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1. 发明申请

US20090170745A1 SUBTILISIN FROM BACILLUS PUMILUS AND DETERGENT AND CLEANING AGENTS CONTAINING SAID NOVEL SUBTILISIN 审中-公开
标题翻译：来自BACILLUS PUMILUS和洗涤剂和含有新型分散素的清洁剂的分散体
公开(公告)号：US20090170745A1
公开(公告)日：2009-07-02
申请号：US12268702
申请日：2008-11-11
申请人： Marion Merkel , Petra Siegert , Susanne Wieland , Karl-Heinz Maurer , Cornelius Bessler
发明人： Marion Merkel , Petra Siegert , Susanne Wieland , Karl-Heinz Maurer , Cornelius Bessler
IPC分类号： C11D7/42 , C12N15/57 , C12N15/75 , C12N9/54 , C12S11/00 , C12S9/00 , C12N15/77 , C12N15/70 , C12N1/21
CPC分类号： C12N9/54 , A61K38/00 , C11D3/386 , C12Y304/21062 , Y02A50/473
摘要： A novel subtilisin-type alkaline protease from Bacillus pumilus and sufficiently related proteins and derivatives thereof. Also washing and cleaning agents comprising the novel subtilisin-type alkaline protease, sufficiently related proteins and derivatives thereof, corresponding washing and cleaning methods, and washing and cleaning agents and other possible technical uses.
摘要翻译：来自短小芽孢杆菌的新型枯草杆菌蛋白酶型碱性蛋白酶和足够相关的蛋白质及其衍生物。还有洗涤和清洁剂，其包含新的枯草杆菌蛋白酶型碱性蛋白酶，足够相关的蛋白质及其衍生物，相应的洗涤和清洁方法，以及洗涤和清洁剂以及其它可能的技术用途。

2. 发明申请

US20090275493A1 Novel Alkaline Protease from Bacillus Gibsonii and Washing and Cleaning Agents containing said Novel Alkaline Protease 审中-公开
标题翻译：来自芽孢杆菌的新型碱性蛋白酶和含有所述新型碱性蛋白酶的洗涤和清洁剂
公开(公告)号：US20090275493A1
公开(公告)日：2009-11-05
申请号：US12502459
申请日：2009-07-14
申请人： Petra Siegert , Susanne Wieland , Julia Engelskirchen , Marion Merkel , Karl-Heinz Maurer , Cornelius Bessler
发明人： Petra Siegert , Susanne Wieland , Julia Engelskirchen , Marion Merkel , Karl-Heinz Maurer , Cornelius Bessler
IPC分类号： C11D3/386 , C07H21/04 , C12P19/34 , C12N15/63 , C12N9/54 , C12N1/21 , C12N1/19
CPC分类号： C11D3/386 , A61K8/66 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C12N9/54
摘要： A novel subtilisin-type alkaline protease from Bacillus gibsonii and to sufficiently related proteins and the derivatives thereof. Also, washing and cleaning agents comprising the novel subtilisin-type alkaline protease, sufficiently related proteins and the derivatives thereof, corresponding washing and cleaning methods and their use in washing and cleaning agents, and other possible technical uses.
摘要翻译：来自芽孢杆菌的新型枯草杆菌蛋白酶型碱性蛋白酶和足够相关的蛋白质及其衍生物。此外，包含新的枯草杆菌蛋白酶型碱性蛋白酶，足够相关的蛋白质及其衍生物的洗涤和清洁剂，相应的洗涤和清洁方法及其在洗涤和清洁剂中的用途以及其它可能的技术用途。

3. 发明申请

US20100234267A1 AGENTS CONTAINING PROTEASES FROM STENOTROPHOMONAS MALTOPHILIA 审中-公开
标题翻译：含有葡萄球菌的蛋白质的试剂
公开(公告)号：US20100234267A1
公开(公告)日：2010-09-16
申请号：US12685215
申请日：2010-01-11
申请人： Petra Siegert , Susanne Wieland , Karl-Heinz Maurer , Cornelius Bessler , Doris Ribitsch , Sonja Heumann , Georg Gübitz , Wolfgang Karl , Peter Remler , Helmut Schwab , Gabriele Berg , Jochen Gerlach
发明人： Petra Siegert , Susanne Wieland , Karl-Heinz Maurer , Cornelius Bessler , Doris Ribitsch , Sonja Heumann , Georg Gübitz , Wolfgang Karl , Peter Remler , Helmut Schwab , Gabriele Berg , Jochen Gerlach
IPC分类号： C11D7/42 , C12N9/48
CPC分类号： C12N9/52 , C11D3/386
摘要： The present invention relates to agent compositions, in particular washing and cleaning agents, that contain a protease from a bacterial strain of the species Stenotrophomonas maltophilia, and to said proteases themselves. The invention further relates to cleaning methods in which said agents are used, and to uses of said agents. The invention further relates to the manufacture and use of these proteases themselves.
摘要翻译：本发明涉及含有来自嗜麦芽寡养单胞菌属细菌菌株的蛋白酶和所述蛋白酶本身的药剂组合物，特别是洗涤和清洁剂。本发明还涉及其中使用所述试剂的清洁方法以及所述试剂的用途。本发明还涉及这些蛋白酶本身的制造和使用。

4. 发明申请

US20130005637A1 PERFORMANCE-ENHANCED PROTEASE VARIANT 有权
标题翻译：性能增强的保护品
公开(公告)号：US20130005637A1
公开(公告)日：2013-01-03
申请号：US13583602
申请日：2011-03-10
申请人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
发明人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
IPC分类号： C12N9/56 , C11D3/386 , C12N1/21
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： Proteases encompassing an amino acid sequence that is at least 70% identical to the amino acid sequence indicated in SEQ ID NO. 1 over its entire length, and exhibit the amino acid substitution I21V in the count in accordance with SEQ ID NO. 1, resp. agents that encompass such proteases, display very good cleaning performance on protease-sensitive stains.
摘要翻译：包含与SEQ ID NO：1所示的氨基酸序列至少70％相同的氨基酸序列的蛋白酶。 1，并且按照SEQ ID NO：1显示计数中的氨基酸取代度I21V。 1，或包含这种蛋白酶的试剂在蛋白酶敏感染色剂上表现出非常好的清洁性能。

5. 发明授权

US09365844B2 Performance-enhanced protease variant 有权
标题翻译：性能增强的蛋白酶变体
公开(公告)号：US09365844B2
公开(公告)日：2016-06-14
申请号：US13583602
申请日：2011-03-10
申请人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
发明人： Petra Siegert , Ulrich Schwaneberg , Ronny Martinez , Marion Merkel , Astrid Spitz , Susanne Wieland , Hendrik Hellmuth , Karl-Heinz Maurer
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： Proteases encompassing an amino acid sequence that is at least 70% identical to the amino acid sequence indicated in SEQ ID NO. 1 over its entire length, and exhibit the amino acid substitution I21V in the count in accordance with SEQ ID NO. 1, agents that encompass such proteases, display very good cleaning performance on protease-sensitive stains.
摘要翻译：包含与SEQ ID NO：1所示的氨基酸序列至少70％相同的氨基酸序列的蛋白酶。 1，并且按照SEQ ID NO：1显示计数中的氨基酸取代度I21V。 1，包含这种蛋白酶的试剂在蛋白酶敏感性污渍上表现出非常好的清洁性能。

6. 发明授权

US09163226B2 Storage-stable liquid washing or cleaning agent containing proteases 有权
标题翻译：储存稳定的液体洗涤剂或含有蛋白酶的清洁剂
公开(公告)号：US09163226B2
公开(公告)日：2015-10-20
申请号：US13422260
申请日：2012-03-16
申请人： Susanne Wieland , Petra Siegert , Astrid Spitz , Karl-Heinz Maurer , Timothy O'Connell , Inken Prueser , Marc-Steffen Schiedel , Thomas Eiting , Dorota Sendor-Mueller , Thorsten Bastigkeit , Konstantin Benda , Sven Mueller
发明人： Susanne Wieland , Petra Siegert , Astrid Spitz , Karl-Heinz Maurer , Timothy O'Connell , Inken Prueser , Marc-Steffen Schiedel , Thomas Eiting , Dorota Sendor-Mueller , Thorsten Bastigkeit , Konstantin Benda , Sven Mueller
IPC分类号： C12Q1/37 , C12N9/50 , D06M16/00 , C11D3/00 , C11D9/50 , C07H21/04 , C12N9/54 , C11D3/36 , C11D7/36 , C11D3/386
CPC分类号： C12N9/54 , C11D3/361 , C11D3/38618 , C11D7/36
摘要： Phosphonate-containing liquid washing or cleaning agent exhibiting advantageous proteolytic activity and improved storage stability comprising a protease having an amino acid sequence which is at least 80% identical to the amino acid sequence stated in SEQ ID NO. 1 and which comprises in position 99 in the numbering according to SEQ ID NO. 1 the amino acid glutamic acid (E) or aspartic acid (D) or the amino acid asparagine (N) or glutamine (Q) or the amino acid alanine (A) or glycine (G) or serine (S).
摘要翻译：含有膦酸盐的液体洗涤剂或洗涤剂显示出有利的蛋白水解活性和改善的储存稳定性，其包含具有与SEQ ID NO：1所示氨基酸序列至少80％相同的氨基酸序列的蛋白酶。 1，并且其包含在根据SEQ ID NO：1的编号中的位置99。氨基酸谷氨酸（E）或天冬氨酸（D）或氨基酸天冬酰胺（N）或谷氨酰胺（Q）或氨基酸丙氨酸（A）或甘氨酸（G）或丝氨酸（S）。

7. 发明授权

US08785365B2 Alpha-amylase variants stabilized against dimerization and/or multimerization, method for the production thereof, and detergents and cleansers containing these alpha-amylase variants 有权
标题翻译：稳定抗二聚和/或多聚化的α-淀粉酶变体，其生产方法，以及含有这些α-淀粉酶变体的洗涤剂和清洁剂
公开(公告)号：US08785365B2
公开(公告)日：2014-07-22
申请号：US11692691
申请日：2007-03-28
申请人： Cornelius Bessler , Susanne Wieland , Karl-Heinz Maurer
发明人： Cornelius Bessler , Susanne Wieland , Karl-Heinz Maurer
IPC分类号： C12N9/28 , C11D3/386 , C12S11/00 , C12S9/00
CPC分类号： C12N9/2417 , C11D3/38681
摘要： The present invention relates to α-amylase variants that are stabilized to dimerization and/or multimerization, in particular at elevated temperatures or high pH, by point mutagenesis of positively polarized or charged or neutral surface amino acids to give more negatively polarized or charged amino acids. The invention further relates to methods of increasing the stability of an α-amylase to dimerization and/or multimerization brought about by electrostatic interactions whereby at least one amino acid residue on the surface of the starting molecule, which makes a neutral or positively polar or charged contribution to the electrostatic potential of said molecule, is replaced with a more negatively polar or negatively charged amino acid residue. The α-amylase variants obtained thereby exhibit better stability to influences of the solvent, increased processivity, and are suited for numerous industrial areas of use, in particular as active ingredients in detergents and cleansers.
摘要翻译：本发明涉及通过正极化或带电荷或中性表面氨基酸的点诱变稳定至二聚化和/或多聚化的α-淀粉酶变体，特别是在升高的温度或高pH下，以产生更多的负极化或带电荷的氨基酸。本发明还涉及增加α-淀粉酶对由静电相互作用引起的二聚化和/或多聚化的稳定性的方法，其中起始分子表面上至少有一个氨基酸残基，其形成中性或正极性或带电对所述分子的静电电位的贡献被更负极性或带负电荷的氨基酸残基取代。由此获得的α-淀粉酶变体对溶剂的影响表现出更好的稳定性，增加的持续性，并且适用于许多工业使用领域，特别是作为洗涤剂和清洁剂中的活性成分。

8. 发明申请

US20050282261A1 Novel choline oxidases 审中-公开
标题翻译：新型胆碱氧化酶
公开(公告)号：US20050282261A1
公开(公告)日：2005-12-22
申请号：US11156003
申请日：2005-06-17
申请人： Kerstin Sauter , Albrecht Weiss , Karl-Heinz Maurer , Stefan Evers , Nina Hoven , Susanne Wieland , Regina Stehr , Cornelius Bessler
发明人： Kerstin Sauter , Albrecht Weiss , Karl-Heinz Maurer , Stefan Evers , Nina Hoven , Susanne Wieland , Regina Stehr , Cornelius Bessler
IPC分类号： A23L29/00 , A61K8/66 , A61Q5/02 , A61Q5/10 , A61Q11/02 , C12N9/04 , D06L4/40 , C12N9/00
CPC分类号： C12N9/0006 , A61K8/66 , A61Q5/02 , A61Q5/10 , A61Q11/02 , C12Y101/03017
摘要： The invention relates to novel choline oxidases, methods for obtaining the same, bodycare products, haircare products, shampoos, oral, dental and dental prosthesis care products, cosmetics, washing products, cleaning products, rinsing products, hand soaps, washing-up detergents and dishwasher detergents comprising novel choline oxidases and uses of the novel choline oxidases.
摘要翻译：本发明涉及新型胆碱氧化酶，其获得方法，身体护理产品，护发产品，洗发剂，口腔，牙科和牙科假体护理产品，化妆品，洗涤产品，清洁产品，漂洗产品，手肥皂，洗涤洗涤剂和洗碗机洗涤剂包含新型胆碱氧化酶和新型胆碱氧化酶的用途。

9. 发明授权

US08080401B2 Alpha-amylase variants having an elevated solvent stability, method for the production thereof and detergents and cleansers containing these alpha-amylase variants 有权
标题翻译：具有提高的溶剂稳定性的α-淀粉酶变体，其制备方法和含有这些α-淀粉酶变体的洗涤剂和清洁剂
公开(公告)号：US08080401B2
公开(公告)日：2011-12-20
申请号：US11692504
申请日：2007-03-28
申请人： Cornelius Bessler , Susanne Wieland , Karl-Heinz Maurer
发明人： Cornelius Bessler , Susanne Wieland , Karl-Heinz Maurer
IPC分类号： C12N9/28 , C12N9/26 , C12N9/00 , C02F3/34 , C11D3/00 , C07H21/04 , C07K14/00
CPC分类号： C11D3/38681 , C12N9/2417
摘要： The present invention relates to α-amylase variants that are stabilized to solvent-exerted hydrolysis, in particular at elevated temperatures or high pH, by point mutagenesis of asparagine (N) or glutamine (Q) residues located on the surface of the molecule to give other amino acid residues. The invention further relates to methods of increasing the stability of an α-amylase to solvent-exerted hydrolysis, in particular at elevated temperatures or high pH, whereby at least one asparagine (N) or glutamine (Q) residue on the surface of the molecule is replaced with a different amino acid residue. The α-amylase variants obtained thereby exhibit better stability to influences of the solvent, increased processivity, and are suited for numerous industrial areas of use, in particular as active ingredients in detergents and cleansers.
摘要翻译：本发明涉及通过位于分子表面上的天冬酰胺（N）或谷氨酰胺（Q）残基的点诱变而稳定化为溶剂施加水解的α-淀粉酶变体，特别是在升高的温度或高pH下，得到其他氨基酸残基。本发明还涉及增加α-淀粉酶对溶剂发生水解的稳定性的方法，特别是在升高的温度或高pH下，其中分子表面上至少有一个天冬酰胺（N）或谷氨酰胺（Q）残基被不同的氨基酸残基取代。由此获得的α-淀粉酶变体对溶剂的影响表现出更好的稳定性，增加的持续性，并且适用于许多工业使用领域，特别是作为洗涤剂和清洁剂中的活性成分。

10. 发明授权

US07569226B2 Alkaline protease from Bacillus sp. (DSM 14392) and washing and cleaning products comprising said alkaline protease 有权
标题翻译：来自芽孢杆菌的碱性蛋白酶（DSM 14392）和包含所述碱性蛋白酶的洗涤和清洁产品
公开(公告)号：US07569226B2
公开(公告)日：2009-08-04
申请号：US10873610
申请日：2004-06-22
申请人： Angrit Weber , Angela Hellebrandt , Susanne Wieland , Karl-Heinz Maurer , Beatrix Kottwitz
发明人： Angrit Weber , Angela Hellebrandt , Susanne Wieland , Karl-Heinz Maurer , Beatrix Kottwitz
IPC分类号： C11D3/20 , A61K39/38 , A61K39/02 , A61K39/07 , C12N15/00 , C12N1/12 , C12N5/02
CPC分类号： C12N9/54 , C11D3/386
摘要： The invention relates to a novel alkaline protease of the subtilisin type from Bacillus sp. (DSM 14392) and various related proteins and derivatives thereof. The invention further relates to washing and cleaning agents comprising novel alkaline proteases of the subtilisin type, various related proteins and derivatives thereof and corresponding washing and cleaning methods and use thereof in washing and cleaning agents and further technical applications.
摘要翻译：本发明涉及一种来自芽孢杆菌属的枯草杆菌蛋白酶的新型碱性蛋白酶。（DSM 14392）及其各种相关蛋白及其衍生物。本发明还涉及包含枯草杆菌蛋白酶类型的新型碱性蛋白酶，各种相关蛋白质及其衍生物以及相应的洗涤和清洁方法及其在洗涤和清洁剂中的应用以及其它技术应用的洗涤和清洁剂。

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