , Elizabeth Anne Saville-Stones
IPC分类号： A01N4390
CPC分类号： C07D495/04 , A01N43/90
摘要： The invention provides the use in combating fungi of compounds of general formula (I) wherein R1 is hydrogen, hydroxy, acyl, acyloxy, optionally substituted amino, Ra, Ra3Si, RaS or RaO, where Ra is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R2 has the same meaning as Ra or can be hydrogen; Z is oxygen or sulfur, M is a thiophene ring, and R3 and R4, which may be the same or different, have the same meaning as Ra or can be optionally substituted amino, hydrogen, halogen, cyano, nitro or a group ORc or S(O)mRc, where Rc has the same meaning as Ra or is hydrogen or acyl and m is 0, 1 or 2; or R3 and R4 together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; together with tautomers of compounds where R1 is hydrogen.
摘要翻译：本发明提供了用于对抗通式（I）的化合物的用途，其中R 1是氢，羟基，酰基，酰氧基，任选取代的氨基，Ra，Ra 3 Si，RaS或RaO，其中R a是任选取代的烷基，任选取代的链烯基，任选取代的炔基，任选取代的环烷基，任选取代的环烯基，任选取代的芳基或任选取代的杂环基; R2具有与Ra相同的含义，也可以是氢; Z是氧或硫，M是噻吩环，并且可以相同或不同的R 3和R 4具有与R a相同的含义或可以是任选取代的氨基，氢，卤素，氰基，硝基或基团OR c或 S（O）m R c，其中R c具有与R a相同的含义或氢或酰基，m为0,1或2; 或R 3和R 4与它们所连接的原子一起形成任选取代的碳环或杂环; 以及R1为氢的化合物的互变异构体。

4. 发明授权

US08389516B2 Antibacterial compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US08389516B2
公开(公告)日：2013-03-05
申请号：US13154592
申请日：2011-06-07
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/506 , A61K31/4436 , A61K31/428 , A61K31/429 , C07D239/42
CPC分类号： C07D417/04 , C07D417/14 , Y02P20/582
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C1-C6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（= O）NR 6 - ， - S（O）NR 6 - ， - C（= O）O-或-S（= O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N或CH，或CF; R2和R3如说明书中所定义。

5. 发明授权

US07977340B2 Antibacterial compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US07977340B2
公开(公告)日：2011-07-12
申请号：US12304303
申请日：2007-06-21
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/4412 , A61K31/4436 , A61K31/497 , A61K31/506 , C07D403/14 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14 , Y02P20/582
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C 1 -C 6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（= O）NR 6 - ， - S（O）NR 6 - ， - C（= O）O-或-S（= O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N或CH，或CF; R2和R3如说明书中所定义。

6. 发明申请

US20120004221A1 Antibacterial Compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US20120004221A1
公开(公告)日：2012-01-05
申请号：US13154485
申请日：2011-06-07
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/437 , A01N43/90 , A61K31/497 , A01P1/00 , A61K31/5377 , A61K31/506 , A61K31/5383 , A61P31/04 , C07D513/04 , A61K31/496
CPC分类号： A61K31/437 , A01N47/36 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C1-C6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（= O）NR 6 - ， - S（O）NR 6 - ， - C（= O）O-或-S（= O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N; R2和R3如说明书中所定义。

7. 发明授权

US08481544B2 Antibacterial compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US08481544B2
公开(公告)日：2013-07-09
申请号：US13154485
申请日：2011-06-07
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/497 , A61K31/4365 , C07D241/12 , C07D513/04
CPC分类号： A61K31/437 , A01N47/36 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C1-C6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（= O）NR 6 - ， - S（O）NR 6 - ， - C（= O）O-或-S（= O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N; R2和R3如说明书中所定义。

8. 发明申请

US20110263590A1 Antibacterial Compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US20110263590A1
公开(公告)日：2011-10-27
申请号：US13154592
申请日：2011-06-07
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/4439 , A61K31/428 , A61K31/497 , A61K31/496 , A61P31/04 , A61K31/506 , A61K31/501 , A61K31/5383 , A61K31/519 , A61K31/444 , A61K31/5377
CPC分类号： C07D417/04 , C07D417/14 , Y02P20/582
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C1-C6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（= O）NR 6 - ， - S（O）NR 6 - ， - C（= O）O-或-S（= O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N或CH，或CF; R2和R3如说明书中所定义。

9. 发明申请

US20090197877A1 Antibacterial Compositions 有权
标题翻译：抗菌组合物
公开(公告)号：US20090197877A1
公开(公告)日：2009-08-06
申请号：US12304303
申请日：2007-06-21
申请人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
发明人： David John Haydon , Lloyd George Czaplewski , Nicholas John Palmer , Dale Robert Mitchell , John Frederick Atherall , Christopher Richard Steele , Tamara Ladduwahetty
IPC分类号： A61K31/5383 , C07D417/10 , A61K31/4439 , A61K31/496 , C07D417/14 , C07D498/04 , A61P31/04
CPC分类号： C07D417/04 , C07D417/14 , Y02P20/582
摘要： Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C1-C3 alkyl; X is —C(═O)NR6—, —S(O)NR6—, —C(═O)O— or —S(═O)O— wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or —(C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.
摘要翻译：式（I）化合物具有抗菌活性：其中：m为0或1; Q是氢或环丙基; Alk是可以含有醚（-O-），硫醚（-S-）或氨基（-NR） - 连接的任意取代的二价C 1 -C 6亚烷基，亚烯基或亚炔基，其中R是氢，-CN或 C1-C3烷基; X是-C（-O）NR 6 - ， - S（O）NR 6 - ， - C（-O）O-或-S（-O）O-，其中R 6是氢，任选取代的C 1 -C 6烷基， C6链烯基，C2-C6炔基，-Cyc或 - （C1-C3烷基）-Cyc，其中Cyc是具有3-7个环原子的任选取代的单环碳环或杂环; Z是N或CH，或CF; R2和R3如说明书中所定义。

10. 发明申请

US20090318486A1 Tricyclic spiro derivatives as CRTH2 modulators 失效
标题翻译：三环螺衍生物作为CRTH2调节剂
公开(公告)号：US20090318486A1
公开(公告)日：2009-12-24
申请号：US11919471
申请日：2006-05-23
申请人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
发明人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
IPC分类号： A61K31/437 , C07D487/10 , A61K31/427 , C07D471/04 , A61P25/00
CPC分类号： C07D487/10
摘要： The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
摘要翻译：本发明涉及式（I）的螺衍生物用于治疗和/或预防具有炎性成分的过敏性疾病，炎性皮肤病和其它疾病的用途。具体地说，本发明涉及螺衍生物用于调节CRTH2活性的用途。

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