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1. 发明授权

US07482147B2 Ubiquitin protease 失效
标题翻译：泛素蛋白酶
公开(公告)号：US07482147B2
公开(公告)日：2009-01-27
申请号：US11313836
申请日：2005-12-21
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
IPC分类号： C12N9/48 , C12N15/00 , C12Q1/00 , C12Q1/68 , C12P21/04 , C07H21/04
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明申请

US20090269350A1 Novel 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC1C, NARC 1A, NARC 25, 86604 and 32222 molecules and uses therefor 失效
标题翻译：新的27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A ，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B，NARC 9，NARC2A，NARC 16B，NARC1C， NARC 1A，NARC 25,86604和32222分子及其用途
公开(公告)号：US20090269350A1
公开(公告)日：2009-10-29
申请号：US12316681
申请日：2008-12-16
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/00 , C07K14/00 , C07K16/00 , C12P21/06 , C12Q1/68 , G01N33/53 , A61K31/7088 , A61K38/16
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 20A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 20A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

3. 发明申请

US20100291099A1 NOVEL 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 AND 32222 MOLECULES AND USES THEREFOR 审中-公开
标题翻译：新的27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A ，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B，NARC 9，NARC2A，NARC 16B，NARC 1C ，NARC 1A，NARC 25,86604和32222分子及其用途
公开(公告)号：US20100291099A1
公开(公告)日：2010-11-18
申请号：US12817236
申请日：2010-06-17
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
IPC分类号： A61K39/395 , A61K38/45 , C12Q1/68 , G01N33/53 , C12P21/02 , C12N9/12 , C12N5/10 , C12N1/21 , G01N33/566 , A61K38/17 , A61K31/7088 , C07K14/47 , C07K16/18 , C07H21/04 , A61P35/00 , A61P11/00 , A61P13/08 , A61P1/16 , A61P9/04 , A61P9/10 , A61P25/28 , A61P25/16 , A61P17/00 , A61P35/02
CPC分类号： C12Q1/48 , C12N9/1288 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/08005 , G01N2333/91 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 20A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 20A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

4. 发明授权

US07029895B2 27411, a novel human PGP synthase 失效
标题翻译： 27411，一种新型人类PGP合成酶
公开(公告)号：US07029895B2
公开(公告)日：2006-04-18
申请号：US10426776
申请日：2003-04-30
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
IPC分类号： C12N9/12 , C12N15/00 , C07H21/04 , C07K1/00
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4， NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B ，NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

5. 发明申请

US20090068187A1 Novel 14275, 54420, 8797, 27439, 68730, 69112 and 52908 molecules and uses therefor 审中-公开
标题翻译：小分子14275,5420,8797,27439,66830,69112和52908分子及其用途
公开(公告)号：US20090068187A1
公开(公告)日：2009-03-12
申请号：US11903752
申请日：2007-09-24
申请人： Maria A. Glucksmann , Rory A.J. Curtis , Fong-Ying Tsai , Martin R. Hodge , Rachel E. Meyers , Kyle J. MacBeth , Rajasekhar Bandaru
发明人： Maria A. Glucksmann , Rory A.J. Curtis , Fong-Ying Tsai , Martin R. Hodge , Rachel E. Meyers , Kyle J. MacBeth , Rajasekhar Bandaru
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/705 , C07K16/28 , C12P21/02 , C12Q1/68 , A61K31/7088 , A61K38/17 , G01N33/567 , G01N33/68 , C12N5/06 , C07K1/113 , A61K38/02
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K2319/00 , C07K2319/02 , C12N9/0071 , C12N9/1051 , C12N9/1205
摘要： The invention provides isolated nucleic acids molecules, designated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14275, 54420, 8797, 27439, 68730, 69112 or 52908 gene has been introduced or disrupted. The invention still further provides isolated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 proteins, fusion proteins, antigenic peptides and anti-14275, 54420, 8797, 27439, 68730, 69112 or 52908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为14275,54420,8797,27439,67830,69112或52908核酸分子。本发明还提供反义核酸分子，含有14275,54420,8797,27439,67830,69112或52908核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中14275， 54420,8797,27439,67830,69112或52908基因被引入或破坏。本发明还进一步提供分离的14275,54420,8797,27439,68730,69112或52908蛋白，融合蛋白，抗原肽和抗-14275,54420,8797,27439,68730,69112或52908抗体。还提供了利用本发明组合物的诊断和治疗方法。

6. 发明授权

US06900303B2 57658, a novel human uridine kinase and uses thereof 失效
标题翻译： 57658，一种新的人尿苷激酶及其用途
公开(公告)号：US06900303B2
公开(公告)日：2005-05-31
申请号：US09896522
申请日：2001-06-28
申请人： Maria A. Glucksmann
发明人： Maria A. Glucksmann
IPC分类号： C12N9/12 , C12N15/54 , C07H21/04 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： C12N9/1205 , C12Y207/01048
摘要： The invention provides isolated nucleic acids molecules, designated 57658 nucleic acid molecules, which encode novel uridine kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 57658 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 57658 gene has been introduced or disrupted. The invention still further provides isolated 57658 proteins, fusion proteins, antigenic peptides and anti-57658 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的尿苷激酶家族成员的分离的核酸分子，命名为57658核酸分子。本发明还提供了反义核酸分子，含有57658个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏57658基因的非人转基因动物。本发明还进一步提供分离的57658蛋白，融合蛋白，抗原肽和抗-57658抗体。还提供了利用本发明组合物的诊断方法。

7. 发明申请

US20110171205A1 NOVEL 15571, 2465, 14266, 2882, 52871, 8203 AND 16852 MOLECULES AND USES THEREFOR 审中-公开
标题翻译：新型15571,2245,14266,2882,52871,8203和16852分子及其用途
公开(公告)号：US20110171205A1
公开(公告)日：2011-07-14
申请号：US13012890
申请日：2011-01-25
申请人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
发明人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC分类号： A61K39/395 , C07H21/04 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , C12Q1/68 , G01N33/53 , A61K38/17 , A61K31/7088 , C12N15/11 , C12N1/21 , A61P25/00 , A61P19/02 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/00 , A61P9/04 , A61P35/00 , A61P3/10 , A61P15/02
CPC分类号： C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。还提供了利用本发明组合物的诊断和治疗方法。

8. 发明授权

US06979564B2 80090, human fucosyltransferase nucleic acid molecules and uses thereof 失效
标题翻译： 80090，人岩藻糖基转移酶核酸分子及其用途
公开(公告)号：US06979564B2
公开(公告)日：2005-12-27
申请号：US10080960
申请日：2001-10-19
申请人： Maria A. Glucksmann , Rachel Meyers
发明人： Maria A. Glucksmann , Rachel Meyers
IPC分类号： C07K14/705 , C12N9/10 , C12N9/16 , C12N15/12 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/10 , C07K14/705 , C12N9/16
摘要： The invention provides isolated nucleic acids molecules, designated 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, which encode novel fucosyltransferase, seven transmembrane receptor, or RhoGAP family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 80090, 52874, 52880, 63497, or 33425 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an 80090, 52874, 52880, 63497, or 33425 gene has been introduced or disrupted. The invention still further provides isolated 80090, 52874, 52880, 63497, or 33425 proteins, fusion proteins, antigenic peptides and anti-80090, 52874, 52880, 63497, or 33425 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为80090,52874,52880,63497或33425核酸分子，其编码新的岩藻糖基转移酶，七个跨膜受体或RhoGAP家族成员。本发明还提供反义核酸分子，含有80090,52874,52880,63497或33425核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人类转基因动物，其中80090,528744,52880 ，63497或33425基因已被引入或破坏。本发明还进一步提供分离的80090,52874,52880,63497或33425蛋白质，融合蛋白质，抗原肽和抗-80090,52874,52880,63497或33425抗体。还提供了利用本发明组合物的诊断方法。

9. 发明申请

US20090226450A1 Novel 15571, 2465, 14266, 2882, 52871, 8203 and 16852 molecules and uses therefor 审中-公开
标题翻译：小分子15571,2245,14266,2882,52871,8203和16852分子及其用途
公开(公告)号：US20090226450A1
公开(公告)日：2009-09-10
申请号：US12386856
申请日：2009-04-23
申请人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
发明人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC分类号： A61K39/395 , C12N15/11 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , G01N33/566 , G01N33/53 , C12Q1/68 , A61K38/02 , A61K38/16 , A61K31/7088
CPC分类号： C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。还提供了利用本发明组合物的诊断和治疗方法。

10. 发明申请

US20090226448A1 Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor 审中-公开
标题翻译：小分子18607,15603,69318,12303,48000,52202,5333,38554,57301,58324,55063,52991,59914,59921和33751分子及其用途
公开(公告)号：US20090226448A1
公开(公告)日：2009-09-10
申请号：US12381747
申请日：2009-03-16
申请人： Maria A. Glucksmann , Rory A.J. Curtis , Jose M. Lora , Katherine M. Galvin , Inmaculada Silos-Santiago
发明人： Maria A. Glucksmann , Rory A.J. Curtis , Jose M. Lora , Katherine M. Galvin , Inmaculada Silos-Santiago
IPC分类号： A61K39/395 , C12N15/12 , C12N5/10 , C07K14/47 , C07K16/18 , C12P21/02 , C12Q1/68 , G01N33/566 , A61K31/7105 , A61K38/48 , A61K38/17 , A61P35/00 , A61P43/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。还提供了利用本发明组合物的诊断和治疗方法。

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