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1. 发明授权

US07959576B2 Apparatus for detecting diastolic heart failure 有权
标题翻译：用于检测舒张性心力衰竭的装置
公开(公告)号：US07959576B2
公开(公告)日：2011-06-14
申请号：US10562302
申请日：2004-05-06
申请人： Maria Torpo , Malin Öhlander , Anders Björling , Karin Ljungström
发明人： Maria Torpo , Malin Öhlander , Anders Björling , Karin Ljungström
IPC分类号： A61B5/021
CPC分类号： A61N1/3627 , A61B8/06 , A61B8/13
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one DHF parameter for detecting a DHF state of the heart of a patient. The DHF includes circuitry for determining, as the DHF parameter, the time duration of a predetermined phase of diastole. A pacemaker has such an apparatus and a control unit that optimizes pacing therapy and pacemaker settings depending on the determined time duration. A corresponding method of detecting diastolic heart failure, DHF, includes determining at least one DHF parameter for detecting a DHF state of the heart of a patient. As the DHF parameter, the time duration of a predetermined phase of diastole is determined.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有DHF确定装置，用于确定用于检测患者心脏的DHF状态的至少一个DHF参数。 DHF包括用于确定舒张期的预定阶段的持续时间作为DHF参数的电路。起搏器具有这样的装置和控制单元，其根据确定的持续时间优化起搏治疗和起搏器设置。检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个DHF参数。作为DHF参数，确定舒张期的预定相位的持续时间。

2. 发明授权

US07483742B2 Detection of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的检测
公开(公告)号：US07483742B2
公开(公告)日：2009-01-27
申请号：US10562109
申请日：2004-04-26
申请人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
发明人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61B5/02154 , A61N1/3627 , A61N1/36564 , A61N1/3702 , G06F19/00
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有用于确定用于检测患者心脏的DHF状态的至少一个血压参数的DHF确定装置。 DHF确定装置包括：压力测量单元，用于在患者的预定工作情况下测量心动周期中的脉搏压力作为血压参数，并且比较器将测量的脉搏压力与预定参考值进行比较。起搏器包括这样的装置和控制单元，其根据所测量的脉搏压力与预定参考值的比较结果优化起搏治疗。检测舒张性心力衰竭DHF的相应方法包括以下步骤：通过将作为所述血压参数的心脏周期中的脉搏压力确定为心动周期中的脉搏压力来确定用于检测患者心脏的DHF状态的至少一个血压参数患者的预定工作情况，并将确定的脉搏压力与预定的参考值进行比较。

3. 发明申请

US20100185252A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：US20100185252A1
公开(公告)日：2010-07-22
申请号：US12528496
申请日：2007-09-27
申请人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
发明人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
IPC分类号： A61N1/365 , A61B5/1455 , A61B5/1468 , A61B5/103
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： In a device and method for a medical implant for monitoring progression of heart failure in a human heart, an activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：在用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法中，活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将该水平的静脉氧含量与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

4. 发明申请

US20100324432A1 METHOD AND DEVICE TO DETECT EATING, TO CONTROL ARTIFICIAL GASTRIC STIMULATION 审中-公开
标题翻译：检测药物的方法和装置，控制人造气刺激
公开(公告)号：US20100324432A1
公开(公告)日：2010-12-23
申请号：US12526137
申请日：2007-02-21
申请人： Anders Björling , Kjell Norén , Malin Öhlander
发明人： Anders Björling , Kjell Norén , Malin Öhlander
IPC分类号： A61B5/026
CPC分类号： A61N1/36007 , A61B5/026 , A61B5/0261 , A61B5/0265 , A61B5/028 , A61B5/0295 , A61B5/0535 , A61B5/4238 , A61B5/6876 , A61B5/6884 , A61B8/06
摘要： In a method and device for detecting the intake of food in a subject at least one parameter related to the blood flow and/or perfusion of a blood vessel and/or an organ in the digestive system of a patient is monitored by a sensor attached to, or in, a blood vessel or organ of the digestive system. The value of each monitored parameter is analyzed and may be used to control the activity of a gastric stimulator.
摘要翻译：在用于检测受试者中食物摄入的方法和装置中，与患者的消化系统中的血流和/或器官的血流和/或器官相关的至少一个参数由附接到或在消化系统的血管或器官中。分析每个监测参数的值，并可用于控制胃刺激剂的活性。

5. 发明授权

US07215996B2 Bi-ventricular heart stimulating device, system and method 有权
标题翻译：双心室心脏刺激装置，系统及方法
公开(公告)号：US07215996B2
公开(公告)日：2007-05-08
申请号：US10499253
申请日：2002-10-04
申请人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
发明人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.
摘要翻译：在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值。在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。时间间隔变化，并且在许多心脏周期上监测关系。设定时间间隔使得该关系满足预定的要求。

6. 发明授权

US07164947B2 Heart stimulator with stimulation controlled by analysis of an average impedance morphology curve 失效
标题翻译：通过分析平均阻抗形态曲线控制刺激的心脏刺激器
公开(公告)号：US07164947B2
公开(公告)日：2007-01-16
申请号：US10619354
申请日：2003-07-14
申请人： Nils Holmström , Anders Björling , Kjell Norén , Karin Ljungström , Sven Kalling
发明人： Nils Holmström , Anders Björling , Kjell Norén , Karin Ljungström , Sven Kalling
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627
摘要： A heart stimulator for electric stimulation of a patient's heart has an impedance measuring unit that measures the impedance between at least two measurement electrodes implanted in a patient such that volume changes of at least one of the chambers of the left heart result in changes in the measured impedance. An analyzer analyzes the measured impedance for the control of the stimulation of the heart. A calculation unit calculates an average impedance morphology curve during a time interval of several cardiac cycles. The analyzer analyzes the average impedance morphology curve for use for the control of the stimulation to optimize the patient hemodynamics.
摘要翻译：用于对患者心脏进行电刺激的心脏刺激器具有阻抗测量单元，其测量植入患者体内的至少两个测量电极之间的阻抗，使得左心脏的至少一个腔室的体积变化导致测量的变化阻抗。分析仪分析测量的阻抗以控制心脏的刺激。计算单元在几个心动周期的时间间隔内计算平均阻抗形态曲线。分析仪分析用于控制刺激的平均阻抗形态曲线，以优化患者的血液动力学。

7. 发明授权

US08483817B2 Method and implantable medical device for assessing a degree of pulmonary edema of a patient 有权
标题翻译：用于评估患者的肺水肿程度的方法和可植入医疗装置
公开(公告)号：US08483817B2
公开(公告)日：2013-07-09
申请号：US12282912
申请日：2006-03-15
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61B5/05
CPC分类号： A61B5/0537 , A61B5/4878 , A61B2562/0219 , A61N1/3627 , A61N1/36521 , A61N1/36542
摘要： In a method and an implantable medical device for assessing a degree of pulmonary edema of a patient, at least two specific body patients of the patent are detected and at least one impedance sensing session is initiated to sense trans-thoracic impedance signals from the patient when the patient is in one of the at least two specific positions. Impedance values are obtained from the impedance signals, and a relation between respective impedance values at the at least two positions is determined. This relation is then used as a metric of pulmonary edema to assess the degree of pulmonary edema, and is provided as an output.
摘要翻译：在用于评估患者的肺水肿程度的方法和可植入医疗装置中，检测到该专利的至少两个特定身体患者，并且启动至少一个阻抗感测会话以感测来自患者的胸部阻抗信号，患者处于至少两个具体位置之一。从阻抗信号获得阻抗值，并且确定至少两个位置处的各个阻抗值之间的关系。然后将该关系用作肺水肿的度量以评估肺水肿的程度，并作为输出提供。

8. 发明授权

US08131366B2 Biventricular heart stimulator and method of controlling a biventricular heart stimulator 有权
标题翻译：双心室心脏刺激器和控制双心室心脏刺激器的方法
公开(公告)号：US08131366B2
公开(公告)日：2012-03-06
申请号：US11885326
申请日：2005-03-02
申请人： Anders Björling , Nils Holmström
发明人： Anders Björling , Nils Holmström
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.
摘要翻译：在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

9. 发明授权

US08103344B2 Method, device, implantable stimulator and dual chamber cardiac therapy system 有权
标题翻译：方法，装置，植入式刺激器和双室心脏治疗系统
公开(公告)号：US08103344B2
公开(公告)日：2012-01-24
申请号：US12446496
申请日：2006-10-31
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/36578 , A61N1/3688
摘要： In a device and method in a dual chamber pacing system operating in an atrial synchronized mode, the cardiac stimulator is connectable to a lead arrangement arranged for sensing atrial electrical and mechanical activity. Upon detection of an atrial arrhythmia based on either of sensed atrial mechanical activity, atrial electrical activity, or a combination thereof, a mode switch from an atrial synchronized ventricle stimulating mode to a non-atrial synchronized mode is triggered.
摘要翻译：在以心房同步模式操作的双室起搏系统中的装置和方法中，心脏刺激器可连接到布置用于感测心房电和机械活动的引线装置。在基于感测到的心房机械活动，心房电活动或其组合中的任一种检测到心房心律失常时，触发从心房同步心室刺激模式到非心房同步模式的模式切换。

10. 发明授权

US07953487B2 Heart stimulating device 有权
标题翻译：心脏刺激装置
公开(公告)号：US07953487B2
公开(公告)日：2011-05-31
申请号：US11917799
申请日：2005-06-16
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/00
CPC分类号： A61B5/1118 , A61B5/01 , A61N1/3627 , A61N1/36542 , A61N1/3655 , A61N1/3702
摘要： An implantable heart stimulating device for indicating congestive heart failure (CHF) has a processor, an activity sensor that generates an activity signal indicative of a patient's activity, and a blood temperature sensor that measures blood temperature inside the heart of the patient and generates a temperature signal indicative of the measured temperature. From the activity signal and the temperature signal, the processor identifies a characteristic dip in the temperature signal related to a predetermined increase in the activity signal. The processor determines a CHF indicator value indicating the degree of CHF based on the magnitude of the temperature sensor dip for at least two increased activity levels.
摘要翻译：用于指示充血性心力衰竭（CHF）的可植入心脏刺激装置具有处理器，产生指示患者活动的活动信号的活动传感器和测量患者心脏内的血液温度并产生温度的血液温度传感器指示测量温度的信号。根据活动信号和温度信号，处理器识别与活动信号的预定增加相关的温度信号中的特征下降。处理器根据至少两个增加的活动水平的温度传感器倾角的大小来确定指示CHF程度的CHF指示符值。

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