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1. 发明申请

US20140359901A1 SEED-SPECIFIC PROMOTER IN COTTON 审中-公开
标题翻译：种子特殊促销商在棉花
公开(公告)号：US20140359901A1
公开(公告)日：2014-12-04
申请号：US14110212
申请日：2012-04-05
申请人： Marie-Therese Scheirlinck , Frank Meulewaeter , John Jacobs
发明人： Marie-Therese Scheirlinck , Frank Meulewaeter , John Jacobs
IPC分类号： C12N15/82
CPC分类号： C12N15/8234 , C12N15/8261 , Y02A40/146
摘要： The present application discloses a(n) (isolated) nucleic acid sequence comprising a nucleotide sequence selected from (a) SEQ ID NO: 1 or a fragment thereof, wherein said fragment comprises at least 400 consecutive nucleotides of SEQ ID NO: 1 and has seed-specific promoter activity; (b) a nucleotide sequence with at least 80% sequence identity with SEQ ID NO: 1 and having seed-specific promoter activity; (c) a nucleotide sequence hybridizing under stringent conditions to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence complementary to the nucleotide sequence of any one of (a) to (c). Further disclosed herein is a chimeric gene comprising the (isolated) nucleic acid described herein operably linked to a nucleic acid coding for an expression product of interest, and optionally a transcription termination and polyadenylation sequence. Also disclosed herein are a vector, a transgenic plant cell, a transgenic plant and a seed as characterized in the claims. Methods disclosed herein relate to the production of a transgenic plant, growing cotton, producing a seed, effecting seed-specific expression of a product in cotton and of altering fiber properties in a cotton plant as characterized in the claims.
摘要翻译：本申请公开了包含选自（a）SEQ ID NO：1或其片段的核苷酸序列的（n）（分离的）核酸序列，其中所述片段包含SEQ ID NO：1的至少400个连续核苷酸，并且具有种子特异性启动子活性; （b）与SEQ ID NO：1具有至少80％序列同一性且具有种子特异性启动子活性的核苷酸序列; （c）在严格条件下与（a）或（b）的核苷酸序列杂交的核苷酸序列; 和（d）与（a） - （c）中任一个的核苷酸序列互补的核苷酸序列。本文进一步公开的是包含本文所述的（分离的）核酸的嵌合基因，其与编码感兴趣的表达产物的核酸以及任选的转录终止和多聚腺苷酸化序列可操作地连接。本文还公开了权利要求中特征的载体，转基因植物细胞，转基因植物和种子。本文公开的方法涉及在权利要求中表征的转基因植物，生长棉花，产生种子，产生棉花中的产品的种子特异性表达和改变棉花植物中的纤维性质的生产。

2. 发明授权

US07148400B1 Methods and means for delivering inhibitory RNA to plants and applications thereof 有权
标题翻译：向植物递送抑制性RNA的方法和方法及其应用
公开(公告)号：US07148400B1
公开(公告)日：2006-12-12
申请号：US09551494
申请日：2000-04-18
申请人： Frank Meulewaeter , Marc Cornelissen , John Jacobs , Gerben Van Eldik , Michael Metzlaff
发明人： Frank Meulewaeter , Marc Cornelissen , John Jacobs , Gerben Van Eldik , Michael Metzlaff
IPC分类号： C12N15/82 , C12N15/83 , C12N15/09
CPC分类号： C12N15/8203 , C12N15/8218
摘要： The invention provides methods and means for the identification of genes involved in the determination of a plant trait or for the identification encoded by a nucleic acid comprising a determined nucleotide sequence. The invention also provides kits comprising viral RNA vectors derived from satellite viruses and corresponding helper viruses for the introduction of inhibitory RNA into plant cells and plants.
摘要翻译：本发明提供了用于鉴定涉及植物性状的确定或由包含确定的核苷酸序列的核酸编码的鉴定的基因的方法和手段。本发明还提供了包含衍生自卫星病毒的病毒RNA载体和用于将抑制性RNA引入植物细胞和植物的相应辅助病毒的试剂盒。

3. 发明授权

US10070740B2 Adjustable fastener 有权
公开(公告)号：US10070740B2
公开(公告)日：2018-09-11
申请号：US14932188
申请日：2015-11-04
申请人： John Jacobs
发明人： John Jacobs
IPC分类号： A47G1/16 , A47G1/20
CPC分类号： A47G1/164 , A47G1/202 , F16B21/073 , F16B45/00 , F16M11/046 , F16M13/02
摘要： An adjustable fastener is provided. The adjustable fastener includes an elongated main body and a mounting bracket for receiving the main body therein. The elongated main body includes a plurality of teeth along the length of the main body. The mounting bracket includes a latching mechanism disposed on a front face thereof, the latching mechanism having a first end including a release lever and a second end including a plurality of ribs extending into an interior volume of the mounting bracket. The ribs on the second end of the latching mechanism engage with the teeth on the main body to slidably secure the main body within the mounting bracket, thereby providing a vertically adjustable fastener.

4. 发明授权

US07338965B2 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines 失效
标题翻译： 3,4-二取代，3,5-二取代和3,4,5-取代的哌啶
公开(公告)号：US07338965B2
公开(公告)日：2008-03-04
申请号：US10299746
申请日：2002-11-19
申请人： Joseph B. Moon , Shon R. Pulley , Daniel H. Rich , David L. Brown , Barbara Jagodzinska , Varghese John , John Jacobs
发明人： Joseph B. Moon , Shon R. Pulley , Daniel H. Rich , David L. Brown , Barbara Jagodzinska , Varghese John , John Jacobs
IPC分类号： A61K31/445 , C07D211/42
CPC分类号： C07D401/04 , C07D211/40 , C07D211/42 , C07D401/12 , C07D405/04 , C07D409/12 , C07D409/14
摘要： The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R1, R2 and R3 are as described in the specification.
摘要翻译：本发明涉及可用于治疗阿尔茨海默病的取代的哌啶，哌嗪，吗啉和硫代吗啉化合物，更具体地涉及能够抑制β-分泌酶的化合物，其是切割淀粉样蛋白前体蛋白以产生淀粉状蛋白β肽（A-β ）是阿尔茨海默病患者大脑中发现的淀粉样斑块的主要成分。本发明的一个实施方案涉及具有以下结构的化合物：其中Z为CR或N，且R 1，R 2和R 3为如说明书中所述。

5. 发明授权

US07257594B2 Method, system, and product for data integration through a dynamic common model 有权
标题翻译：通过动态共同模型进行数据集成的方法，系统和产品
公开(公告)号：US07257594B2
公开(公告)日：2007-08-14
申请号：US10818618
申请日：2004-04-06
申请人： Aderbad Tamboli , John Jacobs
发明人： Aderbad Tamboli , John Jacobs
IPC分类号： G06F17/00
CPC分类号： G06F17/30569 , Y10S707/99932 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99952 , Y10S707/99953
摘要： Data integration including extracting a first native record having a first native format from a first native repository through a first adapter, the first adapter loosely coupled for data integration to a data integration application, the first native format having a datatype; transforming the first native record having first native format to a first native record having dynamic common format, the dynamic common format being a subset of a dynamic common model, the dynamic common model comprising mappings to and from the dynamic common format for all native records in all datatypes; transforming the format of the first native record having dynamic common format to a first native record having second native format; and inserting through a second adapter, also loosely coupled to the application, the first native record the second native format into a second native repository.
摘要翻译：数据集成包括通过第一适配器从第一本地存储库提取具有第一原始格式的第一本地记录，第一适配器松散地耦合用于数据集成到数据集成应用，第一本机格式具有数据类型; 将具有第一本机格式的第一原生记录转换为具有动态通用格式的第一原生记录，所述动态通用格式是动态公共模型的子集，所述动态公共模型包括与所有本机记录的动态通用格式的映射所有数据类型将具有动态通用格式的第一原生记录的格式转换为具有第二原生格式的第一原生记录; 并且通过也松散地耦合到应用的第二适配器插入第二原生格式到第二本地存储库。

6. 发明申请

US20060134736A1 Human growth hormone conjugated with biocompatible polymer 审中-公开
标题翻译：与生物相容性聚合物结合的人生长激素
公开(公告)号：US20060134736A1
公开(公告)日：2006-06-22
申请号：US11314926
申请日：2005-12-20
申请人： John Jacobs , Shiliang Qin , Mingyu Zhang , Huaina Li , Myung-Ok Park
发明人： John Jacobs , Shiliang Qin , Mingyu Zhang , Huaina Li , Myung-Ok Park
IPC分类号： C12P21/06 , A61K38/27 , C07K14/61
CPC分类号： A61K38/27 , A61K47/60 , C07K14/61
摘要： The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 2:1 or less, preferably 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in vivo half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.
摘要翻译：本发明涉及生物相容性聚合物和hGH，特别是PEG-hGH的缀合物，其中活化的生物相容性聚合物以2:1或更低，优选1：1的摩尔比与hGH的羧基缀合，制备方法，和相关的药物组合物。 PEG-hGH缀合物具有高达天然hGH活性的20％，而体内半衰期增加10倍。 PEG-hGH缀合物可用于治疗生长迟缓或生长衰竭，特别是儿童身材矮小以及与老化有关的病症。

7. 发明申请

US20060048801A1 Tungsten plug corrosion prevention method using gas sparged water 审中-公开
标题翻译：钨丝塞防腐方法采用气体喷淋水
公开(公告)号：US20060048801A1
公开(公告)日：2006-03-09
申请号：US11267557
申请日：2005-11-04
申请人： John Jacobs , Elizabeth Dauch
发明人： John Jacobs , Elizabeth Dauch
IPC分类号： B08B3/00
CPC分类号： H01L21/02071 , H01L21/6708 , H01L21/76838
摘要： Disclosed herein is a method of making integrated circuits. In one embodiment the method includes forming tungsten plugs in a integrated circuit and forming electrically conductive interconnect lines after formation of the tungsten plugs, wherein at least one tungsten plug is electrically connected to at least one electrically conductive interconnect line. Separate from the formation of the tungsten plugs and electrically conductive interconnect lines, a gas is introduced into a liquid. At least one electrically conductive interconnect line is then contacted with the gas introduced liquid.
摘要翻译：本文公开了一种制造集成电路的方法。在一个实施例中，该方法包括在集成电路中形成钨插塞并且在形成钨插塞之后形成导电互连线，其中至少一个钨插头电连接到至少一个导电互连线。与钨塞和导电互连线的形成分开，将气体引入液体。然后至少一个导电互连线与引入气体的液体接触。

8. 发明申请

US20050090112A1 Tungsten plug corrosion prevention method using ionized air 失效
标题翻译：钨丝塞防腐方法采用电离空气
公开(公告)号：US20050090112A1
公开(公告)日：2005-04-28
申请号：US10695528
申请日：2003-10-28
申请人： John Jacobs , Elizabeth Dauch
发明人： John Jacobs , Elizabeth Dauch
IPC分类号： H01L21/311 , H01L21/768
CPC分类号： H01L21/76838
摘要： Disclosed herein is a method of making integrated circuits. In one embodiment the method includes forming tungsten plugs in the integrated circuit and forming electrically conductive interconnect lines in the integrated circuit after formation of the tungsten plugs. At least one tungsten plug is electrically connected to at least one electrically conductive interconnect line. Thereafter at least one electrically conductive interconnect line is exposed to ionized air.
摘要翻译：本文公开了一种制造集成电路的方法。在一个实施例中，该方法包括在集成电路中形成钨插塞并在形成钨插塞之后在集成电路中形成导电互连线。至少一个钨插塞电连接到至少一个导电互连线。此后，至少一个导电互连线暴露于电离空气。

9. 发明授权

US09121074B2 Gossypium hirsutum plants with increased fiber strength comprising a fiber strength allele spanning the GLUC1.1A gene from Gossypium barbadense 有权
标题翻译：具有纤维强度增加的陆地棉属植物，其包含横跨来自棉花（Gossypium barbadense）的GLUC1.1A基因的纤维强度等位基因
公开(公告)号：US09121074B2
公开(公告)日：2015-09-01
申请号：US12992907
申请日：2009-05-25
申请人： Tony Arioli , Steven Engelen , John Jacobs , Michel Van Thournout , Stephane Bourot
发明人： Tony Arioli , Steven Engelen , John Jacobs , Michel Van Thournout , Stephane Bourot
IPC分类号： C12N15/82 , C12N9/24 , C12Q1/68
CPC分类号： C12N15/8255 , C12N9/2402 , C12N15/8218 , C12N15/8246 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , C12Y302/01039
摘要： This invention relates to the field of agriculture, more specifically to the use of molecular biology techniques to alter fiber-producing plants, particularly cotton plants, and/or accelerate breeding of such fiber-producing plants. Methods and means are provided to alter fiber qualities, such as increasing fiber strength. Methods are also provided to identify molecular markers associated with fiber strength in a population of cotton varieties and related progenitor plants.
摘要翻译：本发明涉及农业领域，更具体地涉及使用分子生物学技术改变纤维生产植物，特别是棉花植物，和/或加速这种纤维生产植物的育种。提供了改变纤维质量的方法和手段，例如增加纤维强度。还提供了用于鉴定棉花品种和相关祖细胞群体中与纤维强度相关的分子标记的方法。

10. 发明申请

US20120000597A1 Method of manufacturing composite parts 有权
标题翻译：复合零件的制造方法
公开(公告)号：US20120000597A1
公开(公告)日：2012-01-05
申请号：US13138551
申请日：2010-03-01
申请人： Simon Astwood , John Jacobs , Matthew Hocking , Jago Pridie
发明人： Simon Astwood , John Jacobs , Matthew Hocking , Jago Pridie
IPC分类号： B65H81/06
CPC分类号： B29C70/32 , B29C70/44 , B29C70/446
摘要： A method of manufacturing two or more composite parts, the method comprising: assembling the composite parts on a mandrel by laying a series of layers of bands of composite material onto the mandrel with a placement machine,—rotating the mandrel as the bands are laid onto the mandrel; attaching two or more debulk frames (10, 11) to the mandrel between opposed edges of the composite parts after the composite parts have been assembled; wrapping the mandrel, debulk frames (10, 11) and composite parts in a debulk bag; heating the composite parts,—forming a vacuum between the mandrel and the debulk bag so that the debulk bag is sucked into voids between the debulk frames and the heated composite parts and progressively presses against the heated composite parts whereby excess material is squeezed by the debulk bag towards their opposed edges; and removing the debulk bag and the composite parts from the mandrel.
摘要翻译：一种制造两个或多个复合部件的方法，所述方法包括：通过将放置机器的一系列复合材料带放置在所述心轴上来将所述复合部件组装在心轴上，当将所述带放置在所述带上时旋转所述心轴心轴在复合部件组装之后，在复合部件的相对边缘之间将两个或更多个去磁框架（10,11）连接到心轴上; 将心轴，减压框架（10,11）和复合部件包裹在减压袋中; 加热复合部件，在心轴和去毛刺袋之间形成真空，使得去毛刺袋被吸入脱泡框架和被加热的复合部件之间的空隙中，并逐渐地压靠加热的复合部件，由此多余的材料被除垢剂挤压袋子朝向相对的边缘; 并从芯棒上去除去毛刺袋和复合部件。

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