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1. 发明授权

US07236834B2 Electrical lead body including an in-line hermetic electronic package and implantable medical device using the same 有权
标题翻译：电子引线体，包括一个在线密封电子封装和使用该电子封装的可植入医疗器件
公开(公告)号：US07236834B2
公开(公告)日：2007-06-26
申请号：US10742732
申请日：2003-12-19
申请人： Mark A. Christopherson , Jeff Jelen , Beth Anne H. Guck
发明人： Mark A. Christopherson , Jeff Jelen , Beth Anne H. Guck
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/375
摘要： An assembly is provided for an implantable medical lead. The assembly includes a first lead body comprising one or more electrical leads, and a hermetic encasement. The encasement comprises a housing having first and second openings and interior walls, an interior space defined by the interior walls, an electronic network housed within the interior space, and a circuit board extending through the first and second openings. The circuit board comprises a plurality of layers into which the electronic network is at least partially integrated, a first set of one or more terminals electrically coupling the electronic network to the first lead body, and a second set of one or more terminals electrically coupled to the electronic network for external electrical engagement.
摘要翻译：为可植入医疗引线提供组件。组件包括包括一个或多个电引线的第一引线主体和密封封装。外壳包括具有第一和第二开口和内壁的壳体，由内壁限定的内部空间，容纳在内部空间内的电子网络以及延伸穿过第一和第二开口的电路板。所述电路板包括多个层，所述电子网络至少部分地集成到所述多个层中;将所述电子网络电耦合到所述第一引线主体的第一组一个或多个端子，以及第二组一个或多个端子，用于外部电气接合的电子网络。

2. 发明授权

US07254443B2 Implantable medical device including a hermetic connector block extension 有权
标题翻译：可植入医疗装置，包括密封连接器块延伸部
公开(公告)号：US07254443B2
公开(公告)日：2007-08-07
申请号：US10861546
申请日：2004-06-04
申请人： Jeff Jelen , Gary W. King , Mark A. Christopherson , Eric H. Bonde
发明人： Jeff Jelen , Gary W. King , Mark A. Christopherson , Eric H. Bonde
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/3752
摘要： An implantable medical device includes a controlling device for transmitting a first series of command signals, the controlling device comprising a connector block, a first lead body including at least one electrical lead, and a hermetic encasement. The hermetic encasement includes a housing defining an interior space, an electronic network housed within the interior space and configured to receive the first set of command signals from the controlling device and output a second series of command signals based on the first set of command signals, a first set of one or more feedthrough terminals extending through the housing and directly coupling the electronic network to the connector block, and a second set of one or more feedthrough terminals extending through the housing and directly coupling the electronic network to the first lead body.
摘要翻译：可植入医疗装置包括用于传送第一系列命令信号的控制装置，所述控制装置包括连接器块，包括至少一个电引线的第一引线主体和密封外壳。气密包装包括限定内部空间的壳体，容纳在内部空间内的电子网络，并且被配置为从控制装置接收第一组命令信号，并基于第一组命令信号输出第二系列命令信号，第一组一个或多个馈通端子，其延伸穿过壳体并将电子网络直接耦合到连接器块;以及第二组一个或多个馈通端子，其延伸穿过壳体并将电子网络直接耦合到第一引线体。

3. 发明授权

US09888864B2 Method and system for identifying a location for nerve stimulation 有权
公开(公告)号：US09888864B2
公开(公告)日：2018-02-13
申请号：US13634333
申请日：2011-03-10
申请人： John Rondoni , Mark A. Christopherson , Quan Ni
发明人： John Rondoni , Mark A. Christopherson , Quan Ni
IPC分类号： A61B5/053 , A61B5/04 , A61B5/0488 , A61B5/11 , A61B5/00 , A61N1/372 , A61B5/08 , A61B34/20 , A61N1/36 , A61B34/00
CPC分类号： A61B5/0536 , A61B5/04001 , A61B5/0488 , A61B5/08 , A61B5/1104 , A61B5/4519 , A61B5/4818 , A61B5/4893 , A61B5/6814 , A61B5/682 , A61B5/6822 , A61B5/6839 , A61B5/6843 , A61B5/6849 , A61B5/7425 , A61B5/7435 , A61B34/20 , A61B34/25 , A61B2034/2065 , A61B2505/05 , A61B2562/043 , A61N1/36 , A61N1/372 , A61N1/37241 , A61N1/37247
摘要： A system and method for identifying a stimulation location on a nerve is disclosed. The system includes an image-based navigation interface used to facilitate advancing a stimulation element within a patient body toward a target nerve stimulation site. Using the system one determines, separately for each potential target nerve stimulation site, a neuromuscular response of muscles produced upon applying a stimulation signal at the respective separate potential target stimulation sites. The image-based navigation interface is configured to display a graphic identification of which muscles were activated for each respective potential target nerve stimulation site upon applying the stimulation signal.

4. 发明授权

US08911438B2 Tuna device with integrated saline reservoir 有权
标题翻译：金枪鱼装置与综合盐水库
公开(公告)号：US08911438B2
公开(公告)日：2014-12-16
申请号：US11573417
申请日：2005-08-10
申请人： John M. Swoyer , Mark A. Christopherson , Yelena G. Tropsha , Julie M. Woessner
发明人： John M. Swoyer , Mark A. Christopherson , Yelena G. Tropsha , Julie M. Woessner
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/1472 , A61B2018/1475
摘要： Methods and apparatus for ablating a target tissue are discussed. Such methods and apparatus include those that simplify tissue ablation. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. A single step of engaging the actuator causes the electrode to be introduced into the target tissue and causes energy to be delivered from the power supply to the tissue via the electrode. Devices that include an electrode actuator for causing the electrode to be introduced into the target tissue and a fluid actuator for causing the fluid to flow to the target tissue are also discussed. Methods of causing the electrode to be introduced into the target tissue and fluid to flow to the target tissue with a single step and more than one step are also discussed.
摘要翻译：讨论了用于烧蚀靶组织的方法和装置。这些方法和装置包括简化组织消融的方法和装置。例如，讨论了具有耦合到电源和电极的诸如触发机构的致动器的组织消融装置。使执行器接合的一个步骤使得电极被引入目标组织中，并且通过电极将能量从电源传送到组织。还讨论了包括用于使电极引入目标组织的电极致动器和用于使流体流向目标组织的流体致动器的装置。还讨论了将电极引入目标组织中的方法和流体以单步和多于一个步骤流向目标组织。

5. 发明授权

US08340785B2 Self expanding electrode cuff 有权
标题翻译：自扩张电极袖口
公开(公告)号：US08340785B2
公开(公告)日：2012-12-25
申请号：US12114352
申请日：2008-05-02
申请人： Eric H. Bonde , Roy L. Testerman , Timothy P. Herbert , Mark A. Christopherson , Jesse D. Geroy
发明人： Eric H. Bonde , Roy L. Testerman , Timothy P. Herbert , Mark A. Christopherson , Jesse D. Geroy
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0558
摘要： An expandable electrode cuff of an implantable stimulation system that includes a base member, a first flange member extending from a proximal end along a first side wall of the base member to a first distal end, and a second flange member extending from a proximal end along a second side wall of the base member to a second distal end. The first flange member extends over both a top wall of the base member and the second flange member, and the second flange member extends over the top wall to form a lumen. The electrode cuff is capable of being advanced between a first position corresponding to both flange members extending over the top wall, a second position corresponding to the first flange member not extending over the top wall and the second flange member extending over the top wall, and a third position corresponding to both of the flange members not extending over the top wall.
摘要翻译： 1.一种可植入刺激系统的可扩张电极套，其包括基部构件，从基部构件的第一侧壁的近端延伸到第一远端的第一凸缘构件，以及从基端部的近端延伸的第二凸缘构件所述基部构件的第二侧壁到第二远端。第一凸缘构件在基部构件的顶壁和第二凸缘构件上方延伸，并且第二凸缘构件在顶壁上延伸以形成内腔。所述电极套套能够在对应于在所述顶壁上延伸的两个凸缘构件的第一位置，对应于不在所述顶壁上延伸的所述第一凸缘构件的第二位置和在所述顶壁上延伸的所述第二凸缘构件的第二位置之间前进;以及对应于不延伸在顶壁上的两个凸缘构件的第三位置。

6. 发明申请

US20110147046A1 SELF EXPANDING ELECTRODE CUFF 有权
标题翻译：自扩展电极
公开(公告)号：US20110147046A1
公开(公告)日：2011-06-23
申请号：US12990702
申请日：2009-05-01
申请人： Eric H. Bonde , Roy L. Testerman , Timothy P. Herbert , Mark A. Christopherson , Jesse D. Geroy
发明人： Eric H. Bonde , Roy L. Testerman , Timothy P. Herbert , Mark A. Christopherson , Jesse D. Geroy
IPC分类号： H01B5/00
CPC分类号： A61N1/05 , A61N1/0526 , A61N1/0556 , A61N1/0558
摘要： An electrode lead assembly is described. The lead assembly includes an expandable cuff electrode that includes a series of spaced apart electrode elements and a substantially re-closable opening.
摘要翻译：描述电极引线组件。引线组件包括可扩展的袖带电极，其包括一系列间隔开的电极元件和基本上可再闭合的开口。

7. 发明授权

US07322974B2 TUNA device with integrated saline reservoir 有权
标题翻译： TUNA装置与综合盐水库
公开(公告)号：US07322974B2
公开(公告)日：2008-01-29
申请号：US10915310
申请日：2004-08-10
申请人： John M. Swoyer , Yelena G. Tropsha , Julie M. Woessner , Mark A. Christopherson
发明人： John M. Swoyer , Yelena G. Tropsha , Julie M. Woessner , Mark A. Christopherson
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/1472 , A61B2018/1475
摘要： Methods and apparatus for ablating a target tissue are discussed. Such methods and apparatus include those that simplify tissue ablation. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. A single step of engaging the actuator causes the electrode to be introduced into the target tissue and causes energy to be delivered from the power supply to the tissue via the electrode. By way of additional example, a tissue ablation device having an actuator coupled to a fluid source and an electrode is discussed. A single step of engaging the actuator causes conductive fluid to flow from the fluid source to the target tissue location and causes the electrode to be introduced to the target tissue location. The fluid source may be a conductive fluid, such as saline, which may increase the efficiency of ablation. Various other configurations and methods that simplify tissue ablation are also discussed.
摘要翻译：讨论了用于烧蚀靶组织的方法和装置。这些方法和装置包括简化组织消融的方法和装置。例如，讨论了具有耦合到电源和电极的诸如触发机构的致动器的组织消融装置。使执行器接合的一个步骤使得电极被引入目标组织中，并且通过电极将能量从电源传送到组织。作为另外的示例，讨论了具有耦合到流体源和电极的致动器的组织消融装置。使致动器接合的一个步骤导致导电流体从流体源流动到目标组织位置，并且使电极被引入目标组织位置。流体源可以是诸如盐水的导电流体，其可以提高消融效率。还讨论了简化组织消融的各种其它配置和方法。

8. 发明授权

US07282050B2 Ablation of exterior of stomach to treat obesity 有权
标题翻译：消化胃外部治疗肥胖
公开(公告)号：US07282050B2
公开(公告)日：2007-10-16
申请号：US10699207
申请日：2003-10-31
申请人： Warren L. Starkebaum , Thomas R. Prentice , Mark A. Christopherson
发明人： Warren L. Starkebaum , Thomas R. Prentice , Mark A. Christopherson
IPC分类号： A61B18/18
CPC分类号： A61B5/42 , A61B5/04884 , A61B18/1477 , A61B18/1492 , A61B18/22 , A61B2018/00238 , A61B2018/00494 , A61B2018/1425 , A61B2018/143 , A61B2018/1432
摘要： The invention provides methods and devices to treat obesity by ablating tissue from an exterior surface of a stomach of a patient. For example, the invention may involve ablation of exterior stomach tissue to alter gastric myoelectric activity or muscle function from the exterior surface of the stomach to produce abnormal gastric peristalsis without damaging the mucosal lining of the stomach. The invention may further provide methods and devices to monitor the gastric myoelectric activity before and after the ablation procedure.
摘要翻译：本发明提供了通过从患者的胃的外表面烧蚀组织来治疗肥胖的方法和装置。例如，本发明可以涉及外部胃组织的消融，以改变胃外肌肉的肌电活动或肌肉功能，从而产生异常的胃蠕动，而不会损害胃的粘膜。本发明还可以提供在消融过程之前和之后监测胃肌电活动的方法和装置。

9. 发明授权

US07169144B2 Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue 有权
公开(公告)号：US07169144B2
公开(公告)日：2007-01-30
申请号：US10699548
申请日：2003-10-31
申请人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
发明人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1233 , A61B18/14 , A61B18/1402 , A61B18/1815 , A61B2018/00029 , A61B2018/00196 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/1213 , A61B2018/1253 , A61B2018/1417 , A61B2018/1472 , A61B2018/1475 , A61B2218/002 , A61B2218/007
摘要： The present invention provides an apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current, such tissues including but not limited to liver, lung, cardiac, prostate, breast, and vascular tissues and neoplasms. An apparatus in accord with the present invention includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present invention includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters.

10. 发明授权

US06736810B2 Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue 有权
标题翻译：用于创建，维持和控制用于消融组织的虚拟电极的装置和方法
公开(公告)号：US06736810B2
公开(公告)日：2004-05-18
申请号：US09903296
申请日：2001-07-11
申请人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
发明人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1233 , A61B18/14 , A61B18/1402 , A61B18/1815 , A61B2018/00029 , A61B2018/00196 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/1213 , A61B2018/1253 , A61B2018/1417 , A61B2018/1472 , A61B2018/1475 , A61B2218/002 , A61B2218/007
摘要： The present invention provides an apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current, such tissues including but not limited to liver, lung, cardiac, prostate, breast, and vascular tissues and neoplasms. An apparatus in accord with the present invention includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present invention includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters.
摘要翻译：本发明提供了一种用于在射频交流电流处理的组织内或之上产生虚拟电极的装置和方法，所述组织包括但不限于肝脏，肺，心脏，前列腺，乳腺和血管组织，以及肿瘤。根据本发明的装置包括供给要提供给患者的导电或电解液，交流发生器和用于通过间隔或表面递送来产生，维持和控制消融过程的处理器流体到组织并经由虚拟电极向组织递送电力。根据本发明的方法包括将导电流体递送到预定的组织消融部位预定的时间段，向组织施加预定功率水平的射频电流，监测几个参数中的至少一个，并且调整响应于测量的参数施加的功率和/或流体流量。

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