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1. 发明授权

US6117979A Process for making a bioprosthetic device and implants produced therefrom 失效
标题翻译：用于制造生物假体装置和由其制造的植入物的方法
公开(公告)号：US6117979A
公开(公告)日：2000-09-12
申请号：US912392
申请日：1997-08-18
申请人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Raymond Zeeman , Piet Dijkstra , Jan Feijen
发明人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Raymond Zeeman , Piet Dijkstra , Jan Feijen
IPC分类号： A61F2/00 , A61L27/24 , A61L27/36 , C08H1/06 , A61K38/17 , A61F2/02
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3687 , C08H1/06 , A61F2310/00365 , Y10S530/84 , Y10S623/90 , Y10S623/901
摘要： Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collagen-based material in an aqueous medium at an acidic pH to react a portion of the collagen carboxyl groups with the epoxy functionalized crosslinking agent to form crosslinked collagen-based material comprising residual collagen carboxyl groups.
摘要翻译：提供由具有胶原胺基和胶原羧基的胶原基材料制成的生物假体装置及其形成方法。所述方法包括将环氧官能化交联剂与基于胶原的材料在水性介质中在酸性pH下组合以使部分胶原羧基与环氧官能化交联剂反应以形成包含残留胶原羧基的交联胶原基材料。

2. 发明授权

US5350800A Method for improving the biocompatibility of solid surfaces 失效
标题翻译：提高固体表面生物相容性的方法
公开(公告)号：US5350800A
公开(公告)日：1994-09-27
申请号：US5711
申请日：1993-01-19
申请人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
发明人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
IPC分类号： A61L27/00 , A61L29/00 , A61L33/00 , A61L33/10 , A61F2/54 , A61F2/02 , A61K9/22
CPC分类号： A61L33/0029 , A61L33/0041 , A61L33/0047 , A61L33/0088
摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.
摘要翻译：通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法到胺化的固体表面，然后选择性地将羧基还原成生物分子。羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

3. 发明授权

US6024918A Method for attachment of biomolecules to surfaces of medical devices 失效
标题翻译：将生物分子附着到医疗器械表面的方法
公开(公告)号：US6024918A
公开(公告)日：2000-02-15
申请号：US41497
申请日：1998-03-13
申请人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Edouard Koulik , Mirian Gillissen
发明人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Edouard Koulik , Mirian Gillissen
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L33/00 , A61M1/14 , A61M37/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/236 , A61L2300/42 , A61L2300/606 , A61L2400/18
摘要： A method for making a medical device having a biomolecule immobilized on a substrate surface is provided. The method includes coating the substrate surface with an amino-functional polysiloxane; and contacting the amino-functional polysiloxane coated surface with a biomolecule under conditions effective to immobilize the biomolecule.
摘要翻译：提供一种制造具有固定在基板表面上的生物分子的医疗装置的方法。该方法包括用氨基官能的聚硅氧烷涂覆基材表面; 并在有效固定生物分子的条件下使氨基官能的聚硅氧烷涂覆的表面与生物分子接触。

4. 发明授权

US06746481B1 Implatable device including a polyamino acid component 失效
标题翻译：包括聚氨基酸组分的可植入装置
公开(公告)号：US06746481B1
公开(公告)日：2004-06-08
申请号：US09340440
申请日：1999-06-28
申请人： Vincent Larik , Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan
发明人： Vincent Larik , Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan
IPC分类号： A61F206
CPC分类号： A61M25/0045 , A61L31/06 , A61L31/16 , A61L2300/214 , A61M2025/0056 , C08L77/00
摘要： An implantable device for reducing restenosis includes a structure including a polyamino acid component, wherein the polyamino acid component can be in the form of a coating or a film on the structure or it can be an integral part of the structure.
摘要翻译：用于减少再狭窄的可植入装置包括包括聚氨基酸组分的结构，其中聚氨基酸组分可以是结构上的涂层或膜的形式，或者其可以是结构的组成部分。

5. 发明授权

US5767108A Method for making improved heparinized biomaterials 失效
标题翻译：改善肝素化生物材料的方法
公开(公告)号：US5767108A
公开(公告)日：1998-06-16
申请号：US518147
申请日：1995-08-22
申请人： Patrick Cahalan , Theo Lindhout , Benedict Fouache , Michel Verhoeven , Linda Cahalan , Marc Hendriks , Ron Blezer
发明人： Patrick Cahalan , Theo Lindhout , Benedict Fouache , Michel Verhoeven , Linda Cahalan , Marc Hendriks , Ron Blezer
IPC分类号： A61L33/00 , A61L33/12 , A61K31/70
CPC分类号： A61L33/0029 , A61L33/128 , Y10S514/802 , Y10S514/822
摘要： A method of treating a patient with a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophlactic properties of ATIII/heparin are obtained.
摘要翻译：在患有共价连接的肝素化表面的血液接触表面上用具有固定化肝素的医疗装置治疗患者的方法，所述吸附蛋白可被固定化肝素激活以阻断纤维蛋白原的凝结。抗凝血酶III是优选的吸附蛋白。吸附的蛋白质保持在固定化的肝素表面上，直到医疗装置与患者的血液接触。当与患者的血液接触时，吸附的蛋白质将阻止在生物材料 - 血液界面处的初始凝血酶形成。 ATIII的预吸附在有利于最大肝素/ ATIII结合的条件下完成。当预吸附的表面与全血接触时，获得了ATIII /肝素的前体特性的最大优点。

6. 发明授权

US07442205B2 Stents and methods for preparing stents from wires having hydrogel coating layers thereon 失效
标题翻译：用于从其上具有水凝胶涂层的线制备支架的支架和方法
公开(公告)号：US07442205B2
公开(公告)日：2008-10-28
申请号：US11181495
申请日：2005-07-13
申请人： Michel Verhoeven , Linda Lee Cahalan , Patrick Cahalan , Vincent Larik
发明人： Michel Verhoeven , Linda Lee Cahalan , Patrick Cahalan , Vincent Larik
IPC分类号： A61F2/06
CPC分类号： A61L31/145 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.
摘要翻译：公开了其上具有水凝胶涂层的可径向扩张的支架，以及制备这种支架的方法。所述方法包括用包含溶剂和在溶剂中的水溶性聚合物的溶液涂覆线材，蒸发溶剂以在线材上提供聚合物涂层，并交联聚合物涂层以在线材上提供水凝胶涂层。涂覆的线可以制成支架，其优选地具有基本均匀的具有低表面粗糙度的涂层。优选地，涂层具有亲水性质并提供生物相容性表面。涂层还可以提供将生物活性剂递送到体内。

7. 发明授权

US06303179B1 Method for attachment of biomolecules to surfaces through amine-functional groups 失效
标题翻译：通过胺官能团将生物分子附着到表面的方法
公开(公告)号：US06303179B1
公开(公告)日：2001-10-16
申请号：US09245834
申请日：1999-02-08
申请人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Judith Vincent
发明人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Judith Vincent
IPC分类号： A61L5103
CPC分类号： A61L33/0029
摘要： A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source of hydroxide ions and a source of hypohalite ions at a temperature of at least about 20° C. for a time effective to convert at least a portion of the amide-functional groups to amine-functional groups to form a substrate surface comprising an amine-functional polymer, wherein the hydroxide ions are present in a molar excess relative to the hypohalite ions and at a concentration of no more than about 0.1 M, based on the total volume of the reaction mixture. A biomolecule is attached to the resultant amine-functional polymer.
摘要翻译：一种改变其上具有酰胺官能聚合物的表面的基材的表面特性的方法。该方法包括在至少约20℃的温度下将酰胺官能聚合物与氢氧根离子源和次卤酸盐离子源接触，将有效的至少一部分酰胺官能团转化成胺功能基团以形成包含胺官能聚合物的底物表面，其中氢氧根离子相对于次卤酸盐离子以摩尔过量存在，并且以不超过约0.1M的浓度，基于反应的总体积混合物。将生物分子连接到所得的胺官能聚合物上。

8. 发明申请

US20050251250A1 Stents and methods for preparing stents from wires having hydrogel coating layers thereon 失效
标题翻译：用于从其上具有水凝胶涂层的线制备支架的支架和方法
公开(公告)号：US20050251250A1
公开(公告)日：2005-11-10
申请号：US11181495
申请日：2005-07-13
申请人： Michel Verhoeven , Linda Cahalan , Patrick Cahalan , Vincent Larik
发明人： Michel Verhoeven , Linda Cahalan , Patrick Cahalan , Vincent Larik
IPC分类号： A61F2/86 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61L31/145 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.
摘要翻译：公开了其上具有水凝胶涂层的可径向扩张的支架，以及制备这种支架的方法。所述方法包括用包含溶剂和在溶剂中的水溶性聚合物的溶液涂覆线材，蒸发溶剂以在线材上提供聚合物涂层，并交联聚合物涂层以在线材上提供水凝胶涂层。涂覆的线可以制成支架，其优选地具有基本均匀的具有低表面粗糙度的涂层。优选地，涂层具有亲水性质并提供生物相容性表面。涂层还可以提供将生物活性剂递送到体内。

9. 发明授权

US6143354A One-step method for attachment of biomolecules to substrate surfaces 失效
标题翻译：将生物分子附着到基底表面的一步法
公开(公告)号：US6143354A
公开(公告)日：2000-11-07
申请号：US245840
申请日：1999-02-08
申请人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan
发明人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan
IPC分类号： A61L27/34 , A61L33/00 , A61L15/00 , A61L27/00 , H05H1/00
CPC分类号： A61L33/0011 , A61L27/34
摘要： A method of modifying the surface characteristics of a substrate, particularly a polymeric material. The method involves grafting ethylenically unsaturated monomers and attaching biomolecules, such as heparin, to the surface of the substrate, such as a polymeric material, in one step using an oxidizing metal, such as ceric ions.
摘要翻译：改进基材，特别是聚合物材料的表面特性的方法。该方法包括使用氧化金属如铈离子在一个步骤中接枝烯键式不饱和单体并将生物分子如肝素附着到基底表面，例如聚合物材料。

10. 发明授权

US06463335B1 Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive 失效
标题翻译：临时医用电线带电极安装垫，带有可生物降解的粘合剂
公开(公告)号：US06463335B1
公开(公告)日：2002-10-08
申请号：US09518352
申请日：2000-03-03
申请人： Kuno Münch , Marc Hendriks , Michel Verhoeven
发明人： Kuno Münch , Marc Hendriks , Michel Verhoeven
IPC分类号： A61N100
CPC分类号： A61L24/104 , A61K38/39 , A61L24/102 , A61N1/0587
摘要： A temporary cardiac electrical stimulating lead is disclosed having a stimulating electrode mounted in or on an electrode mounting pad disposed at a distal end of the lead, the pad having a biodegradable adhesive disposed thereon and/or therewithin. The adhesive, and preferably also the electrode mounting pad, are capable of biodegradably dissolving over time in human body fluids. The adhesive permits the electrode mounting pad to be attached to a patient's epicardium without the use of sutures, or with fewer sutures than have heretofore been required to suitably affix an electrode mounting pad to a patient's heart. In a preferred embodiment, when the lead body is pulled away from the electrode mounting pad and removed from a patient, any portion of the electrode mounting pad and the adhesive remaining within the patient dissolves over time and disappears.
摘要翻译：公开了一种暂时的心电刺激引线，其具有安装在设置在引线的远端的电极安装垫中或其上的刺激电极，该垫具有设置在其上和/或其内的可生物降解的粘合剂。粘合剂，并且优选地也是电极安装垫，能够随着时间而生物降解地溶解在人体液体中。粘合剂允许电极安装垫连接到患者的心外膜，而不使用缝合线，或者与迄今为止将电极安装垫适当地固定到患者心脏所需的缝合线较少。在优选实施例中，当将引线主体从电极安装垫拉离并从患者移除时，电极安装垫的任何部分和残留在患者内的粘合剂随时间而溶解并消失。

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