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1. 发明授权

US08007792B2 Antibodies directed against hepatitis C virus E1E2 complex, compositions of HCV particles, and pharmaceutical compositions 有权
标题翻译：针对丙型肝炎病毒E1E2复合物的抗体，HCV颗粒的组合物和药物组合物
公开(公告)号：US08007792B2
公开(公告)日：2011-08-30
申请号：US12408080
申请日：2009-03-20
申请人： Marie-Anne Petit , Colette Jolivet-Reynaud , Christian Trepo
发明人： Marie-Anne Petit , Colette Jolivet-Reynaud , Christian Trepo
IPC分类号： A61K39/395
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译：新的构象抗体针对HCV，更具体地针对单克隆抗体。颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒，以及它们的制备方法。

2. 发明授权

US07524650B2 Antibodies directed against hepatitis C virus E1E2 complex, compositions of HCV particles, and pharmaceutical compositions 失效
标题翻译：针对丙型肝炎病毒E1E2复合物的抗体，HCV颗粒的组合物和药物组合物
公开(公告)号：US07524650B2
公开(公告)日：2009-04-28
申请号：US10550295
申请日：2004-03-31
申请人： Marie-Anne Petit , Colette Jolivet-Reynaud
发明人： Marie-Anne Petit , Colette Jolivet-Reynaud
IPC分类号： A61K39/395
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译：新的构象抗体针对HCV，更具体地针对单克隆抗体。颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒及其制备方法。

3. 发明申请

US20070026003A1 Antibodies directed against hepatitis c virus e1e2 complex, compositions of hcv particles, and pharmaceutical compositions 失效
标题翻译：针对丙型肝炎病毒e1e2复合物的抗体，hcv颗粒的组合物和药物组合物
公开(公告)号：US20070026003A1
公开(公告)日：2007-02-01
申请号：US10550295
申请日：2004-03-31
申请人： Marie-Anne Petit , Colette Jolivet-Reynaud
发明人： Marie-Anne Petit , Colette Jolivet-Reynaud
IPC分类号： A61K39/42 , C12Q1/70 , C12N7/00 , C07K16/10
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译：新的构象抗体针对HCV，更具体地针对单克隆抗体。颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒，以及它们的制备方法。

4. 发明授权

US08236506B2 Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the KLK8 gene encoding kallikrein 8 and use thereof for prognosticating survival 有权
标题翻译：通过检测编码激肽释放酶8的KLK8基因的主要替代转录物进行体外诊断支气管肺癌的方法及其在预后中的应用
公开(公告)号：US08236506B2
公开(公告)日：2012-08-07
申请号：US12310622
申请日：2007-09-27
申请人： Mireille Ainciburu , Yves Courty , Colette Jolivet-Reynaud , Chris Planque
发明人： Mireille Ainciburu , Yves Courty , Colette Jolivet-Reynaud , Chris Planque
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12N9/6421 , C12Q1/6886 , C12Q2600/118
摘要： The present invention relates to a method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, characterized in that it comprises the stage of detecting, in a biological sample derived from a patient suspected to be suffering from said bronchopulmonary carcinoma, at least one of the major alternative transcripts of the KLK8 gene encoding kallikrein 8. This method is particularly useful for the survival prognostication of patients suffering from bronchopulmonary carcinoma.
摘要翻译：本发明涉及一种用于体外诊断支气管肺癌，特别是非小细胞支气管癌的方法，其特征在于，其包括检测来自疑似患有所述支气管肺癌，编码激肽释放酶8的KLK8基因的主要替代转录物中的至少一种。该方法对于患有支气管肺癌的患者的生存预后特别有用。

5. 发明申请

US20070117189A1 VIRAL MATERIAL AND NUCLEOTIDE FRAGMENTS ASSOCIATED WITH MULTIPLE SCLEROSIS, FOR DIAGNOSTIC, PROPHYLACTIC AND THERAPEUTIC PURPOSES 有权
标题翻译：与多发性硬化相关的病理材料和核素片段，用于诊断，预防和治疗目的
公开(公告)号：US20070117189A1
公开(公告)日：2007-05-24
申请号：US11463109
申请日：2006-08-08
申请人： Herve PERRON , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve PERRON , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N2740/10022 , C12Q1/6883 , C12Q1/702
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译：分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO：至少50％，优选至少70％：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。

6. 发明申请

US20110039353A1 METHOD FOR DIRECT DETECTION OF ISCHEMIA-MODIFIED ALBUMIN USING A PARTNER FOR BINDING TO AN ALDEHYDE DERIVATIVE RESULTING FROM THE PEROXIDATION OF LIPIDS IN BOUND FORM 审中-公开
标题翻译：使用合作伙伴直接检测异构体修饰的ALBUM的方法，用于结合来自于形式中脂肪过氧化物的ALDEHYDE DERIVATIVE
公开(公告)号：US20110039353A1
公开(公告)日：2011-02-17
申请号：US12865562
申请日：2009-03-10
申请人： Christine Des Rosiers , Colette Jolivet-Reynaud , Jerome Martinez
发明人： Christine Des Rosiers , Colette Jolivet-Reynaud , Jerome Martinez
IPC分类号： G01N33/566 , G01N33/68 , C07K16/18
CPC分类号： G01N33/6893 , C07K16/18 , G01N2333/765 , G01N2800/324
摘要： The present invention relates to the use of at least one partner for binding to an aldehyde derivative resulting from the peroxidation of lipids in protein-bound form, for instance to 4-hydroxy-2-nonenal, to 4-hydroxy-2-hexenal or to malondialdehyde, for the detection of ischemia-modified albumin (IMA) in a biological sample.
摘要翻译：本发明涉及至少一种配偶体与蛋白质结合形式的脂质例如4-羟基-2-壬烯醛过氧化成4-羟基-2-己烯醛的醛衍生物的结合的用途，或用于丙二醛，用于检测生物样品中的缺血 - 修饰的白蛋白（IMA）。

7. 发明授权

US07674888B2 Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权
标题翻译：与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的
公开(公告)号：US07674888B2
公开(公告)日：2010-03-09
申请号：US11581030
申请日：2006-10-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N9/1241 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.
摘要翻译：本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。

8. 发明申请

US20070254317A1 Method for Detecting the Activatable Free Form of Psa and the Use Thereof for Diagnosing Benign Pathologies of the Prostate and Adenocarcinoma of the Prostate 审中-公开
标题翻译：检测Psa可活化自由形式的方法及其用途，用于诊断前列腺前列腺和腺癌的良性病理
公开(公告)号：US20070254317A1
公开(公告)日：2007-11-01
申请号：US10590272
申请日：2005-03-01
申请人： Sandrine Busseret-Michel , Colette Jolivet-Reynaud
发明人： Sandrine Busseret-Michel , Colette Jolivet-Reynaud
IPC分类号： G01N33/53
CPC分类号： G01N33/57434 , G01N2333/96455
摘要： The present invention relates to a method for the in vitro diagnosing of a benign pathology of the prostate or of an adenocarcinoma of the prostate, characterized in that it comprises the step consisting of detection, in a biological sample from a patient suspected of suffering from a benign pathology of the prostate or from an adenocarcinoma of the prostate, of the activatable free form of PSA. This method of diagnosis can be carried out by means of the steps consisting in: i) bringing a binding partner capable of binding specifically to activatable free PSA into contact with a biological sample from a patient suspected of suffering from a benign pathology of the prostate or of an adenocarcinoma of the prostate, ii) demonstrating the capture of the activatable free form of PSA by said binding partner, iii) calculating the ratio of the amount of activatable free form of PSA detected in step ii) to the amount of a form of PSA other than the activatable free form, present in a sample of the same nature taken from the same individual, and iv) determining whether the patients are suffering from an adenocarcinoma of the prostate or from a benign pathology of the prostate by comparing the value of the ratio determined in step iii) with a predetermined threshold value, chosen according to the type of ratio used and representative of the detection limit of each pathology.
摘要翻译：本发明涉及用于体外诊断前列腺或前列腺腺癌的良性病理学的方法，其特征在于它包括以下步骤：检测来自怀疑患有前列腺的良性病理学或来自前列腺的腺癌的可激活的游离形式的PSA。这种诊断方法可以通过以下步骤进行：i）使能够特异性结合可活化游离PSA的结合配偶体与怀疑患有前列腺良性病变的患者的生物样品接触，或的前列腺腺癌，ii）证明通过所述结合配偶体捕获可激活的游离形式的PSA，iii）计算在步骤ii）中检测到的PSA的可活化游离形式的量与所述结合配偶体形式的量的比例存在于从相同个体获得的相同性质的样品中的PSA以外的PSA，以及iv）通过比较前列腺的患者是否患有前列腺腺癌或从前列腺的良性病理确定根据所使用的比例类型选择具有预定阈值的步骤iii）中确定的比例，并代表每个病理学的检测限。

9. 发明授权

US06602853B1 Antigenic peptides reacting with anti-ovary antibodies 失效
标题翻译：与抗卵巢抗体反应的抗原肽
公开(公告)号：US06602853B1
公开(公告)日：2003-08-05
申请号：US09331872
申请日：1999-09-24
申请人： Colette Jolivet-Reynaud , Gilbert Faure , Pascal Dalbon , Michel Jolivet , Marie-Christine Bene
发明人： Colette Jolivet-Reynaud , Gilbert Faure , Pascal Dalbon , Michel Jolivet , Marie-Christine Bene
IPC分类号： A61K3800
CPC分类号： C07K16/18 , A61K38/00 , C07K14/59 , G01N33/689 , G01N2800/36
摘要： Oligopeptides containing one of SEQ ID NOs: 1-5 may be used as antigenic compounds to recognize anti-ovary antibodies. The oligopeptides may also be used as immunogenic compounds to induce the production of anti-ovary antibodies.
摘要翻译：含有SEQ ID NO：1-5之一的寡肽可以用作抗原性化合物以识别抗卵巢抗体。寡肽也可以用作免疫原性化合物以诱导抗卵巢抗体的产生。

10. 发明授权

US06890720B1 Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis 有权
标题翻译：来源于丝聚蛋白的抗原及其用于诊断类风湿关节炎的用途
公开(公告)号：US06890720B1
公开(公告)日：2005-05-10
申请号：US09254032
申请日：1997-09-01
申请人： Guy Serre , Elisabeth Girbal-Neuhauser , Christian Vincent , Michel Simon , Mireille Sebbag , Pascal Dalbon , Colette Jolivet-Reynaud , Michel Arnaud , Michel Jolivet
发明人： Guy Serre , Elisabeth Girbal-Neuhauser , Christian Vincent , Michel Simon , Mireille Sebbag , Pascal Dalbon , Colette Jolivet-Reynaud , Michel Arnaud , Michel Jolivet
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , G01N33/564 , G01N33/53 , A61K39/00 , C07K7/06
CPC分类号： G01N33/564 , C07K14/4713
摘要： The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.
摘要翻译：本发明涉及由存在于患有类风湿关节炎的患者的血清中的抗丝聚蛋白自身抗体特异性鉴定的人造抗原，并且由包含一个丝聚蛋白单元或相关分子的全部或部分序列的一种多肽组成，其中精氨酸自由基被瓜氨酸碱基取代。本发明还涉及该抗原用于诊断类风湿关节炎的用途。

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