专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110039353A1 METHOD FOR DIRECT DETECTION OF ISCHEMIA-MODIFIED ALBUMIN USING A PARTNER FOR BINDING TO AN ALDEHYDE DERIVATIVE RESULTING FROM THE PEROXIDATION OF LIPIDS IN BOUND FORM 审中-公开
标题翻译：使用合作伙伴直接检测异构体修饰的ALBUM的方法，用于结合来自于形式中脂肪过氧化物的ALDEHYDE DERIVATIVE
公开(公告)号：US20110039353A1
公开(公告)日：2011-02-17
申请号：US12865562
申请日：2009-03-10
申请人： Christine Des Rosiers , Colette Jolivet-Reynaud , Jerome Martinez
发明人： Christine Des Rosiers , Colette Jolivet-Reynaud , Jerome Martinez
IPC分类号： G01N33/566 , G01N33/68 , C07K16/18
CPC分类号： G01N33/6893 , C07K16/18 , G01N2333/765 , G01N2800/324
摘要： The present invention relates to the use of at least one partner for binding to an aldehyde derivative resulting from the peroxidation of lipids in protein-bound form, for instance to 4-hydroxy-2-nonenal, to 4-hydroxy-2-hexenal or to malondialdehyde, for the detection of ischemia-modified albumin (IMA) in a biological sample.
摘要翻译：本发明涉及至少一种配偶体与蛋白质结合形式的脂质例如4-羟基-2-壬烯醛过氧化成4-羟基-2-己烯醛的醛衍生物的结合的用途，或用于丙二醛，用于检测生物样品中的缺血 - 修饰的白蛋白（IMA）。

2. 发明申请

US20090111121A1 METHOD FOR DETECTING A BIOMARKER OF OXIDATIVE STRESS IN A BIOLOGICAL SAMPLE 有权
标题翻译：用于检测生物样品中氧化应激生物标志物的方法
公开(公告)号：US20090111121A1
公开(公告)日：2009-04-30
申请号：US12083473
申请日：2006-10-13
申请人： Christine Des Rosiers , Caroline Asselin , Bertrand Bouchard , Jean-Claudo Tardif , Blandine Comte
发明人： Christine Des Rosiers , Caroline Asselin , Bertrand Bouchard , Jean-Claudo Tardif , Blandine Comte
IPC分类号： G01N33/53 , C12Q1/02 , G01N33/68 , G01N33/92
CPC分类号： G01N33/5091 , G01N2800/32
摘要： A method for characterizing oxidative stress. The method includes dosing a ratio of HNE-to-DHN-protein in blood; comparing the ratio of HNE-to-DHN-protein in blood to a predetermined interval of ratio values associated with a predetermined level of oxidative stress; and classifying the oxidative stress as having reached the predetermined level if the ratio of HNE-to-DHN-protein in blood is within the predetermined interval of ratio values.
摘要翻译：表征氧化应激的方法。该方法包括计量血液中HNE-DHN蛋白的比例; 比较血液中HNE与DHN蛋白的比例与预定水平的氧化应激相关的预定间隔值; 并且如果血液中HNE-DHN蛋白的比例在预定的比值范围内，则将氧化应激分类为达到预定水平。

3. 发明授权

US07993859B2 Method for quantifying oxidative stress caused by different biological pathways 有权
标题翻译：用于量化不同生物学途径引起的氧化应激的方法
公开(公告)号：US07993859B2
公开(公告)日：2011-08-09
申请号：US12832176
申请日：2010-07-08
申请人： Christine Des Rosiers , Jean-Francois Lesgards , Jean-Claude Tardif
发明人： Christine Des Rosiers , Jean-Francois Lesgards , Jean-Claude Tardif
IPC分类号： G01N1/00 , G01N33/53
CPC分类号： G01N33/5091
摘要： The present invention relates to methods for detecting a oxidative stress in a biological sample, methods of determining a cumulative record of oxidative injury, and methods of diagnosing diseases of aging, such as cardiovascular diseases, based on the presence or absence of a biomarker or a component thereof. The present invention also relates to a kit for detecting oxidative stress in a biological sample comprising a stabilizing reactant and an antibody. In some embodiments of the invention, the biomarker of oxidative stress is selected from an aldehyde-protein adduct and an aldehyde metabolite-protein adduct, and the proposed method further comprises measuring separately for the same protein biomarkers of oxydative stress formed with different amino acids of the protein.
摘要翻译：本发明涉及用于检测生物样品中的氧化应激的方法，确定氧化损伤的累积记录的方法，以及基于生物标志物的存在或不存在的，诸如心血管疾病的老化疾病的诊断方法其组分。本发明还涉及用于检测包含稳定反应物和抗体的生物样品中的氧化应激的试剂盒。在本发明的一些实施方案中，氧化应激的生物标志物选自醛 - 蛋白质加合物和醛代谢物 - 蛋白质加合物，并且所提出的方法还包括分别测定与不同氨基酸形成的氧化应激相同的蛋白质生物标志物蛋白质。

4. 发明申请

US20060127383A1 Pre-conditioning cells against death 审中-公开
标题翻译：预处理细胞以致死亡
公开(公告)号：US20060127383A1
公开(公告)日：2006-06-15
申请号：US11347059
申请日：2006-02-02
申请人： Pavel Hamet , Johanne Tremblay , Christine Des Rosiers , Huifang Chen
发明人： Pavel Hamet , Johanne Tremblay , Christine Des Rosiers , Huifang Chen
IPC分类号： A61K35/14 , A61K33/00
CPC分类号： A61M1/3681 , A61M1/32 , A61M1/3683 , A61M1/3687 , A61M1/369 , A61M2202/0216 , A61M2205/053 , A61N2005/0661
摘要： Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by preconditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment ha the effect of decreasing apoptosis/necrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.
摘要翻译：治疗哺乳动物身体中的细胞凋亡和/或坏死相关疾病，即放射线暴露障碍，化学暴露和摄入障碍，神经障碍和身体创伤障碍，并通过预处理来抵消它们的发作，通过从哺乳动物体内提取等分试样血液，将提取的等分试样离体处理到氧化应激源，例如暴露于臭氧气体，温度应激器，即高于或低于体温的温度和紫外线，并将经处理的血液等分试样重新注射到哺乳动物体内。这种治疗方法是减少身体凋亡/坏死的作用，并且更好地预处理身体，以抵御随后遇到的凋亡诱导事件。

5. 发明授权

US08030010B2 Method for detecting a biomarker of oxidative stress in a biological sample 有权
标题翻译：用于检测生物样品中氧化应激生物标志物的方法
公开(公告)号：US08030010B2
公开(公告)日：2011-10-04
申请号：US12083473
申请日：2006-10-13
申请人： Christine Des Rosiers , Caroline Asselin , Bertrand Bouchard , Jean-Claude Tardif , Blandine Comte
发明人： Christine Des Rosiers , Caroline Asselin , Bertrand Bouchard , Jean-Claude Tardif , Blandine Comte
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/5091 , G01N2800/32
摘要： A method for characterizing oxidative stress. The method includes dosing a ratio of HNE-to-DHN-protein in blood; comparing the ratio of HNE-to-DHN-protein in blood to a predetermined interval of ratio values associated with a predetermined level of oxidative stress; and classifying the oxidative stress as having reached the predetermined level if the ratio of HNE-to-DHN-protein in blood is within the predetermined interval of ratio values.
摘要翻译：表征氧化应激的方法。该方法包括计量血液中HNE-DHN蛋白的比例; 比较血液中HNE与DHN蛋白的比例与预定水平的氧化应激相关的预定间隔值; 并且如果血液中HNE-DHN蛋白的比例在预定的比值范围内，则将氧化应激分类为达到预定水平。

6. 发明申请

US20100330683A1 METHOD FOR QUANTIFYING OXIDATIVE STRESS CAUSED BY DIFFERENT BIOLOGICAL PATHWAYS 有权
标题翻译：不同生物路径造成氧化应激的方法
公开(公告)号：US20100330683A1
公开(公告)日：2010-12-30
申请号：US12832176
申请日：2010-07-08
申请人： Christine Des Rosiers , Jean-François Lesgards , Jean-Claude Tardif
发明人： Christine Des Rosiers , Jean-François Lesgards , Jean-Claude Tardif
IPC分类号： G01N33/50
CPC分类号： G01N33/5091
摘要： The present invention relates to methods for detecting a oxidative stress in a biological sample, methods of determining a cumulative record of oxidative injury, and methods of diagnosing diseases of aging, such as cardiovascular diseases, based on the presence or absence of a biomarker or a component thereof. The present invention also relates to a kit for detecting oxidative stress in a biological sample comprising a stabilizing reactant and an antibody. In some embodiments of the invention, the biomarker of oxidative stress is selected from an aldehyde-protein adduct and an aldehyde metabolite-protein adduct, and the proposed method further comprises measuring separately for the same protein biomarkers of oxydative stress formed with different amino acids of the protein.
摘要翻译：本发明涉及用于检测生物样品中的氧化应激的方法，确定氧化损伤的累积记录的方法，以及基于生物标志物的存在或不存在的，诸如心血管疾病的老化疾病的诊断方法其组分。本发明还涉及用于检测包含稳定反应物和抗体的生物样品中的氧化应激的试剂盒。在本发明的一些实施方案中，氧化应激的生物标志物选自醛 - 蛋白质加合物和醛代谢物 - 蛋白质加合物，并且所提出的方法还包括分别测定与不同氨基酸形成的氧化应激相同的蛋白质生物标志物蛋白质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式